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Tittel 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES
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Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP3820573
Europeisk (EP) publiserings nummer EP3820573
EP levert
EP søknadsnummer 19782691.0
EP meddelt
Prioritet 2018.07.10, US 201862695920 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Novartis AG (CH)
Oppfinner ADCOCK, Claire (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Krav

Patentkrav1. Forbindelse med formel (I')hvori:X1 og X2 er hver uavhengig av hverandre H, (C1-C4)-alkyl, (C1-C6)-alkoksy, (C1-C4)-haloalkyl, (C1-C6)-haloalkoksy, (C3-C7)-sykloalkyl, halogen, -CN, -OH eller -NH2; Rx er H eller D;R1 erhver R2 er uavhengig av hverandre ved hver forekomst (C1-C6)-alkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkyl, (C1-C6)-haloalkoksy, halogen, -CN, -OH eller -NH2; ellerto R2 sammen med karbonatomene de er bundet til, danner et (C3-C7)-sykloalkyl eller en 4- til 7-leddet heterosykloalkylring som omfatter 1-3 heteroatomer valgt blant O, N og S; eller to R2, når de befinner seg på naboliggende karbonatomer, sammen danner en fenyl- eller en 5- eller 6-leddet heteroarylring som omfatter 1-3 heteroatomer valgt blant O, N og S; ellerR2 og R6 sammen med karbon- og nitrogenatomene de er bundet til, danner en 4- til 6-leddet heterosykloalkylring som valgfritt omfatter 1-2 ytterligere heteroatomer valgt blant O, N og S, og valgfritt substituert med én til fire substituenter hver uavhengig valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN og -NH2; hver R3 er (C1-C6)-alkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkyl, (C1-C6)-haloalkoksy, halogen, -OH eller -NH2;R4 er -OR5 eller -NR6R6';R5 er H, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C7)-sykloalkyl, 5- eller 6-leddet heterosykloalkyl omfattende 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl eller 5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S, hvor alkylet er valgfritt substituert med én til tre substituenter uavhengig av hverandre valgt blant (C6-C10)-aryl og 5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S;R6 og R6' er hver uavhengig av hverandre H, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C2-C6)-hydroksyalkyl, (C3-C7)sykloalkyl, 5- eller 6-leddet heterosykloalkyl omfattende 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl, eller 5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S, hvor alkylet er valgfritt substituert med én til tre R7 og hvor sykloalkylet, heterosykloalkylet, arylen og heteroarylen er valgfritt substituert med én til fire R12; ellerR6 og R6', sammen med nitrogenatomet de er bundet til, danner en 4- til 8-leddet heterosykloalkylring som valgfritt omfatter 1-2 ytterligere heteroatomer valgt blant O, N og S, og valgfritt substituert med én til fire R8; ellerR2 og R6 sammen med karbon- og nitrogenatomene de er bundet til, danner en 4- til 6-leddet heterosykloalkylring som valgfritt omfatter 1-2 ytterligere heteroatomer valgt blant O, N og S, og valgfritt substituert med én til fire substituenter hver uavhengig valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN og -NH2; hver R7 er (C3-C7)-sykloalkyl, 4- til 7-leddet heterosykloalkylring som omfatter 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl eller 5- eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S, hvor sykloalkylet, heterosykloalkylet, arylen og heteroarylen er valgfritt substituert med én til fire R9; hver R8 er uavhengig av hverandre ved hver forekomst halogen, (C1-C6)-alkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkyl, (C1-C6)-haloalkoksy, -CN, -OH, -NR13R14, -NH2, -O(C3-C7)-sykloalkyl, -O-4- til 7-leddet heterosykloalkylring omfattende 1-3 heteroatomer valgt blant O, N og S, -O(C6-C10)-aryl eller -O-5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S, hvor alkoksyen er valgfritt substituert med én til tre R10 og sykloalkylet, heterosykloalkylet, arylen og heteroarylen er valgfritt substituert med én til tre R11; ellerto R8 sammen med atomene de er bundet til, danner et (C4-C7)-sykloalkyl eller en 4-til 7-leddet heterosykloalkylring som omfatter 1-2 heteroatomer valgt blant O, N og S, valgfritt substituert med to R15; eller to R8 når de befinner seg på naboliggende atomer, sammen med atomene de er bundet til, danner en (C6-C10)-aryl eller en 5-eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S; eller to R8 sammen med det samme atom som de er bundet til, danner en =(O); hver R9 er uavhengig av hverandre ved hver forekomst (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkoksy, halogen, (C3-C6)-sykloalkyl, -OH, -CN, -NH2 eller -NR13R14; ellerto R9 sammen med atomene de er bundet til, danner et (C4-C7)-sykloalkyl eller en 5-til 7-leddet heterosykloalkylring som omfatter 1-2 heteroatomer valgt blant O, N og S valgfritt substituert med én eller flere substituenter hver uavhengig av hverandre valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN og -NH2; eller to R9 når på naboliggende atomer sammen med atomene de er bundet til, danner en (C6-C10)-aryl eller en 5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S;hver R10 er uavhengig av hverandre ved hver forekomst valgt blant (C3-C7)-sykloalkyl, 4- til 7-leddet heterosykloalkylring omfattende 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl og 5- eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S;hver R11 er uavhengig av hverandre ved hver forekomst valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkoksy, halogen, -OH, -CN og -NH2;hver R12 er uavhengig av hverandre ved hver forekomst (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkoksy, halogen, -OH, -CN eller -NH2; to R12 sammen med atomene de er bundet til, danner et (C4-C7)-sykloalkyl eller en 4- til 7-leddet heterosykloalkylring som omfatter 1-2 heteroatomer valgt blant O, N og S;R13 og R14 er hver uavhengig av hverandre valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C7)-sykloalkyl, 4- til 7-leddet heterosykloalkylring som omfatter 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl og 5- eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S;to R15 sammen med atomene de er bundet til, danner et (C4-C7)-sykloalkyl eller en 4- til 7-leddet heterosykloalkylring som omfatter 1-2 heteroatomer valgt blant O, N og S;m og m1 er hver uavhengig av hverandre 0, 1 eller 2;n1 er 0, 1, 2 eller 3; oghver s og n er uavhengig av hverandre 1, 2 eller 3, hvor s n er ≤ 4;eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav. 2. Forbindelse ifølge krav 1, som har en formel (I),hver R2 er uavhengig av hverandre ved hver forekomst (C1-C6)-alkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkyl, (C1-C6)-haloalkoksy, halogen, -CN, -OH eller -NH2; ellerto R2 sammen med karbonatomene de er bundet til, danner et (C3-C7)-sykloalkyl eller en 4- til 7-leddet heterosykloalkylring som omfatter 1-3 heteroatomer valgt blant O, N og S; eller to R2, når de befinner seg på naboliggende karbonatomer, sammen danner en fenyl- eller en 5- eller 6-leddet heteroarylring som omfatter 1-3 heteroatomer valgt blant O, N og S; ellerR2 og R6 sammen med karbon- og nitrogenatomene de er bundet til, danner en 5-eller 6-leddet heterosykloalkylring som valgfritt omfatter 1-2 ytterligere heteroatomer valgt blant O, N og S, og valgfritt substituert med én til fire substituenter hver uavhengig valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN og -NH2;hver R3 er (C1-C6)-alkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkyl, (C1-C6)-haloalkoksy, halogen, -OH eller -NH2;R4 er -OR5 eller -NR6R6';R5 er H, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C7)-sykloalkyl, 5- eller 6-leddet heterosykloalkyl omfattende 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl eller 5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S, hvor alkylet er valgfritt substituert med én til tre substituenter uavhengig av hverandre valgt blant (C6-C10)-aryl og 5- eller 6-leddet heteroaryl omfattende 1-3 heteroatomer valgt blant O, N og S; R6 og R6' er hver uavhengig av hverandre H, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C3-C7)-sykloalkyl, 5- eller 6-leddet heterosykloalkyl som omfatter 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl eller 5- eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S, hvor alkylet er valgfritt substituert med én til tre R7; ellerR6 og R6', sammen med nitrogenatomet de er bundet til, danner en 4- til 7-leddet heterosykloalkylring som valgfritt omfatter 1-2 ytterligere heteroatomer valgt blant O, N og S, og valgfritt substituert med én til fire R8; ellerR2 og R6 sammen med karbon- og nitrogenatomene de er bundet til, danner en 5-eller 6-leddet heterosykloalkylring som valgfritt omfatter 1-2 ytterligere heteroatomer valgt blant O, N og S, og valgfritt substituert med én til fire substituenter hver uavhengig valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN og -NH2;hver R7 er (C3-C7)-sykloalkyl, 4- til 7-leddet heterosykloalkylring som omfatter 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl eller 5- eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S, hvor sykloalkylet, heterosykloalkylet, arylen og heteroarylen er valgfritt substituert med én til fire R9; hver R8 er uavhengig av hverandre ved hver forekomst halogen, (C1-C6)-alkyl, (C1-C6)-alkoksy, (C1-C6)-haloalkyl, (C1-C6)-haloalkoksy, -CN, -OH eller -NH2, hvor alkoksyen er valgfritt substituert med én til tre substituenter uavhengig av hverandre valgt blant (C3-C7)-sykloalkyl, 4- til 7-leddet heterosykloalkylring som omfatter 1-3 heteroatomer valgt blant O, N og S, (C6-C10)-aryl og 5- eller 6-leddet heteroaryl som omfatter 1-3 heteroatomer valgt blant O, N og S; ellerto R8 sammen med atomene de er bundet til, danner et (C5-C7)-sykloalkyl eller en 4-til 7-leddet heterosykloalkylring som omfatter 1-2 heteroatomer valgt blant O, N og S;hver R9 er uavhengig av hverandre ved hver forekomst (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN eller -NH2; ellerto R9 sammen med atomene de er bundet til, danner et (C5-C7)-sykloalkyl eller en 5-til 7-leddet heterosykloalkylring som omfatter 1-2 heteroatomer valgt blant O, N og S valgfritt substituert med én eller flere substituenter hver uavhengig av hverandre valgt blant (C1-C6)-alkyl, (C1-C6)-haloalkyl, halogen, -OH, -CN og -NH2;m og m1 er hver uavhengig av hverandre 0, 1 eller 2;n1 er 0, 1, 2 eller 3; og hver s og n er uavhengig av hverandre 1, 2 eller 3, hvor s n er ≤ 4;eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav.3. Forbindelse ifølge krav 1 eller 2, hvor R1 er4. Forbindelse ifølge krav 1 eller 2, hvor n1 er 0, 1 eller 2.5. Forbindelse ifølge et hvilket som helst av kravene 1 til 3, hvor m1 er 0 eller m1 er 2.6. Forbindelse ifølge krav 1 eller 2, hvor R1 er7. Forbindelse ifølge krav 6, hvor n er 2 og s er 1 eller 2.8. Forbindelse ifølge krav 6 eller 7, hvor m er 0 eller 1.9. Forbindelse ifølge krav 1 eller 2, som har en formel (la), formel (lb), formel (Ic), formel (Id), formel (le), formel (If), formel (Ig), formel (Ih), formel (li), formel (Ij), formel (Ik), formel (Il), formel (Im), formel (In), formel (Io), formel (Ip), formel (Iq), formel (Ir), formel (Is) eller formel (It):Ċ eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav.10. Forbindelse ifølge krav 1, valgt blant:3-(5-(((1S,2S)-2-((2,2-difluoretyl)(etyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((2,2-difluoretyl)(etyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((2,2-difluoretyl)(etyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((2,2-difluoretyl)(etyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((2,2-difluoretyl)(etyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion; 3-(5-((1-metyloktahydrosyklopenta[b]pyrrol-6-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-metoksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-metoksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-metoksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-metoksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-metoksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(3-hydroksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-hydroksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-hydroksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-hydroksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-hydroksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-hydroksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-hydroksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-hydroksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-hydroksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-hydroksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(isobutylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(isobutylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(isobutylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(isobutylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(isobutylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4,4-difluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(4,4-difluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4,4-difluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4,4-difluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4,4-difluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(benzyloksy)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(benzyloksy)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(benzyloksy)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(benzyloksy)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(benzyloksy)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(dietylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(dietylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dietylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1S,2S)-2-(((1-(trifluormetyl)syklopropyl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(((1-(trifluormetyl)syklopropyl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1R,2R)-2-(((1-(trifluormetyl)syklopropyl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(((1-(trifluormetyl)syklopropyl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(((1-(trifluormetyl)syklopropyl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-aminosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-aminosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-aminosyklopentyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((1R,2S)-2-aminosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-aminosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-aminosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-aminosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-aminosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-aminosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-aminosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(1,4-dioksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(1,4-dioksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(1,4-dioksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(1,4-dioksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(1,4-dioksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(8-oksa-3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(8-oksa-3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(8-oksa-3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(8-oksa-3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(8-oksa-3-azabisyklo[3.2.1]oktan-3-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-fenoksysykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-fenoksysykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-fenoksysykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-fenoksysykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-((2-fenoksysykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(benzylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(benzylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(benzylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(benzylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(benzylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((3S,4S)-3-(benzylamino)tetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((3R,4S)-3-(benzylamino)tetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3R,4R)-3-(benzylamino)tetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4R)-3-(benzylamino)tetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((3-(benzylamino)tetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(benzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion; 3-(1-okso-5-(((1S,2S)-2-(((R)-1-fenyletyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(((R)-1-fenyletyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1R,2R)-2-(((R)-1-fenyletyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(((R)-1-fenyletyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(((R)-1-fenyletyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(2-fluoretyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(2-fluoretyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(2-fluoretyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(2-fluoretyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etyl(2-fluoretyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(isopropyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(isopropyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(isopropyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(isopropyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etyl(isopropyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-metoksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-metoksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-metoksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-metoksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-metoksysyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-hydroksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-hydroksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-hydroksysykloheksyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((1R,2S)-2-hydroksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-hydroksysykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(etylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(bis(syklopropylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(bis(syklopropylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(bis(syklopropylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(bis(syklopropylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(bis(syklopropylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(piperidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(piperidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1R,2R)-2-(piperidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(piperidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(piperidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-morfolinosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-morfolinosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-morfolinosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-morfolinosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-morfolinosyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(dibenzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dibenzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dibenzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dibenzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dibenzylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;cis-3-(5-((2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;trans-3-(5-((2-(dietylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(metylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(metylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(metylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(metylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(metylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 1-((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-metylpiperidin-4-karbonitril;1-((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-metylpiperidin-4-karbonitril;1-((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-metylpiperidin-4-karbonitril;1-((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-metylpiperidin-4-karbonitril;1-(2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-metylpiperidin-4-karbonitril;3-(5-(((1S,2S)-2-(benzyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(benzyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(benzyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(benzyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(benzyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4S)-3-aminotetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((3R,4S)-3-aminotetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4R)-3-aminotetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-((3-aminotetrahydro-2H-pyran-4-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((1S,2S)-2-(benzylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((1R,2R)-2-(benzylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((1S,2R)-2-(benzylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((1R,2S)-2-(benzylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(2-(benzylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((3R,4S)-4-aminotetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3R,4R)-4-aminotetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4R)-4-aminotetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4S)-4-aminotetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((4-aminotetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((3R,4S)-4-(dietylamino)tetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3R,4R)-4-(dietylamino)tetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4R)-4-(dietylamino)tetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((3S,4S)-4-(dietylamino)tetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((4-(dietylamino)tetrahydrofuran-3-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(etylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 4-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;3-(5-((1S,2S)-2-(dietylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((1R,2S)-2-(dietylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((1R,2R)-2-(dietylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((1S,2R)-2-(dietylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(2-(dietylamino)syklobutoksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(etyl((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(etyl((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(etyl((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(etyl((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(etyl((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril; 3-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;3-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;3-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;3-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;3-(5-(((1S,2S)-2-(isopropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(isopropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(isopropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(isopropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(isopropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;2-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;2-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;2-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;2-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;2-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;3-(5-(((1S,2S)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-hydroksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-hydroksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-hydroksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-hydroksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-hydroksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-hydroksy-4-(trifluormetyl)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-hydroksy-4-(trifluormetyl)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-hydroksy-4-(trifluormetyl)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-hydroksy-4-(trifluormetyl)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-hydroksy-4-(trifluormetyl)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;1-((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-(trifluormetyl)piperidin-4-karbonitril;1-((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-(trifluormetyl)piperidin-4-karbonitril;1-((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-(trifluormetyl)piperidin-4-karbonitril;1-((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-(trifluormetyl)piperidin-4-karbonitril;1-(2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)-4-(trifluormetyl)piperidin-4-karbonitril; 3-(5-(((1S,2S)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2,2-difluoretoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(2,2-difluoretoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(2,2-difluoretoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(2,2-difluoretoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(2,2-difluoretoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(syklopropylmetoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(syklopropylmetoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(3-(syklopropylmetoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(syklopropylmetoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(syklopropylmetoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(benzyloksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(benzyloksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(benzyloksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(benzyloksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(benzyloksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-isopropoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-isopropoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-isopropoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-isopropoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-isopropoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-etoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-etoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-etoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-etoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(3-etoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(benzyloksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(benzyloksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(benzyloksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(benzyloksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(benzyloksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-etoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-etoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-etoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-etoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-etoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(3,3-difluorsyklobutoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(3,3-difluorsyklobutoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(3,3-difluorsyklobutoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(3,3-difluorsyklobutoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(3,3-difluorsyklobutoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-hydroksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(4-hydroksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-hydroksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-hydroksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-hydroksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(4-oksopiperidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-hydroksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-hydroksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-hydroksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-hydroksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-hydroksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-hydroksy-3-metylazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-hydroksy-3-metylazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-hydroksy-3-metylazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-hydroksy-3-metylazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-hydroksy-3-metylazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(isobutylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(isobutylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(isobutylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(isobutylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(isobutylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etyl(metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion3-(1-okso-5-(((1S,2S)-2-((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((3aR,6aS)-tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyridin-2-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyridin-2-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyridin-2-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion 3-(1-okso-5-(((1R,2S)-2-((pyridin-2-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyridin-2-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(pyrrolidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(pyrrolidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(pyrrolidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(pyrrolidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(pyrrolidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(bis((3-metyloksetan-3-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(bis((3-metyloksetan-3-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(bis((3-metyloksetan-3-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(bis((3-metyloksetan-3-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(bis((3-metyloksetan-3-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyridin-3-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyridin-3-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyridin-3-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((pyridin-3-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyridin-3-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyridin-4-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyridin-4-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyridin-4-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((pyridin-4-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyridin-4-ylmetyl)amino)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-metoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-metoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(4-metoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-metoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-metoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4,4-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4,4-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4,4-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4,4-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4,4-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-metoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-metoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-metoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-metoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-metoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(oksetan-3-ylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(oksetan-3-ylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(oksetan-3-ylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(oksetan-3-ylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(etyl(oksetan-3-ylmetyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(isoindolin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(isoindolin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(isoindolin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(isoindolin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(isoindolin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-metoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-metoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-metoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-metoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-metoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-etoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-etoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-etoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-etoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-etoksy-4-metylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-((((1R,4S)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1R,4R)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((((1R,4R)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((((1R,4S)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1R,4R)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;(1S,4R)-4-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)amino)metyl)sykloheksan-1-karbonitril;(1R,4r)-4-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)amino)metyl)sykloheksan-1-karbonitril;(1R,4r)-4-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)amino)metyl)sykloheksan-1-karbonitril;(1S,4r)-4-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)amino)metyl)sykloheksan-1-karbonitril;(1r,4r)-4-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)amino)metyl)sykloheksan-1-karbonitril;4-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)amino)metyl)sykloheksan-1-karbonitril;3-(5-(((1S,2S)-2-(((4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(((4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)(etyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1S,3R)-3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)(etyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1R,3S)-3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)(etyl)amino)metyl)-1-metylsyklobutan-1-karbonitril; trans-3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)(etyl)amino)metyl)-1-metylsyklobutan-1-karbonitril; cis-3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)syklopentyl)(etyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;3-(5-(((1S,2S)-2-(4-fluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-fluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-fluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-fluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-fluorpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(1,5-oksazokan-5-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(1,5-oksazokan-5-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(1,5-oksazokan-5-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(1,5-oksazokan-5-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(1,5-oksazokan-5-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(((1R,4S)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((((1R,4S)-4-metoksysykloheksyl)metyl)(metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;trans-3-(5-((2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;cis-3-(5-((2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((4,4-difluorsykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((4,4-difluorsykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((4,4-difluorsykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((4,4-difluorsykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((4,4-difluorsykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((1H-indol-5-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((1H-indol-5-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((1H-indol-5-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((1H-indol-5-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((1H-indol-5-yl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-(tert-butoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-(tert-butoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-(tert-butoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-(tert-butoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(4-(tert-butoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoi ndolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(2-oksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(2-oksa-8-azaspiro[4.5]dekan-8-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2-klorfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(2-klorfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(2-klorfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(2-klorfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(2-klorfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(2-metoksyfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(6-azaspiro[3.5]nonan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(6-azaspiro[3.5]nonan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(6-azaspiro[3.5]nonan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(6-azaspiro[3.5]nonan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(6-azaspiro[3.5]nonan-6-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(((1S,3R)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(((1s,3S)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(((1s,3S)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(((1s,3R)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etyl(((1s,3s)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dietylamino)-4,4-dimetylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(etyl(((1R,3S)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(((1r,3R)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(((1r,3R)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(((1r,3S)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etyl(((1r,3r)-3-metoksysyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(8-oksa-2-azaspiro[4.5]dekan-2-yl)syklopentyl)oksy)-1-oksoisoi ndolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(8-oksa-2-azaspiro[4.5]dekan-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(8-oksa-2-azaspiro[4.5]dekan-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(8-oksa-2-azaspiro[4.5]dekan-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(8-oksa-2-azaspiro[4.5]dekan-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-tiomorfolinosyklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-tiomorfolinosyklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-tiomorfolinosyklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-tiomorfolinosyklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-tiomorfolinosyklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(1,4-oksazepan-4-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(1,4-oksazepan-4-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(1,4-oksazepan-4-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(1,4-oksazepan-4-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(1,4-oksazepan-4-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-isopropoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-isopropoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-isopropoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-isopropoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-isopropoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-(syklopropylmetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-(syklopropylmetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-(syklopropylmetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-(syklopropylmetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-(syklopropylmetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((3aR,4R,7S,7aS)-oktahydro-2H-4,7-epoksyisoindol-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3- (5-(((1S,2R)-2-((3aR,4R,7S,7aS)-oktahydro-2H-4,7-epoksyisoindol-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3- (5-(((1R,2R)-2-((3aR,4R,7S,7aS)-oktahydro-2H-4,7-epoksyisoindol-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3- (5-(((1R,2S)-2-((3aR,4R,7S,7aS)-oktahydro-2H-4,7-epoksyisoindol-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3- (5-((2-((3aR,4R,7S,7aS)-oktahydro-2H-4,7-epoksyisoindol-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-etoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-etoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-etoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-etoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-etoksypiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(7,8-dihydro-1,6-naftyridin-6(5H)-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(7,8-dihydro-1,6-naftyridin-6(5H)-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(7,8-dihydro-1,6-naftyridin-6(5H)-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(7,8-dihydro-1,6-naftyridin-6(5H)-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(7,8-dihydro-1,6-naftyridin-6(5H)-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((((1S,4R)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1s,4S)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((((1s,4S)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-((((1s,4R)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1s,4s)-4-metoksysykloheksyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((R)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((1S,2R)-2-((R)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((1R,2R)-2-((R)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((R)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-((2-((R)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((S)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((S)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((S)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((S)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((S)-3-metoksypyrrolidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3,3-difluorsyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3,3-difluorsyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3,3-difluorsyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3,3-difluorsyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(((3,3-difluorsyklobutyl)metyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-(difluormetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-(difluormetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-(difluormetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-(difluormetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-(difluormetoksy)piperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(propylamino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(propylamino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(propylamino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(propylamino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(propylamino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(dipropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(dipropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dipropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dipropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dipropylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyridin-4-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyridin-4-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyridin-4-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((pyridin-4-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyridin-4-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyridin-3-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyridin-3-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyridin-3-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1R,2S)-2-((pyridin-3-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyridin-3-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((1-etyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((1-etyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((1-etyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((1-etyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((1-etyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((1-isopropyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((1-isopropyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((1-isopropyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((1-isopropyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((1-isopropyl-1H-pyrazol-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etyl(metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(dimetylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dimetylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dimetylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dimetylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dimetylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((oksetan-3-ylmetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((oksetan-3-ylmetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((oksetan-3-ylmetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((oksetan-3-ylmetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((oksetan-3-ylmetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((2-hydroksyetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((2-hydroksyetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((2-hydroksyetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((2-hydroksyetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((2-hydroksyetyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(pyrrolidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(pyrrolidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1R,2R)-2-(pyrrolidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(pyrrolidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(pyrrolidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-morfolinosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-morfolinosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-morfolinosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-morfolinosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-morfolinosykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1S,2S)-2-((pyridin-2-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyridin-2-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyridin-2-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((pyridin-2-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyridin-2-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((3-hydroksy-3-metylbutyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((3-hydroksy-3-metylbutyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((3-hydroksy-3-metylbutyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((3-hydroksy-3-metylbutyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-((3-hydroksy-3-metylbutyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3-metyloksetan-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-metoksy-4-metylpiperidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-metoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-metoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-metoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-metoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-metoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((6-metylpyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(((6-metylpyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((6-metylpyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((6-metylpyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((6-metylpyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((5-metoksypyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((5-metoksypyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((5-metoksypyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((5-metoksypyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((5-metoksypyridin-2-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((6-metoksypyridin-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((6-metoksypyridin-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((6-metoksypyridin-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((6-metoksypyridin-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((6-metoksypyridin-3-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((2-hydroksy-2-metylpropyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((2-hydroksy-2-metylpropyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((2-hydroksy-2-metylpropyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-((2-hydroksy-2-metylpropyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((2-hydroksy-2-metylpropyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;3-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;3-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;3-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;3-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1S,3R)-3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1R,3R)-3-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1R,3R)-3-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1S,3r)-3-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1r,3r)-3-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1R,3S)-3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1S,3s)-3-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1S,3s)-3-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1R,3s)-3-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril;(1s,3s)-3-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)-1-metylsyklobutan-1-karbonitril; 3-(1-okso-5-(((1S,2S)-2-(piperidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(piperidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(piperidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(piperidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(piperidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((((1S,3R)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1s,3S)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-((((1s,3S)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((((1s,3R)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1s,3s)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((cis-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((cis-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((cis-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((cis-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((cis-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((((1R,3S)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1s,3S)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((((1s,3S)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((((1s,3R)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1s,3s)-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((trans-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((trans-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((trans-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((trans-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(((trans-3-metoksysyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((((1r,4S)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((((1r,4S)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1r,4r)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((4-metyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((4-metyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((4-metyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((4-metyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((4-metyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyrimidin-5-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyrimidin-5-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyrimidin-5-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((pyrimidin-5-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyrimidin-5-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1S,2S)-2-((2-(tetrahydro-2H-pyran-4-yl)etyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((2-(tetrahydro-2H-pyran-4-yl)etyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((2-(tetrahydro-2H-pyran-4-yl)etyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((2-(tetrahydro-2H-pyran-4-yl)etyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((2-(tetrahydro-2H-pyran-4-yl)etyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-7-azaspiro[3.5]nonan-7-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((4-metoksytetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(((4-metoksytetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(((4-metoksytetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(((4-metoksytetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(((4-metoksytetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((2,2-dimetyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(((2,2-dimetyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(((2,2-dimetyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(((2,2-dimetyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(((2,2-dimetyltetrahydro-2H-pyran-4-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((7-oksaspiro[3.5]nonan-2-yl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((7-oksaspiro[3.5]nonan-2-yl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((7-oksaspiro[3.5]nonan-2-yl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((7-oksaspiro[3.5]nonan-2-yl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((7-oksaspiro[3.5]nonan-2-yl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;1-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)syklobutan-1-karbonitril;1-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)syklobutan-1-karbonitril;1-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)syklobutan-1-karbonitril;1-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)syklobutan-1-karbonitril;1-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)syklobutan-1-karbonitril;3-(5-(((1S,2S)-2-(3-(2-klorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(2-klorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(2-klorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl) piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(2-klorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(3-(2-klorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(2-metoksyfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-((pyrazolo[1,5-a]pyrimidin-6-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-((pyrazolo[1,5-a]pyrimidin-6-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-((pyrazolo[1,5-a]pyrimidin-6-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-((pyrazolo[1,5-a]pyrimidin-6-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-((pyrazolo[1,5-a]pyrimidin-6-ylmetyl)amino)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((4,4-difluorsykloheksyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((4,4-difluorsykloheksyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((4,4-difluorsykloheksyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((4,4-difluorsykloheksyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((4,4-difluorsykloheksyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((2,4-difluorbenzyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-((2,4-difluorbenzyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((2,4-difluorbenzyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((2,4-difluorbenzyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((2,4-difluorbenzyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((1R,2R)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((1R,2R)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((1R,2R)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((1R,2R)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((1R,2R)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((1S,2S)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((1S,2S)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((1S,2S)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(((1S,2S)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((1S,2S)-2-metoksysyklopentyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)bisyklo[1.1.1]pentan-1-karbonitril;3-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)bisyklo[1.1.1]pentan-1-karbonitril;3-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)bisyklo[1.1.1]pentan-1-karbonitril;3-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)bisyklo[1.1.1]pentan-1-karbonitril;3-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)bisyklo[1.1.1]pentan-1-karbonitril;3-(5-(((1S,2S)-2-(3-(3-fluorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-(3-fluorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-(3-fluorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-(3-fluorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-(3-fluorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-((((1S,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1s,4S)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((((1s,4S)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((((1s,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1s,4s)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((cis-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((trans-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(bis(((1R,4S)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(bis(((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(bis(((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(bis(((1r,4S)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(bis(((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 4-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)amino)metyl)benzonitril;4-((((1S,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)(metyl)amino)metyl)benzonitril;4-((((1R,2S)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)(metyl)amino)metyl)benzonitril;4-((((1R,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)(metyl)amino)metyl)benzonitril;4-((((1S,2R)-2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)(metyl)amino)metyl)benzonitril;4-(((2-((2-(2,6-dioksopiperidin-3-yl)-1-oksoisoindolin-5-yl)oksy)sykloheksyl)(metyl)amino)metyl)benzonitril;3-(5-(((1S,2S)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3,3-difluorpyrrolidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3,3-difluorpyrrolidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(3,3-difluorpyrrolidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3,3-difluorpyrrolidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3,3-difluorpyrrolidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(etylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(etylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(etylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(etylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(benzylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(benzylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(benzylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(benzylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(benzylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(dietylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dietylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dietylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(4-metoksy-4-metylpiperidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(4-metoksy-4-metylpiperidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(isobutylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(isobutylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(isobutylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(isobutylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(isobutylamino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(propylamino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(propylamino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(propylamino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(propylamino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(propylamino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2R)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(2-oksa-6-azaspiro[3.3]heptan-6-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(2-oksa-6-azaspiro[3.3] heptan-6-yl)sykloheptyl)oksy)-1-oksoisoi ndolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-((((1R,4S)-4-metoksysykloheksyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-((((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-((((1r,4R)-4-metoksysykloheksyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-((((1r,4S)-4-metoksysykloheksyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-((((1r,4r)-4-metoksysykloheksyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheptyl)oksy) isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(((tetrahydro-2H-pyran-4-yl)metyl)amino)sykloheptyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1R,2S)-2-(((3-metyloksetan-3-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3-metyloksetan-3-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3-fluorbisyklo[1.1.1]pentan-1-yl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-metoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-metoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-metoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-metoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-metoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(((3,3-difluorsyklobutyl)metyl)amino)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-((2-(dietylamino)-3-metylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(dietylamino)-3-metylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dietylamino)-3-metylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)-3-metylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)-3-metylsyklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(3-(pyridazin-3-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(3-(pyridazin-3-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(3-(pyridazin-3-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(3-(pyridazin-3-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(3-(pyridazin-3-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion; 3-(1-okso-5-(((1R,2R)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(3-(2,2,2-trifluoretoksy)azetidin-1-yl)syklopentyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3,3-dimetylpiperidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(3-isopropoksyazetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S,3S,4R)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S,3R,4R)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R,3R,4R)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R,3S,4R)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,4R)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S,3S,4S)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S,3R,4S)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R,3R,4S)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R,3S,4S)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,4S)-3-(3-etoksyazetidin-1-yl)bisyklo[2.2.1]heptan-2-yl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2S)-2-(3-(pyrazin-2-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1S,2R)-2-(3-(pyrazin-2-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2R)-2-(3-(pyrazin-2-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-(((1R,2S)-2-(3-(pyrazin-2-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(1-okso-5-((2-(3-(pyrazin-2-yloksy)azetidin-1-yl)sykloheksyl)oksy)isoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-aminosyklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-aminosyklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-aminosyklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-aminosyklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-aminosyklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(dietylamino)syklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2R)-2-(dietylamino)syklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)syklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)syklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-(dietylamino)syklopentyl)oksy)-4-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-aminosyklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-aminosyklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-aminosyklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-aminosyklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-((2-aminosyklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(dietylamino)syklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2R)-2-(dietylamino)syklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2R)-2-(dietylamino)syklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1R,2S)-2-(dietylamino)syklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion; og3-(5-((2-(dietylamino)syklopentyl)oksy)-6-fluor-1-oksoisoindolin-2-yl)piperidin-2,6-dion.eller et farmasøytisk akseptabelt salt, hydrat, solvat, prodrug, stereoisomer eller tautomer derav.11. Forbindelse ifølge krav 1, valgt blant:3-(5-(((1S,2S)-2-(dietylamino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; 3-(5-(((1S,2S)-2-(3-etoksyazetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etylamino)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(etyl(2-fluoretyl)amino)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(3,3-difluorsyklobutoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2-klorfenoksy)azetidin-1-yl)sykloheksyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2-metoksyfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;3-(5-(((1S,2S)-2-(3-(2-klorfenoksy)azetidin-1-yl)syklopentyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion; og3-(5-(((1S,2S)-2-(3-etoksyazetidin-1-yl)sykloheptyl)oksy)-1-oksoisoindolin-2-yl)piperidin-2,6-dion;eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav.12. Forbindelse ifølge krav 1, hvor forbindelsen ereller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav.13. Farmasøytisk sammensetning som omfatter en terapeutisk virksom mengde av en forbindelse ifølge krav 1-12, eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav, og en farmasøytisk akseptabel bærer eller eksipiens.14. Forbindelse ifølge et hvilket som helst av kravene 1-12, eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav, eller en farmasøytisk sammensetning ifølge krav 13 for anvendelse i behandlingen av kreft. 15. Forbindelse for anvendelse ifølge krav 14 eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav, eller den farmasøytiske sammensetning for anvendelse ifølge krav 14, hvor kreften velges blant ikke-småcellet lungekreft (NSCLC), melanom, trippel negativ brystkreft (TNBC), nasofaryngeal kreft (NPC), mikrosatellittstabil tarmkreft (mssCRC), tymom, karsinoid, akutt myelogen leukemi og gastrointestinal stromal tumor (GIST).16. Forbindelse ifølge et hvilket som helst av kravene 1-12 eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav for anvendelse i terapi.17. Kombinasjon som omfatter en forbindelse ifølge et hvilket som helst av kravene 1-12 eller et farmasøytisk akseptabelt salt, hydrat, solvat, stereoisomer eller tautomer derav, og ett eller flere terapeutiske midler.
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Innehaver i EP:
Novartis AG
Lichtstrasse 35 4056 Basel CH

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ADCOCK, Claire
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
BONAZZI, Simone
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
CERNIJENKO, Artiom
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
LAM, Philip
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
LINKENS, Kathryn Taylor
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
MALIK, Hasnain Ahmed
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
THOMSEN, Noel Marie-France
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US
VISSER, Michael Scott
Novartis Institutes for BioMedical Research, Inc. 250 Massachusetts Avenue Cambridge, Massachusetts 02139 US

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Fullmektig i Norge:
ZACCO NORWAY AS
Postboks 488 0213 OSLO NO ( OSLO kommune, Oslo fylke )

Org.nummer: 982702887
Din referanse: V463639NO00
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Kilde: Brønnøysundregistrene
Fullmektig i EP:
Reid, Stephanie Marie
Novartis Pharma AG Lichtstrasse 35 4056 Basel CH

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2018.07.10, US 201862695920 P

2019.04.18, US 201962835543 P

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EP-A1- 3 202 461 (B1)

WO-A1-2014/039960 (B1)

WO-A1-2019/191112 (B1)

WO-A1-2019/038717 (B1)

WO-A1-2019/079569 (B1)

WO-A1-2017/176958 (B1)

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Hva betyr A1, B, B1, C osv? info
Kapitler uten data er fjernet. Melding opprettet: 24.04.2025 05:44:51