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Tittel HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF
Status
Hovedstatus
Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP3966206
Europeisk (EP) publiserings nummer EP3966206
EP levert
EP søknadsnummer 20728365.6
EP meddelt
Prioritet 2019.05.10, US 201962846260 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Deciphera Pharmaceuticals, LLC (US)
Oppfinner FLYNN, Daniel, L. (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Krav

Patentkrav1. En forbindelse representert ved:Formel Ieller et farmasøytisk akseptabelt salt, enantiomer, stereoisomer, eller tautomer derav, hvor:A er 5-leddet heteroaryl med minst ett ringnitrogen; W er CH eller N;R1 er valgt fra gruppen som består av halogen, cyano, C1-C5 alkyl, og C3-C5 sykloalkyl, hvor hver C1-C5alkyl og C3-C5sykloalkyl eventuelt kan være substituert av én, to eller tre uavhengige forekomster av fluor;R2 er valgt fra gruppen som består av H, halogen, cyano, C1-C5alkyl, C3-C6 sykloalkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C5 alkoksy, og C1-C5 alkoksy-C1-C5 alkyl, hvor hver C1-C5 alkyl, C3-C6 sykloalkyl, C2-C5 alkenyl, C2-C5 alkynyl, og C1-C5 alkoksy eventuelt kan være substituert av én, to eller tre uavhengige forekomster av fluor eller cyano;R4 er valgt fra gruppen som består av B, D, NR6R9, NR6-(C(R10)2)p-NR6R9, C(O)-NR6R9, C(O)-B, C(O)-D, og CN;B er valgt fra en N-bundet heterosyklyl som har minst ett nitrogen og eventuelt som har et ytterligere ringnitrogen eller oksygen og heteroaryl, hvor B eventuelt kan være substituert på ett eller flere tilgjengelige karboner med R7 og eventuelt kan være substituert på et tilgjengelig nitrogen med R9;D er valgt fra en C-bundet heterosyklyl som har minst ett nitrogen og eventuelt som har et ytterligere ringnitrogen eller oksygen og heteroaryl, hvor D eventuelt kan være substituert på ett eller flere tilgjengelige karboner med R7 og eventuelt kan være substituert på et tilgjengelig nitrogen med R9; hver forekomst av R7 er uavhengig valgt fra gruppen som består av H, C1-C6 alkyl, C3-C6 sykloalkyl, cyano, og (C(R10)2)h-NR6R9, hvor hver C1-C6 alkyl og C3-C6 sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor, eller to R7 er bundet sammen med atomet de er festet til for å danne okso;hver forekomst av R6 og R9 er uavhengig valgt fra gruppen som består av H, C1-C6 alkyl, C3-C6 sykloalkyl, C1-C5 alkoksy-C2-C5 alkyl, C(=O)R5, SO2R5, og C-bundet heterosyklyl som har minst ett nitrogen og eventuelt som har et ytterligere ringnitrogen eller oksygen, og heteroaryl, hvor hver C1-C6 alkyl og C3-C6 sykloalkyl kan eventuelt være substituert av én eller flere uavhengige forekomster av fluor;hver forekomst av R5 er uavhengig valgt fra gruppen som består av H, C1-C6alkyl, C3-C6sykloalkyl, og heterosyklyl, hvor hver C1-C6 alkyl og C3-C6 sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor;hver forekomst av R10 er uavhengig valgt fra gruppen som består av H, C1-C3 alkyl, og C3-C5 sykloalkyl, hvor hver C1-C3alkyl og C3-C5sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor, eller to R10 er forbundet sammen med karbonet de er festet til for å danne en C3-C5 sykloalkyl;Z er valgt fra gruppen som består av en 4-10 leddet laktamring hvor laktamringen er bundet gjennom nitrogenatomet, hvor et laktamring-atom eventuelt kan være oksygen eller NR6 når laktamringen er en 6-10 leddet ring og et tilgjengelig karbonatom på 4 leddet laktamring eller en 6-10 leddet laktam eventuelt er substituert med én eller flere uavhengige forekomster av R36;hver forekomst av R36 er uavhengig valgt fra C1-C6 alkyl og C3-C6 sykloalkyl, hvor hver C1-C6 alkyl og C3-C6 sykloalkyl kan eventuelt være substituert av én eller flere uavhengige forekomster av fluor, eller to R36 er forbundet sammen med karbonet de er festet til for å danne a C3-C6 sykloalkyl; L er -(C(R10)2)m-;h er 1, 2, eller 3;m er 0, 1, 2, eller 3;n er 2, 3, eller 4; ogp er 2 eller 3; forutsatt at: når m er 0, R4 er C-bundet til ring A, når m er 1, R4 er C-bundet til L, og når m er 2 eller 3, R4 er N-bundet eller C-bundet til L.2. Forbindelsen ifølge krav 1, hvor:er valgt fra gruppen som består avog/ellerZ er valgt fra gruppen som består avog/eller R4 er valgt fra gruppen som består aveller fra gruppen som består av:og/ellerR1 er valgt fra gruppen som består av halogen, C1-C5 alkyl, og C3-C5 sykloalkyl, hvor C1-C5 alkyl og C3-C5 sykloalkyl eventuelt kan være substituert med én, to eller tre uavhengige forekomster av fluor, for eksempel CF3; og/ellerR2 er valgt fra gruppen som består av C1-C5 alkyl, H, og C3-C4 sykloalkyl, for eksempel gruppen som består av C1-C2alkyl og C3-C4sykloalkyl.3. Forbindelsen ifølge krav 1 representert ved:Formel II eller et farmasøytisk akseptabelt salt derav, hvorA-1 er valgt fra gruppen som består avR2 er valgt fra C1-C2 -alkyl, C3-C4-sykloalkyl, og halogen; R4 er valgt fra gruppen som består avhver forekomst av R7 er uavhengig valgt fra gruppen som består av H, C1-C6 alkyl, C3-C6sykloalkyl, hvor hver C1-C6alkyl og C3-C6sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor, eller to R7 er bundet sammen med atomet de er festet til for å danne okso; hver forekomst av R6 og R9 er uavhengig valgt fra gruppen som består av H, C1-C6alkyl, og C3-C6sykloalkyl, hvor hver C1-C6alkyl og C3-C6sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor;Z er valgt fra gruppen som består avhver forekomst av R34 er uavhengig valgt fra H og R36, hvor hver forekomst av R36 er uavhengig valgt fra C1-C6 alkyl og C3-C6 sykloalkyl hvor hver C1-C6 alkyl og C3-C6 sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor, eller to R36 er forbundet sammen med karbonet de er festet til for å danne a C3-C6sykloalkyl;forutsatt at: når m er 0, R4 er C-bundet til pyrazolringen, når m er 1, R4 er C-bundet til L, og når m er 2 eller 3, R4 er C-bundet til L.4. Forbindelsen ifølge krav 3, hvor:A-1 er:og/ellerR1 er valgt fra gruppen som består av CF3, CF2H, klor, brom, og syklopropyl.5. Forbindelsen ifølge krav 1 representert ved:Formel IIIeller et farmasøytisk akseptabelt salt derav, hvorA-1 er valgt fra gruppen som består avR2 er valgt fra C1-C2 -alkyl, C3-C4-sykloalkyl, og halogen; R4 er valgt fra gruppen som består avhver forekomst av R7 er uavhengig valgt fra gruppen som består av H, C1-C6 alkyl, C3-C6 sykloalkyl, hvor hver C1-C6 alkyl og C3-C6 sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor, eller to R7 er bundet sammen med atomet de er festet til for å danne okso;hver forekomst av R6 og R9 er uavhengig valgt fra gruppen som består av H, C1-C6 alkyl, og C3-C6 sykloalkyl, hvor hver C1-C6 alkyl og C3-C6 sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor;Z er valgt fra gruppen som består avhver forekomst av R34 er uavhengig valgt fra H og R36, hvor hver forekomst av R36 er uavhengig valgt fra C1-C6 alkyl og C3-C6 sykloalkyl og hvor hver C1-C6 alkyl og C3-C6 sykloalkyl eventuelt kan være substituert av én eller flere uavhengige forekomster av fluor, eller to R36 er forbundet sammen med karbonet de er festet til for å danne a C3-C6 sykloalkyl; forutsatt at: når m er 0, R4 er C-bundet til pyrazolringen, når m er 1, R4 er C-bundet til L, og når m er 2 eller 3, R4 er C-bundet til L.6. Forbindelsen ifølge krav 5, hvor R1 er valgt fra gruppen som består av CF3, CF2H, klor, brom, og syklopropyl.7. Forbindelsen ifølge krav 1 representert av en formel valgt fra gruppen som består av:Formel IIA.1 Formel IIA.2 Formel IIA.7for eksempel hvor forbindelsen er representert ved: Formel IIA.1 eller Formel IIA.3hvorhver forekomst av R1 er uavhengig valgt fra gruppen som består av brom, klor, CF3, CF2H, og syklopropyl;hver forekomst av R2 er uavhengig valgt fra gruppen som består av C1-C2-alkyl, C3-C4-sykloalkyl, og halogen;hver forekomst av R9 er uavhengig valgt fra gruppen som består av H, C1-C3-alkyl, og C3-C5-sykloalkyl;hver forekomst av R34 er uavhengig valgt fra gruppen som består av H, C1-C2-alkyl, og C3-C5-sykloalkyl; ogn er 3.8. Forbindelsen ifølge krav 1 representert av en formel valgt fra gruppen som består av:Formel IIA.23 Formel IIA.24ogFormel IIA.25hvorhver forekomst av R1 er uavhengig valgt fra gruppen som består av brom, klor, CF3, CF2H, og syklopropyl;hver forekomst av R2 er uavhengig valgt fra gruppen som består av C1-C2-alkyl, C3-C4-sykloalkyl, og halogen;hver forekomst av R9 er uavhengig valgt fra gruppen som består av H, C1-C3-alkyl, og C3-C5-sykloalkyl;hver forekomst av R34 er uavhengig valgt fra gruppen som består av H, C1-C3-alkyl, og C3-C5-sykloalkyl; og n er 3.9. Forbindelsen ifølge krav 1 valgt fra gruppen som består av 1-(3-((5-syklopropyl-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-isopropylpiperidin-4-yl)-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-isopropyl-d7-piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-etylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on, rac-(R)-1-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(3-(pyrrolidin-1-yl)propyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(2-(piperidin-1-yl)etyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((2-((1-(1-etylpyrrolidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(3-(piperidin-1-yl)propyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(2-morfolinoetyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-d3-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(2-(dimetylamino)etyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(3-(dimetylamino)propyl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((2-((1-(1-isopropylpyrrolidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on, 1-(3-((2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-etyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-etyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-etyl-1-(piperidin-4-yl)-1H-pyrazo1-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-etyl-1-(1-etylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-etyl-1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((5-brom-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(2-(pyrrolidin-1-yl)etyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-etyl-1-(1-etylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-iodo-2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-metyl-d3-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-etyl-1-(1-metyl-d3-piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on, 1-(3-((5-brom-2-((3-etyl-1-(1-etylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-(metyl-d3)piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-(2-fluoretyl)piperidin-4-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((5-brom-2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((5-brom-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-metyl-1-(2-(pyrrolidin-1-yl)etyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-brom-2-((3-metyl-1-(2-morfolinoetyl)-1H-pyrazo1-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((5-brom-2-((1-(1-etylpyrrolidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,rac-(R)-1-(3-((2-((1-(1-etylpyrrolidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,2-metyl-2-(3-metyl-4-((4-((3-(2-oksopiperidin-1-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanamid,3-(3-((2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,3-(3-((2-((3-etyl-1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,3-(3-((5-brom-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1 ,3-oksazinan-2-on, 3-(3-((5-klor-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,3-(3-((5-klor-2-((3-etyl-1-(1-isopropylpiperidin-4-yl)-1H-pyrazo1-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)morfolin-3-on,4-(3-((5-syklopropyl-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazo1-4-yl)amino)pyrimidin-4-yl)amino)propyl)morfolin-3-on,4-(3-((5-syklopropyl-2-((3-etyl-1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-(3-((2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-klor-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-syklopropyl-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-klor-2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-klor-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-isopropylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on, 1-(3-((2-((1-(1-isobutylpiperidin-4-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-syklobutylpiperidin-4-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-syklopentylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-(sec-butyl)piperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,(S)-1-(3-((2-((1-(1-isopropylpyrrolidin-3-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(2-morfolinoetyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((3-metyl-1-(2-morfolinoetyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((3-metyl-1-(3-(pyrrolidin-1-yl)propyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((2-((3-metyl-1-(1-metyl-d3-piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,1-(3-((2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,(R)-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-klor-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,(R)-4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,(R)-4-(3-((5-brom-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-klor-2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-brom-2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-brom-2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((5 -klor-2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((2-((1-(2-(dietylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,2-metyl-2-(3-metyl-4-((4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanamid,3-(3-((2-((4-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazo1-3-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,1-(3-((2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,4-(3-((2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,(R)-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,(R)-4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-klor-2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,(R)-4-(3-((5-brom-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-syklopropyl-2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on, 4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-syklopropyl-2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-klor-2-((1-(1-isopropylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-brom-2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,2-metyl-2-(3-metyl-4-((4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanamid,4-(3-((2-((1-(2-(dietylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,1-(3-((5-brom-2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,(R)-1-(3-((5-klor-2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,(R)-1-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(2-(pyrrolidin-1-yl)etyl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(2-morfolinoetyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,(R)-1-(3-((5-brom-2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-brom-2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,(S)-1-(3-((2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on, (S)-1-(3-((2-((1-(1-etylpyrrolidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,rac-(R)-1-(3-((2-((3-metyl-1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((1-(1-isobutylazetidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,2-metyl-2-(3-metyl-4-((4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propannitril, 1-(3-((2-((4-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-3-yl)amino)-5-(trifluormetyl)-pyridin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-3-yl)amino)-5-(trifluormetyl)-pyridin-4-y1)amino)propyl)piperidin-2-on,4-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-pyrazo1-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1 ,3-oksazinan-2-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(l-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1 ,3-oksazinan-2-on,4-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((1-(1-metylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on, 3-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1 ,3-oksazinan-2-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-1-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-5-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-5-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-5-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1 ,3-oksazinan-2-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-5-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-5-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-5-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)oksazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)oksazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)oksazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((4-metyl-2-(1-metylpiperidin-4-yl)tiazol-5-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((4-mety1-2-(1-metylpiperidin-4-yl)tiazol-5-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((4-metyl-2-(1-metylpiperidin-4-yl)tiazol-5-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((4-metyl-2-(1-metylpiperidin-4-yl)oksazol-5-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((4-metyl-2-(1-metylpiperidin-4-yl)oksazol-5-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((4-metyl-2-(1-metylpiperidin-4-yl)oksazo1-5-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-metyl-3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)tetrahydropyrimidin-2(1H)-on, 3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-metyl-3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-diazepan-2-on,1-metyl-4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5 - (trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-5-on,4-metyl-1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-2-on,1-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,4-metyl-1-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-2-on, 3-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on, 4-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5 -(trifluormetyl)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-metyl-3-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)tetrahydropyrimidin-2(1H)-on,3-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on, 1-metyl-3-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-diazepan-2-on,1-metyl-4-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-5-on,4-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on, 1-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azepan-2-on,4-metyl-1-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-2-on,4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-metyl-3-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)tetrahydropyrimidin-2(1H)-on, 3-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-metyl-3-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-diazepan-2-on,1-metyl-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-5-on, 4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,6,6-dimetyl-3-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on, 2,2-dimetyl-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 6,6-dimetyl-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on, 6,6-dimetyl-3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on, 2,2-dimetyl-4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 6,6-dimetyl-4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on, 6,6-dimetyl-3-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,2,2-dimetyl-4-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazo1-4-yl)amino)-pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-3-metyltetrahydropyrimidin-2(1H)-on,3-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-3-metyl-1,3-diazepan-2-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1-metyl-1,4-diazepan-5 -on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-4-metyl-1,4-diazepan-2-on, 1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-4-metyl-1,4-diazepan-2-on, 3-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on, 4-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-3-metyltetrahydropyrimidin-2(1H)-on,3-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on, 1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-3-metyl-1,3-diazepan-2-on, 4-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1-metyl-1,4-diazepan-5-on, 4-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on, 3-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-3-metyl-1,3-diazepan-2-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1-metyl-1,4-diazepan-5-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,3-oksazinan-2-on, 4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-2,2-dimetyl-1,4-oksazepan-3-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,4-oksazepan-5-on,3-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-6, 6-dimetyl-1,3-oksazinan-2-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-2,2-dimetyl-1,4-oksazepan-3-on,4-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,4-oksazepan-5-on,3-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,3-oksazinan-2-on,4-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-2,2-dimetyl-1,4-oksazepan-3-on,4-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,4-oksazepan-5-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)azetidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)azetidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)azetidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-3,3-dimetylazetidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-3,3-dimetylazetidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-3,3-dimetylazetidin-2-on, 2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-okso-1,3-oksazinan-3-yl)propyl)amino)pyrimidin-5-karbonitril,2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril,2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril,2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-okso-1,3-oksazinan-3-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-oksomorfolino)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-metyl-2-oksotetrahydropyrimidin-1(2H)-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-okso-1,3-oksazepan-3-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-metyl-2-okso-1,3-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(4-metyl-7-okso-1,4-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(4-metyl-2-okso-1,4-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-oksopiperidin-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-oksoazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(4-metyl-2-okso-1,4-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-okso-1,3-oksazinan-3-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-oksomorfolino)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-metyl-2-oksotetrahydropyrimidin-1(2H)-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-okso-1,3-oksazepan-3-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-metyl-2-okso-1,3-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(4-metyl-7-okso-1,4-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril, 2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-okso-1,3-oksazepan-3-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-metyl-2-okso-1,3-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(4-metyl-7-okso-1,4-diazepan-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)pyrimidin-5-karbonitril,4-((3-(6,6-dimetyl-2-okso-1,3-oksazinan-3-yl)propyl)amino)-2-((3-metyl-1-(1-metylpyrro lidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(2,2-dimetyl-3-okso-1,4-oksazepan-4-yl)propyl)amino)-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(6,6-dimetyl-5-okso-1,4-oksazepan-4-yl)propyl)amino)-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(6,6-dimetyl-2-okso-1,3-oksazinan-3-yl)propyl)amino)-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(2,2-dimetyl-3-okso-1,4-oksazepan-4-yl)propyl)amino)-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(6,6-dimetyl-5-okso-1,4-oksazepan-4-yl)propyl)amino)-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(6,6-dimetyl-2-okso-1,3-oksazinan-3-yl)propyl)amino)-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril, 4-((3-(2,2-dimetyl-3-okso-1,4-oksazepan-4-yl)propyl)amino)-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(6,6-dimetyl-5-okso-1,4-oksazepan-4-yl)propyl)amino)-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-oksoazetidin-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-oksoazetidin-1-yl)propyl)amino)pyrimidin-5-karbonitril,2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)-4-((3-(2-oksoazetidin-1-yl)propyl)amino)pyrimidin-5-karbonitril,4-((3-(3,3-dimetyl-2-oksoazetidin-1-yl)propyl)amino)-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(3,3-dimetyl-2-oksoazetidin-1-yl)propyl)amino)-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril,4-((3-(3,3-dimetyl-2-oksoazetidin-1-yl)propyl)amino)-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-5-karbonitril, 4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((5-syklopropyl-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-syklopropyl-2-((1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-3-metyltetrahydropyrimidin-2(1H)-on, 3-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-3- metyl-1,3-diazepan-2-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1-metyl-1,4-diazepan-5-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-4-metyl-1,4-diazepan-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)piperidin-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)azepan-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-4-metyl-1,4-diazepan-2-on, 3-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)morfolin-3-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-3-metyltetrahydropyrimidin-2(1H)-on,3-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-3-metyl-1,3-diazepan-2-on, 4-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1-metyl-1,4-diazepan-5 -on, 4-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,3-oksazepan-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrro lidin-3-yl)-1H-pyrazo1-4-yl)amino)pyrimidin-4-yl) amino)propyl) -3- metyl-1,3-diazepan-2-on, 4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1-metyl-1,4-diazepan-5-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,3-oksazinan-2-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-2,2-dimetyl-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,4-oksazepan-5-on,3-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,3-oksazinan-2-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-2,2-dimetyl-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(l-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,4-oksazepan-5-on,3-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,3-oksazinan-2-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-2,2-dimetyl-1,4-oksazepan-3-on,4-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-6,6-dimetyl-1,4-oksazepan-5-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)azetidin-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)azetidin-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)azetidin-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-3,3-dimetylazetidin-2-on, 1-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)-3,3-dimetylazetidin-2-on,1-(3-((5-syklopropyl-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)-3,3-dimetylazetidin-2-on, 1-(3-((2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-(difluormetyl)-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-(difluormetyl)-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-(difluormetyl)-2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)-amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-brom-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-brom-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-brom-2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(8-metyl-8-azabisyklo[3.2.1]oktan-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((5-klor-2-((1-(1-isobutylazetidin-3-yl)-3-metyl-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)pyrrolidin-2-on,4-(3-((2-((2-(3-(dimetylamino)propyl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(2-(dimetylamino)etyl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((5-etyl-2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on, N-(1-metylpiperidin-4-yl)-4-((4-((3-(2-okso-1,3-oksazinan-3-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)tiazole-2-karboksamid,4-(3-((2-((2-(3-(dimetylamino)propyl)oksazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(2-(dimetylamino)etyl)oksazol-4-yl)amino)-5-(trifluormetyl)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((2-(4-metylpiperazine-1-karbonyl)oksazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,3,3-dimetyl-1-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)-amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)azetidin-2-on,4-(3-((2-((1-(3-(dimetylamino)propyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(3-(pyrrolidin-1-yl)propyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((3-metyl-1-(2-morfolinoetyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((3-fluor-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(1-metylpiperidin-4-yl)-3-(trifluormetyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((2-((3-metoksy-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,1-(1-metylpiperidin-4-yl)-4-((4-((3-(2-oksopiperidin-1-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)-1H-pyrazol-3-karbonitril,4-(3-((2-((3-etynyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-3-on,3-(3-((2-((1-(1-metylpiperidin-4-yl)-3-vinyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((3-syklopropyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,8-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-4-oksa-8-azaspiro[2.6]nonan-9-on,8-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-5-oksa-8-azaspiro[2.6]nonan-9-on, 9-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-5-oksa-9-azaspiro[3.6]dekan-10-on, 9-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-6-oksa-9-azaspiro[3.6]dekan-10-on, 4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on,3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,3-oksazepan-2-on,3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,3-oksazinan-2-on,2,2-dimetyl-4-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((5-(difluormetyl)-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-klor-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyridin-4-yl)amino)propyl)-1,3-oksazinan-2-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((3-metyl-1-(3-morfolinopropyl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((1-(2-(dimetylamino)etyl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,(S)-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,1-metyl-3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)tetrahydropyrimidin-2(1H)-on,1-metyl-3-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,3-diazepan-2-on,(R)-4-(3-((2-((3-metyl-1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((5-metyl-2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on, 4-(3-((2-((2-(1-metylpiperidin-4-yl)tiazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((2-(1-metylpiperidin-4-yl)oksazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((5-klor-2-((3-etyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((3-metoksy-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((2-((1-(1-metylpiperidin-4-yl)-3-vinyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,1-((3-metyl-4-((4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyridin-2-yl)amino)-1H-pyrazol-1-yl)metyl)syklopropan-1-karbonitril, 2-metyl-2-(3-metyl-4-((4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyridin-2-yl)amino)-1H-pyrazol-1-yl)propanonitril,6-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)nikotinonitril,4-(3-((5-syklopropyl-2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)-amino)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,4-(3-((2-((1-(1-etylpiperidin-4-yl)-3-metyl-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-5-on,1-(1-metylpiperidin-4-yl)-4-((4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyridin-2-yl)amino)-1H-pyrazol-3-karbonitril,4-(3-((2-((2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on,4-(3-((5-(difluormetyl)-2-((2-(1-metylpiperidin-4-yl)-2H-1,2,3-triazol-4-yl)-amino)pyridin-4-yl)amino)propyl)-1,4-oksazepan-3-on,3-(3-((2-((2-(1-metylpiperidin-4-yl)oksazo1-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)-1 ,3-oksazinan-2-on,1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)pyrrolidin-2-on,1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)piperidin-2-on, 1-(3-((2-((3-metyl-1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyridin-4-yl)amino)propyl)azetidin-2-on,2-metyl-2-(3-metyl-4-((4-((3-(5-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyridin-2-yl)amino)-1H-pyrazol-1-yl)propanamid,1-(1-metylpiperidin-4-yl)-4-((4-((3-(3-okso-1,4-oksazepan-4-yl)propyl)amino)-5-(trifluormetyl)pyrimidin-2-yl)amino)-1H-pyrazol-3-karbonitril,4-(3-((5-(difluormetyl)-2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,4-oksazepan-5-on,3-(3-((5-(difluormetyl)-2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-pyrimidin-4-yl)amino)propyl)-1,3-oksazinan-2-on,1-metyl-4-(3-((2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-5-on, og4-metyl-1-(3-((2-((3-metyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluormetyl)pyrimidin-4-yl)amino)propyl)-1,4-diazepan-2-on,eller farmasøytisk akseptable salter, enantiomerer, stereoisomerer, eller tautomerer derav.10. En farmasøytisk sammensetning som omfatter en forbindelse ifølge ett av kravene 1-9, en farmasøytisk akseptabel eksipiens og eventuelt ett eller flere ytterligere terapeutiske midler.11. Den farmasøytiske sammensetningen ifølge krav 10, hvor et ytterligere terapeutisk middel er til stede og er (i) en MAPKAP-veiinhibitor, for eksempel en MEK-inhibitor slik som en MEK-inhibitor valgt fra gruppen som består av trametinib, selumetinib, cobimetinib, binimetinib, og farmasøytisk akseptable salter derav; en ERK-inhibitor slik som en ERK-inhibitor valgt fra gruppen som består av uliksertinib, SCH772984, LY3214996, ravoksertinib, VX-11e, og farmasøytisk akseptable salter derav; en RAF-inhibitor slik som en RAF-inhibitor valgt fra gruppen som består av LY3009120, LXH254, RAF709, dabrafenib, vemurafenib, og farmasøytisk akseptable salter derav; eller en Ras-inhibitor slik som en Ras-inhibitor valgt fra gruppen som består av AMG-510, MRTX849, og farmasøytisk akseptable salter derav; eller (ii) et kjemoterapeutisk middel, slik som et kjemoterapeutisk middel valgt fra gruppen som består av antitubulinmidler, vinorelbin, DNA-alkyleringsmidler, DNA- interkaleringsmidler, 5fluoruracil, capecitabin, cytarabin, decitabin, 5-azacytadin, gemcitabin, og metotreksat.12. En forbindelse ifølge ett av kravene 1-9 for anvendelse i behandlingen av en forstyrrelse i en pasient med behov for det.13. En forbindelse ifølge ett av kravene 1-9 for anvendelse i en fremgangsmåte for å behandle en kreft i en pasient med behov for det, som omfatter å administrere til pasienten en terapeutisk effektiv mengde av forbindelsen.14. Forbindelsen for anvendelsen ifølge krav 13, hvor kreften er valgt fra gruppen som består av gastrointestinale stromale svulster, spiserørskreft, magekreft, melanomer, gliomer, glioblastomer, ovariekreft, blærekreft, bukspyttkjertelkreft, prostatakreft, lungekreft, brystkreft, nyrekreft, leverkreft, osteosarkomer, multippel myelomer, livmorhals karsinomer, kreft som er metastatiske til bein, papillært skjoldbruskkjertelkarsinom, ikke-småcellet lungekreft, og kolorektal kreft.15. Forbindelsen for anvendelsen ifølge krav 13 eller krav 14, som videre omfatter å administrere til pasienten ett eller flere ytterligere terapeutiske midler, for eksempel hvor det ytterlige terapeutiske middelet er (i) en MAPKAP-veiinhibitor, for eksempel en MEK-inhibitor slik som en MEK-inhibitor valgt fra gruppen som består av trametinib, selumetinib, cobimetinib, binimetinib, og farmasøytisk akseptable salter derav; en ERK-inhibitor slik som en ERK-inhibitor valgt fra gruppen som består av uliksertinib, SCH772984, LY3214996, ravoksertinib, VX-11e, og farmasøytisk akseptable salter derav; en RAF-inhibitor slik som en RAF-inhibitor valgt fra gruppen som består av LY3009120, LXH254, RAF709, dabrafenib, vemurafenib, og farmasøytisk akseptable salter derav; eller en Ras-inhibitor slik som en Ras-inhibitor valgt fra gruppen som består av AMG-510, MRTX849, og farmasøytisk akseptable salter derav; eller (ii) et kjemoterapeutisk middel, slik som et kjemoterapeutisk middel er valgt fra gruppen som består av anti-tubulinmidler, vinorelbin, DNA-alkyleringsmidler, DNA-interkaleringsmidler, 5-fluoruracil, capecitabin, cytarabin, decitabin, 5-azacytadin, gemcitabin, og metotreksat.
Hva betyr A1, B, B1, C osv? info

Klasser info chevron_right

Innehaver(e) info chevron_right

Innehaver i EP:
Deciphera Pharmaceuticals, LLC
200 Smith Street Waltham, MA 02451 US

Oppfinner(e) info chevron_right

FLYNN, Daniel, L.
4165 Blackjack Oak Drive Lawrence, KS 66047 US
AHN, Yu Mi
200 Smith Street Waltham, MA 02451 US
CALDWELL, Timothy
200 Smith Street Waltham, MA 02451 US
VOGETI, Lakshminarayana
200 Smith Street Waltham, MA 02451 US

Fullmektig info chevron_right

Fullmektig i Norge:
ZACCO NORWAY AS
Postboks 488 0213 OSLO NO ( OSLO kommune, Oslo fylke )

Org.nummer: 982702887
Din referanse: V464936NO00
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Kilde: Brønnøysundregistrene
Fullmektig i EP:
Marks & Clerk LLP
15 Fetter Lane London EC4A 1BW GB

Prioritet info chevron_right

2019.05.10, US 201962846260 P

2019.05.10, US 201962846264 P

2019.10.07, US 201962911733 P

2019.10.07, US 201962911736 P

Anførte dokumenter info chevron_right

WO-A1-2019/199864 (B1)

WO-A1-2017/156493 (B1)

Sakshistorikk info chevron_right

Statushistorie

Liste over statusendringer i sakshistorikk
Hovedstatus Beslutningsdato, detaljstatus
EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
EP under behandling Forespørsel om å gjøre EP patent gyldig er mottatt

Korrespondanse

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Liste over sakshistorikk og korrespondanse
Dato Type korrespondanse Journal beskrivelse
Innkommende EP Publiseringsdokument fra EPO
04-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
Utgående EP Registreringsbrev (3210) (PTEP3966206)
03-01 Brev UT EP Registreringsbrev (3210) (PTEP3966206)
Innkommende Søknadsskjema Patent
01-01 Søknadsskjema Patent Søknadsskjema Patent
01-02 Fullmakt V464936NO00_POA
01-03 Hovedbrev V464936NO00_Validation_Request
01-04 EP Krav V464936NO00-Claims-NO
Innkommende EP Publiseringsdokument fra EPO
02-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
Informasjon om ikke tilgjengelige dokumenter

Betaling info chevron_right

Til betaling:

Beskrivelse Forfallsdato Beløp Status
Årsavgift expand_less Ikke betalt
Årsavgift 6. avg. år (EP) 2600,0 Totalbeløp 2600,0   Gå til betaling

Betalingshistorikk:

Liste av betalinger
Beskrivelse / Fakturanummer Betalingsdato Beløp Betaler Status
Årsavgift 5. avg. år (EP) 2024.03.19 2150 Wilma Platzgummer Betalt og godkjent
32313997 expand_more 2023.11.10 5500 ZACCO NORWAY AS Betalt
Denne oversikten kan mangle informasjon, spesielt for eldre saker, om tilbakebetaling, internasjonale varemerker og internasjonale design.

Publikasjon(er) info chevron_right

Lenker til publikasjoner og Norsk Patenttidende (søkbare tekstdokumenter)

Oversettelse av europeisk patentskrift
Allment tilgjengelig patentsøknad
Norsk Patenttidende - ved meddelelse
Nye digitale Norske Tidende, nyhet om tjenesten ved lansering
Om Norske Tidende
Hva betyr A1, B, B1, C osv? info
Kapitler uten data er fjernet. Melding opprettet: 24.04.2025 08:05:50