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Beskrivelse	Verdi
Saken / databasen er sist oppdatert	2025.05.03 12:37:00 info
Tittel	NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
Status Hovedstatus Detaljstatus	I kraft info 2022.04.19 EP patent gjort gjeldende i Norge 2022.04.19 EP patent besluttet gjeldende i Norge
Patentnummer	NO/EP3551627
Europeisk (EP) publiserings nummer	EP3551627
EP levert	2017.12.07
EP søknadsnummer	17816630.2
EP meddelt	2022.02.16
Prioritet	2016.12.08, EP 16202889
Sakstype	Europeisk
Løpedag	2017.12.07
Utløpsdato	2037.12.07
Allment tilgjengelig	2019.10.16
Validert i Norge	2022.04.19
Innehaver	F. Hoffmann-La Roche AG (CH)
Oppfinner	BUETTELMANN, Bernd (CH) .... se mer/flere nedenfor
Fullmektig	PLOUGMANN VINGTOFT NUF (NO)
Lenke til European patent Register	Informasjon i saken, dokumenter og patentfamilie
Patentfamilie	Se i Espacenet

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Beskrivelse og krav chevron_right

Beskrivelse

Krav

PATENTKRAV

1. Forbindelser med formel (I),

hvori

X er valgt fra

i) N og

ii) CH;

Y er valgt fra

i) N og

ii) CR¹⁰;

Z er valgt fra

i) N og

ii) CR¹¹;

R¹er valgt fra

i) C1−6-alkyl,

ii) halogen-C1−6-alkyl,

iii) C1−6-alkoksy,

iv) halogen-C1−6-alkoksy,

v) hydroksy-C1−6-alkyl,

vi) C3−8-sykloalkyl,

vii) halogen og

viii) amino substituert på nitrogenatomet med én eller to substituenter uavhengig valgt fra

a. H,

b. C1−6-alkyl og

c. C3−8-sykloalkyl;

R²er valgt fra

i) H og

i) halogen;

R³er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C3−8-sykloalkyl,

iv) hydroksy-C1−6-alkyl og

v) halogen-C1−6-alkyl;

R⁴er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C1−6-alkoksy,

iv) C3−8-sykloalkyl og

v) halogen;

R⁵er H;

R⁶er valgt fra

i) H,

i) C1−6-alkyl,

ii) C3−8-sykloalkyl substituert med R⁷, R⁸og R⁹,

iii) C3−8-sykloalkyl-C1−6-alkyl substituert med R⁷, R⁸og R⁹, iv) C1−6-alkylsulfonyl-C1−6-alkyl,

v) cyano-C1−6-alkyl,

vi) hydroksy-C1−6-alkyl,

vii) dihydroksy-C1−6-alkyl,

viii) halogen-C1−6-alkyl,

ix) heterosykloalkyl substituert med R⁷, R⁸og R⁹og x) heterosykloalkyl-C1−6-alkyl substituert med R⁷, R⁸og R⁹; R⁷, R⁸og R⁹er uavhengig valgt fra

i) H,

ii) C1−6-alkyl,

iii) C1−6-alkoksy,

iv) C1−6-alkoksyalkyl,

v) C1−6-alkoksykarbonyl,

vi) cyano,

vii) C3−8-sykloalkoksy,

viii) C3−8-sykloalkyl,

ix) halogen-C1−6-alkoksy,

x) halogen-C1−6-alkyl,

xi) halogen,

xii) hydroksy,

xiii) hydroksy-C1−6-alkyl og

xiv) okso;

R¹⁰er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C1−6-alkoksy,

iv) C3−8-sykloalkyl og

v) halogen;

R¹¹er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C1−6-alkoksy,

iv) C3−8-sykloalkyl og

v) halogen;

eller R⁵og R¹⁰sammen danner −(CH2)n−;

eller R⁵og R¹¹sammen danner −(CH2)n−;

eller R⁵og R⁶sammen med nitrogenatomet som de er festet til, danner et heterosykloalkyl substituert med R⁷, R⁸og R⁹;

n er valgt fra 1 og 2;

eller farmasøytisk akseptable salter.

2. Forbindelse ifølge krav 1, hvori

X er valgt fra

i) N og

ii) CH;

Y er valgt fra

i) N og

ii) CR¹⁰;

Z er valgt fra

i) N og

ii) CR¹¹;

R¹er valgt fra

i) C1−6-alkyl,

ii) halogen-C1−6-alkyl,

iii) C1−6-alkoksy,

iv) C3−8-sykloalkyl,

v) halogen og

vi) amino substituert på nitrogenatomet med to uavhengig valgte C1−6-alkyl; R²er valgt fra

i) H,

ii) halogen;

R³er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C3−8-sykloalkyl, og

iv) halogen-C1−6-alkyl;

R⁴er valgt fra

i) H og

ii) C1−6-alkyl;

R⁵er H;

R⁶er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C3−8-sykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. C1−6-alkoksy,

d. C1−6-alkoksyalkyl,

e. C1−6-alkoksykarbonyl,

f. cyano,

g. C3−8-sykloalkoksy,

h. halogen-C1−6-alkoksy,

i. halogen-C1−6-alkyl,

j. halogen,

k. hydroksy og

l.hydroksy-C1−6-alkyl;

iv) C3−8-sykloalkyl-C1−6-alkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. C1−6-alkoksy,

d. C1−6-alkoksyalkyl,

e. C1−6-alkoksykarbonyl,

f. cyano,

g. C3−8-sykloalkoksy,

h. halogen-C1−6-alkoksy,

i. halogen-C1−6-alkyl,

j. halogen,

k. hydroksy og

l. hydroksy-C1−6-alkyl;

v) C1−6-alkylsulfonyl-C1−6-alkyl,

vi) cyano-C1−6-alkyl,

vii) dihydroksy-C1−6-alkyl,

viii) halogen-C1−6-alkyl,

ix) heterosykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. hydroksy og

d. okso;

og hvori heterosykloalkylet er valgt fra

a. oksetanyl,

b. tetrahydrofuranyl,

c. tetrahydropyranyl,

d. oksepanyl,

e. oksabisyklo[2.2.1]heptanyl,

f. oksaspiro[3.3]heptanyl,

g. azetidinyl,

h. tetrahydrotiofenyl og

i. tetrahydrotiopyranyl; og

x) oksetanyl-C1−6-alkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. hydroksy;

R¹⁰er valgt fra

i) H og

ii) halogen;

R¹¹er valgt fra

i) H,

ii) C1−6-alkyl og

iii) C1−6-alkoksy;

eller R⁵og R¹⁰sammen danner −(CH2)n−;

eller R⁵og R¹¹sammen danner −(CH2)n−;

eller R⁵og R⁶sammen med nitrogenatomet de er festet til, danner et heterosykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. C1−6-alkoksy,

d. cyano,

e. halogen,

f. hydroksy og

g. okso;

og hvori heterosykloalkylet er valgt fra

a. azetidinyl,

b. pyrrolidinyl,

c. piperidinyl,

d. morfolinyl,

e. tiomorfolinyl,

f. oksaazabisyklo[3.1.1]heptanyl,

g. oksaazabisyklo[2.2.1]heptanyl,

h. azaspiro[3.3]heptanyl,

i. oksaazaspiro[3.3]heptanyl,

j. tiaazaspiro[3.3]heptanyl;

n er 1;

eller farmasøytisk akseptable salter.

3. Forbindelse ifølge krav 1, hvori

X er valgt fra

i) N og

ii) CH;

Y er valgt fra

i) N og

ii) CR¹⁰;

Z er valgt fra

i) N og

ii) CR¹¹;

R¹er valgt fra

i) C1−6-alkyl,

ii) halogen-C1−6-alkyl,

iii) C1−6-alkoksy,

iv) C3−8-sykloalkyl,

v) halogen og

vi) amino substituert på nitrogenatomet med to uavhengig valgte C1−6-alkyl; R²er valgt fra

i) H,

ii) halogen;

R³er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C3−8-sykloalkyl og

iv) halogen-C1−6-alkyl;

R⁴er valgt fra

i) H og

ii) C1−6-alkyl;

R⁵er H;

R⁶er valgt fra

i) H,

ii) C1−6-alkyl,

iii) C3−8-sykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. C1−6-alkoksy,

d. C1−6-alkoksyalkyl,

e. C1−6-alkoksykarbonyl,

f. cyano,

g. C3−8-sykloalkoksy,

h. halogen-C1−6-alkoksy,

i. halogen-C1−6-alkyl,

j. halogen,

k. hydroksy og

l. hydroksy-C1−6-alkyl;

iv) C3−8-sykloalkyl-C1−6-alkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. C1−6-alkoksy,

d. C1−6-alkoksyalkyl,

e. C1−6-alkoksykarbonyl,

f. cyano,

g. C3−8-sykloalkoksy,

h. halogen-C1−6-alkoksy,

i. halogen-C1−6-alkyl,

j. halogen,

k. hydroksy og

l. hydroksy-C1−6-alkyl;

v) C1−6-alkylsulfonyl-C1−6-alkyl,

vi) cyano-C1−6-alkyl,

vii) dihydroksy-C1−6-alkyl,

viii) halogen-C1−6-alkyl,

ix) heterosykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. hydroksy og

d. okso;

og hvori heterosykloalkylet er valgt fra

a. oksetanyl,

b. tetrahydrofuranyl,

c. tetrahydropyranyl,

d. oksepanyl,

e. oksabisyklo[2.2.1]heptanyl,

f. oksaspiro[3.3]heptanyl,

g. azetidinyl,

h. tetrahydrotiofenyl og

i. tetrahydrotiopyranyl; og

x) oksetanyl-C1−6-alkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. hydroksy;

R¹⁰er valgt fra

i) H og

ii) halogen;

R¹¹er valgt fra

i) H,

ii) C1−6-alkyl og

iii) C1−6-alkoksy;

eller farmasøytisk akseptable salter.

4. Forbindelse ifølge krav 1, hvori

X er valgt fra

i) N og

ii) CH;

Y er valgt fra

i) N og

ii) CR¹⁰;

Z er CR¹¹;

R¹er C1−6-alkyl;

R²er valgt fra

i) H,

ii) halogen;

R³er valgt fra

i) C1−6-alkyl,

ii) C3−8-sykloalkyl og

iii) halogen-C1−6-alkyl;

R⁴er valgt fra

i) H og

ii) C1−6-alkyl;

R⁵er H;

R⁶er valgt fra

i) C1−6-alkyl,

ii) C3−8-sykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H,

b. C1−6-alkyl,

c. C1−6-alkoksyalkyl og

d. halogen-C1−6-alkyl;

iii) hydroksy-C1−6-alkyl,

iv) halogen-C1−6-alkyl,

v) heterosykloalkyl substituert med R⁷, R⁸og R⁹, hvori R⁷, R⁸og R⁹er uavhengig valgt fra

a. H og

b. C1−6-alkyl;

og hvori heterosykloalkylet er valgt fra

a. oksetanyl,

b. tetrahydrofuranyl,

c. tetrahydropyranyl,

d. oksepanyl og

e. oksaspiro[3.3]heptanyl;

R¹⁰er H;

R¹¹er H;

eller farmasøytisk akseptable salter.

5. Forbindelse ifølge krav 1, hvori

X er CH;

Y er N;

Z er CR¹¹;

R¹er C1−6-alkyl;

R²er H;

R³er C1−6-alkyl;

R⁴er H;

R⁵er H;

R⁶er heterosykloalkyl substituert med R⁷, R⁸og R⁹;

R⁷, R⁸og R⁹er H;

R¹¹er H;

eller farmasøytisk akseptable salter.

6. Forbindelse ifølge krav 1, hvori

X er CH;

Y er N;

Z er CR¹¹;

R¹er C1−6-alkyl;

R²er H;

R³er C1−6-alkyl;

R⁴er H;

R⁵er H;

R⁶er tetrahydropyranyl substituert med R⁷, R⁸og R⁹;

R⁷, R⁸og R⁹er H;

R¹¹er H;

eller farmasøytisk akseptable salter.

7. Forbindelse ifølge et hvilket som helst av kravene 1 til 6, valgt fra 6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-yl-pyridin-3-karboksamid;

N-(syklopropylmetyl)-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;

N-etyl-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;

N-((1S)-1-(hydroksymetyl)butyl)-6-((5-metyl-3-(6-rnetyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;

6-((5-syklopropyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-((1S)-1-(hydroksymetyl)butyl)pyridin-3-karboksamid;

6-((5-syklopropyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-yl-pyridin-3-karboksamid;

(S)-N-(1-hydroksypentan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)pyridazin-3-karboksamid;

2-isobutyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

2-metyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

N-isobutyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

2-(2-hydroksyetyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

(S)-2-(1-hydroksypentan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

(S)-N-(1-hydroksypentan-2-yl)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)pyrazin-2-karboksamid;

N-(1,1-dioksotiolan-3-yl)-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid; 6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((3S)-1,1-dioksotiolan-3-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl)metoksy)pyridin-3-karboksamid;

N-((3R)-1,1-dioksotiolan-3-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl)metoksy)pyridin-3-karboksamid;

N-(1,1-dioksotian-4-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl)metoksy)pyridin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-2-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

N-((1S,2R)-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1S,2S)-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1R,2R)-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-syklopropyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1R,2S)-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((3S,4R)-3-hydroksytetrahydropyran-4-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(2-hydroksyetyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(1,1-dioksotian-4-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(syklopropylmetyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(2-cyanoetyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(RS)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1,1,1-trifluorpropan-2-yl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(oksetan-3-yl)pyridazin-3-karboksamid;

(RS)-N-(1,1-dioksotiolan-3-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-etyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-isopropyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-isobutyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(2,2,2-trifluoretyl)pyridazin-3-karboksamid;

N-tert-butyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(3,3-difluorsyklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(4,4-difluorsykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-ylpyridin-3-karboksamid;

(RS)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydrofuran-3-yl)pyridazin-3-karboksamid;

N-metyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(3,3-difluorazetidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

(3,3-difluorpyrrolidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-((3-metyloksetan-3-yl)metyl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-(oksetan-3-ylmetyl)pyridazin-3-karboksamid;

N-((3-hydroksyoksetan-3-yl)metyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-((3R,4R)-3-metyltetrahydropyran-4-yl)pyridazin-3-karboksamid;

(4,4-difluorpiperidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

N-(1-(metoksymetyl)syklopropyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(3-metoksyazetidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

(3-hydroksy-3-metylazetidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

azetidin-1-yl(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

(RS)-N-(2,2-dimetyltetrahydropyran-4-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1-(trifluormetyl)syklopropyl)pyridazin-3-karboksamid;

(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)(morfolino)metanon;

(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)(2-oksa-6-azaspiro[3.3]heptan-6-yl)metanon;

4-metyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-4-yl)pyridazin-3-karboksamid;

(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)(6-oksa-1-azaspiro[3.3]heptan-1-yl)metanon;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1,1,1-trifluor-2-metylpropan-2-yl)pyridazin-3-karboksamid;

(3-fluorazetidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

(3-hydroksyazetidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

(3-fluor-3-metylazetidin-1-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

etyl-1-(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamido)syklopropankarboksylat;

N-(1-cyanosyklopropyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

5-metyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

5-metyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-4-yl)pyridazin-3-karboksamid;

N-(1,1-dioksotian-4-yl)-5-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

N-(2-hydroksy-1,1-dimetyl-etyl)-5-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

N-syklopropyl-5-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

(RS)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(3-metyltetrahydrofuran-3-yl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1-metylsyklopropyl)pyridazin-3-karboksamid;

5-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-(oksetan-3-yl)pyrazin-2-karboksamid;

5-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-(2,2,2-trifluoretyl)pyrazin-2-karboksamid;

N-(4-hydroksy-2-metylbutan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(2-metyl-4-(metylsulfonyl)butan-2-yl)pyridazin-3-karboksamid;

(S)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(3-metyltetrahydrofuran-3-yl)pyridazin-3-karboksamid;

(R)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(3-metyltetrahydrofuran-3-yl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(3-metyloksetan-3-yl)pyridazin-3-karboksamid;

1-(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karbonyl)azetidin-3-karbonitril;

N-(1-(hydroksymetyl)syklopropyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(4,4-difluorsykloheksyl)-5-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

(S)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydrofuran-3-yl)pyridazin-3-karboksamid;

(S)-N-(1-cyanobutan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(R)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydrofuran-3-yl)pyrazin-2-karboksamid;

N-(2-hydroksyetyl)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

2-(1,1-dioksotian-4-yl)-6-[[5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl]metoksy]-1H-pyrrolo[3,4-c]pyridin-3-on;

(S)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydrofuran-3-yl)pyrazin-2-karboksamid;

2-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-6-tetrahydropyran-4-yl-7H-pyrrolo[3,4-b]pyridin-5-on;

N-(1,1-dioksotiolan-3-yl)-5-((5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl)metoksy)pyrazin-2-karboksamid;

N-(syklopropylmetyl)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

2-(4,4-difluorsykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(4-metyltetrahydro-2H-pyran-4-yl)pyridazin-3-karboksamid;

(R)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-3-yl)pyrazin-2-karboksamid;

(R)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-3-yl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(2-oksaspiro[3.3]heptan-6-yl)pyridazin-3-karboksamid;

5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(2-oksaspiro[3.3]heptan-6-yl)pyrazin-2-karboksamid;

5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-((cis)-4-(trifluormetyl)sykloheksyl)pyrazin-2-karboksamid;

(S)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-3-yl)pyridazin-3-karboksamid;

N-((cis)-4-hydroksy-4-metylsykloheksyl)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

N-((trans)-4-hydroksy-4-metylsykloheksyl)-5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyrazin-2-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(4-metyltetrahydro-2H-pyran-4-yl)nikotinamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-2-(tetrahydro-2H-tiopyran-4-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

6-((5-metyl-3-(6-metylpyridazin-3-yl)isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-yl-pyridin-3-karboksamid;

N-((1S)-1-(hydroksymetyl)butyl)-6-((5-metyl-3-(6-metylpyridazin-3-yl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(4-metyltetrahydrotiopyran-4-yl)pyridazin-3-karboksamid;

N-(4-metyl-1,1-dioksidotetrahydro-2H-tiopyran-4-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(2,2-dioksido-2-tia-6-azaspiro[3.3]heptan-6-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

(2,2-dioksido-2-tia-6-azaspiro[3.3]heptan-6-yl)(5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyrazin-2-yl)metanon;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1-metylsyklopentyl)pyridazin-3-karboksamid;

5-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(4,4,4-trifluorbutyl)pyrazin-2-karboksamid;

N-(1-isopropylazetidin-3-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-2-(2-oksaspiro[3.3]heptan-6-yl)-1H-pyrrolo[3,4-c]pyridin-3(2H)-on;

6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1-metylsyklobutyl)pyridazin-3-karboksamid;

6-((5-etyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)nikotinamid;

N-(1,1-dioksidotetrahydro-2H-tiopyran-4-yl)-6-((5-etyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

6-((5-etyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-4-yl)pyridazin-3-karboksamid;

6-((5-etyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(3-metyloksetan-3-yl)pyridazin-3-karboksamid;

N-syklopropyl-6-((5-etyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(R)-N-(1-hydroksypentan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

6-((5-(difluormetyl)-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-((1S)-1-(hydroksymetyl)butyl)pyridin-3-karboksamid;

6-((5-(difluormetyl)-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-yl-pyridin-3-karboksamid;

N-((3R,4S)-3-hydroksytetrahydropyran-4-yl)-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;

6-((3-(6-syklopropyl-3-pyridyl)-5-metyl-isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-yl-pyridin-3-karboksamid;

6-((3-(6-syklopropyl-3-pyridyl)-5-metyl-isoksazol-4-yl)metoksy)-N-((1S)-1-(hydroksymetyl)butyl)pyridin-3-karboksamid;

6-((3-(6-syklopropyl-3-pyridyl)-5-metyl-isoksazol-4-yl)metoksy)-N-(1,1-dioksotian-4-yl)pyridin-3-karboksamid;

N-((1R,2S)-3,3-difluor-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

N-((1R,2R)-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

N-((1S,2R)-3,3-difluor-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

N-((3S,4R)-3-hydroksytetrahydro-2H-pyran-4-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

N-((1S,2S)-2-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

2-fluor-N-metyl-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)nikotinamid;

6-((3-(6-metoksypyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)nikotinamid;

N-isopropyl-6-((3-(6-metoksypyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)nikotinamid;

(S)-N-(1-hydroksypentan-2-yl)-6-((3-(6-metoksypyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)nikotinamid;

(1,1-dioksidotiomorfolino)(6-((3-(6-metoksypyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)pyridin-3-yl)metanon;

(S)-6-((3-(6-(dimetylamino)pyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)-N-(1-hydroksypentan-2-yl)nikotinamid;

4-metoksy-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)nikotinamid;

6-((3-(5-fluor-6-metyl-3-pyridyl)-5-metyl-isoksazol-4-yl)metoksy)-N-tetrahydropyran-4-yl-pyridin-3-karboksamid;

6((3-(5-fluor-6-metyl-3-pyridyl)-5-metyl-isoksazol-4-yl)metoksy)-N-isopropylpyridin-3-karboksamid;

6-((3-(5-fluor-6-metyl-3-pyridyl)-5-metyl-isoksazol-4-yl)metoksy)-N-((1S)-1-(hydroksymetyl)butyl)pyridin-3-karboksamid;

N-((1r,4r)-4-hydroksy-4-metylsykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(1,3-dihydroksy-2-metylpropan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1s,4s)-4-hydroksy-4-metylsykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1R,3S)-3-hydroksy-3-(trifluormetyl)syklopentyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1S,3R)-3-hydroksy-3-(trifluormetyl)syklopentyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(1S,4S)-2-oksa-5-azabisyklo[2.2.1]heptan-5-yl(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

N-((1RS,3RS)-3-hydroksysyklopentyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

trans-N-(4-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

trans-N-(4-metoksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(6,6-difluor-2-azaspiro[3,3]heptan-2-yl)(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

N-(3-hydroksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

3-oksa-6-azabisyklo[3.1.1]heptan-6-yl(6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-yl)metanon;

cis-N-(4-metoksysykloheksyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((3-(6-klorpyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)pyridazin-3-karboksamid;

(S)-6-((3-(6-klorpyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)-N-(tetrahydro furan-3-yl)pyridazin-3-karboksamid;

6-((3-(6-klorpyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)-N-(3-metyloksetan-3-yl)pyridazin-3-karboksamid;

6-((3-(6-klorpyridin-3-yl)-5-metylisoksazol-4-yl)metoksy)-N-(2-oksaspiro[3.3]heptan-6-yl)pyridazin-3-karboksamid;

trans-N-(3-metoksysyklobutyl)-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

cis-N-(3-metoksysyklobutyl)-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-syklopropyl-3-(6-metylpyridazin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)pyridazin-3-karboksamid;

trans-N-((1RS,3RS)-3-metoksysyklopentyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-(6,6-difluorspiro[3.3]heptan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-(fluormetyl)-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-4-yl)pyridazin-3-karboksamid;

cis-N-3-((2,2-difluoretoksy)syklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

trans-N-3-((2,2-difluoretoksy)syklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

cis-N-(3-etoksysyklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

trans-N-(3-etoksysyklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

cis-N-(3-(difluormetoksy)syklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

trans-N-(3-(difluormetoksy)syklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

trans-N-(3-syklopropoksysyklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

cis-N-(3-syklopropoksysyklobutyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((3-(6-klorpyridin-3-yl)-5-syklopropylisoksazol-4-yl)metoksy)-N-(3-metyloksetan-3-yl)pyridazin-3-karboksamid;

6-((3-(6-klorpyridin-3-yl)-5-syklopropylisoksazol-4-yl)metoksy)-N-(2-oksaspiro[3.3]heptan-6-yl)pyridazin-3-karboksamid;

(S)-6-((3-(6-klorpyridin-3-yl)-5-syklopropylisoksazol-4-yl)metoksy)-N-(tetrahydrofuran-3-yl)pyridazin-3-karboksamid;

6-((5-syklopropyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(3-metyloksetan-3-yl)pyridazin-3-karboksamid;

6-((5-syklopropyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(2-oksaspiro[3.3]heptan-6-yl)pyridazin-3-karboksamid;

(S)-6-((5-syklopropyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydrofuran-3-yl)pyridazin-3-karboksamid;

6-((5-syklopropyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-4-yl)pyridazin-3-karboksamid;

6-((5-(fluormetyl)-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(1-(trifluormetyl)syklopropyl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-(trifluormetyl)pyridin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydropyran-4-yl)pyridazin-3-karboksamid;

N-((2S)-7-oksabisyklo[2.2.1]heptan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

(RS)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)-N-(oksepan-4-yl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)-N-((1R,3S,4R)-7-oksabisyklo[2.2.1]heptan-3-yl)pyridazin-3-karboksamid;

N-((2R)-7-oksabisyklo[2.2.1]heptan-2-yl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1R,3R)-3-etoksysyklopentyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

N-((1R,3R)-3-(2,2-difluoretoksy)syklopentyl)-6-((5-metyl-3-(6-metylpyridin-3-yl)isoksazol-4-yl)metoksy)pyridazin-3-karboksamid;

6-((5-(fluormetyl)-3-(6-metylpyridazin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)pyridazin-3-karboksamid;

6-((5-metyl-3-(6-metylpyridazin-3-yl)isoksazol-4-yl)metoksy)-N-(tetrahydro-2H-pyran-4-yl)pyridazin-3-karboksamid;

N-[4-(2,2-difluoretoksy)sykloheksyl]-6-[[5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl]metoksy]pyridazin-3-karboksamid;

N-(4-etoksysykloheksyl)-6-[[5-metyl-3-(6-metylpyridin-3-yl)-1,2-oksazol-4-yl]metoksy]pyridazin-3-karboksamid;

eller farmasøytisk akseptable salter.

8. Forbindelse ifølge et hvilket som helst av kravene 1 til 7, valgt fra N-((1S)-1-(hydroksymetyl)butyl)-6-((5-metyl-3-(6-metyl-3-pyridyl)isoksazol-4-yl)metoksy)pyridin-3-karboksamid;