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Tittel SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Status
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Detaljstatus 		Ikke i kraft info Patent opphørt Ikke betalt årsavgift
Patentnummer NO/EP3322706
Europeisk (EP) publiserings nummer EP3322706
EP levert
EP søknadsnummer 16741825.0
EP meddelt
Prioritet 2015.07.16, US 201562193448 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Array Biopharma, Inc. (US)
Oppfinner ANDREWS, Steven W. (US) .... se mer/flere nedenfor
Fullmektig CURO AS (NO)
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Patentkrav1. Forbindelse med den generelle formelen I:eller et farmasøytisk akseptabelt salt eller en oppløsning av samme, hvori:X1 er CH, CCH3, CF, CCl eller N;X2 er CH, CF eller N;X3 er CH, CF eller N;X4 er CH, CF eller N;hvori ingen, én eller to av X1, X2, X3 og X4 er N;A er H, Cl, CN, Br, CH3, CH2CH3 eller syklopropyl;B er het Ar1;het Ar1 er en 5-leddet heteroarylring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N, S og O, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, hydroksy C1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, cyano C1-C6 alkyl, (C1-C6 alkoksy)C1-C6 alkyl, (C1-C4 alkoksy)CH2C(=O)-, (C1-C4 alkoksy)C(=O)C1-C3 alkyl, C3-C6 sykloalkyl, (RaRbN)C1-C6 alkyl, (RaRbN)C(=O)C1-C6 alkyl, (C1-C6 alkylSO2)C1-C6 alkyl, het Cyca, og 4-metoksybenzyl;Ra og Rb er uavhengig H eller C1-C6 alkyl;het Cyca er en 4-6-leddet heterosyklisk ring som oppviser et ringheteroatom valgt fra N og O, hvori den heterosykliske ringen er valgfritt substituert med halogen, C1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, (C1-C6 alkoksy)C1-C6 alkyl, di(C1-C3 alkyl)NCH2C(=O), (C1-C6 alkoksy)C(=O) eller (C1-C6 alkoksy)CH2C(=O);D er hetCyc1, hetCyc2, hetCyc3 eller hetCyc9;hetCyc1 er en 4-6-leddet heterosyklisk ring som oppviser 1-2 ringatomer valgt fra N og O, hvori den heterosykliske ringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C3 alkyl, fluorC1-C3 alkyl, difluorC1-C3 alkyl, trifluorC1-C3 alkyl og OH, eller nevnte heterosyklisk ring er substituert med en C3-C6 sykloalkylidenring, eller hvori den heterosykliske ringen er substituert med en oksogruppe; hetCyc2 er en 7-8-leddet broforbundet heterosyklisk ring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N og O, hvori den heterosykliske ringen er valgfritt substituert med C1-C3 alkyl;hetCyc3 er en 7-11-leddet heterospirosyklisk ring oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O, hvori ringen er valgfritt substituert med C1-C3 alkyl;hetCyc9 er en kondensert 9-10-leddet heterosyklisk ring som oppviser 1-3 ringnitrogenatomer og valgfritt substituert med okso;E er(a) hydrogen,(b) OH,(c) RaRbN-, hvori Ra er H eller C1-C6 alkyl og Rb er H, C1-C6 alkyl eller fenyl;(d) C1-C6 alkyl valgfritt substituert med ett til tre fluor,(e) hydroksyC1-C6 alkyl- valgfritt substituert med ett til tre fluor,(f) C1-C6 alkoksy valgfritt substituert med ett til tre fluor,(g) hydroksy(C1-C6 alkoksy) valgfritt substituert med ett til tre fluor,(h) (C1-C6 alkoksy)hydroksy C1-C6 alkyl- valgfritt substituert med ett til tre fluor, (i) (C1-C6 alkyl)C(=O)- valgfritt substituert med ett til tre fluor,(j) (hydroksy C1-C6 alkyl)C(=O)- valgfritt substituert med ett til tre fluor,(k) (C1-C6 alkoksy)C(=O)-,(1) (C1-C6 alkoksy)(C1-C6 alkyl)C(=O)-,(m) HC(=O)-,(n) Cyc1,(o) Cyc1C(=O)-, (p) Cyc1(C1-C6 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med én eller flere grupper uavhengig valgt fra gruppen bestående av OH, fluor, C1-C3 alkoksy og RcRdN-, hvor Rc og Rd er uavhengig H eller C1-C6 alkyl,(q) hetCyc4,(r) hetCyc4C(=O)-,(s) hetCyc4(C1-C3 alkyl)C(=O)-,(t) (hetCyc4)C(=O)C1-C2 alkyl-,(u) hetCyc4C(=O)NH-,(v) Ar2,(w) Ar2C(=O)-,(x) Ar2C1-C6 alkyl-,(y) (Ar2)hydroksy C2-C6 alkyl-,(z) Ar2(C1-C3 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med én eller to grupper uavhengig valgt fra gruppen bestående av OH, C1-C6 alkyl (valgfritt substituert med 1-3 fluor), hydroksyC1-C6 alkyl, C1-C6 alkoksy og ReRfN-, hvor Re og Rf er uavhengig H eller C1-C6 alkyl, eller Re og Rf sammen med nitrogenet som de er festet til danner en 5-6-leddet azasyklisk ring som valgfritt oppviser et ekstra ringheteroatom valgt fra N og O,(aa) hetAr2C(=O)-,(bb) (hetAr2)hydroksyC2-C6 alkyl-,(cc) hetAr2(C1-C3 alkyl)C(=O)-, hvori alkylkomponenten er valgfritt substituert med én eller to grupper uavhengig valgt fra gruppen bestående av OH, C1-C6 alkyl, hydroksyC1-C6 alkyl, C1-C6 alkoksy og ReRfN-, hvori Re og Rf er uavhengig H eller C1-C6 alkyl eller Re og Rf sammen med nitrogenet som de er festet til danner en 5-6-leddet azasyklisk ring som valgfritt oppviser et ekstra ringheteroatom valgt fra N og O,(dd) R1R2NC(=O)-,(ee) R1R2N(C1-C3 alkyl)C(=O)-, hvori alkylkomponenten er valgfritt substituert med fenyl,(ff) R1R2NC(=O)C1-C2 alkyl-, (gg) R1R2NC(=O)NH-,(hh) CH3SO2(C1-C6 alkyl)C(=O)-,(ii) (C1-C6 alkyl)SO2-,(jj) (C3-C6 sykloalkyl)CH2SO2-,(kk) hetCyc5-SO2-,(11) R4R5NSO2-,(mm) R6C(=O)NH-,(nn) hetCyc6,(oo) hetAr2C1-C6 alkyl-,(pp) (hetCyc4)C1-C6 alkyl-,(qq) (C1-C6 alkoksy)C1-C6 alkyl- valgfritt substituert med 1-3 fluor,(rr) (C3-C6 sykloalkoksy)C1-C6 alkyl-,(ss) (C3-C6 sykloalkyl)C1-C6 alkyl-, hvori nevnte sykloalkyl er valgfritt substituert med 1-2 fluor,(tt) (RgRhN)C1-C6 alkyl-, hvori Rg og Rh er uavhengig H eller C1-C6 alkyl,(uu) Ar2-O-,(vv) (C1-C6 alkylSO2)C1-C6 alkyl-,(ww) (C1-C6 alkoksy)C(=O)NHC1-C6 alkyl-,(xx) (C3-C6 sykloalkoksy)C(=O)-,(yy) (C3-C6 sykloalkyl)SO2-, hvori nevnte sykloalkyl er valgfritt substituert med C1-C6 alkyl,(zz) Ar4CH2OC(=O)-,(aaa) (N-(C1-C3 alkyl)pyridinonyl)C1-C3 alkyl-, og(bbb) (Ar4SO2)C1-C6 alkyl-;Cyc1 er et C3-C6 sykloalkyl, hvori (a) nevnte sykloalkyl er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av OH, halogen, C1-C6 alkoksy, CN, hydroksyC1-C6 alkyl, (C1-C6 alkoksy)C1-C6 alkyl, og C1-C6 alkyl valgfritt substituert med 1-3 fluor, eller (b) nevnte sykloalkyl er substituert med fenyl, hvori nevnte fenyl er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C3 alkyl, C1-C3 alkoksy og CF, eller (c) nevnte sykloalkyl er substituert med en 5-6-leddet heteroarylring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N og O, hvori nevnte heteroarylring er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C3 alkyl, C1-C3 alkoksy og CF3; Ar2 er fenyl valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, CN, en 5-6-leddet heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O, og RiRjN-hvori Ri og Rj er uavhengig H eller C1-C6 alkyl; hetAr2 er en 5-6-leddet heteroarylring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N, O og S og valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, hydroksyC1-C6 alkyl, (C3-C6)sykloalkyl, (C1-C6 alkoksy)C1-C6 alkyl, CN, OH, og R'R"N-, hvori R' og R" er uavhengig H eller C1-C3 alkyl;hetCyc4 er (a) en 4-6-leddet heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N, O og S hvori nevnte S er valgfritt oksidert til SO2, (b) en 7-8-leddet broforbundet heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O, (c) en 6-12-leddet kondensert bisyklisk heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O og valgfritt uavhengig substituert med 1-2 C1-C6 alkylsubstituenter, eller (d) en 7-10-leddet spirosyklisk heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O, hvori hver av de heterosykliske ringene er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, OH, CN, C1-C6 alkyl (valgfritt substituert med 1-3 fluor), C1-C6 alkoksy, (C1-C6 alkoksy)C1-C6 alkyl, (C3-C6)sykloalkyl, (C1-C6 alkyl)C(=O)-, en 5-6-leddet heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O, og fenyl hvori nevnte fenyl er valgfritt substituert med én eller flere substituenter valgt fra halogen, C1-C6 alkyl og C1-C6 alkoksy;hetCyc5 er en 5-6-leddet heterosyklisk ring som oppviser et ringheteroatom valgt fra O og N;hetCyc6 er en 5-leddet heterosyklisk ring som oppviser ett eller to ringheteroatomer uavhengig valgt fra N og O, hvori ringen er substituert med okso og hvori ringen er i tillegg valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av OH og C1-C6 alkyl;R1 er H, C1-C6 alkyl eller (C1-C6 alkoksy)C1-C6 alkyl;R2 er H, C1-C6 alkyl (valgfritt substituert med 1-3 fluor), (C1-C6 alkoksy)C1-C6 alkyl (valgfritt substituert med 1-3 fluor), Cyc3, hydroksyC1-C6 alkyl (valgfritt substituert med 1-3 fluor), C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), (C1-C6 alkoksy)C(=O), hetCyc7, Ar3, Ar3C1-C3 alkyl-, hydroksyC1-C6 alkoksy eller (3-6C sykloalkyl)CH2O-;Cyc3 er en 3-6-leddet karbosyklisk ring valgfritt substituert med 1-2 grupper uavhengig valgt fra gruppen bestående av C1-C6 alkoksy, OH og halogen;hetCyc7 er en 5-6-leddet heterosyklisk ring som oppviser et ringheteroatom valgt fra O og N hvori ringen er valgfritt substituert med C1-C6 alkyl;Ar3 er fenyl valgfritt substituert med én eller flere substituenter uavhengig valgt fra halogen, C1-C3 alkyl, C1-C3 alkoksy, fluorC1-C3 alkyl, difluorC1-C3 alkyl og trifluorC1-C3 alkyl;R4 og R5 er uavhengig H eller C1-C6 alkyl;R6 er C1-C6 alkyl, hydroksyC1-C6 alkyl, C1-C6 alkoksy, (C1-C6 alkoksy)C1-C6 alkyl, fenyl eller hetCyc8;hetCyc8 er en 5-6-leddet heterosyklisk ring som oppviser et ringheteroatom valgt fra O og N, hvori den heterosykliske ringen er valgfritt substituert med C1-C6 alkyl; ogAr4 er fenyl valgfritt substituert med ett eller flere halogener.2. Forbindelse ifølge krav 1, hvori D er hetCyc1.3. Forbindelse ifølge krav 2, hvori hetCyc1 er en pyrrolidinyl-, piperidinyl-, piperazinyl-, morfolinyleller azetidinylring valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C3 alkyl, fluorC1-C3 alkyl, difluorC1-C3 alkyl, trifluorC1-C3 alkyl og OH, eller hetCyc1 er en piperazinylring substituert med en C3-C6 sykloalkylidenring, eller hetCyc1 er en piperazinylring substituert med en oksogruppe, valgfritt hvori hetCyc1 er piperazinyl.4. Forbindelse ifølge ett av kravene 1-3, hvori E er(a) hydrogen,(d) C1-C6 alkyl valgfritt substituert med én til tre fluor,(e) hydroksyC1-C6 alkyl valgfritt substituert med én til tre fluor,(i) (C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor, (j) (hydroksy C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(k) (C1-C6 alkoksy)C(=O)-,(1) (C1-C6 alkoksy)(C1-C6 alkyl)C(=O)-,(n) Cyc1,(o) Cyc1C(=O)-,(p) Cyc1(C1-C6 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med én eller flere grupper uavhengig valgt fra gruppen bestående av OH, fluor, C1-C3 alkoksy og RcRdN-, hvor Rc og Rd er uavhengig H eller C1-C6 alkyl,(q) hetCyc4,(r) hetCyc4C(=O)-,(s) hetCyc4(C1-C3 alkyl)C(=O)-,(t) (hetCyc4)C(=O)C1-C2 alkyl,(w) Ar2C(=O)-,(x) Ar2C1-C6 alkyl,(y) (Ar2)hydroksy C2-C6 alkyl,(z) Ar2(C1-C3 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med én eller to grupper uavhengig valgt fra gruppen bestående av OH, C1-C6 alkyl, hydroksyC1-C6 alkyl, C1-C6 alkoksy og ReRfN-, hvori Re og Rf er uavhengig H eller C1-C6 alkyl,(aa) hetAr2C(=O)-,(bb) (hetAr2)hydroksyC2-C6 alkyl,(cc) hetAr2(C1-C3 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med én eller to grupper uavhengig valgt fra gruppen bestående av OH, C1-C6 alkyl, hydroksyC1-C6 alkyl, C1-C6 alkoksy og ReRfN-, hvori Re og Rf er uavhengig H eller C1-C6 alkyl,(dd) R1R2NC(=O)-,(ee) R1R2N(C1-C3 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med fenyl, (ff) R1R2NC(=O)C1-C2 alkyl,(hh) CH3SO2(C1-C6 alkyl)C(=O)-,(ii) (C1-C6 alkyl)SO2-, (jj) (C3-C6 sykloalkyl)CH2SO2-,(kk) hetCyc5-SO2-,(11) R4R5NSO2-,(mm) R6C(=O)NH-,(oo) hetAr2C1-C6 alkyl,(pp) (hetCyc4)C1-C6 alkyl,(qq) (C1-C6 alkoksy)C1-C6 alkyl hvori alkoksy-komponenten er valgfritt substituert med 1-3 fluor,(rr) (C3-C6 sykloalkoksy)C1-C6 alkyl,(ss) (C3-C6 sykloalkyl)C1-C6 alkyl hvori nevnte sykloalkyl er valgfritt substituert med 1-2 fluor,(tt) (RgRhN)C1-C6 alkyl hvori Rg og Rh er uavhengig H eller C1-C6 alkyl,(vv) (C1-C6 alkylSO2)C1-C6 alkyl,(ww) (C1-C6 alkoksy)C(=O)NHC1-C6 alkyl, (C3-C6 sykloalkyl)SO2- hvori nevnte sykloalkyl er valgfritt substituert med C1-C6 alkyl,(aaa) (N-(C1-C3 alkyl)pyridinonyl)C1-C3 alkyl, eller(bbb) (Ar4SO2)C1-C6 alkyl.5. Forbindelse ifølge krav 4, hvori E er(d) C1-C6 alkyl valgfritt substituert med én til tre fluor,(e) hydroksyC1-C6 alkyl valgfritt substituert med én til tre fluor,(i) (C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(j) (hydroksy C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(o) CycC(=O)-,(r) hetCyc4C(=O)-,(x) Ar2C1-C6 alkyl,(y) (Ar2)hydroksy C2-C6 alkyl, eller(oo) hetAr2C1-C6 alkyl. 6. Forbindelse ifølge krav 5, hvori E er (x) Ar2C1-C6 alkyl, eller (oo) hetAr2C1-C6 alkyl valgfritt hvori E er hetAr2C1-C6 alkyl, i tillegg valgfritt hvori hetAr2 er pyridyl valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, trifluor C1-C6 alkyl, C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), hydroksyC1-C6 alkyl, CN og (RaRbN)C1-C6 alkyl.7. Forbindelse ifølge krav 5, hvori E er hetCyc4C(=O)- og hetCyc4 er en 5-leddet heterosyklisk ring som oppviser 1-2 ring-heteroatomer uavhengig valgt fra N og O, hvori den heterosykliske ringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra halogen, OH, CN, C1-C6 alkyl (valgfritt substituert med 1-3 fluor), C1-C6 alkoksy og (C1-C6 alkoksy)C1-C6 alkyl, valgfritt hvori hetCyc4 er en 5-leddet heterosyklisk ring som oppviser et ringnitrogenatom, hvori den heterosykliske ringen er valgfritt substituert med C1-C6 alkoksy.8. Forbindelse ifølge krav 3, hvori hetCyc1 er piperidinyl, pyrrolidinyl eller azetidinyl, valgfritt hvori E er:(a) hydrogen,(b) OH,(c) RaRhN-,(f) C1-C6 alkoksy valgfritt substituert med én til tre fluor,(g) hydroksy(C1-C6 alkoksy) valgfritt substituert med én til tre fluor,(k) (C1-C6 alkoksy)C(=O)-,(m) HC(=O)-,(r) hetCyc4C(=O)-,(u) hetCyc4C(=O)NH-,(v) Ar2,(dd) R1R2NC(=O)-,(ff) R1R2NC(=O)C1-C2 alkyl,(gg) R1R2NC(=O)NH-,(mm) R6C(=O)NH-,(nn) hetCyc6,(oo) hetAr2C1-C6 alkyl, eller(uu) Ar2-O-. 9. Forbindelse ifølge krav 1, hvori D er hetCyc2, valgfritt hvori E er(a) hydrogen,(b) OH,(c) RaRbN-, hvori Ra er H eller C1-C6 alkyl og Rb er H, C1-C6 alkyl eller fenyl,(d) C1-C6 alkyl valgfritt substituert med én til tre fluor,(e) hydroksyC1-C6 alkyl valgfritt substituert med én til tre fluor,(f) C1-C6 alkoksy valgfritt substituert med én til tre fluor,(i) (C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(k) (C1-C6 alkoksy)C(=O)-,(o) Cyc1C(=O)-,(w) Ar2C(=O)-,(x) Ar2C1-C6 alkyl,(y) (Ar2)hydroksy C2-C6 alkyl,(aa) hetAr2C(=O)-,(cc) hetAr2(C1-C3 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med én eller to grupper uavhengig valgt fra gruppen bestående av OH, C1-C6 alkyl, hydroksyC1-C6 alkyl, C1-C6 alkoksy og ReRfN-, hvor Re og Rf er uavhengig H eller C1-C6 alkyl, eller Re og Rf sammen med nitrogenet som de er bundet til danner en 5-6-leddet azasyklisk ring som valgfritt oppviser et ekstra ringheteroatom valgt fra N og O,(ee) R1R2N(C1-C3 alkyl)C(=O)- hvori alkylkomponenten valgfritt er substituert med fenyl; eller(oo) hetAr2C1-C6 alkyl, eller(qq) (C1-C6 alkoksy)C1-C6 alkyl hvori alkoksykomponenten valgfritt er substituert med 1-3 fluor.10. Forbindelse ifølge krav 1, hvori D er hetCyc3, valgfritt hvori E er(a) hydrogen,(c) RaRbN-, hvori Ra er H eller C1-C6 alkyl og Rb er H, C1-C6 alkyl eller fenyl;(d) C1-C6 alkyl valgfritt substituert med én til tre fluor, (e) hydroksyC1-C6 alkyl valgfritt substituert med én til tre fluor,(i) (C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(j) (hydroksy C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(k) (C1-C6 alkoksy)C(=O)-,(o) Cyc1C(=O)-,(p) Cyc1(C1-C6 alkyl)C(=O),(r) hetCyc4C(=O)-,(w) Ar2C(=O)-,(x) Ar2C1-C6 alkyl,(y) (Ar2)hydroksy C2-C6 alkyl,(z) Ar2(C1-C3 alkyl)C(=O)- hvori alkylkomponenten valgfritt er substituert med én eller to grupper uavhengig valgt fra gruppen bestående av OH, C1-C6 alkyl (valgfritt substituert med 1-3 fluor), hydroksyC1-C6 alkyl, C1-C6 alkoksy og ReRfN-, hvori Re og Rf er uavhengig H eller C1-C6 alkyl, eller Re og Rf sammen med nitrogenet som de er bundet til danner en 5-6-leddet azasyklisk ring som valgfritt oppviser et ekstra ringheteroatom valgt fra N og O,(dd) R1R2NC(=O)-,(ee) R1R2N(C1-C3 alkyl)C(=O)-,(mm) R6C(=O)NH-,(xx) (C3-C6 sykloalkoksy)C(=O)-,(zz) Ar4CH2OC(=O)-, eller(oo) hetAr2C1-C6 alkyl.11. Forbindelse ifølge ett av kravene 1-10, hvori het Ar1 er en 5-leddet heteroarylring som oppviser 1-2 ringnitrogenatomer, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, og hydroksyC1-C6 alkyl, valgfritt hvori het Ar1 er pyrazolyl eller imidazolyl valgfritt substituert med C1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl eller hydroksyC1-C6 alkyl, i tillegg valgfritt hvori het Ar1 er pyrazolyl valgfritt substituert med C1-C6 alkyl.12. Forbindelse ifølge ett av kravene 1-11, hvori X1 er N, CH eller CH3, X2 er CH eller N, X3 er CH eller N, og X4 er CH eller N, hvori én av X1, X2, X3 og X4 er N., valgfritt hvori X1 er N, ogX2, X3 og X4 er CH.13. Forbindelse ifølge ett av kravene 1-11, hvoriX1 er CCH3,X2 er CH, CF eller N;X3 er CH, CF eller N; ogX4 er CH, CF eller N;hvori én av X2, X3 og X4 er N.14. Forbindelse ifølge ett av kravene 1-11, hvoriX1 er CH, CCH3, CF, CCl eller N;X2 er CH, CF eller N;X3 er CH, CF eller N; ogX4 er CH, CF eller N,hvori to av X1, X2, X3 og X4 er N, valgfritt hvori X1 og X2 er N, og X3 og X4 er CH eller CF.15. Forbindelse ifølge krav 14, hvori X1 og X3 er N, og X2 og X4 er CH eller CF, valgfritt hvori X1 er CH eller CH3, og X2, X3 og X4 er CH.16. Forbindelse ifølge ett av kravene 1-15, hvori A er H, Cl, CN, Br, CH3, eller CH2CH3, valgfritt hvori A er H, eller hvori A er Cl, eller hvori A er CN.17. Forbindelse ifølge krav 1, hvori:X1 er N og hver av X2, X3 og X4 er CH;A er CN eller Cl;B er het Ar1;het Ar1 er en 5-leddet heteroarylring som oppviser 1-2 ringnitrogenatomer, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluorC1-C6 alkyl og hydroksyC1-C6 alkyl;D er hetCyc1; oghetCyc1 er piperazinyl. 18. Forbindelse ifølge krav 1, hvori:X1 er N og hver av X2, X3 og X4 er CH;A er CN;B er het Ar1;het Ar1 er en 5-leddet heteroarylring som oppviser 2 ringnitrogenatomer, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluorC1-C6 alkyl og hydroksyC1-C6 alkyl;D er hetCyc1;hetCyc1 er piperazinyl;E er (i) (C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor, (j) (hydroksy C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor, eller (r) hetCyc4C(=O)-; og hetCyc4 er en 5-leddet heterosyklisk ring som oppviser et ringnitrogenatom, hvori den heterosykliske ringen er valgfritt substituert med C1-C6 alkoksy.19. Forbindelse ifølge krav 1, hvori:X1, X2, X3 og X4 er CH;A er H, Cl eller CN;B er het Ar1;het Ar1 er en 5-leddet heteroarylring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N, S og O, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, hydroksyC1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, cyanoC1-C6 alkyl, (C1-C6 alkoksy)C1-C6 alkyl, (C1-C4 alkoksy)CH2C(=O)-, (C1-C4 alkoksy)C(=O)C1-C3 alkyl, C3-C6 sykloalkyl, (RaRbN)C1-C6 alkyl og hetCyca;D er hetCyc1;hetCyc1 er en 5-6-leddet heterosyklisk ring som oppviser 1-2 ringnitrogenatomer, hvori den heterosykliske ringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C3 alkyl;E er (a) hydrogen,(i) (C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(j) (hydroksy C1-C6 alkyl)C(=O)- valgfritt substituert med én til tre fluor,(k) (C1-C6 alkoksy)C(=O)-,(ee) R1R2N(C1-C3 alkyl)C(=O)- hvori alkylkomponenten er valgfritt substituert med fenyl, eller(ii) (C1-C6 alkyl)SO2-;R1 er H eller C1-C6 alkyl;R2 er H, C1-C6 alkyl (valgfritt substituert med 1-3 fluor), (C1-C6 alkoksy)C1-C6 alkyl (valgfritt substituert med 1-3 fluor), Cyc3, hydroksyC1-C6 alkyl (valgfritt substituert med 1-3 fluor), C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), (C1-C6 alkoksy(C(=O), hetCyc7, Ar3 eller Ar3C1-C3 alkyl-;Cyc3 er en 3-6-leddet karbosyklisk ring valgfritt substituert med 1-2 grupper uavhengig valgt fra gruppen bestående av C1-C6 alkoksy, OH og halogen;Ar3 er fenyl valgfritt substituert med én eller flere substituenter uavhengig valgt fra halogen, C1-C3 alkyl, C1-C3 alkoksy, fluorC1-C3 alkyl, difluorC1-C3 alkyl og trifluorC1-C3 alkyl; oghetCyc7 er en 5-6-leddet heterosyklisk ring som oppviser et ringheteroatom valgt fra O og N hvori ringen er valgfritt substituert med C1-C6 alkyl.20. Forbindelse ifølge krav 1, hvori:X1 er N og hver av X2, X3 og X4 er CH;A er CN;het Ar1 er en 5-leddet heteroarylring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N, S og O, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, hydroksyC1-C6 alkyl, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, cyanoC1-C6 alkyl, (C1-C6 alkoksy)C1-C6 alkyl, (C1-C4 alkoksy)CH2C(=O)-, (C1-C4 alkoksy)C(=O)C1-C3 alkyl, C3-C6 sykloalkyl, (RaRbN)C1-C6 alkyl, og hetCyca;D er hetCyc1;hetCyc1 er piperazinyl; E er (x) Ar2C1-C6 alkyl eller (oo) hetAr2C1-C6 alkyl;Ar2 er fenyl valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, CN, en 5-6-leddet heterosyklisk ring som oppviser 1-2 ringheteroatomer uavhengig valgt fra N og O, og R1RjN-hvor Ri og Rj er uavhengig H og C1-C6 alkyl; oghetAr2 er en 5-6-leddet heteroarylring som oppviser 1-3 ringheteroatomer uavhengig valgt fra N, O og S og valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, C1-C6 alkoksy, fluor C1-C6 alkyl, difluor C1-C6 alkyl, trifluor C1-C6 alkyl, (C3-C6)sykloalkyl, (C1-C6 alkoksy)C1-C6 alkyl, CN og R'R"N-, hvori R' og R" er uavhengig H eller C1-C3 alkyl.21. Forbindelse ifølge krav 20, hvori het Ar1 er en 5-leddet heteroarylring som oppviser 1-2 ringnitrogenatomer, hvori heteroarylringen er valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av C1-C6 alkyl, fluor C1-C6 alkyl, difluorC1-C6 alkyl, trifluor C1-C6 alkyl og hydroksyC1-C6 alkyl, valgfritt hvori het Ar1 er pyrazolyl valgfritt substituert med C1-C6 alkyl.22. Forbindelse ifølge ett av kravene 20-21, hvori E er hetAr2C1-C6 alkyl, valgfritt hvori hetAr2 er pyridyl valgfritt substituert med én eller flere substituenter uavhengig valgt fra gruppen bestående av halogen, C1-C6 alkyl, trifluor C1-C6 alkyl, C1-C6 alkoksy (valgfritt substituert med 1-3 fluor), hydroksyC1-C6 alkyl, CN og (RaRbN)C1-C6 alkyl, i tillegg valgfritt hvori hetAr2 er pyridyl valgfritt substituert med C1-C6 alkoksy (valgfritt substituert med 1-3 fluor).23. Forbindelse ifølge krav 1, valgt fra én avtert-butyl-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-(metylsulfonyl)propanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;((S)-4-(6-(4-(2-hydroksy-3-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(pyridin-2-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(3-hydroksy-3-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-hydroksy-3-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-3-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(2-fluorfenyl)-2-hydroksyacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1S,3S)-3-hydroksysyklopentan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1S,3R)-3-hydroksysyklopentan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3,3-difluorsyklopentan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-hydroksy-2-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-tert-butyl-(3-(4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-3-okso-1-fenylpropyl)karbamat;tert-butyl-tert-butyl(2-(4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-oksoetyl)karbamat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(6-metylpyridin-3-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(1-metyl-1H-pyrazol-5-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(syklopentanekarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(tert-butylamino)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitrildihydroklorid;(S)-4-(6-(4-(3-amino-3-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitrildihydroklorid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-fenylsyklopentankarbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-fenylsyklopropan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-metyl-2-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-fenylsyklobutan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-fenylsykloheksan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-metyl-2-fenylbutanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksypropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-hydroksy-2-metylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksypropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-(dimetylamino)propanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-pivaloylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-metyl-1H-pyrazole-4-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-(1-metyl-1H-imidazol-4-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(5-metylisoxazol-3-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril 2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrazin-2-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril 2,2,2-trifluoracetat;4-(6-(4-(2-(2,6-difluorfenyl)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-(2-metoksyacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-(1,3-dimetyl-1H-pyrazol-4-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-(2-(1-metyl-1H-pyrazol-3-yl)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-(pyridin-3-yl)propanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-prolylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);(R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-prolylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(piperidin-4-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(piperidin-3-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);(R)-4-(6-(4-(2-amino-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(5-metylpyrazin-2-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat); (S)-4-(6-(4-(2-amino-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);4-(6-(4-(2,6-difluorbenzoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril 2,2,2-trifluoracetat;4-(6-(4-(4-(dimetylamino)butanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);(R)-4-(6-(4-(2-hydroksy-4-metylpentanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(3-hydroksybutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksy-4-metylpentanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-hydroksybutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(tetrahydrofuran-2-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,2-difluorpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(tetrahydrofuran-2-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3,3,3-trifluor-2-hydroksypropanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(tetrahydrofuran-3-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-hydroksy-3-metylpentanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(pyrrolidin-1-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-propionylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzoylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-butyrylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(pyridin-3-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-picolinoylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-nicotinoylpiperazin-l-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(tetrahydro-2H-pyran-4-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(tetrahydro-2H-pyran-4-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-syklopropylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-((1r,4r)-4-hydroksysykloheksankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-hydroksysyklopropan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-metoksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-metoksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-metoksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((syklopropylmetyl)sulfonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(metylsulfonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(neopentylsulfonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(isobutylsulfonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((tetrahydro-2H-pyran-4-yl)sulfonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-hydroksypiperidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(piperidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3,3-difluorpiperidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(7-azabisyklo[2,2,1]heptan-7-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1-hydroksybutan-2-yl)piperazin-1-karboksamid;(S)-4-(6-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-dietylpiperazin-1-karboksamid;(R)-4-(6-(4-(3-hydroksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-hydroksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3,3-difluorpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-fluorpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(3-fluorpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(tetrahydrofuran-3-yl)piperazin-1-karboksamid;(R)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(tetrahydrofuran-3-yl)piperazin-1-karboksamid;(R)-4-(6-(4-(3-isopropoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-isopropoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-metyl-N-fenylpiperazin-1-karboksamid; (R)-4-(6-(4-(2-(metoksymetyl)pyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-(metoksymetyl)pyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-cyanopyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(trifluormetyl)pyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-fluorpiperidine-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4,4-difluorpiperidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-fluorpiperidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(5-azaspiro[2,4]heptan-5-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3,3-dimetylpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(morfolin-4-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(4-metylpiperazin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperazin-1-karboksamid;(S)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1-hydroksybutan-2-yl)piperazin-1-karboksamid;4-(6-(4-(heksahydro-1H-furo[3,4-c]pyrrol-5-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,2-dimetylpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpiperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-fenylpiperazin-1-karboksamid;N-(tert-butyl)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksamid;N-benzyl-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-metoksyetyl)-N-metylpiperazin-1-karboksamid-2,2,2-trifluoracetat;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-syklopropylpiperazin-1-karboksamid-2,2,2-trifluoracetat;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-dimetylpiperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isobutylpiperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-etylpiperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-metoksyetyl)piperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-etyl-N-metylpiperazin-1-karboksamid;N-(tert-butyl)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-sulfonamid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrrolidin-1-ylsulfonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(4-klorfenetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-formylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-metyl-2-oksopyrrolidin-3-yl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;2-(4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-N,N-dimetylacetamid-2,2,2-trifluoracetat;2-(4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-N-isopropylacetamid-2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-okso-2-(pyrrolidin-1-yl)etyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;3-(4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-N,N-dimetylpropanamid-2,2,2-trifluoracetat;4-(6-(4-((1R,2R)-1-hydroksy-1-fenylpropan-2-yl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-hydroksy-3,3-dimetylbutyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1S,2S)-1-hydroksy-1-fenylpropan-2-yl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksybutyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-3-metoksypropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(4-klorfenyl)-2-hydroksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-(3-klorfenyl)-2-hydroksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(2,6-difluorfenyl)-2-hydroksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-((1r,2r)-2-hydroksysykloheksyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-hydroksy-2-metylpropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksypropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksypropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((3r,4s)-4-hydroksytetrahydrofuran-3-yl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-hydroksy-3-metylbutyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-2-fenyletyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksy-2-fenyletyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazo1-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1r,2r)-2-hydroksysyklopentyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(4-fluorfenyl)-2-hydroksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;rac-4-(6-(4-((2R*,3S*)-3-hydroksybutan-2-yl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4,7-diazaspiro[2,5]oktan-4-karboksylat;4-(6-(4,7-diazaspiro[2,5]oktan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-(3-hydroksy-3-metylbutanoyl)-4,7-diazaspiro[2,5]oktan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3,3-dimetylbutanoyl)-4,7-diazaspiro[2,5]oktan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; (1S,4S)-tert-butyl-5-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,5-diazabisyklo[2,2,1]heptan-2-karboksylat;4-(6-((1S,4S)-2,5-diazabisyklo[2,2,1]heptan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitrildihydroklorid;4-(6-((1S,4S)-5-(3,3-dimetylbutanoyl)-2,5-diazabisyklo[2,2,1]heptan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl 3-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,8-diazabisyklo[3,2,1]oktan-8-karboksylat;4-(6-(3,8-diazabisyklo[3,2,1]oktan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(8-(3,3-dimetylbutanoyl)-3,8-diazabisyklo[3,2,1]oktan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)karbamat;4-(6-(4-aminopiperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;(R)-N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)tetrahydrofuran-2-karboksamid;N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-2-hydroksy-2-metylpropanamid;(S)-N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-2-hydroksypropanamid;(R)-N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-2-hydroksypropanamid;(S)-N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)tetrahydrofuran-2-karboksamid;N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-2-metoksyacetamid;N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)benzamid; N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)isobutyramid;3-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-1,1-dimetylurea;1-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-3-isopropylurea;Isopropyl-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)karbamat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-oksopyrrolidin-1-yl)piperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-hydroksy-2-oksopyrrolidin-1-yl)piperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-oksooksazolidin-3-yl)piperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-((1R,3s,5S)-8-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-8-azabisyklo[3,2,1]oktan-3-yl)karbamat;4-(6-((1R,3s,5S)-3-amino-8-azabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;tert-butyl-((1R,3r,5S)-8-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-8-azabisyklo[3,2,1]oktan-3-yl)karbamat;4-(6-((1R,3r,5S)-3-amino-8-azabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-hydroksypiperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-isobutoksypiperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-metoksypiperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-((1R,3r,5S)-3-hydroksy-8-azabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-((1R,3r,5S)-3-metoksy-8-azabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl (1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-metylpiperidin-4-yl)karbamat;4-(6-(4-amino-4-metylpiperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-metylpiperidin-4-yl)isobutyramid;tert-butyl-8-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,8-diazaspiro[4,5]dekan-2-karboksylat;4-(6-(2,8-diazaspiro[4,5]dekan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;(R)-4-(6-(2-(2-hydroksy-3-metylbutanoyl)-2,8-diazaspiro[4,5]dekan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-isobutyryl-2,8-diazaspiro[4,5]dekan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[4,5]dekan-2-karboksylat;4-(6-(2,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2-((R)-2-hydroksy-3-metylbutanoyl)-2,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-((S)-2-((R)-2-hydroksy-3-metylbutanoyl)-2,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-((R)-2-((R)-2-hydroksy-3-metylbutanoyl)-2,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-isobutyryl-2,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[3,5]nonan-2-karboksylat; 4-(6-(2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;(R)-4-(6-(2-(2-hydroksy-3-metylbutanoyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-benzoyl-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(2-(2-fenylacetyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(syklopentankarbonyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-acetyl-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-isobutyryl-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;isopropyl 7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[3,5]nonan-2-karboksylat;tert-butyl2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[3,5]nonan-7-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-morfolinopyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; (S)-N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-3-yl)isobutyramid;(R)-N-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-3-yl)isobutyramid;(R)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylmorfolin-2-karboksamid;(S)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylmorfolin-2-karboksamid;(R)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpiperidin-3-karboksamid; (S)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpiperidin-3-karboksamid;(S)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1,1,1-trifluorpropan-2-yl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1-metoksypropan-2-yl)piperidin-4-karboksamid;(R)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1,1,1-trifluorpropan-2-yl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-isopropoksyetyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(3,3,3-trifluor-2-metoksypropyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-metoksy-3-metylbutyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-etoksypiperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(3,3-difluorsyklobutyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-metoksypropyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-((1r,3r)-3-metoksysyklobutyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-((1s,3s)-3-metoksysyklobutyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(3,3,3-trifluorpropyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2,2,2-trifluoretyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isobutyl-N-metylpiperidin-4-karboksamid; 1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-hydroksypropyl)-N-metylpiperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpiperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropyl-N-metylpiperidin-4-karboksamid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrrolidin-1-karbonyl)piperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;2-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-yl)-N-isopropylacetamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-metyl-N-(3,3,3-trifluorpropyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropyl-4-metylpiperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1-metoksypropan-2-yl)-4-metylpiperidine-4-karboksamid;(R)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-metyl-N-(1,1,1-trifluorpropan-2-yl)piperidin-4-karboksamid;Metyl-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-metylpiperidin-4-karboksylat;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-etyl-N-(3,3,3 -trifluorpropyl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-etyl-N-isopropylpiperidin-4-karboksamid;(R)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-etyl-N-(1,1,1-trifluorpropan-2-yl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-etyl-N-(2-hydroksy-2-metylpropyl)piperidin-4-karboksamid;(R)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(3,3,3-trifluorpropyl)pyrrolidin-3-karboksamid; (R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(3-(pyrrolidin-1-karbonyl)pyrrolidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpyrrolidin-3-karboksamid;(S)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(3,3,3-trifluorpropyl)pyrrolidin-3-karboksamid;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(3-(pyrrolidin-1-karbonyl)pyrrolidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpyrrolidin-3-karboksamid;tert-Butyl-4-(5-(3-cyano-6-(1-(difluormetyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(4-(3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin- 1 -yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-Butyl-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(1-metyl-1H-pyrazol-3-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;(R)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-3-yl)-4-(6-(4-(3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; tert-Butyl-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)-3-metylpyridin-2-yl)piperazin-1-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(5-metyl-6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-(3-hydroksy-3-metylbutanoyl)piperazin-1-yl)-5-metylpyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)-5-metylpyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)-5-metylpyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(5-metyl-6-(4-(pyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(2-(piperazin-1-yl)pyrimidin-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;(R)-4-(2-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyrimidin-5-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(2-(4-(3-metylbutanoyl)piperazin-1-yl)pyrimidin-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(2-(4-(2-metoksy-2-fenylacetyl)piperazin-1-yl)pyrimidin-5-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(2-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyrimidin-5-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(2-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyrimidin-5-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(5-(piperazin-1-yl)pyrazin-2-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(5-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyrazin-2-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(5-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyrazin-2-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; tert-Butyl-4-(4-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)fenyl)piperazin-1-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(4-(piperazin-1-yl)fenyl)pyrazol[1,5-a]pyridin-3-karbonitrildihydroklorid;4-(4-(4-(2-metoksyacetyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-(2-hydroksyacetyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-hydroklorid;4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-acetylpiperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-(2-(dimetylamino)acetyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(4-(4-(metylsulfonyl)piperazin-1-yl)fenyl)pyrazol[1,5-a]pyridin-3-karbonitril;Metyl-4-(4-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)fenyl)piperazin-1-karboksylat;4-(4-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)fenyl)-N-metylpiperazin-1-sulfonamid;tert-Butyl-4-(4-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)fenyl)piperidin-1-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(4-(piperidin-4-yl)fenyl)pyrazol[1,5-a]pyridin-3-karbonitrildihydroklorid;4-(4-(1-(3,3-dimetylbutanoyl)piperidin-4-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(1-(2-(dimetylamino)acetyl)piperidin-4-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-(2-hydroksypropyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; (R)-4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-(2-hydroksypropyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-(3-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-(3-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-imidazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-(3,3-dimetylbutanoyl)piperazin-1-yl)fenyl)-6-(5-metyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-Butyl-4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridindihydroklorid;(R)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-fenyletanon;2-(2,6-difluorfenyl)-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;(2,6-difluorfenyl)(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)metanon;(R)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-(p-tolyl)etanon;2-(2,4-difluorfenyl)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;2-(2,6-difluorfenyl)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;2-(3,5-difluorfenyl)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon; (R)-2-(2-klorfenyl)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;(R)-2-(2-fluorfenyl)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;(R)-2-(3-klorfenyl)-2-hydroksy-1-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;N-metyl-4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-fenylpiperazin-1-karboksamid;(R)-2-(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-1-fenyletanol;tert-Butyl-4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;3-klor-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridindihydroklorid;(R)-1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroksy-2-fenyletanon;1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-(dimetylamino)etanon;1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-metoksyetanon;1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etanon;1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-3,3-dimetylbutan-1-on;3-klor-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(metylsulfonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin;3-klor-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-metylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin;tert-Butyl-8-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,8-diazabisyklo[3,2,1]oktan-3-karboksylat; 4-(6-(3,8-diazabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-dihydroklorid;1-(8-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,8-diazabisyklo[3,2,1]oktan-3-yl)-2-(dimetylamino)etanon;tert-Butyl-3-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,6-diazabisyklo[3,1,1]heptan-6-karboksylat;3-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,6-diazabisyklo[3,1,1]heptan-dihydroklorid;3-klor-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(pyrrolidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin; 4-(6-(7-azabisyklo[2,2,1]heptan-7-yl)pyridin-3-yl)-3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin;4-(6-(4-(1-(4-klorfenyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(4-fenyltetrahydro-2H-pyran-4-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(2,4-diklorfenyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(4-metoksyfenyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(4-fluorfenyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-(trifluormetyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(hydroksymetyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-cyanosyklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(3-fluorfenyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-(pyrazin-2-yl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(dimetylamino)-2-(4-fluorfenyl)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-metoksy-2,2-dimetylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(metoksymetyl)syklopropankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1-(metoksymetyl)syklobutankarbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(piperidin-2-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);4-(6-(4-(1-(3-klorfenyl)syklopropan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(4-(trifluormetoksy)fenyl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-morfolinobenzoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-(pyridin-2-yl)syklopropan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);4-(6-(4-(2-(5-fluorpyridin-2-yl)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(4-metylpiperazin-1-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-tris(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-morfolinoacetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-morfolin-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);4-(6-(4-(2-(dietylamino)-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat); 4-(6-(4-(2-(4-cyanofenyl)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-(1-(2-metoksyetyl)-1H-pyrazol-3-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-metyl-5-propylisoxazole-4-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-fenyl-2-(piperidin-1-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-(pyridin-3-yl)syklopropan-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);4-(6-(4-(5-syklopropyl-1H-pyrazole-3-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3,3,3-trifluor-2-metoksy-2-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3,3,3-trifluor-2-metoksy-2-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(3-hydroksy-2-fenylpropanol)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((1-metylsyklopropyl)sulfonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-fenylpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-metoksypiperidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;N-butyl-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-fenylpiperazin-1-karboksamid;(R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-fenylpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-morfolinopyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(3-azabisyklo[3,1,0]heksan-3-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(octahydropyrrolo[1,2-a]pyrazin-2-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-metoksyfenyl)-N-metylpiperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(4-metoksyfenyl)-N-metylpiperazin-1-karboksamid;4-(6-(4-(6,6-dimetyl-3-azabisyklo[3,1,0]heksan-3-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-bis(2-metoksyetyl)piperazin-1-karboksamid;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-syklopropyl-N-metylpiperazin-1-karboksamid-2,2,2-trifluoracetat;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-metylpiperazin-1-karboksamid;4-(6-(4-(3-syklopropylpyrrolidin-1-carbnyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-etylpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-isopropylpyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(3-(trifluormetyl)pyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-isopropoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-isobutylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(syklopropylmetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(pyridin-2-yl)etyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-metoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-etoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(trifluormetoksy)etyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((2-metoksypyridin-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((4,6-dimetylpyrimidin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(1,1-dioksidotetrahydro-2H-thiopyran-4-yl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(isopropylsulfonyl)etyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((tetrahydro-2H-pyran-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-metoksypropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((tetrahydrofuran-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-syklopropoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-propylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-etylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-fenetylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-metoksypropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-metoksy-3-metylbutyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-metoksy-2-metylpropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-metoksypropyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((3r,4s)-4-metoksytetrahydrofuran-3-yl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-metoksy-3,3-dimetylbutyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,2-difluoretyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2,2,2-trifluoretyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(tert-butoksy)etyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-fenyletyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;(S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(1-fenyletyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-((5-fluorpyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-fluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(4-klorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,4-difluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-fluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-fluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,5-difluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-klorpyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((6-metylpyrazin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-metoksybenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((6-metylpyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((3-fluorpyridin-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1,5-dimetyl-1H-pyrazol-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((5-metylisoksazol-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1-metyl-1H-imidazol-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((3-metylpyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1-metyl-1H-pyrazol-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-((1,3-dimetyl-1H-pyrazol-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,6-difluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((4-metylpyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((5-metylpyrazin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1-isopropyl-1H-pyrazol-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1-etyl-1H-pyrazol-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3,5-difluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((1-metyl-1H-pyrazol-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1-metyl-1H-imidazol-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-metoksybenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-metoksybenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((2-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrazin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-klorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(3-klorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((1-acetylpiperidin-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-fluor-2-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-metoksypyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((3,3-difluorsyklobutyl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(dimetylamino)benzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-(dimetylamino)benzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-fluorpyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((3-metoksypyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitrilformat;4-(6-(4-(2-cyanobenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((2-metylpyrimidin-5-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((tetrahydro-2H-pyran-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((2-metylpyrimidin-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(3-cyanobenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-cyanobenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-(2,6-dimetylbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-3-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrimidin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-syklobutylpiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(oksetan-3-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-morfolinoetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(oksetan-3-yl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(metylamino)etyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-(dimetylamino)etyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzyl-3-oksopiperazm-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-((1S,4S)-5-benzyl-2,5-diazabisyklo[2,2,1]heptan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(8-benzyl-3,8-diazabisyklo[3,2,1]oktan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(7-benzyl-2,7-diazaspiro[3,5]nonan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(3,6-Diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(3,6-Diazabisyklo[3,1,1]heptan-6-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(3,8-Diazabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-benzyl-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(3-benzyl-3,6-diazabisyklo[3,1,1]heptan-6-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(3-benzyl-3,8-diazabisyklo[3,2,1]oktan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(syklopropankarbonyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(syklobutankarbonyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(2-(dimetylamino)acetyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(sykloheksankarbonyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(2-etylbutanoyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(2-syklopentylacetyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-(2-sykloheksylacetyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;Syklopentyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[3,5]nonan-2-karboksylat; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(2-(pyrrolidin-1-karbonyl)-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-dimetyl-2,7-diazaspiro[3,5]nonan-2-karboksamid;7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-dietyl-2,7-diazaspiro[3,5]nonan-2-karboksamid;4-(6-(2-benzyl-2,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-Butyl-9-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,9-diazaspiro[5,5]undekan-2-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(tetrahydrofuran-3-yl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);tert-Butyl-(2-(4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)etyl)karbamat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(fenylamino)piperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-fenoksypiperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-klorfenoksy)piperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-hydroksy-4-(trifluormetyl)piperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;tert-butyl-9-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,9-diazaspiro[5,5]undekan-3-karboksylat;tert-butyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,9-diazaspiro[5,5]undekan-9-karboksylat;tert-butyl-8-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-1,8-diazaspiro[4,5]dekan-1-karboksylat;tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-1,7-diazaspiro[4,5]dekan-1-karboksylat; tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-1,7-diazaspiro[3,5]nonan-1-karboksylat;tert-butyl-(7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-7-azaspiro[3,5]nonan-2-yl)karbamat;tert-butyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,8-diazaspiro[4,5]dekan-8-karboksylat;tert-butyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[4,5]dekan-7-karboksylat;tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,7-diazaspiro[4,4]nonan-2-karboksylat;tert-butyl-7-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-1,7-diazaspiro[4,4]nonan-1-karboksylat;tert-butyl-6-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,6-diazaspiro[3,4]oktan-2-karboksylat;tert-butyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,6-diazaspiro[3,5]nonan-6-karboksylat;tert-butyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,5-diazaspiro[3,5]nonan-5-karboksylat;tert-butyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,5-diazaspiro[3,4]oktan-5-karboksylat;benzyl-2-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,5-diazaspiro[3,4]oktan-5-karboksylat-2,2,2-trifluoracetat;tert-butyl-6-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-2,6-diazaspiro[3,3]heptan-2-karboksylat;4-(6-(7-oksa-2-azaspiro[3,5]nonan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(6-oksa-2-azaspiro[3,4]oktan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(7-oksa-2-azaspiro[4,5]dekan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(2-oksa-7-azaspiro[4,4]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(3-hydroksy-3-(trifluormetyl)pyrrolidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(2-(4-fluorfenyl)pyrrolidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(3-fenylpyrrolidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-(4-klorfenyl)piperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-benzylpiperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(4-klorbenzyl)piperidin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2,9-diazaspiro[5,5]undekan-9-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-(2-aminoetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(3,9-diazaspiro[5,5]undekan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,9-diazaspiro[5,5]undekan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(1,8-diazaspiro[4,5]dekan-8-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(1,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(1,7-diazaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2-amino-7-azaspiro[3,5]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid; 4-(6-(2,8-diazaspiro[4,5]dekan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,7-diazaspiro[4,5]dekan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,7-diazaspiro[4,4]nonan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(1,7-diazaspiro[4,4]nonan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,6-diazaspiro[3,4]oktan-6-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,7-diazaspiro[3,5]nonan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,6-diazaspiro[3,5]nonan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,5-diazaspiro[3,5]nonan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(2,5-diazaspiro[3,4]oktan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(7-metyl-2,7-diazaspiro[3,5]nonan-2-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(9-metyl-2,9-diazaspiro[5,5]undekan-2-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(2-metyl-2,9-diazaspiro[5,5]undekan-9-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(1-metyl-1,7-diazaspiro[4,5]dekan-7-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-benzyl-2,6-diazaspiro[3,4]oktan-6-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2,6-diazaspiro[3,3]heptan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(6-benzyl-2,6-diazaspiro[3,3]heptan-2-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-hydroksyetyl)-N-isopropylpiperidin-4-karboksamid-2,2,2-trifluoracetat;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-dimetylpiperidin-4-karboksamid-2,2,2-trifluoracetat;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(syklopropylmetoksy)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-metoksypiperidin-4-karboksamid;N-(tert-butoksy)-1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperidin-4-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-hydroksyetoksy)piperidin-4-karboksamid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(metylsulfonyl)piperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylpiperidin-4-sulfonamid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperidin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isopropylazetidin-3-karboksamid;2-(1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)azetidin-3-yl)-N-isopropylacetamid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperidin-4-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(1-benzylpiperidin-4-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(azetidin-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(pyrrolidin-3-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperidin-3-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(1-benzylazetidin-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(1-benzylpiperidin-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(1-benzylpyrrolidin-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(1-((tetrahydro-2H-pyran-4-yl)metyl)pyrrolidin-3-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(1-(pyrimidin-2-ylmetyl)pyrrolidin-3-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(4-(2-isopropoksyetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-isopropoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-3-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-4-(5-(3-cyano-6-(1-(4-metoksybenzyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(1-(4-metoksybenzyl)-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-(3-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; (S)-4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-(3-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-3-(4-(4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-3-cyanopyrazol[1,5-a]pyridin-6-yl)-1H-pyrazol-1-yl)azetidin-1-karboksylat;6-(1-(azetidin-3-yl)-1H-pyrazol-4-yl)-4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-(1-isopropylazetidin-3-yl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;1-(5-(3-cyano-6-(1,5-dimetyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-etyl-N-isopropylpiperidin-4-karboksamid;(S)-6-(1,5-dimetyl-1H-pyrazol-4-yl)-4-(6-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;1-(5-(3-cyano-6-(1,3-dimetyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-etyl-N-isopropylpiperidin-4-karboksamid;(S)-6-(1,3-dimetyl-1H-pyrazol-4-yl)-4-(6-(4-(3-metoksypyrrolidin-1-karbonyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-etyl-3-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(3-etyl-1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-isopropyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-isobutyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(piperazin-1-yl)pyridin-3-yl)-6-(1,3,5-trimetyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-isopropyl-3-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(tert-butyl)-3-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1,3-dietyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-etyl-3-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(3-etyl-1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-isopropyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-isobutyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1,3,5-trimetyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-isopropyl-3-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1,3-dietyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(1-(tert-butyl)-3-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-4-(5-(3-cyano-6-(3-syklopropyl-1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(3-syklopropyl-1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(3-syklopropyl-1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(3-syklopropyl-1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-4-(5-(3-cyano-6-(3-metylisoksazol-5-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;tert-butyl-4-(5-(3-cyano-6-(3-metyl-1H-pyrazol-5-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat; tert-butyl-4-(5-(3-cyano-6-(1,5-dimetyl-1H-pyrazol-3-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;6-(2-metyloksazol-5-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitrildihydroklorid;6-(3-metylisoksazol-5-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril hydroklorid;6-(3-metyl-1H-pyrazol-5-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;6-(1,5-dimetyl-1H-pyrazol-3-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-6-(3-metylisoksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-isopropoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(3-metyl-1H-pyrazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-isopropoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(3-metylisoksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-etylpiperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-etoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-isopropoksyetyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(3-metylisoksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(3-metyl-1H-pyrazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1,5-dimetyl-1H-pyrazol-3-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 6-(1,5-dimetyl-1H-pyrazol-3-yl)-4-(6-(4-(pyrimidin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(2-(4-benzylpiperazin-1-yl)pyrimidin-5-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;tert-butyl-4-(6-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-3-yl)piperazin-1-karboksylat;6-(1-metyl-1H-pyrazol-4-yl)-4-(5-(piperazin-1-yl)pyridin-2-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(5-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyridin-2-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-(3-metoksypyrrolidin-1-yl)(4-(5-(6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)metanon;3-klor-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin; (S)-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)(3-metoksypyrrolidin-1-yl)metanon;1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-3-metylbutan-1-on;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin;1-(4-(5-(3-klor-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-3-metylbutan-2-ol;4-(5-(3-brom-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;tert-butyl-4-(5-(3-metyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;3-metyl-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin; (R)-2-hydroksy-1-(4-(5-(3-metyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-fenylethan-1-on;4-(6-(4-benzylpiperazin-1-yl)pyridin-3-yl)-3-metyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin; 3-metyl-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin;tert-butyl-4-(5-(3-etyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;3-etyl-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin; (R)-1-(4-(5-(3-etyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)-2-hydroksy-2-fenyletanon;(S)-(4-(5-(3-etyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-yl)(3-metoksypyrrolidin-1-yl)metanon;3-syklopropyl-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin;(S)-4-(6-(4-(2-(dimetylamino)-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;Isobutyl-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;(R)-4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(1-(4-fluorfenyl)etyl)piperazin-1-karboksamid;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(fenylsulfonyl)etyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-(dimetylamino)pyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-fluor-6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((5-klor-6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-etoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-isopropoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-((5,6-dimetoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((2,6-dimetoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksy-4-metylpyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-etoksy-5-fluorpyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((6-(2,2,2-trifluoretoksy)pyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-(difluormetoksy)pyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(6-metoksy-5-metylpiridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((6-(trifluormetyl)pyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksy-2-metylpyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-(tert-butyl)pyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-(2-hydroksypropan-2-yl)pyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-cyanopyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((1-metyl-2-okso-1,2-dihydropyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid; 6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((1-metyl-2-okso-1,2-dihydropyridin-4-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-dihydroklorid; (S)-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-((tetrahydro-2H-pyran-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril; 4-(6-(4-((6-metoksypyridin-3-yl)metyl)-2-oksopiperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(2-benzyl-3-oksoheksahydroimidazo[1,5-a]pyrazin-7(1H)-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-(6-metoksynicotinoyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-(5-fluor-6-metoksynicotinoyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-(3-fluor-4-metoksybenzoyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-(3-klor-4-metoksybenzoyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-(2-(5-fluorpyridin-2-yl)acetyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-((6-metoksypyridin-3-yl)metyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(6-(pyridin-2-ylmetyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(6-(2-etoksyetyl)-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(6-propyl-3,6-diazabisyklo[3,1,1]heptan-3-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(difluormetyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-isopropyl-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-2-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril; (R)-6-(1-(2-hydroksypropyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-(2-hydroksypropyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(2-(isopropylsulfonyl)etyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(2-isopropoksyetyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;3-(4-(3-cyano-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-6-yl)-1H-pyrazol-1-yl)-N,N-dimetylpropanamid;(R)-6-(1-(3-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-6-(1-(3-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-(2-metoksypropyl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;2-(4-(3-cyano-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-6-yl)-1H-pyrazol-1-yl)-N,N-dimetylacetamid;6-(1-(azetidin-3-yl)-1H-pyrazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)-piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);tert-butyl-4-(4-(3-cyano-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-6-yl)-1H-pyrazol-1-yl)piperidin-1-karboksylat;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat); (R)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-(1-(2-metoksyetyl)piperidin-4-yl)-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-6-(1-(3-hydroksy-2-metylpropyl)-5-metyl-1H-pyrazol-3-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(S)-4-(6-(4-(2-metoksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-metoksy-2-fenylacetyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metyloksazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(2-metyloksazol-5-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metylthiazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(2-metylthiazol-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;6-(2,4-dimetylthiazol-5-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-1,2,3-triazol-4-yl)-4-(6-(piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat;(R)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-1,2,3-triazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril 2,2,2-trifluoracetat;tert-butyl-4-(5-(3-cyano-6-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)piperazin-1-karboksylat;(R)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-2,2,2-trifluoracetat; 6-(1-isopropyl-1H-1,2,3-triazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-isopropyl-1H-1,2,3-triazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-isopropyl-1H-1,2,3-triazol-4-yl)-4-(6-(4-(pyrimidin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);6-(1-(2-metoksyetyl)-1H-1,2,3-triazol-4-yl)-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;(R)-4-(6-(4-(2-hydroksy-3-metylbutanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-(2-metoksyetyl)-1H-1,2,3-triazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(5-(3-cyano-6-(1-(2-metoksyetyl)-1H-1,2,3-triazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-isobutylpiperazin-1-karboksamid;4-(5-fluor-6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(2-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyrimidin-5-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(4-(4-(pyridin-2-ylmetyl)piperazin-1-yl)fenyl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(4-(4-(pyrimidin-2-ylmetyl)piperazin-1-yl)fenyl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(4-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)fenyl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;3-klor-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrimidin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin;3-klor-4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin;3-metyl-6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyrimidin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-3-metyl-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin; eller et farmasøytisk akseptabelt salt av samme.24. Forbindelse ifølge krav 1, valgt fra de følgende forbindelsene:((S)-4-(6-(4-(2-hydroksy-3-fenylpropanoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(2-(pyridin-2-yl)acetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2,6-difluorbenzoyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril 2,2,2-trifluoracetat;4-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N,N-dietylpiperazin-1-karboksamid;1-(5-(3-cyano-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-4-yl)pyridin-2-yl)-N-(2-metoksy-3-metylbutyl)piperidin-4-karboksamid;4-(6-(4-(2-(5-fluorpyridin-2-yl)acetyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril-bis(2,2,2-trifluoracetat);4-(6-(4-(2,6-difluorbenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-(2-metoksybenzyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;6-(1-metyl-1H-pyrazol-4-yl)-4-(6-(4-(pyridin-2-ylmetyl)piperazin-1-yl)pyridin-3-yl)pyrazol[1,5-a]pyridin-3-karbonitril;4-(6-(4-((6-metoksypyridin-3-yl)metyl)piperazin-1-yl)pyridin-3-yl)-6-(1-metyl-1H-pyrazol-4-yl)pyrazol[1,5-a]pyridin-3-karbonitril;eller et farmasøytisk akseptabelt salt av samme.25. Farmasøytisk blanding, som omfatter en forbindelse ifølge ett av kravene 1-24, eller et farmasøytisk akseptabelt salt eller en oppløsning av samme, og en farmasøytisk akseptabel bærer eller hjelpestoff.
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Array Biopharma, Inc.
3200 Walnut Street Boulder, CO 80301 US

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ANDREWS, Steven W.
3200 Walnut Street Boulder, Colorado 80301 US
BLAKE, James F.
3200 Walnut Street Boulder, Colorado 80301 US
CHICARELLI, Mark J.
3200 Walnut Street Boulder, Colorado 80301 US
GOLOS, Adam
3200 Walnut Street Boulder, Colorado 80301 US
HAAS, Julia
3200 Walnut Street Boulder, Colorado 80301 US
JIANG, Yutong
3200 Walnut Street Boulder, Colorado 80301 US
KOLAKOWSKI, Gabrielle R.
3200 Walnut Street Boulder, Colorado 80301 US

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CURO AS
Vestre Rosten 81 7075 TILLER NO ( TRONDHEIM kommune, Trøndelag fylke )

Org.nummer: 936803911
Din referanse: O-145051
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2015.07.16, US 201562193448 P

2015.12.31, US 201562274018 P

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US-A1- 2012 277 247 (B1)

WO-A1-2011/022439 (B1)

WO-A1-2014/184069 (B1)

WO-A1-2012/171337 (B1)

WO-A1-2011/045344 (B1)

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Hva betyr A1, B, B1, C osv? info
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