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Tittel HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
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Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP3814357
Europeisk (EP) publiserings nummer EP3814357
EP levert
EP søknadsnummer 19736566.1
EP meddelt
Prioritet 2018.06.27, US 201862690653 P
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver PTC Therapeutics, Inc. (US)
Oppfinner SYDORENKO, Nadiya (US) .... se mer/flere nedenfor
Fullmektig Nordic Patent Service A/S (DK)
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Patentkrav1. Forbindelse, eller en form derav, valgt fra gruppen som består av:5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazin-5-yl]fenol;5-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazin;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]fenol;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin;2-[6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin;5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenol;3-[2-hydroksy-4-(1H-pyrazol-4-yl(fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl(-7H-imidazo[4,5-c]pyridazin-6-ol;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenol;2-[7-(piperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol; 6-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin;6-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenol;2-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo-[2,3-b]pyrazin; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenol;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenol;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin-3-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenol;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]fenol;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(8-azabisyklo[3.2.1]okt-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenol;3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin;4-fluor-2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 4-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;7-[(3-ekso)-8-azabisyklo[3.2.1]okt-3-yl]-3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metylpyridin-2(1H)-on;4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]bifenyl-3,4'-diol;5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[6-metoksy-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[6-(metylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(piperazin-1-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1-etyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-propyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[6-(etylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;5-(1-metyl-1H-pyrazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-metyl-1H-pyrazol-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(1,2,2,6,6-pentametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenol;6-fluor-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl][1,1'-bifenyl]-3,4'-diol;2-fluor-3-(1H-pyrazol-4-yl)-6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 4-{2-fluor-5-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metylpyridin-2(1H)-on;2-[3-(2,2-dimetylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenol;2-{3-[(1R,5S)-1,5-dimetyl-8-azabisyklo[3.2.1]oktan-3-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]benzen-1,4-diol;3-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyrazin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyridin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-fluor-5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,4-triazolo-1-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(4H-1,2,4-triazolo-4-yl)fenol;5-(pyridin-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-3-ol;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-5-ol;5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[1-(difluormetyl)-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,3-triazolo-1-yl)fenol;5-(2-metylpyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[2-(trifluormetyl)pyridin-4-yl]fenol;5-(pyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyridazin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyrimidin-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridazin-3-ol;5-(1H-pyrrolo-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]kinolin-7-ol;(3E)-3-(hydroksyimino)-6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1.2.3]triazolo[4,5-c]pyridazin-6-yl]-2,3-dihydro-1H-inden-5-ol;4-klor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[6-(dimetylamino)pyridin-3-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(imidazo[1,2-a]pyrazin-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;1-syklopropyl-4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-2(1H)-on;4-fluor-5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(imidazo[1,5-a]pyridin-7-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(tiofen-3-yl)fenol;5-(imidazo[1,2-a]pyridin-7-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-imidazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;1-metyl-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-1H-benzimidazol-6-ol;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-2(1H)-on;5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-1H-indazol-6-ol;5-(furan-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-2-yl)fenol;2-metyl-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-1H-benzimidazol-6-ol;5-(1-metyl-1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(2-aminopyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[2-(dimetylamino)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(3-fluorpyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-[5-(difluormetoksy)pyridin-2-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[2-(metylamino)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)furo[3,2-c]pyridazin-3-yl]fenol; 5-(3-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-5-yl)fenol;5-(3-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1H-pyrazol-3-karbonitril;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1,3-tiazol-5-karbonitril;5-(1,3-oksazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,3-triazolo-4-yl)fenol;5-(6-metoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[2-(difluormetoksy)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-imidazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3,4-tiadiazol-2-yl)fenol;6-[4-(1H-pyrazol-4-yl)-1H-benzotriazolo-7-yl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin;5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1,2-oksazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(5-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-etyl-5-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 5-(2-etoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(6-etoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[1,5-a]pyridin-7-yl)fenol;5-(3-klor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-4(3H)-on;5-(3-klor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol5-(3-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(3-metoksy-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metyl-1H-pyrazol-3-karbonitril;5-(5-metyl-1,3-tiazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,2,4-tiadiazol-5-yl)fenol;5-(4-fluor-1H-benzotriazolo-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]pyridin-3-ol;5-(3-brom-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-metyl-1H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[3-(trifluormetyl)-1H-pyrazol-4-yl]fenol; 5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]pyridin-3-ol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]pyridin-3-ol;5-(imidazo[1,2-a]pyrazin-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-fluor-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-metyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(3H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)fenol;5-(3-fluor-1-metyl-1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(2,4-dimetyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metyl-1,3-tiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metyl-2H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)fenol;5-(3-metyl-1,2,4-tiadiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-fluor-2-metyl-1,3-tiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(5-metyl-1H-pyrazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-metyl-1H-pyrazol-1-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol; 5-(3-metyl-1H-pyrazol-1-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(2-metyl-1,3-oksazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-metoksy-1,3,5-triazin-2-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(imidazo[1,2-a]pyrimidin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(3-fluor-1H-pyrazol-4-yl)-2-(1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl)fenol;5-(imidazo[1,2-b]pyridazin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol;2-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;5-(pyridin-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(pyridin-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(pyrimidin-5-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;2-{3-[(3S,4R)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;5-(1-metyl-1H-pyrazol-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;2-{3-[3-(tert-butylamino)syklobutyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;4-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-1-metylpyridin-2(1H)-on;6-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-3-metylpyrimidin-4(3H)-on;5-(3-fluor-1H-pyrazol-4-yl)-2-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}fenol; 2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol;2-{3-[3-(tert-butylamino)syklopentyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol; og2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol;hvori en form av forbindelsen velges fra gruppen som består av en salt-, hydrat-, solvat-, racemat-, enantiomer-, diastereomer-, stereoisomer- og tautomerform derav.2. Forbindelsen, eller formen derav, ifølge krav 1, valgt fra gruppen som består av:5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazin-5-yl]fenol;5-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazin;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]fenol;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin;2-[6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin;5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenol;3-[2-hydroksy-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-6-ol;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenol;2-[7-(piperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol; 6-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin;6-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenol;2-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazin;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenol;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenol;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin-3-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenol;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]fenol;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(8-azabisyklo[3.2.1]okt-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(177-pyrazol-4-yl)fenol;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenol;3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin;4-fluor-2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;7-[(3-ekso)-8-azabisyklo[3.2.1]okt-3-yl]-3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metylpyridin-2(1H)-on;4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]bifenyl-3,4'-diol;5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[6-metoksy-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[6-(metylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;2-[7-(piperazin-1-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol; 5-(1-etyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-propyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[6-(etylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenol;5-(1-metyl-1H-pyrazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 5-(1-metyl-1H-pyrazol-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(1,2,2,6,6-pentametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenol;6-fluor-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl][1,1'-bifenyl]-3,4'-diol;2-fluor-3-(1H-pyrazol-4-yl)-6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-{2-fluor-5-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metylpyridin-2(1H)-on;2-[3-(2,2-dimetylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenol;2-{3-[(1R,5S)-1,5-dimetyl-8-azabisyklo[3.2.1]oktan-3-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]benzen-1,4-diol;3-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyrazin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyridin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-fluor-5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,4-triazolo-1-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(4H-1,2,4-triazolo-4-yl)fenol;5-(pyridin-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-3-ol; 2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-5-ol;5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[1-(difluormetyl)-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,3-triazolo-1-yl)fenol;5-(2-metylpyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[2-(trifluormetyl)pyridin-4-yl]fenol;5-(pyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyridazin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(pyrimidin-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridazin-3-ol;5-(1H-pyrrolo-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]kinolin-7-ol;(3E)-3-(hydroksyimino)-6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-2,3-dihydro-1H-inden-5-ol;4-klor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[6-(dimetylamino)pyridin-3-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 5-(imidazo[1,2-a]pyrazin-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;1-syklopropyl-4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-2(1H)-on;4-fluor-5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(imidazo[1,5-a]pyridin-7-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(tiofen-3-yl)fenol;5-(imidazo[1,2-a]pyridin-7-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-imidazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;1-metyl-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-1H-benzimidazol-6-ol;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-2(1H)-on;5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-1H-indazol-6-ol;5-(furan-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-2-yl)fenol;2-metyl-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-1H-benzimidazol-6-ol;5-(1-metyl-1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(2-aminopyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[2-(dimetylamino)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(3-fluorpyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-[5-(difluormetoksy)pyridin-2-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[2-(metylamino)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)furo[3,2-c]pyridazin-3-yl]fenol;5-(3-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-5-yl)fenol;5-(3-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1H-pyrazol-3-karbonitril;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1,3-tiazol-5-karbonitril;5-(1,3-oksazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,3-triazolo-4-yl)fenol;5-(6-metoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-[2-(difluormetoksy)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1H-imidazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3,4-tiadiazol-2-yl)fenol;6-[4-(1H-pyrazol-4-yl)-1H-benzotriazolo-7-yl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin;5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 5-(2-metoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1,2-oksazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(5-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-etyl-5-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-etoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(6-etoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[1,5-a]pyridin-7-yl)fenol;5-(3-klor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-4(3H)-on;5-(3-klor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(3-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(3-metoksy-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metyl-1H-pyrazol-3-karbonitril;5-(5-metyl-1,3-tiazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,2,4-tiadiazol-5-yl)fenol;5-(4-fluor-1H-benzotriazolo-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]pyridin-3-ol;5-(3-brom-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(1-metyl-1H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[3-(trifluormetyl)-1H-pyrazol-4-yl]fenol;5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]pyridin-3-ol;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]pyridin-3-ol;5-(imidazo[1,2-a]pyrazin-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-fluor-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-metyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(3H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)fenol;5-(3-fluor-1-metyl-1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(2,4-dimetyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metyl-1,3-tiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(2-metyl-2H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)fenol; 5-(3-metyl-1,2,4-tiadiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-fluor-2-metyl-1,3-tiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(5-metyl-1H-pyrazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-metyl-1H-pyrazol-1-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(3-metyl-1H-pyrazol-1-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(2-metyl-1,3-oksazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenol;5-(4-metoksy-1,3,5-triazin-2-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(imidazo[1,2-a]pyrimidin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;5-(3-fluor-1H-pyrazol-4-yl)-2-(1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl)fenol; og5-(imidazo[1,2-b]pyridazin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenol;hvori en form av forbindelsen velges fra gruppen som består av en salt-, hydrat-, solvat-, racemat-, enantiomer-, diastereomer-, stereoisomer- og tautomerform derav.3. Forbindelsen, eller formen derav, ifølge krav 1, valgt fra gruppen som består av:2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol;2-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;5-(pyridin-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(pyridin-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;5-(pyrimidin-5-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol; 2-{3-[(3S,4R)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;5-(1-metyl-1H-pyrazol-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenol;2-{3-[3-(tert-butylamino)syklobutyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol;4-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-1-metylpyridin-2(1H)-on;6-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-3-metylpyrimidin-4(3H)-on;5-(3-fluor-1H-pyrazol-4-yl)-2-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}fenol;2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol;2-{3-[3-(tert-butylamino)syklopentyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenol; og2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol;4. Forbindelsen ifølge krav 1, eller en form derav, hvori forbindelsen er et sammensatt salt, eller form derav, valgt fra gruppen som består av:5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazin-5-yl]fenolhydroklorid;5-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazinhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]fenolhydroklorid;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazinhydroklorid;2-[6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazinhydroklorid; 5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenolhydroklorid;3-[2-hydroksy-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-6-ol-hydroklorid;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(piperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;6-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazinhydroklorid;6-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazinhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazinhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin-3-yl]fenolhydroklorid; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[7-(8-azabisyklo[3.2.1]okt-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenolhydroklorid;3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazinhydroklorid;4-fluor-2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;4-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydrobromid;7-[(3-ekso)-8-azabisyklo[3.2.1]okt-3-yl]-3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazinhydroklorid;4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]bifenyl-3,4'-diolhydrobromid;5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydrobromid;2-[6-metoksy-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[6-(metylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[6-(etylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid; 2-[3-(1,2,2,6,6-pentametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenoldihydroklorid;6-fluor-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl][1,1'-bifenyl]-3,4'-diolhydrobromid;2-fluor-3-(1H-pyrazol-4-yl)-6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;4-{2-fluor-5-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metylpyridin-2(1H-on-hydroklorid;2-[3-(2,2-dimetylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-{3-[(1R,5S)-1,5-dimetyl-8-azabisyklo[3.2.1]oktan-3-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]benzen-1,4-dioldihydroklorid;3-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyrazin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyridin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;4-fluor-5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,4-triazolo-1-yl)fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(4H-1,2,4-triazolo-4-yl)fenolhydroklorid;5-(pyridin-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-3-ol-dihydroklorid;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-5-ol-dihydroklorid; 5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-[1-(difluormetyl)-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,3-triazolo-1-yl)fenolhydroklorid;5-(2-metylpyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[2-(trifluormetyl)pyridin-4-yl]fenoldihydroklorid;5-(pyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyridazin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(2-metoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridazin-3-ol-hydroklorid;6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]kinolin-7-ol-hydrobromid;4-klor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydrobromid;4-fluor-5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydrobromid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(tiofen-3-yl)fenolhydroklorid;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-2(1H)-on-hydroklorid;5-(furan-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-2-yl)fenolhydroklorid; 5-(1-metyl-1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenoldihydroklorid;5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenoldihydroklorid;5-[5-(difluormetoksy)pyridin-2-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolformiat;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)furo[3,2-c]pyridazin-3-yl]fenolhydroklorid;5-(3-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-5-yl)fenolhydroklorid;5-(3-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1H-pyrazol-3-karbonitrilhydroklorid;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1,3-tiazol-5-karbonitrilhydroklorid;5-(1,3-oksazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolformiat;5-[2-(difluormetoksy)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3,4-tiadiazol-2-yl)fenolhydroklorid;6-[4-(1H-pyrazol-4-yl)-1H-benzotriazolo-7-yl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazintrifluoracetat;5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(2-metoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1,2-oksazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(5-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid; 5-(1-etyl-5-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(2-etoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(6-etoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[1,5-a]pyridin-7-yl)fenolhydroklorid;5-(3-klor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-4(3H)-on-hydroklorid;5-(3-klor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(3-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(3-metoksy-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metyl-1H-pyrazol-3-karbonitrilhydroklorid;5-(5-metyl-1,3-tiazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,2,4-tiadiazol-5-yl)fenolhydroklorid;5-(4-fluor-1H-benzotriazolo-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]pyridin-3-ol-dihydroklorid;5-(3-brom-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1-metyl-1H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid; 2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[3-(trifluormetyl)-1H-pyrazol-4-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]pyridin-3-ol-hydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]pyridin-3-ol-dihydroklorid;5-(imidazo[1,2-a]pyrazin-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(4-fluor-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(4-metyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(3H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)fenoldihydroklorid;5-(2,4-dimetyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(2-metyl-1,3-tiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(2-metyl-2H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)fenolhydroklorid;5-(3-metyl-1,2,4-tiadiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(5-metyl-1H-pyrazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(3-metyl-1H-pyrazol-1-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenoldihydroklorid;5-(4-metoksy-1,3,5-triazin-2-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenoldihydroklorid; 5-(imidazo[1,2-a]pyrimidin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenolhydroklorid;5-(3-fluor-1H-pyrazol-4-yl)-2-(1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl)fenolhydroklorid;5-(imidazo[1,2-b]pyridazin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazolo-2-yl)fenolhydroklorid;2-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;5-(pyridin-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;5-(pyridin-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;5-(pyrimidin-5-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;2-{3-[(3S,4R)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;5-(1-metyl-1H-pyrazol-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;2-{3-[3-(tert-butylamino)syklobutyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;4-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-1-metylpyridin-2(1H)-on-hydroklorid;6-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-3-metylpyrimidin-4(3H)-on-dihydroklorid;2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(2H-1,2,3-triazolo-2-yl)fenolhydroklorid; og2-{3-[3-(tert-butylamino)syklopentyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;hvori en form av forbindelsen velges fra gruppen som består av en hydrat-, solvat-, racemat-, enantiomer-, diastereomer-, stereoisomer- og tautomerform derav. 5. Forbindelsen ifølge krav 4, eller en form derav, hvori forbindelsen er et sammensatt salt valgt fra gruppen som består av:5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazin-5-yl]fenolhydroklorid;5-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-imidazo[4,5-b]pyrazinhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]fenolhydroklorid;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazinhydroklorid;2-[6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;3-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-6-metyl-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazinhydroklorid;5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenolhydroklorid;3-[2-hydroksy-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-6-ol-hydroklorid;5-(1H-pyrazol-4-yl)-2-[5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(piperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;6-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazinhydroklorid;6-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazinhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[2,5-difluor-4-(1H-pyrazol-4-yl)fenyl]-5-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[2,3-b]pyrazinhydroklorid; 5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[1-(piperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazin-3-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)tieno[3,2-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)tieno[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]fenolhydroklorid;2-[7-(8-azabisyklo[3.2.1]okt-2-en-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-6-en-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[7-(8-azabisyklo[3.2.1]okt-3-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[7-(3-oksa-9-azabisyklo[3.3.1]non-7-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-5H-pyrrolo[3,2-c]pyridazin-3-yl]fenolhydroklorid;3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-7-(2,2,6,6-tetrametylpiperidin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazinhydroklorid;4-fluor-2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid; 4-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydrobromid;7-[(3-ekso)-8-azabisyklo[3.2.1]okt-3-yl]-3-[2,3-difluor-4-(1H-pyrazol-4-yl)fenyl]-6,7-dihydro-5H-pyrrolo[2,3-c]pyridazinhydroklorid;4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]bifenyl-3,4'-diolhydrobromid;5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydrobromid;2-[6-metoksy-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[6-(metylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[6-(etylamino)-7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-[3-(1,2,2,6,6-pentametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenoldihydroklorid;6-fluor-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl][1,1'-bifenyl]-3,4'-diolhydrobromid;2-fluor-3-(1H-pyrazol-4-yl)-6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;4-{2-fluor-5-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metylpyridin-2(1H-on-hydroklorid;2-[3-(2,2-dimetylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-{3-[(1R,5S)-1,5-dimetyl-8-azabisyklo[3.2.1]oktan-3-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenolhydroklorid;2-(1H-pyrazol-4-yl)-5-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]benzen-1,4-dioldihydroklorid;3-fluor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyrazin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyridin-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid; 4-fluor-5-(1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,4-triazolo-1-yl)fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(4H-1,2,4-triazolo-4-yl)fenolhydroklorid;5-(pyridin-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-3-ol-dihydroklorid;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-5-ol-dihydroklorid;5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-[1-(difluormetyl)-1H-pyrazol-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-1,2,3-triazolo-1-yl)fenolhydroklorid;5-(2-metylpyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[2-(trifluormetyl)pyridin-4-yl]fenoldihydroklorid;5-(pyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(pyridazin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(2-metoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridazin-3-ol-hydroklorid; 6-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]kinolin-7-ol-hydrobromid;4-klor-5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydrobromid;4-fluor-5-(pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydrobromid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(tiofen-3-yl)fenolhydroklorid;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyridin-2(1H)-on-hydroklorid;5-(furan-3-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-2-yl)fenolhydroklorid;5-(1-metyl-1H-pyrazol-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenoldihydroklorid;5-[1-(2H3)metyl-1H-pyrazol-4-yl]-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenoldihydroklorid;5-[5-(difluormetoksy)pyridin-2-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolformiat;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametyl-1,2,3,6-tetrahydropyridin-4-yl)furo[3,2-c]pyridazin-3-yl]fenolhydroklorid;5-(3-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3-tiazol-5-yl)fenolhydroklorid;5-(3-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1H-pyrazol-3-karbonitrilhydroklorid;2-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1,3-tiazol-5-karbonitrilhydroklorid;5-(1,3-oksazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolformiat; 5-[2-(difluormetoksy)pyridin-4-yl]-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,3,4-tiadiazol-2-yl)fenolhydroklorid;6-[4-(1H-pyrazol-4-yl)-1H-benzotriazolo-7-yl]-3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazintrifluoracetat;5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(2-metoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1,2-oksazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(5-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1-etyl-5-fluor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(2-etoksypyridin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(6-etoksypyrimidin-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[1,5-a]pyridin-7-yl)fenolhydroklorid;5-(3-klor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;6-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}pyrimidin-4(3H)-on-hydroklorid;5-(3-klor-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(3-fluor-1-metyl-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(3-metoksy-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid; 4-{3-hydroksy-4-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenyl}-1-metyl-1H-pyrazol-3-karbonitrilhydroklorid;5-(5-metyl-1,3-tiazol-2-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1,2,4-tiadiazol-5-yl)fenolhydroklorid;5-(4-fluor-1H-benzotriazolo-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-pyrrolo[2,3-c]pyridazin-3-yl]pyridin-3-ol-dihydroklorid;5-(3-brom-1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(1-metyl-1H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-[3-(trifluormetyl)-1H-pyrazol-4-yl]fenol77;5-(1H-pyrazol-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]pyridin-3-ol-hydroklorid;5-(1H-pyrazol-4-yl)-2-[7-(2,2,6,6-tetrametylpiperidin-4-yl)-7H-imidazo[4,5-c]pyridazin-3-yl]pyridin-3-ol-dihydroklorid;5-(imidazo[1,2-a]pyrazin-6-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(4-fluor-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(4-metyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(3H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)fenoldihydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)fenoldihydroklorid;5-(2,4-dimetyl-1H-imidazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid; 5-(2-metyl-1,3-tiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(2-metyl-2H-1,2,3-triazolo-4-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)fenolhydroklorid;5-(3-metyl-1,2,4-tiadiazol-5-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenolhydroklorid;5-(5-metyl-1H-pyrazol-1-yl)-2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]fenoldihydroklorid;5-(3-metyl-1H-pyrazol-1-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenoldihydroklorid;5-(4-metoksy-1,3,5-triazin-2-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenoldihydroklorid;5-(imidazo[1,2-a]pyrimidin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenolhydroklorid;5-(3-fluor-1H-pyrazol-4-yl)-2-(1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl)fenolhydroklorid; og5-(imidazo[1,2-b]pyridazin-6-yl)-2-(3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl)fenolhydroklorid;hvori en form av forbindelsen velges fra gruppen som består av en hydrat-, solvat-, racemat-, enantiomer-, diastereomer-, stereoisomer- og tautomerform derav.6. Forbindelsen ifølge krav 4, eller en form derav, hvori forbindelsen er et sammensatt salt, valgt fra gruppen som består av:2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazolo-2-yl)fenolhydroklorid;2-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;5-(pyridin-4-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;5-(pyridin-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid; 5-(pyrimidin-5-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;2-{3-[(3S,4R)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;5-(1-metyl-1H-pyrazol-3-yl)-2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]fenolhydroklorid;2-{3-[3-(tert-butylamino)syklobutyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;4-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-1-metylpyridin-2(1H)-on-hydroklorid;6-(4-{3-[(3S,4S)-3-fluor-2,2,6,6-tetrametylpiperidin-4-yl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-3-hydroksyfenyl)-3-metylpyrimidin-4(3H)-on-dihydroklorid;2-[1-(2,2,6,6-tetrametylpiperidin-4-yl)-1H-pyrazolo[3,4-c]pyridazin-5-yl]-5-(2H-1,2,3-triazolo-2-yl)fenolhydroklorid; og2-{3-[3-(tert-butylamino)syklopentyl]-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl}-5-(1H-pyrazol-4-yl)fenoldihydroklorid;hvori en form av forbindelsen velges fra gruppen som består av en hydrat-, solvat-, racemat-, enantiomer-, diastereomer-, stereoisomer- og tautomerform derav.7. Forbindelsen ifølge ett av kravene 1 eller 4 for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.8. Forbindelsen for anvendelse ifølge krav 7, hvori den effektive mengden av forbindelsen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.9. Forbindelsen ifølge ett av kravene 1 eller 4 i blanding med én eller flere farmasøytisk akseptable eksipiens(er) i en farmasøytisk sammensetning for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.10. Forbindelsen for anvendelse ifølge krav 9, hvori den effektive mengden av forbindelsen i den farmasøytiske sammensetningen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag. 11. Farmasøytisk sammensetning omfattende forbindelsen ifølge ett av kravene 1 eller 4 og minst én farmasøytisk akseptabel eksipiens.12. Forbindelsen ifølge ett av kravene 2 eller 5 for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.13. Forbindelsen for anvendelse ifølge krav 12, hvori den effektive mengden av forbindelsen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.14. Forbindelsen ifølge ett av kravene 2 eller 5 i blanding med én eller flere farmasøytisk akseptable eksipiens(er) i en farmasøytisk sammensetning for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.15. Forbindelsen for anvendelse ifølge krav 14, hvori den effektive mengden av forbindelsen i den farmasøytiske sammensetningen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.16. Farmasøytisk sammensetning omfattende forbindelsen ifølge ett av kravene 2 eller 5 og minst én farmasøytisk akseptabel eksipiens.17. Forbindelsen ifølge ett av kravene 3 eller 6 for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.18. Forbindelsen for anvendelse ifølge krav 17, hvori den effektive mengden av forbindelsen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.19. Forbindelsen ifølge ett av kravene 3 eller 6 i blanding med én eller flere farmasøytisk akseptable eksipiens(er) i en farmasøytisk sammensetning for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav. 20. Forbindelsen for anvendelse ifølge krav 19, hvori den effektive mengden av forbindelsen i den farmasøytiske sammensetningen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.21. Farmasøytisk sammensetning omfattende forbindelsen ifølge ett av kravene 3 eller 6 og minst én farmasøytisk akseptabel eksipiens.22. Forbindelse eller en form derav ifølge krav 1, hvori forbindelsen er 2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazolo-2-yl)fenol.23. Forbindelsen eller formen derav ifølge krav 22, hvori forbindelsen er et sammensatt salt, hvori det sammensatte saltet er 2-[3-(2,2,6,6-tetrametylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazolo-2-yl)fenolhydroklorid.24. Forbindelsen ifølge ett av kravene 22 eller 23 for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.25. Forbindelsen for anvendelse ifølge krav 24, hvori den effektive mengden av forbindelsen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.26. Forbindelsen ifølge ett av kravene 22 eller 23 i blanding med én eller flere farmasøytisk akseptable eksipiens(er) i en farmasøytisk sammensetning for anvendelse i en medisinsk fremgangsmåte omfattende behandling eller lindring av Huntingtons sykdom (HD) hos et individ med behov derav.27. Forbindelsen for anvendelse ifølge krav 26, hvori den effektive mengden av forbindelsen i den farmasøytiske sammensetningen er i et område på fra 0,001 mg/kg/dag til 500 mg/kg/dag.28. Farmasøytisk sammensetning omfattende forbindelsen ifølge ett av kravene 22 eller 23 og minst én farmasøytisk akseptabel eksipiens.
Hva betyr A1, B, B1, C osv? info

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Innehaver i EP:
PTC Therapeutics, Inc.
500 Warren Corporate Center Drive Warren, NJ 07059 US

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SYDORENKO, Nadiya
37 Sycamore Place Princeton, NJ 08540 US
ALAM, Md Rauful
300 N. Randolphville Road 124 Piscataway, NJ 08854 US
ARNOLD, Michael A.
17 Mulberry Lane Flemington, NJ 08822 US
BABU, Suresh
225 Concord Place Pennington, NJ 08534 US
BHATTACHARYYA, Anuradha
115 Inverness Drive Edison, NJ 08820 US
CHEN, Guangming
932 Sunset Ridge Bridgewater, NJ 08807 US
GERASYUTO, Aleksey I.
20 Skyline Drive Flemington, NJ 08822 US
KARP, Gary Mitchell
37 Cartwright Drive Princeton Junction, NJ 08550 US
KASSICK, Andrew J.
268 Clematis Drive Wexford, PA 15090 US
MAZZOTTI, Anthony R.
1420 Campbell Street Rahway, NJ 07065 US
MOON, Young-Choon
32 Park View Drive Warren, NJ 07059 US
NARASIMHAN, Jana
2257 New York Avenue Scotch Plains, NJ 07076 US
PATEL, Jigar
14 Mercer Street Edison, NJ 08820 US
TURPOFF, Anthony
94 Meadowbrook Drive Hillsborough, NJ 08844 US
WOLL, Matthew G.
413 Mountainview Terrace Dunellen, NJ 08812 US
YAN, Wuming
16 Morning Watch Road Wayne, NJ 07470 US
ZHANG, Nanjing
4 Pickering Circle Princeton, NJ 08540 US

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Fullmektig i Norge:
Nordic Patent Service A/S
Bredgade 30 1260 KØBENHAVN K DK
Din referanse: V2405-010-NO
Fullmektig i EP:
V.O.
P.O. Box 87930 2508 DH Den Haag NL

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2018.06.27, US 201862690653 P

Anførte dokumenter info chevron_right

ABDUL KHADER K K ET AL: "Regioselective synthesis of C-2 substituted imidazo[4,5-b]pyridines utilizing palladium catalysed C-N bond forming reactions with enolizable heterocy", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 55, no. 10, 1 February 2014 (2014-02-01), pages 1778 - 1783, XP028662807, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2014.01.114 (B1)

EP-A1- 2 841 428 (B1)

INGO KNEPPER ET AL: "3-Acylindoles as versatile starting materials for pyridine ring annulation: synthesis of 1-deazapurine isosteres", TETRAHEDRON, vol. 67, no. 29, 14 May 2011 (2011-05-14), AMSTERDAM, NL, pages 5293 - 5303, XP055609452, ISSN: 0040-4020, DOI: 10.1016/j.tet.2011.05.037 (B1)

MARIUSZ MOJZYCH ET AL: "Synthesis of pyrazolo[4,3- e ][1,2,4]triazine sulfonamides, novel Sildenafil analogs with tyrosinase inhibitory activity", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, vol. 22, no. 23, 18 October 2014 (2014-10-18), NL, pages 6616 - 6624, XP055609447, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2014.10.009 (B1)

US-A1- 2014 121 197 (B1)

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