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Tittel SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS
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Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP4069691
Europeisk (EP) publiserings nummer EP4069691
EP levert
EP søknadsnummer 20825397.1
EP meddelt info
Prioritet 2019.12.06, US 201962944869 P
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Vertex Pharmaceuticals Incorporated (US)
Oppfinner DURRANT, Steven, John (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Krav

Patentkrav1. Forbindelse med formel (I)eller et farmasøytisk akseptabelt salt derav, hvor:X2a er N, N+-O- eller C-R2a;X4a er N, N+-O- eller C-R4a;X5a er N, N+-O- eller C-R5a;X6a er N, N+-O- eller C-R6a;hver R uavhengig er H eller C1-C6-alkyl;hver av R2a, R4a, R5a og R6a uavhengig er H, halo, C1-C6-alkyl eller C1-C6 haloalkyl;hver av R4b1 og R4b2 uavhengig er H, C1-C6-alkyl, C3-C6-sykloalkyl eller C1-C6-haloalkyl;hver av R5b1 og R5b2 uavhengig er H, C1-C6-alkyl, C3-C6-sykloalkyl eller C1-C6-haloalkyl;X3c er N eller C-R3c;X4c er N eller C-R4c;X5c er N eller C-R5c;X6c er N eller C-R6c;R2c er H, OH, halo, C1-C6-alkyl, C2-C6-alkenyl, C1-C6-haloalkyl, C1-C6-alkoksy, C1-C6-haloalkoksy eller -L1-L2-(C3-C6-sykloalkyl), hvor sykloalkylet eventuelt er substituert med 1-2 halo;L1 er en binding eller O;L2 er en binding eller C1-C6-alkylen;R3c er H, halo, C1-C6-alkyl eller C1-C6-haloalkyl;R4c er H, halo, C1-C6-alkyl eller C1-C6-haloalkyl;R5c er H, halo, C1-C6-alkyl eller C1-C6-haloalkyl; ogR6c er H, halo, C1-C6-alkyl eller C1-C6-haloalkyl;forutsatt at ikke mer enn to av X2a, X4a, X5a og X6a er N eller N+-O-; ogforutsatt at ikke mer enn én av X3c, X4c, X5c og X6c er N.2. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt derav, hvor:x2a er C-R2a;X5a er C-R5a;X6a er C-R6a; hver av R4b1 og R4b2 uavhengig er H, C1-C6-alkyl eller C1-C6-haloalkyl;hver av R5b1 og R5b2 uavhengig er H, C1-C6-alkyl eller C1-C6-haloalkyl;X3c er C-R3c;X4c er C-R4c;X5c er C-R5c;X6c er C-R6c; ogR2c er H, OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoksy eller C1-C6-haloalkoksy.3. Forbindelse ifølge krav 1 eller 2, hvor forbindelsen har formel (I-A)eller et farmasøytisk akseptabelt salt derav.4. Forbindelse ifølge krav 1 eller 2, hvor forbindelsen har formel (I-B)eller et farmasøytisk akseptabelt salt derav.5. Forbindelse ifølge et hvilket som helst av kravene 1-4, eller et farmasøytisk akseptabelt salt derav, hvor:(a) X4a er C-R4a og R4a er H eller halo; eller hvor X4a er N; og/eller(b) hver R er H eller CH3, eventuelt hvor hver R er H; og/eller(c) X2a er C-R2a; og R2a er H, halo eller C1-C6-alkyl, eventuelt hvor X2a er C-R2a; og R2a er H; og/eller (d) X5a er C-R5a; og R5a er H, halo eller C1-C6-alkyl; eventuelt hvor X5a er C-R5a; og R5a er H; og/eller (e) X6a er C-R6a; og R6a er H, halo eller C1-C6-alkyl; eventuelt hvor X6a er C-R6a; og R6a er H; og/eller (f) hver av R4b1 og R4b2 uavhengig er H, C1-C6-alkyl eller C3-C6-sykloalkyl; eller hver av R4b1 ogR4b2 uavhengig er H eller C1-C6-alkyl; eller hver av R4b1 og R4b2 uavhengig er H eller CH3; eller R4b1 er C1-C6-alkyl og R4b2 er H; eller R4b1 er H og R4b2 er C1-C6-alkyl; eller R4b1 er CH3 og R4b2 er H; eller R4b1 er H og R4b2 er CH3; og/eller (g) hver av R5b1 og R5b2 uavhengig er H, C1-C6-alkyl eller C1-C6-haloalkyl; eller hver av R5b1 og R5b2 uavhengig er C1-C6-alkyl eller C1-C6-haloalkyl; eller hver av R5b1 og R5b2 uavhengig er H, CH3 eller CF3; eller R5b1 er C1-C6-alkyl og R5b2 er C1-C6-haloalkyl; eller R5b1 er C1-C6-haloalkyl og R5b2 er C1-C6-alkyl; eller R5b1 er CH3 og R5b2 er CF3; eller R5b1 er CF3 og R5b2 er CH3; og/eller(h) R2c er OH, C1-C6-alkoksy eller C1-C6-haloalkoksy; og/eller(i) X3c er C-R3c, eventuelt hvor R3c er H, halo eller C1-C6-alkyl; og/eller(j) X4c er C-R4c; og R4c er H, halo eller C1-C6-haloalkyl, eventuelt hvor R4c er halo; og/eller(k) X5c er C-R5c; og R5c er H eller halo, eventuelt hvor R5c er H; og/eller(l) X6c er C-R6c; og R6c er H eller halo, eventuelt hvor R6c er H.6. Forbindelse ifølge krav 1, eller et farmasøytisk akseptabelt salt derav, hvor forbindelsen er valgt fra:7. Forbindelse ifølge krav 1, eller et farmasøytisk akseptabelt salt derav, hvor forbindelsen er valgt fra:(2R,3R,4R,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3R,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid, (2R,3S,4R,SR)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-[2-(difluormetoksy)-4-fluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4R,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-[2-metoksy-3-(trifhiorometyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-[2-metoksy-3-(trifluormetyl)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4R,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5R)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5S)-4-[[3-[3-(difluormetyl)-4-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,5R)-N-(3-karbamoyl-4-fhioro-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4R,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid, (2R,3R,4R,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4S,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4R,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4R,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4S,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4R,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4R,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4S,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4S,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4R,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4S,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4S,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4R,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4S,5R)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4S,5S)-N-(3-karbamoylfenyl)-3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, (2S,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3R,4R,SR)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, (2S,3S,4R,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(2-etoksy-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3R,4R,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3R,4R,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3R,4S,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3S,4R,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3R,4R,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3R,4S,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3S,4R,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3R,4R,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3S,4S,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3R,4S,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3S,4R,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3S,4S,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3R,4S,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3S,4R,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3S,4S,5R)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2S,3S,4S,5S)-3-[3,4-difluor-2-(trideuteriometoksy)fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid, 4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-1-oksido-pyridin-1-ium-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid, (2R,3R,4R,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofiiran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3-klor-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-N-metyl-pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5 - (trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(4-fluor-2-hydroksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[5-tert-butyl-3-(3,4-difluor-2-metoksy-fenyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (25,3S,5S)-4-[[3-(4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3 S,5 S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-[2-(difluormetoksy)-4-fluor-fenyl]-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,5S)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(2,4-difluor-3-metyl-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(3-etyl-4-fluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,5R)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(25,3S,5S)-4-[[3-(2-fluor-6-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(2,2,2-trifluoretyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,5S)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(25,3S,5S)-4-[[5-(1,1-difluoretyl)-3-(3,4-difluor-2-metoksy-fenyl)-5-metyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5S)-4-[[3-(3,4-difluor-2-isopropoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3,4-difluorfenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4-etyl-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-m etyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[4-syklopropyl-3-(3,4-difluor-2-metoksy-fenyl)-5-metyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(difluormetyl)-4,5-dimetyltetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5,5-trimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,SR)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifhiorometyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifhiorometyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(3,4-difluor-2-metoksy-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5R)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,5S)-4-[[3-(4-fluor-2-metoksy-3-metyl-fenyl)-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-5-isopropyl-4-metyl-tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,6-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid, 6-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,6-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrazin-2-karboksamid,5-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid, 5-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,5-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-3-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -5 -metyl-pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid, 4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,2-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3R,4S,5R)-3-(3,4-difhioro-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid, 2-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,2-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-4-karboksamid,6-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,6-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid, 6-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyrimidin-4-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-fluor-pyridin-2-karboksamid,(2R,3R,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid, (2R,3R,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3R,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4R,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2R,3S,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3R,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4R,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4S,5R)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,(2S,3S,4S,5S)-N-(3-karbamoyl-4-fluor-fenyl)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karboksamid,5-deuterio-4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 5-deuterio-4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,5-deuterio-4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid, 4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid, 4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-fluor-pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid, 4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-6-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -3 -metyl-pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -3 -metyl-pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid, 4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -3 -metyl-pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-3-metyl-pyridin-2-karboksamid,3-deuterio-4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,3-deuterio-4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 3-deuterio-4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 3-deuterio-4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 3-deuterio-4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 6-deuterio-4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3,4-difluor-2-metyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,2R,3R,4R,5S-4- 3-4-difluormet l-3-fluor-2-metoks -fen l-4,5-dimet l-5-trifluormet l tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,SR)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,SR)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5 S)-4- [[3 - [4-(difluormetyl)-3 -fluor-2-metoksy-fenyl] -4,5 -dimetyl-5 - (trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,SR)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(25,3 S,4R,SR)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(25,3 S,4S,5 R)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(25,3 S,4S,5 S)-4-[[3-[4-(difluormetyl)-3-fluor-2-metoksy-fenyl]-4,5-dimetyl-5-(trifluormetyl) tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,SR)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5 S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,SR)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3 S,4R,SR)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-trifluormet ltetrah drofuran-2-karbon lamino ridin-2-karboksamid, (2S,3R,4R,5R)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4R,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5R)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5R)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5R)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5R)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5S)-4-[[3-[2-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4R,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4R,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3 S,4R,SR)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4R,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4R,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5R)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5S)-4-[[3-[4-metoksy-6-(trifluormetyl)-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4R,SR)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4R,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5R)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5R)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4R,5R)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4S,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4R,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4R,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5R)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,SR)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5R)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3S,4S,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5R)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4S,5S)-4-[[3-[6-(difluormetyl)-2-metoksy-3-pyridyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2R,3R,4R,5R)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,SR)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3 S,4S,SR)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluor,ometyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3S,4R,5R)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3-metoksy-2-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4R,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3R,4S,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, (2S,3R,4S,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2S,3S,4S,5S)-4-[[3-(3-metoksy-2-metyl-4-pyridyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4- [[(2R,3 S,4R,5R)-3 - [2- [(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl] -4,5 -dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4- [[(2 S,3 S,4R,5R)-3 - [2- [(3,3 -difluorsyklobutyl)metoksy] -3,4-difluor-fenyl] -4,5 -dimetyl-5 -(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4- [[(2 S,3 R,4 S,5 S)-3 - [2- [(3,3 -difluorsyklobutyl)metoksy] -3,4-difluor-fenyl] -4,5 -dimetyl-5 -(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 4-[[(2S,3S,4S,5R)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-[2-[(3,3-difluorsyklobutyl)metoksy]-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5- (trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-[2-(syklobutoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 4-[[(2R,3R,4R,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S, 3S,4R, 5R)-3-(5-deuterio-3,4-difluor-2-metoksy -fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(5-deuterio-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 4-[[(2R,3R,4S,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(3,4-difluor-2-vinyl-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,(2R,3R,4R,5R)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2R,3R,4R,5S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -5 -metyl-pyridin-2-karboksamid,(2R,3R,4S,5R)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -5 -metyl-pyridin-2-karboksamid,(2R,3S,4R,5R)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid, (2S,3R,4R,5R)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2R,3R,4S,5S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2R,3S,4R,5S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2S,3R,4R,5 S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2R,3 S,4S,SR)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2S,3R,4S,SR)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2S,3S,4R,5R)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2R,3S,4S,5S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2S,3R,4S,5S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2S,3S,4R,5S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]-5-metyl-pyridin-2-karboksamid,(2S,3S,4S,5R)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -5 -metyl-pyridin-2-karboksamid, (25,3 S,4S,5 S)-4-[[3-[2-(difluormetoksy)-3,4-difluor-fenyl]-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino] -5 -metyl-pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 4-[[(2R,3S,4R,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5S)-3-(5-klor-3,4-difluor-2-metoksy-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4R,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3R,4S,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4R,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4R,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid, 4-[[(2R,3S,4S,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2R,3S,4S,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3R,4S,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4R,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid,4-[[(2S,3S,4S,5R)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid og4-[[(2S,3S,4S,5S)-3-(2-etyl-3,4-difluor-fenyl)-4,5-dimetyl-5-(trifluormetyl)tetrahydrofuran-2-karbonyl]amino]pyridin-2-karboksamid.8. Forbindelse ifølge et hvilket som helst av kravene 1-7.9. Forbindelse ifølge krav 8, hvor forbindelsen har formel10. Forbindelse ifølge krav 8, hvor forbindelsen har formel11. Forbindelse ifølge krav 8, hvor forbindelsen har formel 12. Forbindelse ifølge krav 8, hvor forbindelsen har formel13. Forbindelse ifølge krav 8, hvor forbindelsen har formelhvor forbindelsen har den absolutte stereokjemien til den tredje eluerende isomeren når en blanding av racemiske diastereomerer (epimere i 5-posisjonen) er atskilt av chiral SFC med bruk av a (R,R) 25 cm x 21,2 mm, 1-(3,5-dinitrobenzamido)-1,2,3,4-tetrahydrofenantren-modifisert 5 µm silika-søyle.14. Forbindelse ifølge krav 8, hvor forbindelsen har formel15. Forbindelse ifølge krav 8, hvor forbindelsen har formel hvor forbindelsen har den absolutte stereokjemien til den andre eluerende isomeren når en racemisk blanding av enantiomerer er atskilt av chiral SFC med bruk av en 25 cm x 10 mm søyle omfattende amylose-tris-[(S)-αmetylbenzylkarbamat] belagt på 5 µm silika.16. Farmasøytisk sammensetning omfattende forbindelsen ifølge et hvilket som helst av kravene 1-7, eller et farmasøytisk akseptabelt salt derav, eller forbindelsen ifølge et hvilket som helst av kravene 8-15 og én eller flere farmasøytisk akseptable bærere eller vehikler.17. Forbindelse ifølge et hvilket som helst av kravene 1-7, eller et farmasøytisk akseptabelt salt derav, forbindelse ifølge et hvilket som helst av kravene 8-15 eller farmasøytisk sammensetning ifølge krav 16, for bruk i en fremgangsmåte ved hemming av en spenningsavhengig natriumkanal hos et individ, eventuelt hvor den spenningsavhengige natriumkanalen er NaV1,8.18. Forbindelse ifølge et hvilket som helst av kravene 1-7, eller et farmasøytisk akseptabelt salt derav, forbindelse ifølge et hvilket som helst av kravene 8-15 eller farmasøytisk sammensetning ifølge krav 16, for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av kronisk smerte, smerte i tarm, nevropatisk smerte, muskelskjelettsmerte, akutt smerte, inflammatorisk smerte, kreftsmerte, idiopatisk smerte, postkirurgisk smerte, visceral smerte, multippel sklerose, Charcot-Marie-Tooths syndrom, inkontinens, patologisk hoste, eller hjertearytmi, hvor fremgangsmåten omfatter å administrere en virksom mengde av forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetningen til individet.19. Forbindelse, farmasøytisk akseptabelt salt eller farmasøytisk sammensetning for bruk ifølge krav 18, hvor forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetning er for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av nevropatisk smerte; eventuelt hvor:(a) den nevropatiske smerten omfatter postherpetisk nevralgi; eller(b) den nevropatiske smerten omfatter tynnfibernevropati eller idiopatisk tynnfibernevropati; eller (c) den nevropatiske smerten omfatter diabetisk nevropati.20. Forbindelse, farmasøytisk akseptabelt salt eller farmasøytisk sammensetning for bruk ifølge krav 18, hvor forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetning er for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av muskelskjelettsmerte; eventuelt hvor muskelskjelettsmerten omfatter osteoartrittsmerte.21. Forbindelse, farmasøytisk akseptabelt salt eller farmasøytisk sammensetning for bruk ifølge krav 18, hvor forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetningen er for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av akutt smerte; eventuelt hvor den akutte smerten omfatter akutt postoperativ smerte.22. Forbindelse, farmasøytisk akseptabelt salt eller farmasøytisk sammensetning for bruk ifølge krav 18, hvor forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetningen er for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av postkirurgisk smerte; eventuelt hvor:(a) den postkirurgiske smerten omfatter smerte etter bunionektomi; eller(b) den postkirurgiske smerten omfatter smerte etter brokkreparasjon; eller(c) den postkirurgiske smerten omfatter smerte etter abdominoplastikk.23. Forbindelse, farmasøytisk akseptabelt salt eller farmasøytisk sammensetning for bruk ifølge krav 18, hvor forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetningen er for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av visceral smerte.24. Forbindelse ifølge et hvilket som helst av kravene 1-7, eller et farmasøytisk akseptabelt salt derav, forbindelse ifølge et hvilket som helst av kravene 8-15 eller farmasøytisk sammensetning ifølge krav 16, for bruk i en fremgangsmåte ved behandling eller reduksjon av besværet hos et individ av smerte, hvor fremgangsmåten omfatter å administrere en virksom mengde av forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetningen til individet.25. Forbindelse, farmasøytisk akseptabelt salt eller farmasøytisk sammensetning for bruk ifølge et hvilket som helst av kravene 17-24, hvor individet behandles med ett eller flere ytterligere terapeutiske midler som blir administrert samtidig med, før eller etter behandling med forbindelsen, det farmasøytisk akseptable saltet eller den farmasøytiske sammensetningen.
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Innehaver i EP:
Vertex Pharmaceuticals Incorporated
50 Northern Avenue Boston, MA 02210 US

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DURRANT, Steven, John
50 Northern Avenue Boston, MA 02210 US
AHMAD, Nadia
50 Northern Avenue Boston, MA 02210 US
BECK, Elizabeth, Mary
50 Northern Avenue Boston, MA 02210 US
CARVALHO MEIRELES, Lidio
50 Northern Avenue Boston, MA 02210 US
CHUDYK, Ewa, Iwona
50 Northern Avenue Boston, MA 02210 US
ETXEBARRIA JARDI, Gorka
50 Northern Avenue Boston, MA 02210 US
GALAN, Bhairavi
50 Northern Avenue Boston, MA 02210 US
HADIDA RUAH, Sara, S.
50 Northern Avenue Boston, MA 02210 US
HURLEY, Dennis, James
50 Northern Avenue Boston, MA 02210 US
KNEGTEL, Ronald, Marcellus
50 Northern Avenue Boston, MA 02210 US
NEUBERT, Timothy, Donald
50 Northern Avenue Boston, MA 02210 US
PINDER, Joanne, Louise
50 Northern Avenue Boston, MA 02210 US
PONTILLO, Joseph
50 Northern Avenue Boston, MA 02210 US
PULLIN, Robert
50 Northern Avenue Boston, MA 02210 US
SCHMIDT, Yvonne
50 Northern Avenue Boston, MA 02210 US
SHAW, David, Matthew
50 Northern Avenue Boston, MA 02210 US
SKERRATT, Sarah
50 Northern Avenue Boston, MA 02210 US
STAMOS, Dean
50 Northern Avenue Boston, MA 02210 US
THOMSON, Stephen, Andrew
50 Northern Avenue Boston, MA 02210 US
VIRANI, Anisa, Nizarali
50 Northern Avenue Boston, MA 02210 US
WRAY, Christopher
50 Northern Avenue Boston, MA 02210 US

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Fullmektig i Norge:
ZACCO NORWAY AS
Postboks 488 0213 OSLO NO ( OSLO kommune, Oslo fylke )

Org.nummer: 982702887
Din referanse: V482328NO00
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Kilde: Brønnøysundregistrene
Fullmektig i EP:
Carpmaels & Ransford LLP
One Southampton Row London WC1B 5HA GB

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2019.12.06, US 201962944869 P

Anførte dokumenter info chevron_right

US-A1- 2019 016 671 (B1)

M. F. JARVIS ET AL: "From the Cover: A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 104, no. 20, 15 May 2007 (2007-05-15), pages 8520 - 8525, XP055030736, ISSN: 0027-8424, DOI: 10.1073/pnas.0611364104 (B1)

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Utgående EP Registreringsbrev (3210) (PTEP4069691)
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01-02 Fullmakt P083386EP - NO POA_12719531
01-03 EP Krav V482328NO00_Claims_NO 807231
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Årsavgift 5. avg. år (EP) 2024.12.11 2150 CPA GLOBAL LIMITED Betalt og godkjent
32415490 expand_more 2024.12.05 7150 ZACCO NORWAY AS Betalt
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Hva betyr A1, B, B1, C osv? info
Kapitler uten data er fjernet. Melding opprettet: 07.05.2025 06:14:55