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2019.02.12, US 201962804523 P
2019.06.20, US 201962863904 P
2019.09.30, US 201962908431 P
2019.11.07, US 201962932015 P
ANNE DAVIT-SPRAUL, MONIQUE FABRE, SOPHIE BRANCHEREAU, CHRISTIANE BAUSSAN, EMMANUEL GONZALES, BRUNO STIEGER, OLIVIER BERNARD, EMMAN: "ATP8B1 and ABCB11 Analysis in 62 Children with Normal Gamma- Glutamyl Transferase Progressive Familial Intrahepatic Cholestasis (PFIC): Phenotypic Differences Between PFIC1 and PFIC2 and Natural History", HEPATOLOGY, vol. 51, no. 5, 2010, pages 1645 - 1655, XP055731568, DOI: 10.1002/hep.23539 (B1)
WO-A1-2018/002827 (B1)
CHEN HUEY-LING ET AL: "Expression of Hepatocyte Transporters and Nuclear Receptors in Children With Early and Late-Stage Biliary Atresia", PEDIATRIC RESEARCH, vol. 63, no. 6, 1 June 2008 (2008-06-01), US, pages 667 - 673, XP055978248, ISSN: 0031-3998, DOI: 10.1203/PDR.0b013e318170a6b5 (B1)
CLINICAL TRIALS.GOV: "Study Record Versions Contacts/Locations and Study Status History of Changes for Study: NCT03566238 This Study Will Investigate the Efficacy and Safety of A4250 in Children With PFIC 1 or 2 (PEDFIC 1)", CLINICAL TRIALS .GOV, 8 February 2019 (2019-02-08), pages 1 - 16, XP055975866, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/history/NCT03566238?V_18=View#StudyPageTop> [retrieved on 20221028] (B1)
CLINICAL TRIALS.GOV: "Study Record Versions History of Changes for Study: NCT02057718 Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis (INDIGO)", 5 September 2017 (2017-09-05), pages 1 - 13, XP055975938, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/history/NCT02057718?V_16=View#StudyPageTop> [retrieved on 20221028] (B1)
CLINICAL TRIALS.GOV: "Study Record Versions History of Changes for Study: NCT03659916 Long Term Safety & Efficacy Study Evaluating The Effect of A4250 in Children With PFIC Types 1 & 2", CLINICAL TRIALS.GOV, 11 February 2019 (2019-02-11), pages 1 - 11, XP055975930, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/history/NCT03659916?V_5=View#StudyPageTop> [retrieved on 20221028] (B1)
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1 May 2019 (2019-05-01), BAUMANN U: "Effects of the ileal bile acid transport inhibitor A4250 on pruritus and serum bile acids in patients with biliary atresia: phase 2 study results", XP002807947, Database accession no. EMB-628093576 (B1)
DATABASE PubChem COMPOUND 25 October 2006 (2006-10-25), "PubChem COMPOUND SUMMARY CID9939892 | C36H45N3O7S2", XP055731571, retrieved from NCBI Database accession no. CID9939892 (B1)
EUDRACT 2015-001157-32: "Clinical Trial Results: An exploratory Phase II Study to demonstrate the Safety and Efficacy of A4250 in Children with Cholestatic Pruritus Summary", EU CLINICAL TRIALS REGISTER, 14 October 2017 (2017-10-14), EU Clinical Trials Register, pages 1 - 19, XP055975770, Retrieved from the Internet <URL:https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-001157-32/results> [retrieved on 20221028] (B1)
HEGADE VINOD S ET AL: "Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study", THE LANCET, ELSEVIER, AMSTERDAM, NL, vol. 389, no. 10074, 8 February 2017 (2017-02-08), pages 1114 - 1123, XP029946669, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(17)30319-7 (B1)
MALATACK JEFFREY ET AL: "Case RepoRt A Drug Regimen for Progressive Familial Cholestasis Type 2", PEDIATRICS, 1 January 2018 (2018-01-01), pages 1 - 5, XP055975631, Retrieved from the Internet <URL:https://publications.aap.org/pediatrics/article/141/1/e20163877/37702/A-Drug-Regimen-for-Progressive-Familial> [retrieved on 20221027], DOI: 10.1542/peds.2016-3877 (B1)
MELISSA PALMER ET AL: "A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis", BMC PHARMACOLOGY AND TOXICOLOGY, BIOMED CENTRAL LTD, LONDON, UK, vol. 19, no. 1, 16 March 2018 (2018-03-16), pages 1 - 13, XP021254505, DOI: 10.1186/S40360-018-0200-Y (B1)
STRAUTNIEKS S S ET AL: "Severe Bile Salt Export Pump Deficiency: 82 Different ABCB11 Mutations in 109 Families", GASTROENTEROLOGY, ELSEVIER INC, US, vol. 134, no. 4, 1 April 2008 (2008-04-01), pages 1203 - 1214.e8, XP022584853, ISSN: 0016-5085, [retrieved on 20080118], DOI: 10.1053/J.GASTRO.2008.01.038 (B1)
THOMPSON RICHARD: "Oral Abstracts (Abstracts 1-263)", HEPATOLOGY, vol. 66, no. S1, 1 October 2017 (2017-10-01), US, pages 1 - 148, XP093090080, ISSN: 0270-9139, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.29500> DOI: 10.1002/hep.29500 (B1)
THOMPSON RICHARD: "Oral Abstracts (Abstracts 1-288)", HEPATOLOGY, vol. 70, no. S1, 1 October 2019 (2019-10-01), US, pages 1 - 1, XP055977389, ISSN: 0270-9139, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hep.30940> [retrieved on 20221031], DOI: 10.1002/hep.30940 (B1)
US-A1- 2014 243 281 (B1)
US-B2- 9 040 518 (B1)
WO-A1-2017/167935 (B1)
BAUMANN U: "Effects of the ileal bile acid transport inhibitor A4250 on pruritus and serum bile acids in patients with biliary atresia: phase 2 study results", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 20190501 LIPPINCOTT WILLIAMS AND WILKINS NLD, vol. 68, no. Supplement 1, 1 May 2019 (2019-05-01), pages 767 20190605 to 20190608 Glasgow - 768 CONF, ISSN: 1536-4801 (B1)
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EP Varsel om betaling av første årsavgift (3319) (PTEP3923943)
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Betalingshistorikk:
Beskrivelse / Fakturanummer | Betalingsdato | Beløp | Betaler | Status |
---|---|---|---|---|
Årsavgift 6. avg. år (EP) | 2025.02.19 | 2600 | ANAQUA SERVICES | Betalt og godkjent |
32411168 expand_more expand_less | 2024.09.02 | 7150 | ZACCO NORWAY AS | Betalt |
Valideringsgebyr EP-patent
7150 = 1 X 7150
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