Nøkkelinformasjon info chevron_right

Viktig informasjon i saken hentes i sanntid direkte fra EPO sitt register (European Patent Register), slik at du enkelt og raskt får oversikt i saken.
Beskrivelse Verdi
Saken / databasen er sist oppdatert info  
Tittel AMINOIMIDAZOPYRIDAZINES AS KINASE INHIBITORS
Status
Hovedstatus
Detaljstatus 		Ikke i kraft info Patent opphørt Ikke betalt årsavgift
Patentnummer NO/EP3704118
Europeisk (EP) publiserings nummer EP3704118
EP levert
EP søknadsnummer 18804177.6
EP meddelt
Prioritet 2017.10.30, US 201762578607 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Bristol-Myers Squibb Company (US)
Oppfinner MERTZMAN, Michael E. (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
Lenke til European patent Register Informasjon i saken, dokumenter og patentfamilie
Patentfamilie Se i Espacenet

Sammendrag og figur info chevron_right

EPO translation logo


Se forsidefigur og sammendrag i Espacenet

Beskrivelse og krav info chevron_right

T3

Beskrivelse

Krav

Patentkrav1. Forbindelse som har formel (I), eller en stereoisomer, tautomer, salt eller solvat derav, hvoriR1 er H, halogen, C1-3alkyl, C1-3halogenalkyl, C1-3deuteroalkyl, C1-3alkoksy, C1-3halogenalkoksy, C1-3alkoksy, C1-3halogenalkoksy eller C1-3deuteroalkoksy; R2 er H, C1-3alkyl, C1-3alkoksy, C1-3halogenalkyl, C1-3halogenalkoksy,C1-3deuteroalkyl, C1-3deuteroalkoksy, halogen, NH2 eller CN;L er C(O)NRa elleralternativt er -L-A- -CH2-NRaC(O)-;Ra er uavhengig H, C1-4alkyl eller C1-4deuteroalkyl;alternativt er Ra ((fosfonooksy)alkylkarbonyloksy)alkyl, ((amino)alkylkarbonyloksy)alkyl, ((amino)sykloalkylkarbonyloksy)alkyl, ((((fofonooksy)alkyl)karbonyloksy)alkyl)oksykarbonyl, ((((fosfonooksy)sykloalkyl)karbonyloksy)alkyl)oksykarbonyl, ((((amino)alkyl)karbonyloksy)alkyl)oksykarbonyl, ((((amino)sykloalkyl)karbonyloksy)alkyl)oksykarbonyl eller ((((fosfonooksy)(alkoksy)benzoyl)alkyl)oksykarbonyl;A er C1-4alkyl substituert med 0–1 OH, C1-4alkoksy substituert med 0–1 OH, C1-4deuteroalkyl substituert med 0–1 OH, C3-6sykloalkyl-C1-3-alkyl-, C1-3-alkyl-C3-6sykloalkyl-, heterosyklyl-C0-3alkyl hvori alkylet er substituert med 0–1 OH og heterosyklusen er en 3–6-leddet ring som inneholder 1–2 heteroatomer valgt fra O, N eller S og er substituert med 0–2 av OH, halogen eller C1-3alkyl; R3 er fenyl, eller en 5- til 6-leddet heterosyklus som har 1–4 heteroatomer valgt fra N og O, hvori en hvilken som helst av fenyl- eller heteroarylgruppene er substituert med 0–3 R3a;R3a er halogen, C1-6alkyl, C1-6alkoksy, hydroksy-C1-6alkoksy, C1-6deuteroalkyl, C1-6deuteroalkoksy, C1-6halogenalkyl, C1-6halogenalkoksy, C3-6sykloalkyl, C3-6halogensykloalkyl, C3-6sykloalkoksy, C3-6sykloalkyl-C1-3alkoksy-,C3-6sykloalkyl-C1-3deuteroalkoksy-, C3-6sykloalkyl-C1-3halogenalkoksy-,C1-6alkoksy-C1-3alkyl-, C3-6sykloalkoksy-C1-3alkyl-, C1-4alkyl-SO2-, C3-6sykloalkyl-SO2-, aryl, C6-10aryl-O-, C6-10aryl-S-, NRcRdCO-, (OH)2P(O)-O-, heterosyklus-, heterosyklus-O-, heterosyklus-CH2-, heterosyklus-C(O)-, hvori hvert heterosyklus er uavhengig en 4–6-leddet ring som har 1–2 heteroatomer valgt fra N og O, og hvori hvert alkyl, sykloalkyl, aryl eller heterosyklus er substituert med 0–2 Rb;alternativt kan 2 R3a på tilstøtende atomer gå sammen for å danne -O-CH2-O-, -O-CH2-CH2-, -O-(CH2)3- eller -O-(CH2)2-O-;Rb, ved hver forekomst, er uavhengig OH, C1-3alkyl, hydroksyC1-3alkyl,C1-3alkoksy, halogen, C=O eller C1-3halogenalkyl eller C3-6sykloalkyl;Rc og Rd er uavhengig valgt fra H, C1-3alkyl, C1-3deuteroalkyl, C3-6sykloalkyl, eller tatt sammen med N som de festes til for å danne en 4–6-leddet heterosyklisk ring, som har 0–1 ytterligere heteroatomer valgt fra N, O og S, og er substituert med 0–4 substituenter valgt fra deuterium eller halogen;R4 er H, Cl, F, Br, C1-4alkyl, C1-4alkoksy, C1-4halogenalkyl, C1-4deuteroalkyl, C1-4deuteroalkoksy, syklopropyl eller NReRf:Re og Rf er uavhengig valgt fra H, C1-3alkyl, C1-3deuteroalkyl, C3-6sykloalkyl, eller tatt sammen med N som de festes til for å danne en 4–6-leddet ring substituert med 0–4 substituenter valgt fra deuterium eller halogen;R5 er H, HO-, C1-3alkyl-C(O)O-, CN, C1-3alkoksy, NRgRh-, (OH)2P(O)O- eller NH2CHR8CO- der R8 er H, C1-3alkyl eller C1-3alkoksy-C1-3alkyl;R5a og R5b er hver uavhengig valgt fra H, C1-3alkyl,eller R5a og R5b tas sammen for å danne en 3–6-leddet karbosyklisk eller heterosyklisk ring som er substituert med 0–2 av F, C1-3alkyl ellerC1-3halogenalkyl, den heterosykliske ringen har 0–2 heteroatomer valgt fra N, O og S; eller R5 er fraværende og R5a og R5b tas sammen for å danne en 3–6-leddet karbosyklisk eller heterosyklisk ring som er substituert med 0–1 av F, eller C1-3alkyl, den heterosykliske ringen har 0–2 heteroatomer valgt fra N, O og S; Rg og Rh er uavhengig valgt fra H, C1-3alkyl, C1-3deuteroalkyl eller C3-6sykloalkyl; alternativt forenes Rg og Rh, sammen med nitrogenet som de festes til, for å danne piperidinyl, morfolinyl, piperazinyl, pyrrolidinyl eller azetidinyl, alle disse er substituert med 0–3 Ri;Ri er C1-3alkyl, halogen eller C1-3halogenalkyl;Ri er halogen eller OH;R6 er H eller C1-3alkyl;X er N eller C-R7; der R7 er H, halogen, CN, C1-3alkyl, C1-3alkoksy,C1-3halogenalkyl eller C1-3halogenalkoksy; ogn er 0, 1 eller 2.2. Forbindelser som har formel (I), eller en stereoisomer, tautomer, salt eller solvat derav, hvoriR1 er H, halogen, C1-3alkyl, C1-3halogenalkyl, C1-3deuteroalkyl, C1-3alkoksy, C1-3halogenalkoksy, C1-3alkoksy, C1-3halogenalkoksy eller C1-3deuteroalkoksy; R2 er H, C1-3alkyl, C1-3alkoksy, C1-3halogenalkyl, C1-3halogenalkoksy,C1-3deuteroalkyl, C1-3deuteroalkoksy, halogen, NH2 eller CN;L er C(O)NRa eller -NRaC(O)-;alternativt er -L-A- -CH2-NRaC(O)-;Ra er uavhengig H, C1-4alkyl eller C1-4deuteroalkyl;A er C1-4alkyl substituert med 0–1 OH, C1-4deuteroalkyl substituert med 0–1 OH, C3-6sykloalkyl-C1-3-alkyl-, C1-3-alkyl-C3-6sykloalkyl-; R3 er fenyl, eller en 5- til 6-leddet heterosyklus som har 1–4 heteroatomer valgt fra N og O, hvori en hvilken som helst av fenyl- eller heteroarylgruppene er substituert med 0–3 R3a;R3a er halogen, C1-6alkyl, C1-6alkoksy, hydroksy-C1-6alkoksy, C1-6deuteroalkyl, C1-6deuteroalkoksy, C1-6halogenalkyl, C1-6halogenalkoksy, C3-6sykloalkyl,C3-6halogensykloalkyl, C3-6sykloalkoksy, C3-6sykloalkyl-C1-3alkoksy-,C3-6sykloalkyl-C1-3deuteroalkoksy-, C3-6sykloalkyl-C1-3halogenalkoksy-,C1-6alkoksy-C1-3alkyl-, C3-6sykloalkoksy-C1-3alkyl-, C1-4alkyl-SO2-, C3-6sykloalkyl-SO2-, C6-10aryl-S-, NRcRdCO-, heterosyklus-, heterosyklus-O-, heterosyklus-CH2-, hvori hvert heterosyklus er uavhengig en 4–6-leddet ring som har 1–2 heteroatomer valgt fra N og O, og hvori hvert alkyl, sykloalkyl eller heterosyklus er substituert med 0–2 Rb;Rb, ved hver forekomst, er uavhengig C1–3alkyl, halogen, C=O eller C1–3halogenalkyl;Rc og Rd er uavhengig valgt fra H, C1-3alkyl, C1-3deuteroalkyl, C3-6sykloalkyl, eller tatt sammen med N som de festes til for å danne en 4–6-leddet heterosyklisk ring, som har 0–1 ytterligere heteroatomer valgt fra N, O og S, og er substituert med 0–4 substituenter valgt fra deuterium eller halogen;R4 er H, Cl, F, Br, C1-4alkyl, C1-4alkoksy, C1-4halogenalkyl, C1-4deuteroalkyl, C1-4deuteroalkoksy, syklopropyl eller NReRf:Re og Rf er uavhengig valgt fra H, C1-3alkyl, C1-3deuteroalkyl, C3-6sykloalkyl, eller tatt sammen med N som de festes til for å danne en 4–6-leddet ring substituert med 0–4 substituenter valgt fra deuterium eller halogen;R5 er H, HO-, C1-3alkyl-C(O)O-, CN, C1-3alkoksy, NRgRh-, (OH)2P(O)O- eller NH2CHR8CO- der R8 er H, C1-3alkyl eller C1-3alkoksy-C1-3alkyl;R5a og R5b er hver uavhengig valgt fra H, C1-3alkyl,eller R5a og R5b tas sammen for å danne en 3–6-leddet karbosyklisk eller heterosyklisk ring som er substituert med 0–1 av F, eller C1-3alkyl, den heterosykliske ringen har 0–2 heteroatomer valgt fra N, O og S;eller R5 er fraværende og R5a og R5b tas sammen for å danne en 3–6-leddet karbosyklisk eller heterosyklisk ring som er substituert med 0–1 av F, eller C1-3alkyl, den heterosykliske ringen har 0–2 heteroatomer valgt fra N, O og S; Rg og Rh er uavhengig valgt fra H, C1-3alkyl, C1-3deuteroalkyl eller C3-6sykloalkyl; R6 er H eller C1-3alkyl;X er N eller C-R7; der R7 er H, halogen, CN, C1-3alkyl, C1-3alkoksy,C1-3halogenalkyl eller C1-3halogenalkoksy.3. Forbindelse ifølge kravene 1–2, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriR3 er fenyl, eller pyridinyl, eller pyrrolyl, hvorav alle er substituert med 0–3 R3a.4. Forbindelse ifølge et hvilket som helst av kravene 1–3, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriA er C1-4alkyl substituert med 0–1 OH, C1–4deuteroalkyl substituert med 0–1 OH.5. Forbindelse ifølge et hvilket som helst av kravene 1–4, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriR3 er fenyl, substituert med 0–3 R3a.6. Forbindelse ifølge et hvilket som helst av kravene 1–5, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriR3a er halogen, C1-6alkyl, C1-6alkoksy eller NRcRdCO-.7. Forbindelse ifølge et hvilket som helst av kravene 1–5, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriR1 er H eller C1-4alkyl;R2 er H, C1-3alkyl eller C1-3alkoksy;R4 er H, Cl, F eller C1-4alkyl, C1-4alkoksy.8. Forbindelse ifølge et hvilket som helst av kravene 1–7, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriA er -CH2-, CD2-, -CH2CH2-, -CH(CH3)-, -CH(CD3)-, -CH2CH2CH(CH3)-, -CH2CH2CH(OH)- eller -CH2-syklopropyl-.9. Forbindelse ifølge et hvilket som helst av kravene 1–8, eller en stereoisomer, tautomer, salt eller solvat derav, hvori L er C(O)NH;R6 er H;X er N eller CR7; ogR7 er H eller halogen.10. Forbindelse ifølge et hvilket som helst av kravene 1–9, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriX er N.11. Forbindelse ifølge et hvilket som helst av kravene 1–9, eller en stereoisomer, tautomer, salt eller solvat derav, hvoriX er CR7.12. Forbindelse ifølge krav 1, eller salt derav, hvori forbindelsen er valgt fra: N-[(5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-yl)metyl]-2-fluor-5-(trifluormetoksy)benzamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl](D2)metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metoksypyridin-3-karboksamid;2-metoksy-5-[2-(2-metoksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-2-metoksy-5-[2-(2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;5-[2-(2-cyanoacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-2-metoksypyridin-3-karboksamid; 5-[2-(2-cyano-2,2-dimetylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylpyridin-3-karboksamid; N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksy-5-[2-(2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksy-6-metyl-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksy-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3-fluorfenyl]metyl}-5-[2-(2-hydroksy-2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]-2-metoksypyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-({2-[(1-hydroksypropan-2-yl)oksy]fenyl}metyl)-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-(trifluormetyl)pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[2-(propan-2-yloksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopentyloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-[3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;2-fluor-N-(6-{3-[(3-fenylbutyl)karbamoyl]fenyl}imidazo[1,2-b]pyridazin-2-yl)pyridin-4-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-(3-fenylbutyl)pyridin-3-karboksamid; 5-[2-(2-cyano-2,2-dimetylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-[(2-{[2-(hydroksymetyl)fenyl]sulfanyl}fenyl)metyl]-2-metylpyridin-3-karboksamid; 5-[2-(2-cyano-2,2-dimetylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylpyridin-3-karboksamid;5-[2-(2-cyano-2,2-dimetylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;5-[2-(2-cyano-2,2-dimetylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-(trifluormetyl)pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,6-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(trifluormetyl)pyridin-3-karboksamid; 5-[2-(2-cyanoacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metoksy-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-[2-(2-cyanoacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metoksypyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metoksypyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-5-[2-(2-hydroksy-2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]-2-metoksypyridin-3-karboksamid;5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(2-fluor-5-metoksybenzyl)-2,6-dimetylnikotinamid;N-(2-fluor-5-(trifluormetoksy)benzyl)-5-(2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl)-2,6-dimetylnikotinamid;N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(2-fluor-5-metoksyfenyl)metyl]-2-(D3)metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-(D3)metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(2,2,2-trifluoretoksy)fenyl]metyl}-2-(D3)metoksypyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid;N-({3,5-difluor-2-[(3R)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid; N-({3,5-difluor-2-[(3S)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid; N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl](deutero)metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-(D3)metoksypyridin-3-karboksamid;N-{[3,5-difluor-2-(oksetan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid;N-({2-[syklopropyl(deutero)metoksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid; N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}-2-(D3)metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}-2-(D3)metoksypyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,4-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksy-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid; N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)metoksy-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-(D3)metoksypyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-({3,5-difluor-2-[(3S)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; N-({3,5-difluor-2-[(3R)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; N-({3,5-difluor-2-[(2-metyloksan-4-yl)oksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; N-[(2-{[(2R,6S)-2,6-dimetyloksan-4-yl]oksy}-3-fluorfenyl)metyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; N-({2-[(2,6-dimetyloksan-4-yl)oksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetyl-N-{[3-(2,2,2-trifluoretoksy)pyridin-2-yl]metyl}pyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl](deutero)metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl](2,2,2-deutero)etyl]-2,6-dimetylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetyl-N-{[2-(2,2,2-trifluoretoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]-2,6-dimetylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl](2,2,2-deutero)etyl]-2,6-dimetylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2,6-dimetylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(2,2,2-trifluoretoksy)fenyl]metyl}-2,6-dimetylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetyl-N-{[3-(2,2,2-trifluoretoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetyl-N-{[3-(trifluormetyl)fenyl](deutero)metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl](deutero)metyl}-2,6-dimetylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-2,6-dimetylpyridin-3-karboksamid; N-{[3,5-difluor-2-(oksetan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluor-5-(trifluormetoksy)fenyl]metyl}-2,6-dimetylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2,6-dimetylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2,6-dimetylpyridin-3-karboksamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)pyridin-3-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)pyridin-3-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetyl-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetyl-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid; N-({3,5-difluor-2-[(3S)-oksolan-3-yloksy]fenyl}metyl)-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimetylpyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimetylpyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetyl)fenyl](deutero)metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimetylpyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimetylpyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimetylpyridin-3-karboksamid;N-({3,5-difluor-2-[(2-metyloksan-4-yl)oksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[2-(syklobutylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-({3,5-difluor-2-[(3S)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[3,5-difluor-2-(oksan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(2-fluor-5-metoksyfenyl)metyl]-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[3-(2,2,2-trifluoretoksy)pyridin-2-yl]metyl}pyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(2,2,2-trifluoretoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;N-({2-[(2,6-dimetyloksan-4-yl)oksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-[(1R)-1-[2-(trifluormetyl)fenyl]etyl]pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(2,2,2-trifluoretoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluor-5-(trifluormetyl)fenyl](2,2,2-deutero)etyl]-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl](2,2,2-deutero)etyl]-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(2,2,2-trifluoretoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl](2,2,2-deutero)etyl]-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[3-(trifluormetyl)fenyl](deutero)metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl](deutero)metyl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-[(1R)-1-[3-(trifluormetoksy)fenyl](2,2,2-deutero)etyl]pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-({2-[(morfolin-4-yl)metyl]fenyl}metyl)pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-({2-[(propan-2-yloksy)metyl]fenyl}metyl)pyridin-3-karboksamid;N-{[3,5-difluor-2-(oksetan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[3,5-difluor-2-(2-metylpropoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(2-metylpropoksy)fenyl]metyl}pyridin-3-karboksamid; N-[(2-syklopropoksy-3,5-difluorfenyl)metyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[4-fluor-2-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;N-({2-[syklopropyl(deutero)metoksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{1-[2-(syklopropylmetoksy)-6-fluorfenyl]etyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{1-[3-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;N-{1-[2-(syklopropylmetoksy)-6-fluorfenyl]etyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{1-[3-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,6-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(oksan-4-yloksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{1-[2-(syklopropylmetoksy)-3,5-difluorfenyl]etyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[2-(1-syklopropyletoksy)-3,4-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[2-(1-syklopropyletoksy)-3,4-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{1-[2-(syklopropylmetoksy)-3,5-difluorfenyl]etyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[2-(1-syklopropyletoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(1-syklopropyletoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[3-(1-syklopropyletoksy)pyridin-2-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;N-{[3-(syklopropylmetoksy)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-[(3,6-difluor-2-metoksyfenyl)metyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[3-(syklopropylmetoksy)-4-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-metyl-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(1-syklopropyletoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-metoksypyridin-3-karboksamid;N-{[2-klor-5-(trifluormetyl)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(1-syklopropyletoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid; N-{[2-(syklopropylmetoksy)-4,6-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[4-fluor-2-(oksan-4-yloksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-((3,5-difluor-2-((tetrahydro-2H-pyran-4-yl)oksy)fenyl)metyl-d2)-2-metoksynikotinamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(syklopentyloksy)-6-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropansulfonyl)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(syklopentyloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(1H-pyrrol-1-yl)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[(1S,2S)-2-(4-fluorfenyl)syklopropyl]metyl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(morfolin-4-yl)fenyl]metyl}pyridin-3-karboksamid;N-{[3-(syklopentyloksy)pyridin-2-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(propan-2-yloksy)fenyl]metyl}pyridin-3-karboksamid; N-{[2-(syklopentyloksy)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-({2-[(2,6-dimetyloksan-4-yl)oksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-[(2-{[(2R,6S)-2,6-dimetyloksan-4-yl]oksy}-3-fluorfenyl)metyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-({3,5-difluor-2-[(3R)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-({3,5-difluor-2-[(3S)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-({3,5-difluor-2-[(2-metyloksan-4-yl)oksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(2,2,2-trifluoretoksy)fenyl]metyl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid; N-({2-[syklopropyl(deutero)metoksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,4-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metyl-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)metoksy-6-metylpyridin-3-karboksamid;N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metylpyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metylpyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metylpyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl](deutero)metyl}-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metylpyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-5-[2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-metylpyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-3-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-({3,5-difluor-2-[(3S)-oksolan-3-yloksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-({3,5-difluor-2-[(2-metyloksan-4-yl)oksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-({2-[(2,6-dimetyloksan-4-yl)oksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(2,2,2-trifluoretoksy)fenyl]metyl}-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[4-(trifluormetyl)pyridin-2-yl]metyl}pyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl](deutero)metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[2-(2,2,2-trifluoretoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[3-(2,2,2-trifluoretoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(2,2,2-trifluoretoksy)fenyl]metyl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluor-5-(trifluormetyl)fenyl](2,2,2-deutero)etyl]-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl](2,2,2-deutero)etyl]-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl](2,2,2-deutero)etyl]-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl](2,2,2-deutero)etyl]-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl](deutero)metyl}-2-metylpyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-metylpyridin-3-karboksamid; 5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,4-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)pyridin-3-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)-6-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopentyloksy)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid; N-{[2-(syklopentyloksy)-6-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[2-(oksolan-3-yloksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopentyloksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-6-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl](2,2,2-deutero)etyl]-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-metyl-N-(3-fenylbutyl)pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-metyl-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]pyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-(3-fenylbutyl)pyridin-3-karboksamid; N-{[2-(syklopropylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[2-(syklopentyloksy)-6-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[3-(syklopentyloksy)pyridin-2-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[2-(syklopentyloksy)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-({2-[syklopropyl(deutero)metoksy]-3,5-difluorfenyl}metyl)-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yllpyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yllpyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl]metyl}-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yllpyridin-3-karboksamid;2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,4-difluorfenyl]metyl}-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-2-metoksy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-2-metyl-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-metylpyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metylpyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-metoksypyridin-3-karboksamid; 5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-N-{[4-fluor-3-(trifluormetoksy)fenyl]metyl}-2-metoksypyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-(3-fenylbutyl)pyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-({2-[syklopropyl(deutero)metoksy]-3,5-difluorfenyl}metyl)-5-{2-acetamido-3-metylimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-2-metoksy-5-[2-(2-metoksyacetamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-2-metoksy-5-[2-(2-metoksyacetamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksy-5-[2-(2-metoksyacetamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;2-metoksy-5-[2-(2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,4-difluorfenyl]metyl}-2-metoksy-5-[2-(2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;N-{[3,5-difluor-2-(oksan-4-yloksy)fenyl]metyl}-2-metoksy-5-[2-(2-metylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridin-3-karboksamid;2-klor-N-({2-[syklopropyl(deutero)metoksy]-3,5-difluorfenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;2-klor-N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}pyridin-3-karboksamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}pyridin-3-karboksamid; 2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;2-klor-N-{[2-(1-syklobutyletoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;2-klor-N-{[2-klor-5-(trifluormetyl)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetyl)fenyl]etyl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetoksy)fenyl]etyl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluor-5-(trifluormetoksy)fenyl]etyl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N,6-dimetyl-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl](deutero)metyl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-N,6-dimetyl-N-{[2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-4,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-[(3,6-difluor-2-metoksyfenyl)metyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid; N-{[2-(syklopropylmetoksy)-3,4-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl](deutero)metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{1-[3-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{1-[2-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{1-[3-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluor-5-(trifluormetyl)fenyl]metyl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{[2-(trifluormetoksy)fenyl](deutero)metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-4,6-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-3-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid; N-{[2-(syklopropylmetoksy)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(1-syklopentyletoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(1-syklopentyletoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{2-[3-(trifluormetoksy)fenyl]etyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{[3-(trifluormetyl)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{[2-(oksolan-3-yloksy)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{[2-(oksolan-3-yloksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)-4,6-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[3-(syklopropylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-({2-[(4,4-difluorsykloheksyl)metoksy]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksy-6-metylpyridin-3-karboksamid; N-{[3-(syklopentylmetoksy)pyridin-2-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)pyridin-3-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklobutylmetoksy)pyridin-3-yl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid; N-{[2-(syklopentylmetoksy)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopentylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)-4-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;N-{[2-(syklopropylmetoksy)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksy-6-metyl-N-{[3-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;2-((6-(5-((2-fluor-5-(trifluormetoksy)benzyl)karbamoyl)-2,6-dimetylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)amino)-2-oksoetyldihydrogenfosfat;6-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;6-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(trifluormetoksy)fenyl]metyl}pyridin-3-karboksamid;N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-3,5-difluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metoksypyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(2,2,2-trifluoretoksy)fenyl]metyl}-2,6-dimetylpyridin-3-karboksamid;N-{[5-(syklopropylmetoksy)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimetylpyridin-3-karboksamid;({6-[5-({[2-fluor-5-(trifluormetoksy)fenyl]metyl}karbamoyl)-2,6-dimetylpyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl}karbamoyl)metylacetat;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-etyl-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-etyl-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}pyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-N,2-dimetylpyridin-3-karboksamid; N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]-2-metyl-5-(2-{2-[4-(trifluormetyl)piperidin-1-yl]acetamido}imidazo[1,2-b]pyridazin-6-yl)pyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]-2-metyl-5-{2-[2-(4-metylpiperazin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]-2-metyl-5-{2-[2-(pyrrolidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;5-{2-[2-(4,4-difluorpiperidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylpyridin-3-karboksamid; 5-{2-[2-(3,3-difluorazetidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylpyridin-3-karboksamid; N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metyl-5-{2-[2-(4-metylpiperazin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metyl-5-{2-[2-(morfolin-4-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;5-{2-[2-(dimetylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylpyridin-3-karboksamid;N-((R)-1-(2-fluor-5-(trifluormetoksy)fenyl)etyl)-5-(2-((S)-2-hydroksypropanamido)imidazo[1,2-b]pyridazin-6-yl)-2-metylnikotinamid;N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metyl-5-{2-[2-(metylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid; 5-[2-(2-aminoacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylpyridin-3-karboksamid;{[6-(5-{[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]karbamoyl}-6-metylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]karbamoyl}metylacetat;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-[2-(4,4-difluorpiperidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid; N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-[2-(3,3-difluorazetidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid; N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-2-metyl-5-{2-[2-(morfolin-4-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid; N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-2-metyl-5-{2-[2-(morfolin-4-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridin-3-karboksamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-[2-(dimetylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[1-(4-fluorfenyl)etyl]-1H-pyrazol-4-yl}-2-metylpyridin-3-karboksamid;N-{1-[(4-klorfenyl)metyl]-1H-imidazol-4-yl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[(4-fluorfenyl)metyl]-1H-imidazol-4-yl}-2-metylpyridin-3-karboksamid;N-(1-benzyl-1H-imidazol-4-yl)-5-12-acetamidoimidazo[1,2-b]pyridazin-6-yl}1-2-metylpyridin-3-karboksamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(1-metyl-1H-pyrazol-4-yl)fenyl]metyl}-2-metylpyridin-3-karboksamid;N-[6-(5-{3-[(4-fluorfenyl)(hydroksy)metyl]piperidin-1-karbonyl}-6-metylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[3-(4-fluorfenyl)-2-hydroksy-2-metylpropyl]-2-metylpyridin-3-karboksamid;N-[6-(5-{3-[(4-fluorfenyl)metyl]-3-hydroksypiperidin-1-karbonyl}-6-metylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamid;5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-3-fluor-N-(2-fluor-5-(1-metyl-1H-pyrazol-4-yl)benzyl)-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluor-N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluor-N-{[2-fluor-3-(trifluormetoksy)fenyl]metyl}-2-metylbenzamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-[2-(dimetylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}-3-fluor-2-metylbenzamid; N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-3-fluor-2-metyl-5-{2-[2-(metylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}benzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluor-2-metyl-N-[(2-fenoksyfenyl)metyl]benzamid;N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-6-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluor-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,3-difluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}benzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,3-difluor-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]benzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4,5-trifluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}benzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4,5-trifluor-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}benzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-5-fluorbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksybenzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-5-fluor-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-4-metylbenzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-5-fluor-4-metylbenzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metoksybenzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]-6-metoksybenzamid;N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-5-fluorfenyl]metyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metoksybenzamid;N-{[2-(syklopropylmetoksy)fenyl]metyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metoksybenzamid;(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluor-N-(1-(2-fluor-5-(trifluormetoksy)fenyl)etyl-2,2,2-d3)-6-metoksybenzamid; 3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-difluor-N-[(1S)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]benzamid;(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2,6-difluor-N-(1-(2-fluor-5-(trifluormetoksy)fenyl)etyl-2,2,2-d3)benzamid;N-{[2-(4,4-difluorpiperidin-1-karbonyl)-5-fluorfenyl]metyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-difluorbenzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-dimetylbenzamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-dimetylbenzamid;N-{[3-klor-2-fluor-5-(trifluormetyl)fenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-dimetylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetyl)fenyl]metyl}-2-(trifluormetyl)benzamid;2-klor-N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}benzamid;2-klor-N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}benzamid;6-klor-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]benzamid;6-klor-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-N-{[2-fluor-5-(1-metyl-1H-pyrazol-4-yl)fenyl]metyl}benzamid;6-klor-N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluorbenzamid;6-klor-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-N-{[4-(trifluormetoksy)fenyl]metyl}benzamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluor-N-[(1R)-1-[2-fluor-5-(trifluormetoksy)fenyl]etyl]benzamid;2-klor-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-4-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metylbenzamid; (S)-N-(2-fluor-5-(trifluormetoksy)benzyl)-5-(2-(2-hydroksypropanamido)imidazo[1,2-b]pyridazin-6-yl)-2-metylbenzamid;(R)-5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(1-(2-fluor-5-(trifluormetoksy)fenyl)etyl)-2-metylbenzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;N-[(3S)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;N-(1-benzyl-1H-pyrazol-4-yl)-5-f2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-(2-hydroksy-3-fenoksypropyl)-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[(1S,2S)-2-(4-fluorfenyl)syklopropyl]metyl}-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-6-(1-metyl-1H-pyrazol-4-yl)fenyl]metyl}-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(1-metyl-1H-pyrazol-4-yl)fenyl]metyl}-2-metylbenzamid;N-{[5-(3,3-difluorazetidin-1-karbonyl)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-4-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;N-{[5-(3,3-dimetylpyrrolidin-1-karbonyl)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;N-({3,5-difluor-2-[(3S)-3-hydroksypyrrolidin-1-karbonyl]fenyl}metyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluor-2-(piperidin-1-karbonyl)fenyl]metyl}-2-metylbenzamid;N-{[5-(1-syklopropyl-1H-pyrazol-4-yl)-2-fluorfenyl]metyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metylbenzamid;N-{[2-(1-syklopropyl-1H-pyrazol-4-yl)-5-fluorfenyl]metyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metylbenzamid; N-{[2-(3,3-difluorpyrrolidin-1-karbonyl)-3,4-difluorfenyl]metyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metylbenzamid;(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluor-N-(1-(2-fluor-5-(trifluormetoksy)fenyl)etyl-2,2,2-d3)-6-metylbenzamid;(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluor-N-(1-(2-fluor-5-(trifluormetyl)fenyl)etyl-2,2,2-d3)-6-metylbenzamid;N-[(3,5-difluor-2-metoksyfenyl)metyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-6-metylbenzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluor-2-metylbenzamid;N-{[5-(2,2-dimetylpyrrolidin-1-karbonyl)-2-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluor-2-metylbenzamid;5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(2-fluor-5-(trifluormetoksy)benzyl)-2-(metoksy-d3)-4-metylbenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksybenzamid;N-{[2-(2,2-dimetylpyrrolidin-1-karbonyl)-5-fluorfenyl]metyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluor-2-metoksybenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluor-N-[(2-fluor-6-metoksyfenyl)metyl]-2-metoksybenzamid;5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-2-metoksy-4-metylbenzamid;N-(2-fluor-5-(trifluormetoksy)benzyl)-5-(2-(2-hydroksyacetamido)imidazo[1,2-b]pyridazin-6-yl)-2-metoksy-4-metylbenzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-difluor-N-[(1R)-1-[2-fluor-5-(trifluormetyl)fenyl]etyl]benzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}benzamid;3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(5-(2,2-dimetylazetidin-1-karbonyl)-2-fluorbenzyl)-2-fluorbenzamid;3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluor-N-((2-fluor-5-(trifluormetoksy)fenyl)metyl-d2)benzamid; 3-{2-[2-(4,4-difluorpiperidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-fluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}benzamid;N-[(3R)-3-(4-klorfenyl)-3-hydroksypropyl]-2-fluor-3-(2-{2-[4-(trifluormetyl)piperidin-1-yl]acetamido}imidazo[1,2-b]pyridazin-6-yl)benzamid; (S)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluor-N-(1-(2-fluor-5-(trifluormetoksy)fenyl)etyl-2,2,2-d3)-4-metylbenzamid; (429)3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluor-N-((2-fluor-5-(trifluormetoksy)fenyl)metyl-d2)-4-metylbenzamid;4-klor-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}benzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluor-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}benzamid;3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluor-5-(trifluormetoksy)fenyl]metyl}-4-metylbenzamid; og(R)-(((5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-metylnikotinoyl)(1-(2-fluor-5-(trifluormetoksy)fenyl)etyl)karbamoyl)oksy)metyl-3-metoksy-4-(fosfonooksy)benzoat.13. Farmasøytisk sammensetning omfattende én eller flere forbindelser ifølge et hvilket som helst av kravene 1–12, eller en stereoisomer, tautomer, farmasøytisk akseptabelt salt derav, eler solvat derav, og en farmasøytisk akseptabel bærer.14. Forbindelse ifølge et hvilket som helst av kravene 1–12, eller en stereoisomer, tautomer, farmasøytisk akseptabelt salt eller solvat derav, for anvendelse i terapi.15. Forbindelse ifølge et hvilket som helst av kravene 1–12, eller en stereoisomer, tautomer, farmasøytisk akseptabelt salt eller solvat derav, for anvendelse i behandlingen av en sykdom valgt fra inflammatorisk tarmsykdom, ulcerøs kolitt, Crohns sykdom, psoriasis, revmatoid artritt (RA), og hjertesvikt.
Hva betyr A1, B, B1, C osv? info

Klasser info chevron_right

Innehaver(e) info chevron_right

Innehaver i EP:
Bristol-Myers Squibb Company
Route 206 and Province Line Road Princeton, NJ 08543 US

Oppfinner(e) info chevron_right

MERTZMAN, Michael E.
c/o Bristol-Myers Squibb Company Route 206&Province Line Road Princeton New Jersey 08543 US
DZIERBA, Carolyn Diane
c/o Bristol-Myers Squibb Company 100 Binney Street Cambridge MA 02142 US
GUERNON, Jason M.
c/o Bristol-Myers Squibb Company Route 206&Province Line Road Princeton New Jersey 08543 US
HART, Amy C.
c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton New Jersey 08543 US
LUO, Guanglin
c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton New Jersey 08543 US
MACOR, John E.
c/o Sanofi 153 2nd Avenue Waltham Massachusetts 02451 US
PITTS, William J.
c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton New Jersey 08643 US
SHI, Jianliang
c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton New Jersey 08543 US
SPERGEL, Steven H.
c/o Bristol-Myers Squibb Company Route 206 and Province Line Road Princeton New Jersey 08543 US

Fullmektig info chevron_right

Fullmektig i Norge:
ZACCO NORWAY AS
Postboks 488 0213 OSLO NO ( OSLO kommune, Oslo fylke )

Org.nummer: 982702887
Din referanse: V351093NO00
  • Foretaksnavn:
  • Foretaksform:
  • Næring:
  • Forretningsadresse:
     

Kilde: Brønnøysundregistrene
Fullmektig i EP:
Dehns
St. Bride's House 10 Salisbury Square London EC4Y 8JD GB

Prioritet info chevron_right

2017.10.30, US 201762578607 P

2018.02.06, US 201862626853 P

Anførte dokumenter info chevron_right

PHILIP A. HARRIS ET AL: "Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis", ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 12, 12 December 2013 (2013-12-12), pages 1238-1243, XP55123759, ISSN: 1948-5875, DOI: 10.1021/ml400382p (B1)

WO-A1-2018/148626 (B1)

US-A1- 2009 163 489 (B1)

PHILIP A. HARRIS ET AL: "Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 4, 10 February 2017 (2017-02-10), pages 1247-1261, XP055448328, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01751 (B1)

Sakshistorikk info chevron_right

Statushistorie

Liste over statusendringer i sakshistorikk
Hovedstatus Beslutningsdato, detaljstatus
Patent opphørt Ikke betalt årsavgift
EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
EP under behandling Forespørsel om å gjøre EP patent gyldig er mottatt

Korrespondanse

expand_more file_download  
Liste over sakshistorikk og korrespondanse
Dato Type korrespondanse Journal beskrivelse
Utgående EP Opphørt for ikke betalt årsavgift (3206)
08-01 Via Altinn-sending EP Opphørt for ikke betalt årsavgift (3206)
Utgående EP Påminnelse om ikke betalt årsavgift (3331) (PTEP3704118)
07-01 Via Altinn-sending EP Påminnelse om ikke betalt årsavgift (3331) (PTEP3704118)
Innkommende EP Publiseringsdokument fra EPO
06-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
Innkommende EP Publiseringsdokument fra EPO
05-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
Utgående EP Varsel om betaling av første årsavgift (3319) (PTEP3704118)
04-01 Via Altinn-sending EP Varsel om betaling av første årsavgift (3319) (PTEP3704118)
Utgående EP Registreringsbrev (3210) (PTEP3704118)
03-01 Brev UT EP Registreringsbrev (3210) (PTEP3704118)
Innkommende Søknadsskjema Patent
01-01 Søknadsskjema Patent Søknadsskjema Patent
01-02 Hovedbrev NO_Validation_Request_Feb_09,_2022_232235
01-03 Fullmakt V161209NO POA_9967729
01-04 EP oversettelse V351093NO00-claims-NO 228479
Innkommende EP Publiseringsdokument fra EPO
02-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
Informasjon om ikke tilgjengelige dokumenter

Betaling info chevron_right

Til betaling:

Betalingshistorikk:

Liste av betalinger
Beskrivelse / Fakturanummer Betalingsdato Beløp Betaler Status
Årsavgift 5. avg. år (EP) 2022.10.11 1650 CPA GLOBAL LIMITED Betalt og godkjent
32202419 expand_more 2022.02.14 5500 ZACCO NORWAY AS Betalt
Denne oversikten kan mangle informasjon, spesielt for eldre saker, om tilbakebetaling, internasjonale varemerker og internasjonale design.

Publikasjon(er) info chevron_right

Lenker til publikasjoner og Norsk Patenttidende (søkbare tekstdokumenter)

Oversettelse av europeisk patentskrift
Allment tilgjengelig patentsøknad
Norsk Patenttidende - ved meddelelse
Nye digitale Norske Tidende, nyhet om tjenesten ved lansering
Om Norske Tidende
Hva betyr A1, B, B1, C osv? info
Kapitler uten data er fjernet. Melding opprettet: 26.04.2025 02:13:26