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Tittel N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE
Status
Hovedstatus
Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP3359541
Europeisk (EP) publiserings nummer EP3359541
EP levert
EP søknadsnummer 16788232.3
EP meddelt
Prioritet 2015.10.09, US 201562239647 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver AbbVie Overseas S.à r.l. (LU)
Oppfinner BROWN, Brian S. (US) .... se mer/flere nedenfor
Fullmektig CURO AS (NO)
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Krav

Patentkrav1. Forbindelse med formel (I) eller et farmasøytisk akseptabelt salt av samme,idetR1 er G1A, C1-C6 haloalkyl, eller C1-C6 alkyl; idet C1-C6 haloalkylen og C1-C6 alkylen hver er valgfritt substituert med én G1A;G1A er ved hver forekomst uavhengig fenyl, 5-6-leddet monosyklisk heteroaryl, 4-7-leddet monosyklisk heterosyklus, 5-11-leddet kondensert bisyklisk heterosyklus, eller C3-C6 monosyklisk sykloalkyl; idet hver G1A er valgfritt substituert med 1, 2, 3, eller 4 substituenter uavhengig valgt fra gruppen bestående av R1a og G1B;G1B er ved hver forekomst uavhengig 4-7-leddet monosyklisk heterosyklus som valgfritt er substituert med 1, 2, 3, eller 4 uavhengige valgte R1b grupper;R2 er hydrogen, C2-C4 alkenyl, C1-C6 alkyl, C1-C6 haloalkyl, -OR2xa, -N(R2xa)(R2xb), eller G2A;R2xaer ved hver forekomst uavhengig C1-C6 alkyl, C1-C6 haloalkyl, eller G2B;R2xb er hydrogen, C1-C3 alkyl, eller C1-C3 haloalkyl;G2A og G2B er hver uavhengig en 4-7-leddet monosyklisk heterosyklus eller en C3-C6 monosyklisk sykloalkyl; idet G2A og G2B er hver valgfritt substituert med 1, 2, eller 3 uavhengige valgte R2a grupper;R3 er G3A, -G3B-L1-G3C, -G3B-L3-G3C-G3E, -(C1-C6 alkylenyl)-G3D, -OR3a, eller -N(R3a)(R3b);R3a er ved hver forekomst uavhengig G3D, C1-C6 haloalkyl, eller C1-C6 alkyl; idet the C1-C6 haloalkyl og the C1-C6 alkyl er hver valgfritt substituert med én eller to substituenter uavhengig valgt fra gruppen bestående av G3D, -OR3xa, og -N(R3xb)2;R3xa og R3xb er hver, ved hver forekomst, uavhengig hydrogen, C1-C6 haloalkyl, C1-C6 alkyl, eller G3D;R3b er hydrogen, C1-C6 alkyl, eller C1-C6 haloalkyl;L1 er en binding, C1-C6 alkylenyl, (C1-C6 alkylenyl)r-L2-(C1-C6 alkylenyl)s, eller O-(C1-C6 alkylenyl)-C(O), idet den venstre enden av L1 komponenten/gruppen er festet til G3B;L2 er O, N(Rx), C(O), N(Rx)C(O), eller C(O)N(Rx); idet hver Rx er uavhengig hydrogen, C1-C6 alkyl, eller C1-C6 haloalkyl;L3 er en binding eller C1-C6 alkylenyl;r er 0 eller 1;s er 0 eller 1; G3A, G3B, og G3C og hver uavhengig C3-C11 sykloalkyl, fenyl, 5-6-leddet monosyklisk heteroaryl, eller 4-11-leddet heterosyklus; idet G3A, G3B, og G3C er hver valgfritt substituert med 1, 2, 3, eller 4 uavhengige valgte Re grupper;G3D er ved hver forekomst uavhengig C3-C8 monosyklisk sykloalkyl, 4-7-leddet monosyklisk heterosyklus, en 5-11-leddet kondensert bisyklisk heterosyklus, eller en 5-11-leddet spiro heterosyklus; idet hver G3D er valgfritt substituert med 1, 2, 3, eller 4 substituenter uavhengig valgt fra gruppen bestående av Re og G3E;G3E er ved hver forekomst uavhengig C3-C8 monosyklisk sykloalkyl eller 4-7-leddet monosyklisk heterosyklus; idet hver G3E er valgfritt substituert med 1, 2, 3, eller 4 uavhengige valgte Re grupper;R4 er hydrogen, C1-C3 alkyl, eller C1-C3 haloalkyl;R5 er C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, -N(R5ax)(R5bx), -OR5dx, eller G5A; idet the C1-C6 alkyl og the C1-C6 haloalkyl er hver valgfritt substituert med én eller to substituenter uavhengig valgt fra gruppen bestående av G5A, -CN, -N3, -OR5ax, -S(O)2R5ax, -S(O)2N(R5ax)(R5bx), -N(R5ax)(R5bx), -N(R5bx)S( O)2R5cx, -N(R5bx)C(O)R5cx, -N(R5bx)C(O)N(R5ax)(R5bx), -N(R5bx)C(O)OR5xc, -C(O )R5ax, -C(O)OR5ax, -C(O)N(R5bx)S(O)2R5cx, og -C(O)N(R5ax)(R5bx);R5ax og R5bx er hver, ved hver forekomst, uavhengig hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, -OR5ex, -(C1-C6 alkylenyl)-OR5ex, G5A, eller -(C1-C6 alkylenyl)-G5A;R5cx er ved hver forekomst uavhengig C1-C6 alkyl, C1-C6 haloalkyl, G5A, eller -(C1-C6 alkylenyl)-G5A;R5dx er C1-C6 alkyl, eller C1-C6 haloalkyl;R5ex er hydrogen, C1-C6 alkyl, eller C1-C6 haloalkyl;G5A er ved hver forekomst uavhengig C3-C11 sykloalkyl, fenyl, 5-6-leddet monosyklisk heteroaryl, eller 4-11-leddet heterosyklus; idet hver G5A er valgfritt substituert med 1, 2, 3, eller 4 uavhengige valgte R5a grupper;R5a er ved hver forekomst uavhengig C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, C1-C6 haloalkyl, okso, G5B, -CN, NO2, -ORb, -OC(O)Rc, -OC(O)N(Rd)2, -SRb, -S(O)2Rb, -S(O)2N(Rd)2, -C(O)Rb, -C (O)ORb, -C(O)N(Rd)2, -C(O)N(Rd)S(O)2Rc, -N(Rd)2, -N(Rd)C(O)Rc, -N(Rd)S(O)2 Rc, -N(Rd)C(O)O(Rb), -N(Rd)C(O)N(Rd)2, -N(Rd)S(O)2N(Rd)2, -(C1-C6 alkylenyl)-CN, -(C1-C6 alkylenyl)-G5B, -(C1-C6 alkylenyl)-ORb, -(C1-C6 alkylenyl)-OC(O)Rc, -(C1-C6 alkylenyl)-OC(O)N(Rd)2, -(C1-C6 alkylenyl)-SRb, -(C1-C6 alkylenyl)-S(O)2Rb, -(C1-C6 alkylenyl)-S(O)2N(Rd)2, -(C1-C6 alkylenyl)-C(O)Rb, -(C1-C6 alkylenyl)-C(O)ORb, -(C1-C6 alkylenyl)-C(O)N(Rd)2, -(C1-C6 alkylenyl)-C(O)N(Rd)S(O)2Rc, -(C1-C6 alkylenyl)-N(Rd)2, -(C1-C6 alkylenyl)-N(Rd)C(O)Rc, -(C1-C6 alkylenyl)-N(Rd)S(O)2Rc, -(C1-C6 alkylenyl)-N(Rd)C(O)O(Rc), -(C1-C6 alkylenyl)-N(Rd)C(O)N(Rd)2, eller -(C1-C6 alkylenyl)-N(Rd)S(O)2N(Rd)2;Rb og Rd er hver, ved hver forekomst, uavhengig hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, alkoksyalkyl, G5B, eller -(C1-C6 alkylenyl)-G5B; Rc er ved hver forekomst uavhengig C1-C6 alkyl, C1-C6 haloalkyl, alkoksyalkyl, G5B, eller -(C1-C6 alkylenyl)-G5B;G5B er ved hver forekomst uavhengig C3-C6 monosyklisk sykloalkyl, fenyl, 5-6-leddet monosyklisk heteroaryl, eller 4-7-leddet monosyklisk heterosyklus; idet hver G5B er valgfritt substituert med 1, 2, 3, eller 4 uavhengige valgte R5b grupper;Re er ved hver forekomst uavhengig C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl, C1-C6 haloalkyl, halogen, okso, -CN, -N3,-NO2, -ORf, -OC(O)Rg, -OC(O)NRfRh, -SRf, -S(O)2Rf, -S(O)2NRfRh, -C(O)Rf, -C( O)ORf, -C(O)NRfRh, -C(O)N(Rh)S(O)2Rf, -N(Rf)2, -N(Rh)C(O)Rh, -N(Rh)S(O)2Rg, -N(Rh)C(O)O(Rg), -N(Rh)C(O)NRfRh, eller -N(Rh)S(O)2NRfRh; idet the C1-C6 haloalkyl og the C1-C6 alkyl er hver valgfritt substituert med 1 eller 2 substituenter uavhengig valgt fra gruppen bestående av -CN, NO2, -ORf, -OC(O)Rg, -OC(O)NRfRh, -SRf, -S(O)2Rf, -S(O)2NRfRh, -C(O)Rf, -C( O)ORf, -C(O)NRfRh, -C(O)N(Rh)S(O)2Rf, -N(Rf)2, -N(Rh)C(O)Rg, -N(Rh)S(O)2Rg, -N(Rh)C(O)O(Rg), -N(Rh)C(O)NRfRh, og -N(Rh)S(O)2NRfRh;Rf er ved hver forekomst uavhengig hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, -(C1-C6 alkylenyl)-CN, -(C1-C6 alkylenyl)-ORm, -(C1-C6 alkylenyl)-OC(O)Rn, -(C1-C6 alkylenyl)-OC(O)N(Rm)2, -(C1-C6 alkylenyl)-SRm, -(C1-C6 alkylenyl)-S(O)2Rm, -(C1-C6 alkylenyl)-S(O)2N(Rm)2, -(C1-C6 alkylenyl)-C(O)Rm, -(C1-C6 alkylenyl)-C(O)ORm, -(C1-C6 alkylenyl)-C(O)N(Rm)2, -(C1-C6 alkylenyl)-C(O)N(Rm)S(O)2Rn, -(C1-C6 alkylenyl)-N(Rm)2, -(C1-C6 alkylenyl)-N(Rm)C(O)Rn, -(C1-C6 alkylenyl)-N(Rm)S(O)2Rn, -(C1-C6 alkylenyl)-N(Rm)C(O)O(Rn), -(C1-C6 alkylenyl)-N(Rm)C(O)N(Rm)2, eller -(C1-C6 alkylenyl)-N(Rm)S(O)2N(Rm)2Rg er ved hver forekomst uavhengig C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, -(C1-C6 alkylenyl)-CN, -(C1-C6 alkylenyl)-ORm, -(C1-C6 alkylenyl)-OC(O)Rn, -(C1-C6 alkylenyl)-OC(O)N(Rm)2, -(C1-C6 alkylenyl)-SRm, -(C1-C6 alkylenyl)-S(O)2Rm, -(C1-C6 alkylenyl)-S(O)2N(Rm)2, -(C1-C6 alkylenyl)-C(O)Rm, -(C1-C6 alkylenyl)-C(O)ORm, -(C1-C6 alkylenyl)-C(O)N(Rm)2, -(C1-C6 alkylenyl)-C(O)N(Rm)S(O)2Rn, -(C1-C6 alkylenyl)-N(Rm)2, -(C1-C6 alkylenyl)-N(Rm)C(O)Rn, -(C1-C6 alkylenyl)-N(Rm)S(O)2Rn, -(C1-C6 alkylenyl)-N(Rm)C(O)O(Rn), -(C1-C6 alkylenyl)-N(Rm)C(O)N(Rm)2, eller -(C1-C6 alkylenyl)-N(Rm)S(O)2N(Rm)2;Rh er ved hver forekomst uavhengig hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, eller -(C1-C6 alkylenyl)-ORm;R1a, R1b, R2a, og R5b er hver, ved hver forekomst, uavhengig C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, C1-C6 haloalkyl, okso, -CN, NO2, -ORm, -OC(O)Rn, -OC(O)N(Rm)2, -SRm, -S(O)2Rm, -S(O)2N(Rm)2, -C(O)Rm, -C(O)ORm, -C(O)O(benzyl), -C(O)N(Rm)2, -C(O)N(Rm)S(O)2Rn, -N(Rm)2, -N(Rm) (alkoksyalkyl), -N(alkoksyalkyl)2, -N(Rm)C(O)Rn, -N(Rm)S(O)2Rn, -N(Rm)C(O)O(R n), -N(Rm)C(O)N(Rm)2, -N(Rm)S(O)2N(Rm)2, -(C1-C6 alkylenyl)-CN, -(C1-C6;alkylenyl)-ORm, -(C1-C6 alkylenyl)-OC(O)Rn, -(C1-C6 alkylenyl)-OC(O)N(Rm)2, -(C1-C6 alkylenyl)-SRm, -(C1-C6 alkylenyl)-S(O)2Rm, -(C1-C6 alkylenyl)-S(O)2N(Rm)2, -(C1-C6 alkylenyl)-C(O)Rm, -(C1-C6 alkylenyl)-C(O)ORm, -(C1-C6 alkylenyl)-C(O)N(Rm)2, -(C1-C6 alkylenyl)-C(O)N(Rm)S(O)2Rn, -(C1-C6 alkylenyl)-N(Rm)2, -(C1C6 alkylenyl)-N(Rm)C(O)Rn, -(C1-C6 alkylenyl)-N(Rm)S(O)2Rn, -(C1-C6 alkylenyl)-N(Rm)C(O)O(Rn), -(C1-C6 alkylenyl)-N(Rm)C(O)N(Rn)2, eller -(C1-C6 alkylenyl)-N(Rm)S(O)2N(Rn)2;Rm er ved hver forekomst uavhengig hydrogen, C1-C6 alkyl, eller C1-C6 haloalkyl;Rn er ved hver forekomst uavhengig C1-C6 alkyl eller C1-C6 haloalkyl;R6 er hydrogen, C1-C6 alkyl, eller C1-C6 haloalkyl; ellerR5 og R6 sammen form en C1-C6 alkylenyl eller -N(Rz)-(C1-C6 alkylenyl)- idet the N(Rz) er festet til the S(O)2 komponent/gruppe med formel (I); ogRz er hydrogen, C1-C6 alkyl, eller C1-C6 haloalkyl.2. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R1 er G1A, C1-C6 haloalkyl, eller C1-C6 alkyl;fortrinnsvis, idet R1 er G1A;mer foretrukket idet R1 er G1A; idet G1A er valgfritt substituert fenyl eller valgfritt substituert 5-6-leddet monosyklisk heteroaryl.3. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R2 er C1-C6 alkyl, C1-C6 haloalkyl, -OR2xa, eller G2A; fortrinnsvis idet R2 er C1-C6 alkyl, C1-C6 haloalkyl, eller G2A; og G2A er en valgfritt substituert C3-C6 monosyklisk sykloalkyl.4. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R2 er -OR2xa. 5. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R3 er G3A, -G3B-L1-G3C, eller -OR3a; fortrinnsvis idet R3 er G3A eller -G3B-L1-G3C; mer foretrukket idet(a) R3 er G3A; og G3A er valgfritt substituert fenyl, valgfritt substituert 5-6-leddet monosyklisk heteroaryl, eller valgfritt substituert 4-11-leddet heterosyklus; eller(b) R3 er -G3B-L1-G3C; G3B er fenyl, 5-6-leddet monosyklisk heteroaryl, eller 4-7-leddet monosyklisk heterosyklus; hver av hvilke er valgfritt substituert; og G 3C er C3-C6 monosyklisk sykloalkyl, fenyl, 5-6-leddet monosyklisk heteroaryl, eller 4-7-leddet monosyklisk heterosyklus; hver av hvilke er valgfritt substituert.6. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R3 er -OR3a; og R3a er G3D, C1-C6 haloalkyl, eller C1-C6 alkyl; idet C1-C6 haloalkylen og C1-C6 alkylen hver er substituert med én eller to substituenter uavhengig valgt fra gruppen bestående av G3D, -OR3xa, og -N(R3xb)2.7. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R5 er C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, eller C1-C6 haloalkyl; idet C1-C6 alkylen og C1-C6 haloalkylen hver er valgfritt substituert med én eller to substituenter uavhengig valgt fra gruppen bestående av G5A, -CN, -N3, -OR5ax, -S(O)2R5ax, -S(O)2N(R5ax)(R5bx), -N(R5ax)(R5bx), -N(R5bx)S(O) 2R5cx, -N(R5bx)C(O)R5cx, N(R5bx)C(O)N(R5ax)(R5bx), -N(R5bx)C(O)OR5cx, -C(O)R5ax, -C(O)OR5ax, -C(O)N(R5bx)S(O)2R5cx, og -C(O)N(R5ax)(R5bx).8. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R5 er -N(R5ax)(R5bx), eller G5A.9. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idetR1 er G1A, C1-C6 haloalkyl, eller C1-C6 alkyl; ogR2 er C1-C6 alkyl, C1-C6 haloalkyl, eller G2A;fortrinnsvis idet R1 er G1A;R2 er C1-C6 alkyl eller G2A; ogR3 er G3A, -G3B-L1-G3C, eller -OR3a.10. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet(a) R1 er G1A; R2 er C1-C6 alkyl eller G2A; og R5 er C1-C6 alkyl eller C1-C6 haloalkyl; eller(b) R1 er G1A; R2 er C1-C6 alkyl eller G2A; og R5 er C1-C6 alkyl som er substituert med én substituent valgt fra gruppen bestående av G5A, -CN, -N3, -OR5ax, -N(R5ax)(R5bx), -N(R5bx)C(O)R5cx, -N(R5bx)C(O)OR5cx, -C(O) OR5ax, og -C(O)N(R5ax)(R5bx); eller(c) R1 er G1A; R2 er C1-C6 alkyl eller G2A; og R5 er -N(R5ax)(R5bx); eller(d) R1 er G1A; R2 er C1-C6 alkyl eller G2A; og R5 er G5A.11. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet(a) R1 er G1A; idet G1A er valgfritt substituert fenyl, eller valgfritt substituert 5-6-leddet monosyklisk heteroaryl; R2 er C1-C6 alkyl eller G2A; idet G2A er en valgfritt substituert C3-C6 monosyklisk sykloalkyl; R3 er G3A, -G3B-L1-G3C, eller -OR3a; og R5 er C1-C6 alkyl som er substituert med én substituent valgt fra gruppen bestående av G5A, -CN, -N3, -OR5ax, -N(R5ax)(R5bx), -N(R5bx)C(O)R5cx, -N(R5bx)C(O)OR5cx, -C( O)OR5ax, og -C(O)N(R5ax)(R5bx); eller (b) R1 er G1A; idet G1A er valgfritt substituert fenyl eller valgfritt substituert 5-6-leddet monosyklisk heteroaryl; R2 er C1-C6 alkyl eller G2A; idet G2A er en valgfritt substituert C3-C6 monosyklisk sykloalkyl; R3 er G3A, -G3B-L1-G3C, eller -OR3a; og R5 er C1-C6 alkyl eller C1-C6 haloalkyl; eller(c) R1 er G1A; idet G1A er valgfritt substituert fenyl eller valgfritt substituert 5-6-leddet monosyklisk heteroaryl; R2 er C1-C6 alkyl, eller G2A; idet G2A er en valgfritt substituert C3-C6 monosyklisk sykloalkyl; R3 er G3A, -G3B-L1-G3C, eller -OR3a; og R5 er -N(R5ax)(R5bx) eller -OR5dx; eller(d) R1 er G1A; idet G1A er valgfritt substituert fenyl eller valgfritt substituert 5-6-leddet monosyklisk heteroaryl; R2 er C1-C6 alkyl, eller G2A; idet G2A er en valgfritt substituert C3-C6 monosyklisk sykloalkyl; R3 er G3A, -G3B-L1-G3C, eller -OR3a; og R5 er G5A. 12. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R3 er -G3B-L3-G3C-G3E; G3B er fenyl, 5-6-leddet heteroaryl, eller 4-11-leddet heterosyklus; hver av hvilke er valgfritt substituert; G3C er valgfritt substituert 4-11-leddet heterosyklus; og G3E er valgfritt substituert C3-C8 monosyklisk sykloalkyl.13. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet R1 er G1A; idet G1A er fenyl, 5-6-leddet monosyklisk heteroaryl, eller C3-C6 monosyklisk sykloalkyl; hver av hvilke er valgfritt substituert; R2 er C1-C6 alkyl, -OR2xa, eller G2A; idet G2A er en valgfritt substituert C3-C6 monosyklisk sykloalkyl; og R3 er G3A, -G3B-L1-G3C, -G3B-L3-G3C-G3E, -(C1-C6 alkylenyl)-G3D, eller -OR3a, og fortrinnsvis idet R5 er C1-C6 alkyl eller C1-C6 haloalkyl.14. Forbindelse ifølge ett av kravene 1 - 13 eller et farmasøytisk akseptabelt salt av samme, idet R6 er hydrogen.15. Forbindelse ifølge ett av kravene 1- 13 eller et farmasøytisk akseptabelt salt av samme, idet R6 er C1-C6 alkyl eller C1-C6 haloalkyl.16. Forbindelse ifølge ett av kravene 1-6, 9, og 13 eller et farmasøytisk akseptabelt salt av samme, idet R5 og R6 sammen danner en C1-C6 alkylenyl en -N(Rz)-(C1-C6 alkylenyl)- idet N(Rz) gruppen er festet til S(O)2 komponenten med formel (I).17. Forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt av samme, idet forbindelsen er valgt fra gruppen bestående av:N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(benzensulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-N-(trifluormetansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(syklopropansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-[3-(trifluormetoksy)fenyl]-1H-pyrazolo[34-6]pyridin-6-karboksamid;4-[4-(dimetylamino)fenyl]-N-(metansulfonyl)-1-fenyl-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-sykloheksyl-4-[2-(dimetylamino)pyrimidin-5-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 1-[3-(azetidin-1-yl)fenyl]-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-[2-(morfolin-4-yl)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-tert-butyl-1-syklopentyl-N-(metansulfonyl)-4-[6-(morfolin-4-yl)pyridin-3-yl]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-metyl-1-fenyl-4-(piperidin-1-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(dimetylamino)fenyl]-N-(metansulfonyl)-1-(6-metoksypyridin-3-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(3-klor-4-metylfenyl)-N-(metansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-3-metyl-1-fenyl-4-(piperidin-1-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; N-(metansulfonyl)-4-[2-(morfolin-4-yl)pyrimidin-5-yl]-1-fenyl-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(24-difluorfenyl)-N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-[6-(dimetylamino)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(35-difluorfenyl)-N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(35-dimetylfenyl)-N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(34-difluorfenyl)-N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(dimetylamino)fenyl]-N-(metansulfonyl)-3-metyl-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1-(3-metylfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1-(3-metylfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-[2-(dimetylamino)pyrimidin-5-yl]-N-(metansulfonyl)-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[2-(dimetylamino)pyrimidin-5-yl]-N-(etansulfonyl)-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(dimetylamino)pyridin-3-yl]-N-(metansulfonyl)-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(dimetylamino)pyridin-3-yl]-N-(etansulfonyl)-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(dimetylamino)fenyl]-N-(metansulfonyl)-3-metyl-1H-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[6-(morfolin-4-yl)pyridin-3-yl]-1-fenyl-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-[6-(morfolin-4-yl)pyridin-3-yl]-1-fenyl-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-1-[3-(3-metoksyazetidin-1-yl)fenyl]-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(44-difluorsykloheksyl)-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-(oxan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-(oxan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{4-[3-(dimetylamino)azetidin-1-yl]fenyl}-N-(metansulfonyl)-3-metyl-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-{4-[3-(dimetylamino)azetidin-1-yl]fenyl}-N-(etansulfonyl)-3-metyl-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(33-dimetylazetidin-1-yl)fenyl]-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-[6-(morfolin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(etansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(3-fluorpyrrolidin-1-yl)phrnyl]-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 1-sykloheksyl-N-(etansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1 -sykloheksyl-4-[2-(dimetylamino)pyrimidin-5-yl]-N-(metansulfonyl)-3-metyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-sykloheksyl-4-[2-(dimetylamino)pyrimidin-5-yl]-N-(etansulfonyl)-3-metyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 3-{-sykloheksyl-4-[2-(dimetylamino)pyrimidin-5-yl] -6-[(etansulfonyl)karbamoyl]-1H-pyrazolo[34-6]pyridin-3-yl}azetidine-1-karboksylat;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-[6-(morfolin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(etansulfonyl)-4-[6-(morfolin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-syklopentyl-4-[6-(dimetylamino)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-syklopentyl-4-[6-(dimetylamino)pyridin-3-yl]-N-(etansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-[2-(morfolin-4-yl)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(24-difluorfenyl)-N-(metansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1H-pyrazolo[3 4-6]pyridin-6-karboksamid;1-(24-difluorfenyl)-N-(etansulfonyl)-3-metyl-4-[6-(morfolin-4-yl)pyridin-3-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(etansulfonyl)-4-[2-(morfolin-4-yl)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-{6-[(2-metoksyetyl)(metyl)amino]pyridin-3-yl}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-[6-(33-difluorpyrrolidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(3-klorfenyl)-N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(3-klorfenyl)-N-(etansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 1-(3-fluorfenyl)-N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-1-(3-fluorfenyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-[4-(trifluormetoksy)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1-[4-(trifluormetoksy)fenyl]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(metansulfonyl)-1-(3-metoksyfenyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfbnyl)-1-(3-metoksyfenyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3 -syklobutyl-N-(metansulfonyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-{4-[(2-metoksyetyl)(metyl)amino]fenyl}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-1-{3-[(2-metoksyetyl)(metyl)amino]fenyl}-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-4-[2-(dimetylamino)pyrimidin-5-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-4-[2-(dimetylamino)pyrimidin-5-yl]-N-(etansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-acetamidofenyl)-1-sykloheksyl-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-1-sykloheksyl-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-{4-[(2-metoksyetyl)(metyl)amino]fenyl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-{6-[(2-metoksyetyl)(metyl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; N-(metansulfonyl)-4-{6-[(2-metoksyetyl)(metyl)amino]pyridin-3-yl}-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{4-[(2-metoksyetyl)(metyl)amino]fenyl}-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(etansulfonyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-{2- [metyl (oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-3-syklopropyl-4-[6-(dimetylamino)pyridin-3-yl]-N-(etansulfonyl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-sykloheksyl-4-[6-(26-dimetylmorfolin-4-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-[6-(22-dimetylmorfolin-4-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-{4-[metyl(oxan-4-yl)amino]fenyl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{4-[metyl(oxan-4-yl)amino]fenyl}-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyano-4-metylpiperidin-1-yl)pyridin-3-yl]-1-sykloheksyl-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-N-metansulfonyl)-1-[3-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{4-[3-(dimetylamino)pyrrolidin-1-yl]fenyl}-N-(metansulfonyl)-3-metyl-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(metansulfonyl)-1-(3-metylfenyl)-4-(piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-1-(3-metylfenyl)-4-(piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-3-syklobutyl-1-sykloheksyl-N-(metansulfonyl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-syklobutyl-1-sykloheksyl-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 1-[3-(3-hydroksyazetidin-1-yl)fenyl]-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-[6-(3-metoksypyrrolidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 3-{4-(4-acetamidofenyl)-1-(35-difluorfenyl)-6-[(metansulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-3-yl}azetidine-1-karboksylat;1-sykloheksyl-4-[6-(3-fluorpiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{4-[(2-metoksyetyl)(metyl)amino]fenyl}-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{4-[metyl(oxan-4-yl)amino]fenyl}-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-{4-[metyl(oxan-4-yl)amino]fenyl}-1-[3-(pyrrolidin-1-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-[2-(morfolin-4-yl)pyrimidin-5-yl]-1-fenyl-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(24-difluorfenyl)-N-(etansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(3-klor-4-metylfenyl)-N-(etansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(35-dimetylfenyl)-N-(etansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(34-difluorfenyl)-N-(etansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfbnyl)-4-(4-metoksypiperidin-1-yl)-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-(4-metoksypiperidin-1-yl)-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-sykloheksyl-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{2-[(2-metoksyetyl)(metyl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{6-[bis(2-metoksyetyl)amino]pyridin-3-yl}-1-sykloheksyl-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{6-[metyl(oxolan-3-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{2-[metyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1-[3-(tnfluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[6-(dimetylamino)pyridin-2-yl]-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1-[3-(trifluormetoksy)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(34-difluorfenyl)-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-[6-(morfolin-4-yl)pyridin-2-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(26-difluor-4-metoksyfenyl)-1-(3-fluor-5-metoksyfenyl)-N-(metansulfonyl)-3-metyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-1-(35-difluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-1-(3-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{4-[(2-metoksyetyl)(metyl)amino]fenyl}-3-(propan-2-yl)-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-{2-[metyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-N-(metansulfonyl)-3-(propan-2-yl)-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-[2-(morfolin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-3-(1-metylsyklobutyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-3-(1-metylsyklobutyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-(24-difluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-6]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-(24-difluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-1-(24-difluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(11-dioxo-1λ6-thiolane-3-sulfonyl)-4-(4-metoksypiperidin-1-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-1-(oxan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-4-(4-metoksypiperidin-1-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(4-metoksypiperidin-1-yl)-1-fenyl-N-(33,3-trifluorpropan-1-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(11-difluor-5-azaspiro[2,4]heptan-5-yl)-N-(metansulfonyl)-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-{4-[-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-(4-propoksypiperidin-1-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[3-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-{4-[2-okso-2-(pyrrolidin-1-yl)etoksy]piperidin-1-yl}-1-fenylpyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-(3-metylfenyl)-3- (propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-(piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-(1-oxa-7-azaspiro[3,5]nonan-7-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-cyanopiperidin-1-yl)-1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(2-metoksyetyl)piperidin-1-yl]-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; N-(metansulfonyl)-4-(3-metoksypiperidin-1-yl)-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(etansulfonyl)-4-(3-metoksypiperidin-1-yl)-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-[4-(fluormetyl)piperidin-1-yl]-N-(metansulfonyl)-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(metansulfonyl)piperidin-1-yl]-1-(3-metylfenyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyanopiperidin-1-yl)fenyl]-N-(metansulfonyl)-3-(propan-2-yl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[(2-metoksyetyl)(metyl)amino]-1-(3-metylfenyl)-3 -(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-1-(3-metylfenyl)-4-(8-oxa-2-azaspiro[4,5]decan-2-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-butoksypiperidin-1-yl)-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(4-metoksy-4-metylpiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;2-[(2-{[3-syklobutyl-4-(4-metoksypiperidin-1-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl]sulfamoyl} etyl)karbamoyl]benzoic syre;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(2-metylpropoksy)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(4-metoksypiperidin-1-yl)-1-fenyl-N-(22,2-trifluoretansulfonyl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(1-oxa-7-azaspiro[3,5]nonan-7-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[3-(difluormetyl)piperidin-1-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(6-oxa-2-azaspiro[3,5]nonan-2-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(1-oxa-8-azaspiro[4,5]decan-8-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-4-(sykloheksylmetoksy)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-(piperidin-1-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(2-metoksyetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(2-azaspiro[3,4]octan-2-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(3-azabisyklo[3,1,0]heksan-3-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-1-[2-(morfolin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-3-(propan-2-yl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-syklobutyl-N-(metansulfonyl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(metansulfonyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-cyanopiperidin-1-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(2-azaspiro[35]nonan-2-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[3-(metoksymetyl)azetidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(cis-3-metoksysyklobutyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(33-difluorsyklobutyl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(33-dimetylsyklobutyl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(3-fluorsyklobutyl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[2-(oxan-4-yl)etoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(2S)-2-fluor-2-(oxan-4-yl)etoksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(metansulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-syklobutyl-N-(metansulfonyl)-1-[2-(morfolin-4-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(11-difluor-5-azaspiro[2,4]heptan-5-yl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-(5-oxa-2-azaspiro[3,5]nonan-2-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-(7-oxa-2-azaspiro[3,5]nonan-2-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(5-azaspiro[2,5]octan-5-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[(2-metoksyetyl)(metyl)amino]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(4-metoksypiperidin-1-yl)-N-(oxane-4-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;benzyl 4-{[3-syklobutyl-4-(4-metoksypiperidin-1-yl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl]sulfamoyl}piperidin-1-karboksylat;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(cis-3-fluorsyklobutyl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(trans-3-fluorsyklobutyl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[(cis-4-metoksysykloheksyl)oksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[(trans-4-metoksysykloheksyl)oksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{4-[(benzyloksy)metyl]piperidin-1-yl}-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-(2-azaspiro[3,3]heptan-2-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 5-{3-syklobutyl-6-[(metansulfonyl)karbamoyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-4-yl}octahydro-1H-pyrrolo[32-c]pyridin-1-karboksylat;4-(1-acetyloctahydro-5H-pyrrolo[32-c]pyridin-5-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-(4-metoksypiperidin-1-yl)-1-[6-(morfolin-4-yl)pyridin-2-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-4-{4-[(1S)-2-(dimetylamino)-1-fluoretyl]piperidin-1-yl}-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(fluormetyl)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(2-metoksypropan-2-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(3-azaspiro[5,5]undecan-3-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(34-difluorfenyl)-N-(etansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(etansulfonyl)-1-(3-fluorfenyl)-4-{6-[metyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(syklopropansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-3-[(propan-2-yl)oksy]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopipcridin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-1-[2-(morfolin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(syklopentyloksy)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(sykloheksyloksy)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(syklopropylmetoksy)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1-(2-metylpropyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-(oxolan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-[4-(morfolin-4-yl)fenyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-(4-metoksyfenyl)-3-metyl-1-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-syklopropyl-N-(2-metoksyetansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(2R)-2-fluor-2-(oxan-4-yl)etoksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-4-[(33-difluorsyklopentyl)metoksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(syklopropansulfonyl)-3-metyl-4-[4-(morfolin-4-yl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-cyanopiperidin-1-yl)-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(1-metoksyetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-[4-(11,1-trifluor-2-metoksypropan-2-yl)pipendin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[2-(11-dioxo-1λ6 4-thiazinan-4-yl)etoksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(hydroksymetyl)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-(1-metyl-1H-pyrazole-4-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{6-[bis(2-metoksyetyl)amino]pyridin-3-yl}-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-metoksy-4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-[2-(morfolin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-[2-(morfolin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(12-dimetyl-1H-imidazol-4-sulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{6-[bis(2-metoksyetyl)amino]pyridin-3-yl}-N-(metansulfonyl)-1-[2-(morfolin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-N-(1H-pyrazole-4-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[(3-metyloxetan-3-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-{4-[(11-dioxo-1λ6 4-thiazinan-4-yl)metyl]-4-metoksypiperidin-1-yl}-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-(trans-3-metylsyklobutyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-1-fenyl-3-[(piperidin-4-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;tert-butyl 4-({4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-6-[(metansulfonyl)karbamoyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-3-yl}oksy)piperidin-1-karboksylat;3-syklobutyl-N-[2-(13-dioxo-13-dihydro-2H-isoindol-2-yl)etansulfonyl]-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-aminoetansulfonyl)-3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(syklobutylmetyl)-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(syklobutylmetyl)-N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1 -yl] -1 -(2-metylpropyl)-3 - (propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-(2-metylpropyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-4-[4-(22,2-trifluoretyl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-[2-(morfolin-4-yl)etansulfonyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-(1-metyl-6-okso-16-dihydropyridazin-3-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-4-[(3-metyloxetan-3-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-[4-(propan-2-yl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-1-fenyl-4-[4-(propan-2-yl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-[3-(morfolin-4-yl)propan-1-sulfonyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[2-(dimetylamino)etansulfonyl]-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(1-acetyl-4-fluorpiperidin-4-yl)metoksy]-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(2-metoksyetansulfonyl)-3-[(oxolan-3-yl)oksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(2-metoksyetansulfonyl)-3-(trans-3-metylsyklobutyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-[(oxolan-3-yl)oksy]-1-fenyl-1H-pyrazolo[34-6]pyridin-6-karboksamid;1-[3-(dimetylamino)fenyl]-N-(metansulfonyl)-4-[(oxan-4-yl)metoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-[2-(morfolin-4-yl)pyrimidin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-syklobutylpiperazin-1-yl)-N-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[3-(morfolin-4-yl)propoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(33-difluor-1-metylsyklobutyl)metoksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[(oxolan-2-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(oxan-4-yl)metoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[2-(oxan-4-yl)etoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-(1-metyl-1H-imidazol-4-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(35-dimetyl-12-oxazole-4-sulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 3-({3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)propanoat;3-({3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)propionsyre;N-[3-(dimetylamino)propan-1-sulfonyl]-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-N-[3-(pyrrolidin-1-yl)propan-1-sulfonyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[3-(morfolin-4-yl)propoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(3-metyloxetan-3-yl)metoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(2-metoksypropan-2-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(oxolan-2-yl)metoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(1-acetylpiperidin-4-yl)metoksy]-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 4-[({3-syklobutyl-6-[(metansulfonyl)karbamoyl]-1-fenyl-1H-pyrazolo [34-b]pyridin-4-yl}oksy)metyl]piperidin-1-karboksylat;3-syklobutyl-N-[3-(dimetylamino)-3-oxopropan-1-sulfonyl]-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[3-(dimetylamino)propoksy]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-N-(metansulfonyl)-3-[(oxetan-3-yl)oksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(2-metoksyetyl)(metyl)amino]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-[3-(azetidin-1-yl)propan-1-sulfonyl]-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[3-(dimetylamino)propoksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-4-[4-(2-hydroksypropan-2-yl)piperidin-1-yl]-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[2-(1-metylpiperidin-2-yl)etoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(33-difluor-1-metylsyklobutyl)metoksy]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-(fluorfenyl)-N-(metansulfonyl)-4-[3-(piperidin-1-yl)propoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(1-acetyl-4-fluorpiperidin-4-yl)metoksy]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-{2-[(oxcean-3-yl)(propan-2-yl)amino]etoksy}-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-4-{[4-(propan-2-yl)morfolin-3-yl]metoksy}-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(13-dimetoksypropan-2-yl)oksy]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(14-dioxan-2-yl)metoksy]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-{2-[(oxetan-3-yl)oksy]etoksy} -3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-[3-(piperidin-1-yl)propoksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(2-hydroksypropan-2-yl)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(oxan-4-yl)metoksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(dimetylamino)piperidin-1-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(1'-metyl[44'-bipiperidin]-1-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(1-acetylpiperidin-4-yl)metoksy]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 4-({[1-(4-fluorfenyl)-6-[(metansulfonyl)karbamoyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-4-yl]oksy}metyl)piperidin-1-karboksylat;3-syklobutyl-N-(metansulfonyl)-4-[2-(1-metylpiperidin-2-yl)etoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(13-dimetoksypropan-2-yl)oksy]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[3,4-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-{2-[(oxetan-3-yl)(propan-2-yl)amino]etoksy}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(cyanometyl)-4-hydroksypiperidin-1-yl]-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-azidofenyl)-N-(3-azidopropan-1-sulfonyl)-1-[3-(dimetylamino)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-fenyl-4-[4-(22,2-trifluoretyl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-1-fenyl-4-[4-(22,2-trifluoretyl)piperazin-1-yl]-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-{4-[2-(morfolin-4-yl)etyl]piperidin-1-yl}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;rac-4-[(3aR,7aS)-1-acetyloctahydro-5H-pyrrolo[32-c]pyridin-5-yl]-3-syklobutyl-N-[3-(morfolin-4-yl)propan-1-sulfonyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(syklopropansulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(metansulfonyl)-1-[2-(morfolin-4-yl)pyridin-4-yl]-4-[(oxan-4-yl)metoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-[1-(4-fluorfenyl)-6-[(metansulfonyl)karbamoyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-4-yl]piperazin-1-karboksylat;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(3-metyl-2-okso-1-oxa-38-diazaspiro[4,5]decan-8-yl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-4-[3-(trifluormetyl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(2-metoksyetyl)piperazin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(24-dioxo-138-triazaspiro[4,5]decan-8-yl)-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(etoksymetyl)-4-fluorpiperidin-1-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{4-fluor-4-[(2-metoksyetoksy)metyl]piperidin-1-yl}-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(3R,4R)-3-fluor-4-hydroksypiperidin-1-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-fluor-4-(metoksymetyl)piperidin-1-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-{3-fluor-3-[(2-metoksyetoksy)metyl]piperidin-1-yl}-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[3-(morfolin-4-yl)propan-1-sulfonyl]-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-1-(4-fluorfenyl)-N-(metansulfonyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(3R)-3-(hydroksymetyl)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(3R)-3-(hydroksymetyl)piperidin-1-yl]-N-[3-(morfolin-4-yl)propan-1-sulfonyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(oxan-4-yl)metoksy]-1-fenyl-N-[4-(pyrrolidin-1-yl)piperidin-1-sulfonyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-[(2S)-2-(4-metylpiperazin-1-karbonyl)pyrrolidin-1-sulfonyl]-4-[(oxan-4-yl)metoksy]-1-fenyl-pyrazolo[34-b]pyridin-6-karboksamid;N-([14'-bipiperidine]-1'-sulfonyl)-3-syklobutyl-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-syklobutyl-N-[metyl(propyl)sulfamoyl]-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[etyl(propyl)sulfamoyl]-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-[({3-syklobutyl-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)amino]piperidin-1-karboksylat;N-(4-acetyl-14-diazepane-1-sulfonyl)-3-syklobutyl-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(morfolin-4-sulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[4-(morfolin-4-yl)piperidin-1-sulfonyl]-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[4-(4-metylpiperazin-1-karbonyl)piperidin-1-sulfonyl]-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(4-metylpiperazin-1-sulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metylpropan-2-sulfonyl)-4-[(oxan-4-yl)metoksy]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-azidofenyl)-N-(men-3-yne-1-sulfonyl)-1-[3-(dimetylamino)fenyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(cyanometansulfonyl)-3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-hydroksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(3-hydroksypropan-1-sulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-N-(piperidin-4-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-(oxolane-3-sulfonyl)-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-(26-dimetylpyridin-4-yl)-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-6]pyridin-6-karboksamid; 3-syklobutyl-4-(11-dioxo-1λ6 4-thiazinan-4-yl)-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-N-[2-(1H-pyrazol-1-yl)etansulfonyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;benzyl [2-({3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)etyl]karbamat;3-syklobutyl-4-[4-(metoksymetyl)piperidin-l-yl]-N-(1-metylsyklopropan-1-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-(2-metylpropan-1-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl ({3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl} sulfamoyl)acetat;benzyl 3-({3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)pyrrolidin-1-karboksylat;tert-butyl 4-[1-(4-fluorfenyl)-6-[(metansulfonyl)karbamoyl]-3-(propan-2-yl)-1H-pyrazolο[34-b]pyridin-4-yl]piperidin-1-karboksylat; og3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[2-(metoksymetyl)morfolin-4-yl]piperidin-1-yl}-1H-pyrazolo[34-6]pyndine-6-karboksamid;3-syklobutyl-N-(morfolin-4-sulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]pipendin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[4-(propan-2-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(morfolin-4-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;N-(2-amino-2-oxoetansulfonyl)-3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-(2-metoksypyridin-4-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-acetamidoetansulfonyl)-3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-N-(pyrrolidin-3-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-N-[4-(pyrrolidin-1-yl)piperidin-1-sulfonyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-[(2S)-2-(4-metylpiperazin-1-karbonyl)pyrrolidin-1-sulfonyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-{4-[(2S)-2-(metoksymetyl)pyrrolidin-1-yl]piperidin-1-sulfonyl}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-[metyl(propyl)sulfamoyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[etyl(propyl)sulfamoyl]-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-[({3-syklobutyl-4-[4-(metoksymetyl)piperidm-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)amino]piperidin-1-karboksylat;N-(4-acetyl-14-diazepane-1-sulfonyl)-3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-{4-[(2R)-2-(metoksymetyl)pyrrolidin-1-yl]piperidin-1-sulfonyl}-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-(morfolin-4-sulfonyl)-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-[4-(morfolin-4-yl)piperidin-1-sulfonyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-[4-(4-metylpiperazin-1-karbonyl)piperidin-1-sulfonyl]-1-fenyl-1H-pyrazolo[34-b]]pyridin-6-karboksamid;3-syklobutyl-N-(4-fluorpiperidine-1-sulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-N-(4-metylpiperazin-1-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(syklopropansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{4-[(morfolin-4-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(2-metoksyetansulfonyl)-4-{4-[(morfolin-4-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[(morfolin-4-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(2-metoksyetansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[(morfolin-4-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-{4-[(morfolin-4-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(etansulfonyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(syklopropansulfonyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(2-metoksyetansulfonyl)-4-{4-[2-(morfolin-4-yl)etyl]pipendin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[2-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[(14-dioxan-2-yl)metansulfonyl]-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(2-metoksyetansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-[4-(4-metylpiperazin-1-karbonyl)fenyl]-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridme-6-karboksamid;1-sykloheksyl-N-(dimetylsulfamoyl)-4-[4-(4-metylpiperazin-1-karbonyl)fenyl]-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridme-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[(morfolin-4-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[2-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(dimetylsulfamoyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(etansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(syklopropansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-N-(oxolane-3-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-(2-metylpyridin-4-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-{4-[2-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[metyl(propyl)sulfamoyl]-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-[({3-syklobutyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)amino]piperidin-1-karboksylat;3-syklobutyl-N-(4-fluorpiperidine-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyndine-6-karboksamid;3-syklobutyl-N-(1-metylsyklopropan-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(syklopropansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-{4-[(2S)-2-(metoksymetyl)pyrrolidin-1-yl]piperidin-1-sulfonyl}-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[1-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{4-[(4-metylpiperazin-1-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[(4-metylpiperazin-1-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[(piperidin-1-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]]pyridin-6-karboksamid;1-sykloheksyl-N-(dimetylsulfamoyl)-3-[(propan-2-yl)oksy]-4-{4-[(pyrrolidin-1-yl)metyl]fenyl}-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-{4-[1-(morfolin-4-yl)etyl]pipendin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-1-(4-fluorfenyl)-4-{4-[1-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-1-(4-fluorfenyl)-N-(2-metoksyetansulfonyl)-4-{4-[(morfolin-4-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(2-hydroksyetansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid;N-(klormetansulfonyl)-3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-1-(4-fluorfenyl)-N-(oxolane-3-sulfonyl)-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-{4-[2-(morfolin-4-yl)etyl]piperidin-1-yl}-N-(oxolane-3-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-([14'-bipiperidine]-1'-sulfonyl)-3-syklobutyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-[3-(morfolin-4-yl)propan-1-sulfonyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(4-metylpiperazin-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-{[(3-syklobutyl-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karbonyl)sulfamoyl]amino}piperidin-1-karboksylat;3-syklobutyl-N-{4-[(2R)-2-(metoksymetyl)pyrrolidin-1-yl]piperidin-1-sulfonyl}-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(4-fluorpiperidine-1-sulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]pipendin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(4-metylpiperazin-1-sulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(1-metylsyklopropan-1-sulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(syklopropansulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]pipendin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metoksyetansulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(2-metylpropan-2-sulfonyl)-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(etansulfonyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-(syklobutyloksy)-1-sykloheksyl-4-{4-[(morfolin-4-yl)metyl]fenyl}-N-(oxolane-3-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(oxolane-3-sulfonyl)-4-[4-(pyridin-4-yl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-[4-(pyridin-4-yl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(etansulfonyl)-4-[4-(pyridin-4-yl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-[(2-metoksyetyl)(metyl)sulfamoyl]-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyndine-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-[2-(oxan-4-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-(2-metoksypyridin-4-yl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[(morfolin-4-yl)metyl]fenyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[2-(morfolin-4-yl)etyl]fenyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(men-3-yne-1-sulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(etansulfonyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[(1R)-1-(morfolin-4-yl)etyl]pipendin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[(1S)-1-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-(syklobutyloksy)-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[(morfolin-4-yl)metyl]fenyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-[metyl(propan-2-yl)sulfamoyl]-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-[etyl(metyl)sulfamoyl]-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(3-metoksyazetidine-1-sulfonyl)-4-[4-(morfolin-4-yl)pipridin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-N-(pyrrolidin-1-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-N-(22,2-trifluoretansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(morfolin-4-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid;4-([14'-bipiperidin]-1'-yl)-3-syklobutyl-1-(4-fluorfenyl)-N-(2-metoksyetansulfbnyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(dimetylsulfamoyl)-1-[2-(morfolin-4-yl)pyridin-4-yl]-4-[(oxan-4-yl)metoksy]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-[2-(oxan-4-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(2-hydroksyetansulfonyl)-4-{4-[2-(morfolin-4-yl)etyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl 4-(1-{3-syklobutyl-6-[(dimetylsulfamoyl)karbamoyl]-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-4-yl}piperidin-4-yl)piperazin-1-karboksylat;4-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-1-(4-fluorfenyl)-4-{4-[(morfolin-4-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-{4-[(morfolin-4-yl)metyl]piperidin-1-yl}-N-(oxolane-3-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-[1-(4-fluorfenyl)-6-[(metansulfonyl)karbamoyl]-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-4-yl]piperidin-1-karboksylat;etyl 4-{6-[(dimetylsulfamoyl)karbamoyl]-1-(4-fluorfenyl)-3-(propan-2-yl)-1H-pyrazolo[34-b]pyridin-4-yl}piperidin-1-karboksylat;3-syklobutyl-N-(dimetylsulfamoyl)-1-(3-metylfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(3-metoksyfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-[4-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(etoksymetyl)-4-fluorpiperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-{4-fluor-4-[(2-metoksyetoksy)metyl]piperidin-1-yl}-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-{3-fluor-3-[(2-metoksyetoksy)metyl]piperidin-1-yl}-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-4-[4-fluor-4-(metoksymetyl)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(4-cyanopiperidine-1-sulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-N-(oxetane-3-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(syklopropansulfonyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(1-metylsyklopropan-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-1-(3-metylfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1--yl]-1-[4-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluor-3-metylfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(3-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluor-3-metylfenyl)-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(3-fluorfenyl)-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-[3-(trifluormetyl)fenyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(4-metylpiperazin-1-yl)metyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[(morfolin-4-yl)metyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[(morfolin-4-yl)metyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{[4-(metoksymetyl)piperidin-1-yl]metyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(4-cyano[14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-[4-(3-cyanoazetidin-1-yl)piperidin-1-yl]-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[4-(3-metoksypyrrolidm-1-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-(4-fluor[14'-bipiperidin]-1'-yl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(44-difluor[14'-bipiperidin]-1'-yl)-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(2-cyanomorfolin-4-yl)piperidin-1-yl]-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[metyl(oxan-4-yl)amino]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-{2-[(propan-2-yl)oksy]pyridin-4-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-{2-[(propan-2-yl)oksy]pyridin-4-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1-[2-(oxan-4-yl)pyridin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[4-(2-oxa-5-azabisyklo[2,2,1]heptan-5-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[3-(morfolin-4-yl)-1-oxa-8-azaspiro[4,5]decan-8-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(dimetylsulfamoyl)-3-[(propan-2-yl)oksy]-4-{4-[4-(propan-2-yl)piperazin-1-yl]fenyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-[4-(2-metylpyridin-4-yl)piperazin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-4-[6-(4-syklopropylpiperazin-1-yl)pyridin-3-yl]-N-(dimetylsulfamoyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(3-fluorpyrrolidin-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(3-metoksypyrrolidin-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-syklobutyl-N-(dimetylsulfamoyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-[4-(metoksymetyl)piperidin-1-sulfonyl]-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[4-(3-fluorpyrrolidin-1-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{6-[4-(propan-2-yl)piperazin-1-yl]pyridin-3-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[1-(morfolin-4-yl)etyl]fenyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-{4-[4-(dimetylamino)piperidin-1-karbonyl]fenyl}-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-{4-[4-(dimetylamino)piperidin-1-karbonyl]fenyl}-N-(2-metoksyetansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-{4-[4-(dimetylamino)piperidin-1-karbonyl]fenyl}-N-(dimetylsulfamoyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[4-(propan-2-yl)piperazin-1-yl]fenyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl]piperidin-1-yl]-N-(dimetylsulfamoyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(syklopropansulfonyl)-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-[6-(4-metylpiperazin-1-yl)pyridin-3-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{6-[4-(2-metoksyetyl)piperazin-1-yl]pyridin-3-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-4-{4-[4-(propan-2-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-N-[metyl(propyl)sulfamoyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-N-(morfolin-4-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-N-(metansulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-N-(1-metylsyklopropan-1-sulfonyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-N-(metylsulfamoyl)-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-[4-(4-syklopropylpiperazin-1-yl)fenyl]-N-(dimetylsulfamoyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[3-(trifluormetyl)pyrrolidin-1-yl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid; 4-[4-(3-cyanopyrrolidin-1-yl)piperidin-1-yl]-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(3-cyano[14'-bipiperidin]-1'-yl)-3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-(3-fluor[14'-bipiperidin]-1'-yl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-{4-[3-(trifluormetyl)pyrrolidin-1-yl]piperid-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(3-cyanopyrrolidin-1-yl)piperidin-1-yl]-3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-(3-cyano[14'-bipiperidin]-1'-yl)-3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(3-fluor[14'-bipiperidin]-1'-yl)-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-N-(piperidin-1-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(3-fluorazetidine-1-sulfonyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[4-(3-metoksyazetidin-1-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[3-(trifluormetyl)[14'-bipiperidin]-1'-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-(3-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(22-dimetylmorfolin-4-yl)piperidin-1-yl]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(2-acetamidoetansulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-[2-(difluormetoksy)pyridin-4-yl]-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(azetidine-1-sulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-[(2R)-2-(metoksymetyl)pyrrolidin-1-sulfonyl]-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-N-[(oxan-4-yl)sulfamoyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-[metyl(oxan-4-yl)sulfamoyl]-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid; 3-syklobutyl-N-(33-difluorazetidine-1-sulfonyl)-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid;4-[(3S)-4-benzyl-3-metylpiperazin-1-yl]-3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[(3R)-4-benzyl-3-metylpiperazin-1-yl]-3-syklobutyl-1-sykloheksyl-N-(dimetylsulfamoyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[4-(4-syklopropylpiperazin-1-yl)piperidin-1-yl]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-4-(9-syklopropyl-39-diazaspiro[5,5]undecan-3-yl)-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[4-(3-metoksyazetidin-1-yl)pipridin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[3-(trifluormetyl)[14'-bipiperidin]-1'-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-(3-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-4-[4-(22-dimetylmorfolin-4-yl)piperidin-1-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-(1-{3-syklobutyl-6-[(dimetylsulfamoyl)karbamoyl]-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-4-yl}piperidin-4-yl)piperazme-1-karboksylat;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[(2-metoksyetyl)(metyl)ammo]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metoksysulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[1-(44-difluorsykloheksyl)piperidin-4-yl]-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[1-(44-difluorsykloheksyl)piperidin-4-yl]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{[4-(morfolin-4-yl)piperidin-1-yl]metyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-{[4-(morfolin-4-yl)piperidin-1-yl]metyl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-{4-[(4-syklopropylpiperazin-1-yl)metyl]fenyl}-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[1-(oxan-4-yl)piperidin-4-yl]-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-{1-[(oxan-4-yl)metyl]piperidin-4-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{1-[(oxan-4-yl)metyl]piperidin-4-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-{1-[(25-dimetoksyoxolan-3-yl)metyl]piperidin-4-yl}-1-(4-fluorfenyl)-N-(metansulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[1-(33,3-trifluorpropyl)piperidin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[1-(33,3-trifluorpropyl)piperidin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-(4-hydroksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;metyl {3-syklobutyl-1-(4-fluorfenyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamate;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[4-(2-metoksyetyl)piperazin-1-yl]piperidm-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-[3-(morfolin-4-yl)pyrrolidin-1-sulfonyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(4-syklopropylpiperazin-1-sulfonyl)-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-[4-(2-metoksyetyl)piperazin-1-sulfonyl]-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-4-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[1-(oxan-4-yl)piperidin-4-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[1-(syklopropylmetyl)piperidin-4-yl]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[9-(oxetan-3-yl)-39-diazaspiro[5,5]undecan-3-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(1-syklopropylpiperidin-4-yl)metoksy]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-[(1-syklobutylpiperidin-4-yl)metoksy]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-4-[(1-sykloheksylpiperidin-4-yl)metoksy]-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-{[1-(oxan-4-yl)piperidin-4-yl]metoksy}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-{1-[(25-dimetoksyoxolan-3-yl)metyl]piperidin-4-yl}-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-{2-[(propan-2-yl)oksy]pyrimidin-4-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(2-etoksypyrimidin-4-yl)-4-[4-(morfolin-4-yl)pipridin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(22-difluor-2H-13-benzodioxol-5-yl)-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(4-metylpiperazin-1-sulfonyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridme-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[1-(propan-2-yl)octahydro-5H-pyrrolo[3 2-c]pyridin-5-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(1-syklobutyloctahydro-5H-pyrrolo[32-c]pyridin-5-yl)-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[1-(oxetan-3-yl)octahydro-5H-pyrrolo[3 2-c]pyridin-5-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-[1-(oxan-4-yl)octahydro-5H-pyrrolo[32-c]pyridin-5-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-N-(metylsulfamoyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-N-sulfamoyl-1H-pyrazolo[3 4-b]pyridin-6-karboksamid;1-sykloheksyl-4-[4-(heksahydropyrrolo[34-c]pyrrole-2(1H)-karbonyl)fenyl]-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(azetidine-1-sulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-6]pyridin-6-karboksamid;1-sykloheksyl-4-(4-{[3-(dimetylamino)azetidin-1-yl]metyl}fenyl)-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-6]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-4-(4-{[4-(propan-2-yl)piperazin-1-yl]metyl[fenyl)-1H-pyrazolo[34-b]]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{4-[(4-metoksypiperidin-1-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{4-[(5-metylheksahydropyrrolo[34-c]pyrrol-2(1H)-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid; 1-sykloheksyl-N-(metansulfonyl)-4-[4-(5-metylheksahydropyrrolo[34-clpyrrole-2(1H)-karbonyl)fenyl]-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metylsulfamoyl)-4-{4-[4-(propan-2-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;4-[4-(4-cyano-1-metylpiperidin-4-yl)fenyl]-1-sykloheksyl-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridme-6-karboksamid;1-sykloheksyl-4-{4-[3-(dimetylamino)azetidine-1-karbonyl]fenyl}-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-N-(metansulfonyl)-4-{4-[(8-metyl-2-oxa-58-diazaspiro[3,5]nonan-5-yl)metyl]fenyl}-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-{4-[(4-etylpiperazin-1-yl)metyl]fenyl}-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-sykloheksyl-4-(4-{[4-(dimetylamino)piperidin-1-yl]metyl}fenyl)-N-(metansulfonyl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridin-6-karboksamid;1-(4-fluorfenyl)-N-(metansulfonyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-3-[(propan-2-yl)oksy]-1H-pyrazolo[34-b]pyridme-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(3-metoksyazetidme-1-sulfonyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(3-fluorazetidine-1-sulfonyl)-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-N-(morfolin-4-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(morfolin-4-yl)sykloheksyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)sykloheksyl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-4-(4-fluor[14'-bipiperidin]-1'-yl)-1-(4-fluorfenyl)-N-(metylsulfamoyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;N-(azetidine-1-sulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-{4-[4-(propan-2-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-[3-(difluormetoksy)fenyl]-N-(dimetylsulfamoyl)-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(metansulfonyl)-N-metyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-N-metyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(metansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-metyl-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid; 3-syklobutyl-N-(etansulfonyl)-N-metyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-N-(etansulfonyl)-N-metyl-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;2-(3-syklobutyl-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karbonyl)-6-metyl-1λ626-thiadiazinane-11-dione;2-(3-syklobutyl-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karbonyl)-1λ6 2-thiazolidine-11-dione;3-syklobutyl-N-(metansulfonyl)-N-metyl-1--fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karboksamid;2-(3-syklobutyl-1-fenyl-4-{4-[(pyrrolidin-1-yl)metyl]piperidin-1-yl}-1H-pyrazolo[34-b]pyridin-6-karbonyl)-1λ6 2-thiazinane-11-dione;2-{3-syklobutyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}-6-metyl-1λ6 26-thiadiazinane-11-dione;2-{3-syklobutyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}-1λ6 2-thiazolidine-11-dione;2-{3-syklobutyl-4-[4-(morfolin-4-yl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}-1λ6 2-thiazinane-11-dione;2-{3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}-1λ6 2-thiazolidine-11-dione;2-{3-syklobutyl-4-[4-(metoksymetyl)piperidin-1-yl]-1-fenyl-1H-pyrazolo[34-b]pyridin-6-karbonyl}-1λ6 2-thiazinane-11-dione;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-(metylsulfamoyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(2-metoksyetansulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-6]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-(morfolin-4-sulfonyl)-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-N-(3-hydroksypropan-1-sulfonyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;etyl 4-[({3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karbonyl}sulfamoyl)amino]piperidin-1-karboksylat;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-[(oxetan-3-yl)sulfamoyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-[(oxan-4-yl)sulfamoyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid;3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-N-[4-(morfolin-4-yl)piperidin-1-sulfbnyl]-1H-pyrazolo[34-b]pyridin-6-karboksamid; etyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(2-metoksyetansulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;etyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(morfolin-4-sulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;etyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(metansulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;etyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(metylsulfamoyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;2-metylpropyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(metansulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;2-metylpropyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(morfolin-4-sulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;2-metylpropyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(2-metoksyetansulfonyl)karbamoyl]-1H-pyrazolo[34-b]pyridin-4-yl}piperazin-1-karboksylat;2-metylpropyl 4-{3-syklobutyl-1-(4-fluorfenyl)-6-[(metylsulfamoyl)karbamoyl]-1H-pyrazolo[3 4-b]pyridin-4-yl}piperazin-1-karboksylat;3-syklobutyl-1-(4-fluorfenyl)-4-(9-metyl-39-diazaspiro[5,5]undecan-3-yl)-N-(morfolin-4-sulfonyl)-1H-pyrazolo[34-6]pyridin-6-karboksamid; ogN-(2-aminopyridine-3-sulfonyl)-3-syklobutyl-1-(4-fluorfenyl)-4-[4-(metoksymetyl)piperidin-1-yl]-1H-pyrazolo[34-b]pyridin-6-karboksamid.18.3-Syklobutyl-N-(dimetylsulfamoyl)-1-(4-fluorfenyl)-4-(4-metoksy[14'-bipiperidin]-1'-yl)-1H-pyrazolo[34-b]pyridin-6-karboksamid, eller et farmasøytisk akseptabelt salt av samme.19. Farmasøytisk blanding omfattende en terapeutisk effektiv mengde av en forbindelse ifølge krav 1 eller 18, eller et farmasøytisk akseptabelt salt av samme, i kombinasjon med en farmasøytisk akseptabelt bærer.20. Farmasøytisk blanding ifølge krav 19 videre omfattende (i) én forsterker, og én eller flere ekstra forbedrer(e), eller (ii) ett eller flere ekstra terapeutiske midler, fortrinnsvis idet de ekstra terapeutiske midler er valgt fra gruppen bestående av CFTR modulatorer og CFTR forsterkere. 21. Forbindelse ifølge krav 1 eller 18 eller et farmasøytisk akseptabelt salt av samme, eller en farmasøytisk blanding ifølge krav 19, for anvendelse i medisin.22. Forbindelse ifølge krav 1 eller 18 eller et farmasøytisk akseptabelt salt av samme, eller en farmasøytisk blanding ifølge krav 19, for anvendelse i behandlingen av cystisk fibrose.
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Innehaver i EP:
AbbVie Overseas S.à r.l.
26 Boulevard Royal 2449 Luxembourg LU
Galapagos NV
Generaal De Wittelaan L11/A3 2800 Mechelen BE

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BROWN, Brian S.
812 Washington Evanston, Illinois 60202 US
CLAES, Pieter Isabelle Roger
Klokstraat 112 9050 Gentbrugge BE
COWART, Marlon D.
43 Dahlia Lane Round Lake Beach, Illinois 60073 US
DE LEMOS, Elsa
102 Avenue Gaston Roussel 93230 Romainville FR
GFESSER, Gregory A.
110 Timber Lane Lindnhurst, Illinois 60046 US
JANSEN, Koen Karel
Sint Jorislaan 19 2300 Turnhout BE
JI, Jianguo
1973 Sparrow Court Libertyville, Illinois 60048 US
KYM, Philip R.
1002 Gracewood Avenue Libertyville, Illinois 60048 US
PATEL, Sachin V.
1259 Wild Meadow Road Round Lake, Illinois 60073 US
SHRESTHA, Anurupa
378 Pine Lake Circle Vernon Hills, Illinois 60061 US
SWIFT, Elizabeth C.
2514 Green Bay Road Highland Park, Illinois 60035 US
WANG, Xueqing
1742 Larkdale Road Northbrook, Illinois 60062 US
DE BLIECK, Ann
Vleeshouwersstraat 74 9112 Sinaai BE
DESROY, Nicolas
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
AKKARI, Rhalid
Galapagos SASU 102 Avenue Gaston Roussel 932330 Romaineville FR
ALVEY, Luke Jonathan
Galapagos SASU 102 Avenue Gaston Roussel 932330 Romaineville FR
BOCK, Xavier Marie
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
DUTHION, Béranger
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
GOSMINI, Romain Luc Marie
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
HOUSSEMAN, Christopher Gaëtan
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
LEFRANCOIS, Jean-Michel
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
MAMMOLITI, Oscar
Galapagos NV Generaal de Wittelaan L11/A3 2800 Mechelen BE
MENET, Christel Jeanne Marie
Confo Therapeutices Pleinlaan 2 Building E 7th Floor E7.6 1050 Brussels BE
MERAYO, Nuria Merayo
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
NEWSOME, Gregory John Robert
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
PALISSE, Adeline Marie Elise
Galapagos NV Generaal de Wittelaan L11/A3 93230 Romainville FR
PIZZONERO, Mathieu Rafaël
Galapagos SASU 102 Avenue Gaston Roussel 93230 Romainville FR
VAN DER PLAS, Steven Emiel
Galapagos NV Generaal de Wittelaan L11/A3 2800 Mechelen BE

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Fullmektig i Norge:
CURO AS
Vestre Rosten 81 7075 TILLER NO ( TRONDHEIM kommune, Trøndelag fylke )

Org.nummer: 936803911
Din referanse: O-128629
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Kilde: Brønnøysundregistrene
Fullmektig i EP:
J A Kemp LLP
80 Turnmill Street London EC1M 5QU GB

Prioritet info chevron_right

2015.10.09, US 201562239647 P

2016.03.17, US 201662309794 P

Anførte dokumenter info chevron_right

WO-A1-2014/081820 (B1)

US-A1- 2009 197 911 (B1)

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Utgående EP Registreringsbrev (3210) (PTEP3359541)
03-01 Brev UT EP Registreringsbrev (3210) (PTEP3359541)
Innkommende, AR394703191 Søknadsskjema Patent
01-01 Søknadsskjema Patent Søknadsskjema Patent
01-02 Fullmakt EP3359541 - Norway - GPOA_ AbbVie
01-03 Fullmakt EP3359541 - Norway - GPOA_Galapagos
01-04 EP oversettelse EP3359541 Norway claims
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Årsavgift 9. avg. år (EP) 2024.09.25 3710 MASTER DATA CENTER INC Betalt og godkjent
Årsavgift 8. avg. år (EP) 2023.09.25 2550 MASTER DATA CENTER INC Betalt og godkjent
Årsavgift 7. avg. år (EP) 2022.09.26 2200 MASTER DATA CENTER INC Betalt og godkjent
Årsavgift 6. avg. år (EP) 2021.09.27 2000 MASTER DATA CENTER INC Betalt og godkjent
32016330 expand_more 2020.11.18 5500 CURO AS Betalt
Årsavgift 5. avg. år (EP) 2020.09.25 1650 MASTER DATA CENTER INC Betalt og godkjent
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Kapitler uten data er fjernet. Melding opprettet: 26.04.2025 00:52:53