ANONYMOUS: "Archive History for NCT01358877: A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer", 1 November 2016 (2016-11-01), XP055473466, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/history/NCT01358877?V_112=View#StudyPageTop> [retrieved on 20180508] (B1)

ANONYMOUS: "Genentech: Press Releases: Phase III APHINITY Study Shows Genentech's Perjeta Regimen Helped People with an Aggressive Type of Early Breast Cancer Live Longer without their Disease Returning Compared to Herceptin and Chemotherapy", 1 March 2017 (2017-03-01), XP055473424, Retrieved from the Internet <URL:https://www.gene.com/media/press-releases/14655/2017-03-01/phase-iii-aphinity-study-shows-genentech> [retrieved on 20180508] (B1)

ANONYMOUS: "History of Changes for Study: NCT00545688 A Study of Pertuzumab in Combination With Herceptin in Patients With HER2 Positive Breast Cancer.", 16 December 2015 (2015-12-16), XP093064833, Retrieved from the Internet <URL:https://classic.clinicaltrials.gov/ct2/history/NCT00545688?A=4&B=117&C=Side-by-Side#StudyPageTop> [retrieved on 20230718] (B1)

ANONYMOUS: "History of Changes for Study: NCT01358877 A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer", 1 September 2016 (2016-09-01), XP093064832, Retrieved from the Internet <URL:https://classic.clinicaltrials.gov/ct2/history/NCT01358877?A=105&B=111&C=Side-by-Side#StudyPageTop> [retrieved on 20230718] (B1)

ANONYMOUS: "History of Changes for Study: NCT02132949 A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Ca", 1 March 2017 (2017-03-01), XP093064834, Retrieved from the Internet <URL:https://classic.clinicaltrials.gov/ct2/history/NCT02132949?A=4&B=60&C=Side-by-Side#StudyPageTop> [retrieved on 20230718] (B1)

US-A1- 2017 035 907 (B1)

HOPE S RUGO: "Highlights in Breast Cancer From the 2016 American Society of Clinical Oncology Annual Meeting Analysis Supports Use of Anthracyclines in High-Risk Breast Cancer", CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY VOLUME, 1 July 2016 (2016-07-01), XP055473387, Retrieved from the Internet <URL:http://www.hematologyandoncology.net/files/2016/07/ho0716ASCO-1.pdf> [retrieved on 20180508] (B1)

JASMEET C. SINGH ET AL: "Pathologic Complete Response with Neoadjuvant Doxorubicin and Cyclophosphamide Followed by Paclitaxel with Trastuzumab and Pertuzumab in Patients with HER2-Positive Early Stage Breast Cancer: A Single Center Experience", THE ONCOLOGIST, vol. 22, no. 2, 1 February 2017 (2017-02-01), US, pages 139 - 143, XP055521066, ISSN: 1083-7159, DOI: 10.1634/theoncologist.2016-0268 (B1)

LUCA GIANNI ET AL: "Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial", THE LANCET ONCOLOGY, vol. 13, no. 1, 1 January 2012 (2012-01-01), pages 25 - 32, XP055052201, ISSN: 1470-2045, DOI: 10.1016/S1470-2045(11)70336-9 (B1)

Summary of product characteristics - Perjeta XP93039794 XP093039794 (B1)

GUNTER VON MINCKWITZ ET AL: "Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer", NEW ENGLAND JOURNAL OF MEDICINE, THE - NEJM -, vol. 377, no. 2, 13 July 2017 (2017-07-13), US, pages 122 - 131, XP055473189, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1703643 (B1)