AMOGH SIVARAPATNA ET AL: "Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor", BIOMATERIALS., vol. 53, 1 June 2015 (2015-06-01), pages 621-633, XP055270220, GB ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.02.121 (B1)

YUKI IMURA ET AL: "Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity", ANALYTICAL CHEMISTRY, vol. 82, no. 24, 15 December 2010 (2010-12-15), pages 9983-9988, XP055163485, ISSN: 0003-2700, DOI: 10.1021/ac100806x (B1)

GIOVANNI G GIOBBE ET AL: "Functional differentiation of human pluripotent stem cells on a chip", NATURE METHODS, vol. 12, no. 7, 1 June 2015 (2015-06-01), pages 637-640, XP055328192, ISSN: 1548-7091, DOI: 10.1038/nmeth.3411 (B1)

ILKA MASCHMEYER ET AL: "A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents", LAB ON A CHIP, vol. 15, no. 12, 1 January 2015 (2015-01-01), pages 2688-2699, XP055459923, ISSN: 1473-0197, DOI: 10.1039/C5LC00392J (B1)

JACKSON G. DESTEFANO ET AL: "Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs)", FLUIDS AND BARRIERS OF THE CNS, vol. 14, no. 1, 4 August 2017 (2017-08-04) , XP055485049, DOI: 10.1186/s12987-017-0068-z (B1)

JONATHAN SHEMESH ET AL: "Flow-induced stress on adherent cells in microfluidic devices", LAB ON A CHIP, vol. 15, no. 21, 1 January 2015 (2015-01-01), pages 4114-4127, XP055485067, ISSN: 1473-0197, DOI: 10.1039/C5LC00633C (B1)

KYTTALA AIJA ET AL: "Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential", STEM CELL REPORTS, vol. 6, no. 2, February 2016 (2016-02), pages 200-212, XP002779239, (B1)

MASCHMEYER ILKA ET AL: "Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance tes", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 95, 6 April 2015 (2015-04-06), pages 77-87, XP029282584, ISSN: 0939-6411, DOI: 10.1016/J.EJPB.2015.03.002 (B1)

MATERNE EVA-MARIA ET AL: "A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing", JOURNAL OF BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 205, 9 February 2015 (2015-02-09), pages 36-46, XP029240260, ISSN: 0168-1656, DOI: 10.1016/J.JBIOTEC.2015.02.002 (B1)

OBI S ET AL: "Shear stress induces arterial differentiation of bone marrow-derived endothelial progenitor cells", MICRO-NANOMECHATRONICS AND HUMAN SCIENCE, 2009. MHS 2009. INTERNATIONAL SYMPOSIUM ON, IEEE, PISCATAWAY, NJ, USA, 9 November 2009 (2009-11-09), pages 650-655, XP031579353, ISBN: 978-1-4244-5094-7 (B1)

R. BOOTH ET AL: "A multiple-channel, multiple-assay platform for characterization of full-range shear stress effects on vascular endothelial cells", LAB ON A CHIP, vol. 14, no. 11, 1 January 2014 (2014-01-01), pages 1880-1890, XP055485066, ISSN: 1473-0197, DOI: 10.1039/C3LC51304A (B1)

WO-A1-2014/052835 (B1)

WO-A2-2017/136462 (B1)

YOSUKE K. KUROKAWA ET AL: "Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems", TISSUE ENGINEERING. PART C, METHODS DEC 2008, vol. 23, no. 8, 1 August 2017 (2017-08-01) , pages 474-484, XP055485163, US ISSN: 1937-3384, DOI: 10.1089/ten.tec.2017.0133 (B1)

FRANK SONNTAG ET AL: "Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure", JOURNAL OF BIOTECHNOLOGY, vol. 148, no. 1, 1 July 2010 (2010-07-01), pages 70-75, XP055185845, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2010.02.001 (B1)