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Tittel 2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER
Status
Hovedstatus
Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP3580211
Europeisk (EP) publiserings nummer EP3580211
EP levert
EP søknadsnummer 18703958.1
EP meddelt
Prioritet 2017.02.09, EP 17155406, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Bayer Aktiengesellschaft (DE)
Oppfinner GUTCHER, Ilona (DE) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Krav

Patentkrav1. En forbindelse med den generelle formelen (I):hvorR1 representerer C2-C6-hydroksyalkyl, hvor nevnte C2-C6-hydroksyalkylgrupper er eventuelt substituert en gang med cyano, -COOR10, -CONR11R12, C1-C4-alkoksy eller C3-C6-sykloalkyl og eventuelt en til tre ganger med halogen, ellerC3-C6-sykloalkyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen, ellerC3-C6-sykloalkyl-C1-C3-alkyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen, eller(C3-C6-sykloalkyl)2-C1-C3-alkyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen, eller4- til 6-leddet heterosykloalkyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen;R2 representerer klor, cyano, dimetylamino, metyl, fluormetyl, difluormetyl, trifluormetyl, metoksy, difluormetoksy eller trifluormetoksy;R3 representerer hydrogen, fluor, klor eller metyl;R4 representerer hydrogen eller fluor;R5 representerer monosyklisk heteroaryl, som eventuelt er substituert en til tre ganger, uavhengig av hverandre, med R6;R6 representerer C1-C4-alkyl, C1-C4-halogenalkyl, C3-C6-sykloalkyl, C1-C4-alkoksy, halogen eller cyano;X representerer CH eller N;R10 representerer C1-C4-alkyl;R11 og R12 er de samme eller er forskjellige og representerer, uavhengig av hverandre, hydrogen eller C1-C3-alkyl, ellertilsammen med nitrogenatomet som de er bundet til, danner en 4-til 6-leddet nitrogenholdig heterosyklisk ring, hvor nevnte ring eventuelt inneholder et ytterligere heteroatom som er valgt fra O, S, NH, NRa hvor Ra representerer en C1-C4-alkylgruppe; deres polymorfe, enantiomerer, diastereomerer, racemater, tautomerer, N-oksider, hydrater og solvater, så vel som deres fysiologisk akseptable salter og solvater av disse saltene, så vel som blandinger av de samme.2. 2. Forbindelse ifølge krav 1, hvor:R1 representerer C2-C6-hydroksyalkyl, hvor nevnte C2-C6-hydroksyalkylgrupper er eventuelt substituert en gang med cyano, -COOR10, -CONR11R12, C1-C2-alkoksy eller syklopropyl og eventuelt en til tre ganger med halogen, ellerC4-C6-sykloalkyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen, ellerC3-C6-sykloalkyl-metyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen, eller(C3-C6-sykloalkyl)2-metyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen, eller5- eller 6-leddet heterosykloalkyl substituert en gang med hydroksy og eventuelt en gang med C1-C3-alkyl og/eller en til tre ganger med halogen;R2 representerer klor, cyano, dimetylamino, metyl, fluormetyl, difluormetyl, trifluormetyl, metoksy, difluormetoksy eller trifluormetoksy;R3 representerer hydrogen eller fluor;R4 representerer hydrogen eller fluor;R5 representerer monosyklisk heteroaryl, som eventuelt er substituert en til tre ganger, uavhengig av hverandre, med R6;R6 representerer metyl, difluormetyl, metoksy, halogen eller cyano;X representerer CH eller N;R10 representerer C1-C4-alkyl;R11 og R12 er de samme eller er forskjellige og representerer, uavhengig av hverandre, hydrogen eller C1-C3-alkyl, ellertilsammen med nitrogenatomet som de er bundet til, danner en 4- til 6-leddet nitrogenholdig heterosyklisk ring, hvor nevnte ring eventuelt inneholder et ytterligere heteroatom som er valgt fra O, S, NH, NRa hvor Ra representerer en C1-C4-alkylgruppe;deres polymorfe, enantiomerer, diastereomerer, racemater, tautomerer, N-oksider, hydrater og solvater, så vel som deres fysiologisk akseptable salter og solvater av disse saltene, så vel som blandinger av de samme.3. Forbindelsen ifølge krav 1, hvor:R1 representerer C2-C5-hydroksyalkyl, hvor nevnte C2-C5-hydroksyalkylgrupper er eventuelt substituert en gang med cyano, -COOCH3, -CONH2, metoksy eller syklopropyl og eventuelt en til tre ganger med fluor, eller C4-C6-sykloalkyl substituert en gang med hydroksy og eventuelt en gang med metyl og/eller en til to ganger med fluor, ellerC3-C4-sykloalkyl-metyl substituert en gang med hydroksy, eller 5- eller 6-leddet heterosykloalkyl substituert en gang med hydroksy, hvor nevnte heterosykloalkyl inneholder et oksygenatom;R2 representerer klor, dimetylamino, metyl, fluormetyl, difluormetyl, trifluormetyl, difluormetoksy eller trifluormetoksy;R3 representerer hydrogen;R4 representerer hydrogen eller fluor;R5 representerer en gruppe som er valgt fra:hvor * indikerer festepunktet for nevnte gruppe med resten av molekylet;R6a representerer hydrogen, metyl, fluor eller klor;X representerer CH eller N;deres polymorfe, enantiomerer, diastereomerer, racemater, tautomerer, N-oksider, hydrater og solvater, så vel som deres fysiologisk akseptable salter og solvater av disse saltene, så vel som blandinger av de samme.4. Forbindelse ifølge krav 1, 2 eller 3 som er valgt fra gruppen bestående av:N-(1-hydroksy-3-metylbutan-2-yl)-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2R)-1-hydroksy-3-metylbutan-2-yl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid; N-[(2S)-1-hydroksy-3-metylbutan-2-yl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksybutan-2-yl)-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2R)-1-hydroksybutan-2-yl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksybutan-2-yl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2R)-1-hydroksypropan-2-yl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksypropan-2-yl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(3,3,3-trifluor-2-hydroksypropyl)-2,3-dihydropyridazin-4-karboksamid;6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;N-(3,3-difluor-2-hydroksypropyl)-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2R)-3,3-difluor-2-hydroksypropyl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-3,3-difluor-2-hydroksypropyl]-6-(4-metylfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksy-3-metylbutan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-[(2S)-1-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(3,3,3-trifluor-2-hydroksypropyl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(3,3-difluor-2-hydroksypropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-3,3-difluor-2-hydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-3,3-difluor-2-hydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(2-hydroksy-3-metoksypropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-2-hydroksy-3-metoksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-2-hydroksy-3-metoksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(2,3-dihydroksypropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-2,3-dihydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-[(2S)-2,3-dihydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksy-3-metoksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-1-hydroksy-3-metoksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksy-3-metoksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1,3-dihydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2S)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid;2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;2-((1-metyl-1H-pyrazol-4-yl)-3-okso-N-(3,3,3-trifluor-2-hydroksypropyl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid; N-[(2R)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-syklobutyl-1H-pyrazol-4-yl)-3-okso-N-(3,3,3-trifluor-2-hydroksypropyl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-syklobutyl-1H-pyrazol-4-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-syklobutyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-syklobutyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-syklobutyl-1H-pyrazol-4-yl)-N-(1-hydroksypropan-2-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(1-syklobutyl-1H-pyrazol-4-yl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(3R,4R)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-N-[(3S,4S)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridaziN-4-karboksamid;N-[(cis)-2-hydroksysykloheksyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2R)-2-hydroksysykloheksyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridaziN-4-karboksamid;2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid; 2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-6-[4-(trifluormetoksy )fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(cis)-2-hydroksysykloheksyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1S,2R)-2-hydroksysykloheksyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(trans)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1S,2S)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(cis)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1S,2R)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-[(trans)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(cis)-2-hydroksysykloheksyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(1S,2R)-2-hydroksysykloheksyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3R,4R)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid; N-[(3S,4S)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-(1-hydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-(2-hydroksy-2-metylpropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;1,5-anhydro-2-({[6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-yl]karbonyl} amino)-2,4-dideoxy-D-erytro-pentitol;6-[4-(difluormetyl)fenyl]-N-(2-hydroksy-2-metylpropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(trans)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3R,4S)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3S,4R)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-(1-hydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;N-(2-hydroksy-2-metylpropyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-[(2R)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1,3-dihydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(2,3-dihydroksypropyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-2,3-dihydroksypropyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-2,3-dihydroksypropyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksy-3-metoksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-1-hydroksy-3-metoksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksy-3-metoksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-[(2S)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-N-(1-syklopropyl-2-hydroksyetyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-[(1R)-1-syklopropyl-2-hydroksyetyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1S)-1-syklopropyl-2-hydroksyetyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(3,3,3-trifluor-2-hydroksypropyl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-[(2R)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(3,3-difluor-2-hydroksypropyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-3,3-difluor-2-hydroksypropyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-3,3-difluor-2-hydroksypropyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-(1-hydroksypropan-2-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(2R)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-(2-hydroksy-2-metylpropyl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-(1-hydroksy-3-metylbutan-2-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(2S)-1-hydroksy-3-metylbutan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-(1,3-dihydroksypropan-2-yl)-2-(5-fluorpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-(1-hydroksy-3-metoksypropan-2-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(2R)-1-hydroksy-3-metoksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(2S)-1-hydroksy-3-metoksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-fluor-3-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-1-fluor-3-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-(1-syklopropyl-2-hydroksyetyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S)-1-syklopropyl-2-hydroksyetyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-syklopropyl-2-hydroksyetyl)-2-(5-fluorpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(2,3-dihydroksypropyl)-2-(5-fluorpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2R)-2,3-dihydroksypropyl]-2-(5-fluorpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-2,3-dihydroksypropyl]-2-(5-fluorpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid; N-(3,3-difluor-2-hydroksypropyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-(2-hydroksysyklopentyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1R,2R)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1R,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2R)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(cis)-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2R)-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-(3,3,3-trifluor-2-hydroksypropyl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid; N-(1-hydroksy-3-metoksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksy-3-metoksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid;N-(2,3-dihydroksypropyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2R)-2,3-dihydroksypropyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-2,3-dihydroksypropyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-(1,3-dihydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2R)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyrimidin-5-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyrimidin-5-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl]-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-[(2S)-1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(cis)-2-hydroksysykloheksyl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(1S,2R)-2-hydroksysykloheksyl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(cis)-2-hydroksysykloheksyl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(1S,2R)-2-hydroksysykloheksyl]-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(cis)-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2R)-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-3-okso-N-(3,3,3-trifluor-2-hydroksypropyl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(cis)-2-hydroksysyklopentyl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(1S,2R)-2-hydroksysyklopentyl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(trans)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-[(1S,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-(3,3,3-trifluor-2-hydroksypropyl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(trans)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(cis)-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksypropan-2-yl)-6-[4-(trifluormethoxy)fenyl]-2,3-dihydropyridazine-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl]-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;3-okso-2-(pyridin-3-yl)-N-[(2S)-1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl]-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(cis)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1R,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-[(trans)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid 6-[4-(difluormetyl)fenyl]-N-[(1S,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-[(trans)-3,3-difluor-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2R)-3,3-difluor-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridaziN-4-karboksamid;N-[(1R,2S)-3,3-difluor-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-N-[(trans)-3,3-difluor-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1S,2R)-3,3-difluor-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(1R,2S)-3,3-difluor-2-hydroksysykloheksyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-[(cis)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1S,2R)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-(1-syklopropyl-2-hydroksyetyl)-6-[4-(difluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-[(1S)-1-syklopropyl-2-hydroksyetyl]-6-[4-(difluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[4-(difluormetyl)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-6-(4-metylfenyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid; N-[(2S)-1-hydroksypropan-2-yl]-6-(4-metylfenyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(trans)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(3S,4R)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(3R,4S)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid;N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3S,4S)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3R,4R)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(trans)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3S,4R)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(3R,4S)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klor-2-fluorfenyl)-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klor-2-fluorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid; 3-(4-klorfenyl)-N-[(cis)-2-hydroksysykloheksyl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;3-(4-klorfenyl)-N-[(1S,2R)-2-hydroksysykloheksyl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(trans)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(1S,2S)-2-hydroksysyklopentyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid;N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridaziN-4-karboksamid;3-(4-klorfenyl)-N-[(cis)-2-hydroksysyklopentyl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;3-(4-klorfenyl)-N-[(1S,2R)-2-hydroksysyklopentyl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;6-(4-klorfenyl)-N-[(trans)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(3S,4R)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(3R,4S)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(3R,4R)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(3S,4S)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid; 3-(4-klorfenyl)-N-[(trans)-2-hydroksysyklopentyl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;3-(4-klorfenyl)-N-[(1S,2S)-2-hydroksysyklopentyl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;1,5-anhydro-2-({[6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-yl]karbonyl}amino)-2,4-dideoxy-cis-pentitol;1,5-anhydro-2-({[6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-yl]karbonyl}amino)-2,4-dideoxy-D-erytro-pentitol;1,5-anhydro-2,4-dideoxy-2-[(f3-okso-2-(pyridin-3-yl)-6-[4-(trifluormethoxy)fenyl]-2,3-dihydropyridazin-4-yl}karbonyl)amino]-cis-pentitol;1,5-anhydro-2,4-dideoxy-2-[({3-okso-2-(pyridin-3-yl)-6-[4-(trifluormethoxy)fenyl]-2,3-dihydropyridazin-4-yl}karbonyl)amino]-D-erytropentitol;3-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-6-okso-6H-1,4'-bipyridazin-5-karboksamid;3-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid;3-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-6-okso-6H-1,4'-bipyridazin-5-karboksamid;6-(4-cyanofenyl)-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-cyanofenyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;3-(4-klorfenyl)-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-6-okso-6H-1,4'-bipyridazin-5-karboksamid; 6-[6-(difluormetyl)pyridin-3-yl]-N-[(cis)-4-metyltetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(3R, 4S)-4-metyltetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[6-(difluormetyl)pyridin-3-yl]-N-[(3S,4R)-4-metyltetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyrimidin-5-yl)-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-2,3-dihydropyridaziN-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyrimidin-5-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-3-okso-2-(pyrimidin-5-yl)-N-[(2S)-1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl]-2,3-dihydropyridazin-4-karboksamid;N-[(1-hydroksysyklopropyl) metyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;N-[(1-hydroksysyklobutyl) metyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-3-okso-2-(1H-pyrazol-4-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(1H-pyrazol-4-yl)-2,3-dihydropyridazin-4-karboksamid;6-[4-(dimetylamino)fenyl]-N-(1-hydroksypropan-2-yl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-[4-(dimetylamino)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-2-(1-metyl-1H-pyrazol-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid; 6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-2-(3-metyl-1H-pyrazol-5-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-2-(3-metyl-1H-pyrazol-5-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-(1-hydroksypropan-2-yl)-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridazin-4-karboksamid;6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridazin-4-karboksamid;N-[(1-hydroksysyklobutyl)metyl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid(+)-3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 26-(4-klorfenyl)-3-okso-2-(1,2-tiazol-4-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-3-okso-2-(1,2-tiazol-4-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-N-[(1-hydroksysyklobutyl) metyl]-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2R)-1-fluor-3-hydroksypropan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridaziN-4-karboksamidN-[(2R)-3-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(2R)-1-fluor-3-hydroksypropan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(1S,2R)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid, N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamidN-[(2S)-3-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid,N-[(1S)-1-syklopropyl-2-hydroksyetyl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamidN-(2-hydroksy-2-metylpropyl)-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridaziN-4-karboksamidN-[(1S,2S)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamidN-[(2R)-1-fluor-3-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid3-Okso-2-(1H-pyrazol-4-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid3-Okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid2-[1-(difluormetyl)-1H-pyrazol-4-yl]-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-cis-4-hydroksytetrahydrofuran-3-yl-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid3-Okso-2-(lH-pyrazol-4-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid(+)-N-cis-2-hydroksysyklobutyl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 1(+)-N-cis-4-hydroksytetrahydrofuran-3-yl-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 2 N-[(2S)-3,3-difluor-2-hydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-2-(5-fluor-2-tienyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamidN-[(2R)-1-fluor-3-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridazin-4-karboksamid2-[1-(difluormetyl)-1H-pyrazol-4-yl]-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-cis-2-hydroksysyklobutyl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-2-(5-metyl-3-tienyl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-N-[(1S)-1-cyano-2-hydroksyetyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid2-[1-(difluormetyl)-1H-pyrazol-4-yl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid(+)-N-cis-4-hydroksytetrahydrofuran-3-yl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 1(-)-N-(3,3-difluor-2-hydroksypropyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 2(-)-N-cis-4-hydroksytetrahydrofuran-3-yl-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 16-(4-klorfenyl)-2-(5-klor-3-tienyl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamidN-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-2-(1,2-oksazol-4-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridaziN-4-karboksamid2-[1-(difluormetyl)-1H-pyrazol-4-yl]-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-3-okso-2-(pyrimidin-5-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamidN-[(1S)-1-syklopropyl-2-hydroksyetyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(1R,2S)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamidN-(2-hydroksy-2-metylpropyl)-3-okso-2-(1,2-tiazol-4-yl)-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridaziN-4-karboksamid(-)-3-okso-2-(pyridin-3-yl)-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 16-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-2-(5-metyl-3-tienyl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-2-(5-klor-3-tienyl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamidN-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(1H-pyrazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-fluor-2-hydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-2-(5-metyl-3-tienyl)-3-okso-2,3-dihydropyridazin-4-karboksamid N-(3,3-difluor-2-hydroksypropyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 1N-[(1R,2R)-2-hydroksysyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid(+)-6-(4-klorfenyl)-N-cis-2-hydroksysyklobutyl-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid enantiomer 16-(4-klorfenyl)-2-(5-klor-3-tienyl)-N-(2-hydroksy-2-metylpropyl)-3-okso-2,3-dihydropyridazin-4-karboksamidN-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid(-)-N-cis-4-hydroksytetrahydrofuran-3-yl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid, enantiomer 26-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-2-(1,2-oksazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(1S)-1-cyano-2-hydroksyetyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-fluor-2-hydroksypropyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-2-[1-(difluormetyl)-1H-pyrazol-4-yl]-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamidN-[(2R)-1-hydroksy-3-metoksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-N-cis-2-hydroksysyklobutyl-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(1S)-1-syklopropyl-2-hydroksyetyl]-2-(5-fluorpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1H-pyrazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid 2-[1-(difluormetyl)-1H-pyrazol-4-yl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid2-[1-(difluormetyl)-1H-pyrazol-4-yl]-N-(2-hydroksy-2-metylpropyl)-3-okso-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(1-hydroksysyklopropyl)metyl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-2-[1-(difluormetyl)-1H-pyrazol-4-yl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyrimidin-5-yl)-2,3-dihydropyridazin-4-karboksamidN-(2-hydroksy-2-metylpropyl)-3-okso-2-(1H-pyrazol-4-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamidMetyl N-{[6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-yl]karbonyl}-D-serinat(-)-N-cis-2-hydroksysyklobutyl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid enantiomer 26-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-2-(1,2-oksazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2S)-3-fluor-2-hydroksypropyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-3-okso-2-(pyrimidin-5-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-2-[1-(difluormetyl)-1H-pyrazol-4-yl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridaziN-4-karboksamid6-(4-klorfenyl)-N-[(1S)-1-syklopropyl-2-hydroksyetyl]-3-okso-2-(pyrimidin-5-yl)-2,3-dihydropyridazin-4-karboksamidMetyl N-{[6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-yl] karbonyl}-D-serinat 6-[4-(fluormetyl)fenyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1H-pyrazol-4-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyrimidin-5-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-2-[1-(difluormetyl)-1H-pyrazol-4-yl]-N-(2-hydroksy-2-metylpropyl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2R)-1-hydroksypropan-2-yl]-3-okso-2-(pyrimidin-5-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid(-)-6-(4-klorfenyl)-N-cis-2-hydroksysyklobutyl-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid, enantiomer 26-[4-(fluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-N-[(2R)-1,1,1-trifluor-3-hydroksypropan-2-yl]-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(fluormetyl)fenyl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid N-[(2R)-1-amino-3-hydroksy-1-oksopropan-2-yl]-6-(4-klorfenyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamidN-cis-4-hydroksytetrahydrotiofen-3-yl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid(-)-N-cis-4-hydroksytetrahydrotiofen-3-yl-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetyl)fenyl]-2,3-dihydropyridazin-4-karboksamid, enantiomer 2N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid3-okso-2-(pyridin-3-yl)-N-[(2R)-3,3,3-trifluor-2-hydroksypropyl]-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridaziN-4-karboksamidN-[(2S)-3,3-difluor-2-hydroksypropyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-fluor-2-hydroksypropyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(4,4,4-trifluor-3-hydroksybutan-2-yl)-2,3-dihydropyridazin-4-karboksamid Isomer 16-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(4,4,4-trifluor-3-hydroksybutan-2-yl)-2,3-dihydropyridazin-4-karboksamid Isomer 26-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(4,4,4-trifluor-3-hydroksybutan-2-yl)-2,3-dihydropyridazin-4-karboksamid Isomer 36-(4-klorfenyl)-3-okso-2-(pyridin-3-yl)-N-(4,4,4-trifluor-3-hydroksybutan-2-yl)-2,3-dihydropyridazin-4-karboksamid Isomer 46-(4-klorfenyl)-2-(5-fluorpyridin-3-yl)-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid 6-(4-klorfenyl)-2-(5-klorpyridin-3-yl)-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2S)-1-hydroksypropan-2-yl]-2-(5-metylpyridin-3-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-2,3-dihydropyridazin-4-karboksamid Isomer 16-[4-(difluormetoksy)fenyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-N-(1,1,1-trifluor-3-hydroksy-3-metylbutan-2-yl)-2,3-dihydropyridazin-4-karboksamid isomer 26-[4-(difluormetoksy)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(dimetylamino)fenyl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(dimetylamino)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamidN-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetyl)fenyl]-3-okso-2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-3-okso-2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetyl)fenyl]-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid Isomer 16-(4-klorfenyl)-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid 6-(4-klorfenyl)-N-(2-hydroksy-2-metylsyklopentyl)-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetyl)fenyl]-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid isomer 16-[4-(difluormetyl)fenyl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetyl)fenyl]-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid Isomer 23-(4-klorfenyl)-6-okso-N-[(2S)-3,3,3-trifluor-2-hydroksypropyl]-6H-1,4'-bipyridazin-5-karboksamid6-[4-(difluormetyl)fenyl]-N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetyl)fenyl]-N-[(cis)-4-hydroksytetrahydrofuran-3-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid isomer 26-(4-klorfenyl)-N-[(2R)-1-hydroksypropan-2-yl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1H-pyrazol-4-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-2,3-dihydropyridaziN-4-karboksamidN-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(1,2-tiazol-4-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(cis)-2-hydroksy-2-metylsyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamidN-[(cis)-2-hydroksy-2-metylsyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid, isomer 1N-[(cis)-2-hydroksy-2-metylsyklopentyl]-3-okso-2-(pyridin-3-yl)-6-[4-(trifluormetoksy)fenyl]-2,3-dihydropyridazin-4-karboksamid, isomer 2 6-[4-(difluormetoksy)fenyl]-N-(2-hydroksy-2-metylpropyl)-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-[4-(difluormetoksy)fenyl]-N-[(2S,3S)-3-hydroksybutan-2-yl]-3-okso-2-(pyridin-3-yl)-2,3-dihydropyridazin-4-karboksamid6-(4-klorfenyl)-N-[(cis)-2-hydroksy-2-metylsyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid; isomer 16-(4-klorfenyl)-N-[(cis)-2-hydroksy-2-metylsyklopentyl]-2-(1-metyl-1H-pyrazol-4-yl)-3-okso-2,3-dihydropyridazin-4-karboksamid; Isomer 22-(5-fluorpyridin-3-yl)-N-[(2S)-1-hydroksy-3-metylbutan-2-yl]-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid2-(5-fluorpyridin-3-yl)-N-[(1S,2R)-2-hydroksysyklopentyl]-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamidN-[(1S)-1-syklopropyl-2-hydroksyetyl]-2-(5-fluorpyridin-3-yl)-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid2-(5-fluorpyridin-3-yl)-N-[(2S)-3-hydroksy-3-metylbutan-2-yl]-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamidN-[(1S)-1-cyano-2-hydroksyetyl]-2-(5-fluorpyridin-3-yl)-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid2-(5-fluorpyridin-3-yl)-N-[(2R)-3-hydroksy-3-metylbutan-2-yl]-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid1,5-anhydro-2,4-dideoxy-2-[({2-(5-fluorpyridin-3-yl)-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridaziN-4-yl}karbonyl)amino]-D-erytropentitol2-(5-fluorpyridin-3-yl)-N-(2-hydroksy-2-metylpropyl)-3-okso-6-[6-(trifluormetyl)pyridin-3-yl]-2,3-dihydropyridazin-4-karboksamid N-[(2S)-1-hydroksypropan-2-yl]-3-okso-2-(pyridin-3-yl)-6-[5-(trifluormetyl)pyridin-2-yl]-2,3-dihydropyridaziN-4-karboksamidderes polymorfe, enantiomerer, diastereomerer, racemater, tautomerer, N-oksider, hydrater og solvater, så vel som deres fysiologisk akseptable salter og solvater av disse saltene, så vel som blandinger av de samme.5. En fremgangsmåte for fremstilling av en forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4, hvor nevnte fremgangsmåte omfatter trinnet av å tillate en mellomforbindelse med den generelle formelen (VII):hvor X, R2, R3, R4 og R5 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3,til å reagere med en forbindelse med den generelle formelen (VIII):H2N-R1 (VIII),hvor R1 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3,hvorved man får en forbindelse med den generelle formelen (I):hvor X, R1, R2, R3, R4 og R5 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3.6. En fremgangsmåte for fremstilling av en forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4, hvor nevnte fremgangsmåte omfatter trinnet av å tillate en mellomforbindelse med den generelle formelen (XII): hvor X, R1, R2, R3 og R4 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3,til å reagere med en forbindelse med generell formelen (XIV):hvor R5 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3 og R' og R" representerer samtidig H eller C1-C4-alkyl eller danner tilsammen en C2-C7-alkylengruppe som en del av en 1,2- eller 1,3-diolborester eller en -CO-CH2-(NCH3)-CH2-CO-gruppe;hvorved man får en forbindelse med den generelle formelen (I):hvor X, R1, R2, R3, R4 og R5 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3.7. En forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4 for bruk i behandling eller profylakse av en sykdom.8. En farmasøytisk sammensetning som omfatter en forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4 og et eller flere farmasøytisk akseptable hjelpestoffer.9. En farmasøytisk kombinasjon som omfatter:• en eller flere første aktive ingredienser, spesielt forbindelser med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4, og• en eller flere farmasøytiske aktive antikreftforbindelser eller• en eller flere farmasøytiske aktive immunkontrollinhibitorer. 10. En farmasøytisk kombinasjon ifølge krav 9, karakterisert ved at den farmasøytiske aktive immunkontrollinhibitoren er et antistoff.11. En farmasøytisk kombinasjon ifølge krav 9 og 10, karakterisert ved at den farmasøytiske aktive immunkontrollinhibitoren er antistoffet TPP-3911.12. Forbindelse for bruk av den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4 for behandling eller profylakse av en sykdom.13. Bruk av en forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4 for fremstilling av et medikament for behandling eller profylakse av en sykdom.14. Forbindelse for bruk ifølge krav 12 eller 13, hvor sykdommen er kreft eller tilstander med dysregulert immunrespons eller andre lidelser som er assosiert med avvikende AHR-signalisering, så som flytende og faste tumorer.15. En forbindelse med den generelle formelen (VII):hvor X, R2, R3, R4 og R5 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3.16. Bruk av en forbindelse med den generelle formelen (VII)hvor X, R2, R3, R4 og R5 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3, for fremstilling av en forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4. 17. En forbindelse med den generelle formelen (XII):hvor X, R1, R2, R3 og R4 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3.18. Bruk av en forbindelse med den generelle formelen (XII)hvor X, R1, R2, R3 og R4 er som definert for forbindelsen med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 3, for fremstilling av en forbindelse med den generelle formelen (I) ifølge et hvilket som helst av kravene 1 til 4.
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GUTCHER, Ilona
Paul Robesonstrasse 28 10439 Berlin DE
RÖHN, Ulrike
Boyenstrasse 42 10115 Berlin DE
SCHMEES, Norbert
Bondickstrasse 61 13469 Berlin DE
ZORN, Ludwig
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RÖSE, Lars
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KOBER, Christina
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PLATTEN, Michael
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2017.02.09, EP 17155406

2017.11.21, EP 17202882

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EP-A1- 1 130 015 (B1)

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