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Tittel AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS
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Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP3288940
Europeisk (EP) publiserings nummer EP3288940
EP levert
EP søknadsnummer 16723204.0
EP meddelt
Prioritet 2015.04.29, US 201562154313 P
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Janssen Pharmaceutica NV (BE)
Oppfinner BERRY, Cynthia G.B. (US) .... se mer/flere nedenfor
Fullmektig AWA NORWAY AS (NO)
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Patentkrav1. Forbindelse med formel (I):hvorX er N eller CR6;R1 er et medlem valgt fra gruppen bestående av: H, -C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-alkoksy, -(CH2)2C(=O)OCH3, -(CH2)1-3OH, -(CH2)1-2O-C1-5-alkyl, -CH(CH3)OCH3, -C(CH3)2OCH3, -CH2SO2CH3, -C(=O)H, -NH-C1-5-alkyl, -N(C1-5-alkyl)2, -C(=O)N(H)C1-5-alkyl, -C(=O)N(C1-5-alkyl)2, -C3-8-cykloalkyl, -(CH2)-C3-8-cykloalkyl, -CH(CH3)-C3-8-cykloalkyl, -NH-C3-8-cykloalkyl, -C(=O)NH-cyklopropyl, -C(=O)-NH-fenyl, -C(=O)-azetidinyl, -C(=O)-pyrrolidinyl, azetidinyl, fenyl, benzyl, oksetanyl, tetrahydrofuranyl, tetrahydropyranyl, -CH2-pyrazinyl, furanyl, tienyl og pyridinyl, hvor -C3-8-cykloalkyl-, fenyl-, oksetanyl-, azetidinyl-, tetrahydrofuranyl-, tetrahydropyranyl-, pyridinyl-, pyrazinyl-, furanyl- og tienylringene hver uavhengig er valgfritt substituert med 1-3 substituenter valgt fra gruppen bestående av: halogen, -C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-halogenalkoksy, -OH og -C(=O)OC1-5-alkyl;R2 er valgt fra gruppen bestående av:hvor hver R2 er uavhengig valgfritt substituert med et medlem valgt fra gruppen bestående av: 3H, halogen, -C1-5-alkyl, -C1-5-alkenyl, -CN, -OH, CH=CHCH2OH, -(CH2)3COH, C(=O)OC1-5-alkyl og fenyl;R3 er valgt fra gruppen bestående av: H, halogen, -C1-5-alkyl, -S-C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-alkoksy, -NR3aR3b, -OH, -(CH2)1-3OH, -CH=CHCH2OH, -C3-8-cykloalkyl, piperidinyl, piperazinyl, morfolinyl og pyridyl;hver R3a og R3b er uavhengig valgt fra gruppen bestående av H og C1-5-alkyl;R4 er valgt fra gruppen bestående av: H, halogen, -CH3 og -CF3;R5 er valgt fra gruppen bestående av: H, -OH, -C1-5-alkyl, -C1-5-alkoksy, -C1-5-halogenalkyl, -C1-5-halogenalkoksy, -NR5aR5b, azetidinyl og morfolinyl;hver R5a og R5b er uavhengig valgt fra gruppen bestående av: -C1-5-alkyl og -C1-5-halogenalkyl;R6 er valgt fra gruppen bestående av: H, -OH, -CHF2 og -Br; ogR7 er H eller -C1-5-alkyl;og farmasøytisk akseptable salter, N-oksider eller solvater derav.2. Forbindelse ifølge krav 1, hvor R6 er H.3. Forbindelse ifølge krav 1, hvora) R1 er H, -C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-alkoksy, -(CH2)2C(=O)-OCH3, -(CH2)3-OH, -C(CH3)2OCH3, -(CH2)1-2-O-C1-5-alkyl, -CH(CH3)-OCH3, -CH2SO2CH3, -NH-C1-5-alkyl, -N(C1-5-alkyl)2, -C(=O)N(H)C1-5-alkyl eller -C(=O)N(C1-5-alkyl)2; eller:b) R1 er H, -C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-alkoksy, -(CH2)3-OH, -(CH2)1-2-O-C1-5-alkyl, -C(CH3)2OCH3 eller -CH(CH3)OCH3; eller:c) R1 er -C3-8-cykloalkyl, -(CH2)-C3-8-cykloalkyl, -CH(CH3)-C3-8-cykloalkyl, NH-C3-8-cykloalkyl, -C(=O)NH-cyklopropyl, -C(=O)-NH-fenyl, -C(=O)azetidinyl, -C(=O)-pyrrolidinyl, azetidinyl, fenyl, benzyl, oksetanyl, tetrahydrofuranyl, tetrahydropyranyl, -CH2-pyrazinyl, furanyl, tienyl eller pyridinyl, hvor -C3-8-cykloalkyl-, fenyl-, oksetanyl-, azetidinyl- og pyridinylringene hver uavhengig er valgfritt substituert med 1-3 substituenter uavhengig valgt fra gruppen bestående av: halogen, -C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-halogenalkoksy, -OH og -C(=O)OC1-5-alkyl; eller:d) R1 er cyklopropyl, cyklobutyl, cyklopentyl, cykloheksyl, 1-fluorcyklopropyl, 3-fluorcyklobutyl, cyklopropanol, 2-furyl, 3-metyloksetan-3-yl, 2-tetrahydrofuran-3-yl, tetrahydropyran-4-yl, 2-tienyl, cyklopentylmetyl, pyrazin-2-ylmetyl, -C(=O)-NH-cyklopropyl, -C(=O)-NH-fenyl, -C(=O)-azetidinyl, -C(=O)-pyrrolidinyl eller NH-cykloheksyl;eller:e) R1 er -C3-8-cykloalkyl, fenyl, -CH2-fenyl eller pyridyl, hvor hvert fenyl, -CH2-fenyl eller pyridyl er valgfritt substituert med 1-3 substituenter uavhengig valgt fra gruppen bestående av: halogen, -C1-5-alkyl, -C1-5-halogenalkyl, -C1-5-halogenalkoksy og -OH; eller:f) R1 er fenyl, 2-klorfenyl, 4-fluorfenyl, 4-(difluormetyl)fenyl, 4-(trifluormetyl)fenyl, 4-(trifluormetoksy)fenyl, 4-fluor-3-metyl-fenyl, p-tolyl, mtolyl, pyridyl, 2-klor-4-pyridyl, 2-brom-4-pyridyl, 2-fluor-4-pyridyl, 2-[19F]fluor-4-pyridyl, 2-[18F]fluor-4-pyridyl, 5-fluor-2-pyridyl, 6-fluor-3-pyridyl eller pyridin-2-ol; eller:g) R1 er -C1-5-alkyl, -C1-5,halogenalkyl eller -C3-8-cykloalkyl, hvor -C3-8-cykloalkylet er valgfritt substituert med halogen.4. Forbindelse ifølge krav 1, hvor:a) R2 erhvor hver R2 er uavhengig valgfritt substituert med et medlem valgt fra gruppen bestående av: halogen, -C1-5-alkyl, -C1-5-alkenyl, -CN, -OH,CH=CHCH2OH, -(CH2)3COH, C(=O)C1-5-alkyl og fenyl; eller:b) R2 erhvor hver R2 er uavhengig valgfritt substituert med et medlem valgt fra gruppen bestående av: halogen, -C1-5-alkyl, -C1-5-alkenyl, -CN, -OH,CH=CHCH2OH, -(CH2)3COH, C(=O)OC1-5-alkyl og fenyl; ogR7 er H eller -CH3; eller:c) R2 erhvor hver R2 er uavhengig valgfritt substituert med et medlem valgt fra gruppen bestående av: halogen, -C1-5-alkyl, -C1-5-alkenyl, -CN, -OH, CH=CHCH2OH, -(CH2)3COH, C(=O)OC1-5-alkyl og fenyl; og R7 er H eller -CH3; eller:d) R2 er 1H-indazol-3-ol, 1H-indazol-5-yl, 1H-indazol-6-yl, 3-brom-1H-indazol-5-yl, 3-fluor-1H-indazol-5-yl, 1H-indazol-3-karbonitril, (E)-3-(1H-indazol-7-yl)-prop-2-en-1-ol, (1H-indazol-7-yl)propan-1-ol, 4-klor-1H-indazol-6-yl, 4-metyl-1H-indazol-6-yl, 7-brom-1H-indazol-5-yl, 7-fenyl-1H-indazol-5-yl, 7-propyl-1H-indazol-5-yl, 5-metyl 1H-indazol-7-karboksylat, tert-butyl-1H-indazol-1-karboksylat, 1H-indol-5-yl, 1H-pyrrolo[2,3-b]pyridin-5-yl eller 1H-pyrazolo-[3,4-b]pyridin-5-yl; eller: e) R2 er indolin-2-on, 7-metylindolin-2-on, 7-fluorindolin-2-on, 7-klorindolin-2-on, indolin-2,3-dion, 1,3-dihydropyrrolo[2,3-b]pyridin-2-on, 1,3-dihydrobenzimidazol-2-on, 3H-1,3-benzoksazol-2-on, 4-fluor-3H-1,3-benzoksazol-2-on, 4-brom-3H-1,3-benzoksazol-2-on, 3H-1,3-benzotiazol-2-on, 4-metyl-3H-1,3-benzotiazol-2-on, 3-metylbenzo[d]tiazol-2(3H)-on eller 4-klor-3H-1,3-benzotiazol-2-on; eller:f) R2 er 1H-indazol-3-ol, 1H-indazol-5-yl, 3-brom-1H-indazol-5-yl, 3-fluor-1H-indazol-5-yl, 1H-indazol-3-karbonitril, (E)-3-(1H-indazol-7-yl)prop-2-en-1-ol, (1H-indazol-7-yl)propan-1-ol, 7-brom-1H-indazol-5-yl, 7-fenyl-1H-indazol-5-yl, 7-propyl-1H-indazol-5-yl, 5-metyl 1H-indazol-7-karboksylat, tert-butyl-1H-indazol-1-karboksylat, indolin-2-on, 7-metylindolin-2-on, 7-fluorindolin-2-on, 7-klorindolin-2-on, 3H-1,3-benzotiazol-2-on, 4-metyl-3H-1,3-benzotiazol-2-on, 3-metylbenzo[d]tiazol-2(3H)-on eller 4-klor-3H-1,3-benzotiazol-2-on.5. Forbindelse ifølge krav 1, hvor R3 er H, halogen, -C1-5-alkyl, -C1-5-halogenalkyl, -OCH3, -NH2, -N(CH3)2 eller -OH.6. Forbindelse ifølge krav 1, hvor R4 er H, fluor eller -CH3.7. Forbindelse ifølge krav 1, hvor R5 er H, -OH, -C1-5-alkyl, -C1-5-halogenalkyl eller -C1-5-halogenalkoksy; fortrinnsvis hvor R5 er H.8. Forbindelse ifølge krav 1, hvor R6 er H.9. Forbindelse ifølge krav 1, hvor R7 er H.10. Forbindelse ifølge krav 1, hvor:a) X er N;R1 er H, C1-5-alkyl, C1-5-halogenalkyl, C1-5-alkoksy, fenyl eller C3-8-cykloalkyl, hvor C3-8-cykloalkylet og fenylet hver uavhengig er valgfritt substituert med 1-3 halogensubstituenter;R2 er R3 er H, C1-5-alkyl eller C1-5-halogenalkyl; eller:b) X er CR6, hvor R6 er H;R1 er H, C1-5-alkyl, C1-5-halogenalkyl, C1-5-alkoksy, fenyl eller C3-8-cykloalkyl, hvor C3-8-cykloalkylet og fenylet hver uavhengig er valgfritt substituert med 1-3 halogensubstituenter;R2 erhver R2 er uavhengig valgfritt substituert med halogen og -C1-5-alkyl;R3 er H, C1-5-alkyl eller C1-5-halogenalkyl; ogR4 er H.11. Forbindelse valgt fraa) gruppen bestående av:3-(1H-Indazol-5-yl)-2-fenyl-5-(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-fenylimidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-5-metyl-2-fenylimidazo[4,5-b]pyridin; 2-(4-Fluorfenyl)-3-(1H-indazol-5-yl)-5-metylimidazo[4,5-b]pyridin;2-(4-Fluorfenyl)-3-(1H-indol-5-yl)-5-metoksyimidazo[4,5-b]pyridin;5-[2-(4-Fluorfenyl)-5-metoksyimidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-Klor-2-(4-fluorfenyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;2-(2-Klorfenyl)-3-(1H-indazol-5-yl)-5-metylimidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-6-metyl-2-fenylimidazo[4,5-b]pyridin;5-Klor-3-(1H-indazol-5-yl)-2-fenylimidazo[4,5-b]pyridin;5-Klor-2-cyklopentyl-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;tert-Butyl-5-(5-metyl-2-fenylimidazo[4,5-b]pyridin-3-yl)indazol-1-karboksylat;3-(1H-Indol-5-yl)-2-fenyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;6-[2-Fenyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(5-Fluor-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-[2-(4-Fluorfenyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(5-Metyl-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-(5-Metoksy-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-[2-tert-Butyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-(4-Fluorfenyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;5-[2-(4-Fluorfenyl)imidazo[4,5-b]pyridin-3-yl]-1,3-dihydrobenzimidazol-2-on; 2-(4-Fluorfenyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;5-[2-(4-Fluorfenyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;6-[2-(4-Fluorfenyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;6-(2-Fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;3-(1H-Indol-5-yl)-2-fenylimidazo[4,5-b]pyridin;6-[2-(4-Fluorfenyl)-5-metylimidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-(6-Fluor-3-pyridyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-(2-Fluor-4-pyridyl)-5-metylimidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[5-Klor-2-(4-fluorfenyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-(2-Fluor-4-pyridyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(5-Brom-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;5-[2-(4-Fluorfenyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-(2-Fenylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;5-[2-(4-Fluorfenyl)-5-metylimidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Fenyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[5-Fluor-2-(4-fluorfenyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on; 6-[2-Cyklopentyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-Cykloheksyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-Cyklopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-Tetrahydropyran-4-yl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;2-Cyklopropyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;6-[2-Etyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-Isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-Metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;5-[2-Metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Cykloheksyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Cyklobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Tetrahydropyran-4-yl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Isobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;(racemisk)-5-[2-Tetrahydrofuran-3-yl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[5-(Trifluormetyl)-2-(3,3,3-trifluorpropyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on; 5-[2-(Cyklopentylmetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Cyklopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Benzyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-(Pyrazin-2-ylmetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;2-Cyklopentyl-3-(1H-indol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-tert-Butyl-3-(1H-indol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[2-Cyklopentyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-tert-Butyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;4-[2-(4-Fluorfenyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin-7-yl]morfolin;5-[2-(4-Fluorfenyl)-7-morfolinimidazo[4,5-b]pyridin-3-yl]indolin-2-on;6-[2-Fenyl-5-(1-piperidyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(5-Morfolin-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-[5-(Dimetylamino)-2-fenylimidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(5-(Difluormetyl)-2-fenyl-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]tiazol-2(3H)-on;6-[2-[4-(Difluormetyl)fenyl]imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[7-(Difluormetyl)-2-fenylimidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(7-Isopropyl-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on; 6-(2-(4-Fluorfenyl)-5-(hydroksymetyl)-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]-tiazol-2(3H)-on;6-(2-(4-Fluorfenyl)-7-hydroksy-5-metyl-3H-imidazo[4,5-b]pyridin-3-yl)benzo-[d]tiazol-2(3H)-on;5-(2-(3-Hydroksypropyl)-5-(trifluormetyl)-3H-imidazo[4,5-b]pyridin-3-yl)-indolin-2-on;5-(2-Cyklobutyl-5-metylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;5-(2-Etyl-5-metylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;5-[2-(3-Metyloksetan-3-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-(2-Metoksyetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;2-Cyklobutyl-5-cyklopropyl-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;5-Cyklopropyl-3-(1H-indazol-5-yl)-2-isopropylimidazo[4,5-b]pyridin;6-[2-Cyklobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;Azetidin-1-yl-[3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]-metanon;6-[5-Amino-2-(4-fluorfenyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;5-[2-(1-Etylpropyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-(2-Isopropyl-5-metylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;3-(1H-Indazol-5-yl)-N-fenyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-karboksamid; 5-Cyklopropyl-2-(4-fluorfenyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;5-(2-Cyklopropyl-5-metylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;3-(1H-Indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;2-(Difluormetyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-(2-tienyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-(2-Furyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[2-(1,1-Difluoretyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-(Difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-(5-Klor-2-cyklopropylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;(racemisk)-5-[2-sec-Butyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-(2,2-Dimetylpropyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;3-(1H-Indazol-5-yl)-2-metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[2-Etyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;(racemisk)-3-(1H-Iindazol-5-yl)-2-tetrahydrofuran-3-yl-5-(trifluormetyl)-imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-isobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;(racemisk)-3-(1H-Indazol-5-yl)-2-sec-butyl-5-(trifluormetyl)imidazo[4,5-b]-pyridin; 2-Cyklobutyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-Cyklopentyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-Etyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[2-Cyklopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1,3-dihydrobenzimidazol-2-on;6-[2-Cyklopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;2-tert-Butyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-(4-Fluorfenyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;6-(5-Hydroksy-2-fenylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;2-(4-Fluorfenyl)-3-(1H-pyrazolo[3,4-b]pyridin-5-yl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-(2,2,2-trifluoretyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-Etoksy-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;1-[3-(1H-Indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]-cyklopropanol;2-(1,1-Difluoretyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;(R/S)-2-(1-fluoretyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-tert-Butyl-2-(4-fluorfenyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;2-Cyklobutyl-3-(1H-indazol-5-yl)-5-isopropylimidazo[4,5-b]pyridin;2-(4-Fluorfenyl)-3-(1H-indazol-5-yl)-5-isopropylimidazo[4,5-b]pyridin; 2-(4-Fluor-3-metyl-fenyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;3-(1H-Indazol-5-yl)-2-(m-tolyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-(p-tolyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-(4-pyridyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-Cyklopropyl-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-N,N-dimetyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-karboksamid;3-(1H-Indazol-5-yl)-N-metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-karboksamid;N-Cyklopropyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-karboksamid;3-(1H-Indazol-5-yl)-2-metoksy-5-(trifluormetyl)imidazo[4,5-b]pyridin;N-Etyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-amin;N-Cykloheksyl-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-amin;6-[2-Cyklobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(2-Cyklobutyl-5-metyl-7-morfolinimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(2-Cyklopropyl-7-metylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on; 6-(2-Cyklopropyl-5-metyl-7-morfolinimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;5-Klor-2-cyklobutyl-3-(1H-indazol-5-yl)-7-metylimidazo[4,5-b]pyridin;3-(7-Brom-1H-indazol-5-yl)-2-cyklobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[5-Metyl-2-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Cyklopropyl-5-(difluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[5-(Difluormetyl)-2-isopropylimidazo[4,5-b]pyridin-3-yl]indolin-2-on;6-[5-Metyl-2-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-(2-Cyklopropyl-5-metylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-(2-Isopropyl-5-metylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;6-(2-Cyklobutyl-5-metylimidazo[4,5-b]pyridin-3-yl)-3H-1,3-benzotiazol-2-on;5-[2-(1,1-Difluoretyl)-5-metylimidazo[4,5-b]pyridin-3-yl]indolin-2-on;2-Cyklopropyl-3-(1H-indazol-5-yl)-5-metylimidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-isopropyl-5-metylimidazo[4,5-b]pyridin;2-Cyklobutyl-3-(1H-indazol-5-yl)-5-metylimidazo[4,5-b]pyridin;6-[2-(1,1-Difluoretyl)-5-metylimidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;3-(1H-Indazol-5-yl)-5-metyl-2-(trifluormetyl)imidazo[4,5-b]pyridin;2-(1,1-Difluoretyl)-3-(1H-indazol-5-yl)-5-metylimidazo[4,5-b]pyridin;5-[5-(Difluormetyl)-2-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on; 5-[2-(1,1-Difluoretyl)-5-(difluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;2-(4-Fluorfenyl)-3-(1H-indol-5-yl)-5-metylsulfanylimidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-fenylimidazo[4,5-b]pyridin-5-ol;2-Cyklopropyl-3-(1H-indazol-5-yl)-5-metoksyimidazo[4,5-b]pyridin;6-[2-Etyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;6-[2-Isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;6-[2-Tetrahydropyran-4-yl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;(R/S)-6-[2-Tetrahydrofuran-3-yl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;6-[2-(Etoksymetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;6-[2-tert-Butyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;5-[2-(2-Fluor-4-pyridyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;2-(2-Fluor-4-pyridyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[2-(3-Fluorcyklobutyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;(R)-3-(1H-Indazol-5-yl)-2-sec-butyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;(S)-3-(1H-Indazol-5-yl)-2-sec-butyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-(5-Fluor-2-pyridyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin; 3-(1H-Indazol-5-yl)-5-isopropyl-2-(trifluormetyl)imidazo[4,5-b]pyridin;5-tert-Butyl-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-N-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-karboksamid;[3-(1H-Indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]-pyrrolidin-1-ylmetanon;2-(4-Fluorfenyl)-3-(1H-indol-5-yl)imidazo[4,5-b]pyridin;4-[2-(4-Fluorfenyl)-3-(1H-indol-5-yl)imidazo[4,5-b]pyridin-7-yl]morfolin;3-(1H-Indazol-5-yl)-2-[4-(trifluormetyl)fenyl]imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-2-[4-(trifluormetoksy)fenyl]imidazo[4,5-b]pyridin;5-[2-[4-(Trifluormetyl)fenyl]imidazo[4,5-b]pyridin-3-yl]indolin-2-on;tert-Butyl-3-[3-(2-oksoindolin-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]-azetidin-1-karboksylat;5-[2-(Azetidin-3-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-(2,5-Dimetylimidazo[4,5-b]pyridin-3-yl)indolin-2-on;2-Cyklopentyl-3-(1H-indol-5-yl)-5-piperazin-1-ylimidazo[4,5-b]pyridin;Metyl-3-[3-(2-oksoindolin-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]-propanoat;3-(7-Brom-1H-indazol-5-yl)-2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;6-(2-Cyklobutyl-5-(trifluormetyl)-3H-imidazo[4,5-b]pyridin-3-yl)-3-metylbenzo-[d]tiazol-2(3H)-on; 3-(7-3H-1H-indazol-5-yl)-2-isopropyl-5-(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;3-(7-Brom-1H-indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Fenyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin;2,5-bis(trifluormetyl)-3-(7-vinyl-1H-indazol-5-yl)-3H-imidazo[4,5-b]pyridin;6-(5-(Trifluormetyl)-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]tiazol-2(3H)-on;3-(3-Fluor-1H-indazol-5-yl)-2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-Klor-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;5-Etyl-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-(4-Fluorfenyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;2-Etoksy-3-(3-fluor-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-Cyklopropyl-3-(3-fluor-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;2-Isopropyl-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-isopropylimidazo[4,5-b]pyridin;3-(1H-indazol-5-yl)-7-metyl-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-7-metyl-2-(trifluormetyl)imidazo[4,5-b]pyridin;7-Metyl-3-(7-metyl-1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin; 3-(1H-pyrazolo[3,4-b]pyridin-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Oksido-1H-pyrazolo[3,4-b]pyridin-7-ium-5-yl)-2,5-bis(trifluormetyl)-imidazo[4,5-b]pyridin;6-[5-(difluormetyl)-2-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;3-(7-Klor-1H-indazol-5-yl)-2,5-bis(difluormetyl)imidazo[4,5-b]pyridin;5-Cyklobutyl-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;5-(2-Etyl-5-metylimidazo[4,5-b]pyridin-3-yl)indolin-2,3-dion;5-(Difluormetyl)-3-(1H-indazol-5-yl)-2-isopropylimidazo[4,5-b]pyridin;5-(1,1-Difluoretyl)-3-(1H-indazol-5-yl)-2-isopropylimidazo[4,5-b]pyridin;2,5-bis(difluormetyl)-3-(7-metyl-1H-indazol-5-yl)imidazo[4,5-b]pyridin;2-(2-Fluor-4-pyridyl)-5-metyl-3-(7-metyl-1H-indazol-5-yl)imidazo[4,5-b]-pyridin;N-(2-Fluoretyl)-2-isopropyl-N-metyl-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-7-amin;5-[2-(2-Fluor-4-pyridyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2,3-dion;Metyl-3-[3-(2,3-dioksoindolin-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]-propanoat;2-(2-Fluor-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-7-(2-fluoretoksy)-2,5-bis(trifluormetyl)imidazo-[4,5-b]pyridin; (E)-3-(5-(2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin-3-yl)-1H-indazol-7-yl)prop-2-en-1-ol;3-(5-(2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin-3-yl)-1H-indazol-7-yl)-propan-1-ol;3-(7-Propyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin;(E)-3-(3-(7-Metyl-1H-indazol-5-yl)-2-(trifluormetyl)-3H-imidazo[4,5-b]pyridin-5-yl)prop-2-en-1-ol;3-(3-(7-Metyl-1H-indazol-5-yl)-2-(trifluormetyl)-3H-imidazo[4,5-b]pyridin-5-yl)-propan-1-ol;3-(7-Metyl-1H-indazol-5-yl)-5-propyl-2-(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;4-[3-(1H-Indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-yl]pyridin-2-ol;3-(1H-Indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-cyklopropyl-5-(difluormetyl)imidazo[4,5-b]pyridin;5-(Difluormetyl)-2-(4-fluorfenyl)-3-(7-metyl-1H-indazol-5-yl)imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-5-(difluormetyl)-2-(4-fluorfenyl)imidazo[4,5-b]-pyridin;6-[7-Morfolin-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;4-[3-(1H-Indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-7-yl]-morfolin;2-(1,1-Difluorpropyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin; 6-[2-(1,1,2,2,2-Pentafluoretyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-(Difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-(Difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzoksazol-2-on;3-(3-Fluor-1H-indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;5-(Difluormetyl)-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;6-[2-Metoksy-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;6-[2-Etoksy-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;2-Metoksy-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-Etoksy-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;5-[2-Etoksy-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Metoksy-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;3-(1H-indazol-5-yl)-2-(metylsulfonylmetyl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;2-(3-Fluorcyklobutyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-(3-Fluorcyklobutyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin; 3-(7-Klor-1H-indazol-5-yl)-2-(3-fluorcyklobutyl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(3-fluorcyklobutyl)-5-metylimidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(3-fluorcyklobutyl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;2-(1-Metoksy-1-metyl-etyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)-imidazo[4,5-b]pyridin;2-(1,1-Difluoretyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;2-(1-Fluor-1-metyl-etyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(1-fluor-1-metyl-etyl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-Cyklopropyl-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;(*R)-2-(1-Fluoretyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;(*S)-2-(1-Fluoretyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(1-fluorcyklopropyl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-(1-Fluorcyklopropyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;3-(1H-Indazol-5-yl)-N-isopropyl-N-metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-2-karboksamid; 2-(2-Klor-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-(2-Brom-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;5-(Difluormetyl)-2-(2-fluor-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-5-(difluormetyl)-2-(2-fluor-4-pyridyl)imidazo[4,5-b]-pyridin;3-(4-Klor-1H-indazol-6-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;6-[2-(1,1-Difluoretyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on;3-(7-Klor-1H-indazol-5-yl)-2-(1,1-difluoretyl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-5-metyl-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-5-(difluormetyl)-2-isopropylimidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-klor-indolin-2-on;7-Klor-5-[2-(difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-(Difluormetyl)-2-isopropyl-3-(7-metyl-1H-indazol-5-yl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-5-(difluormetyl)-2-metylimidazo[4,5-b]pyridin;5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-metylindolin-2-on; 5-[2-(1,1-Difluoretyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-metylindolin-2-on;3-(7-Klor-1H-indazol-5-yl)-2-(difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(difluormetyl)-5-metylimidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-6-fluor-2-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Brom-1H-indazol-5-yl)-2-(difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-4-metyl-3H-1,3-benzotiazol-2-on;6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-4-klor-3H-1,3-benzotiazol-2-on;6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-4-fluor-3H-1,3-benzoksazol-2-on;Metyl-5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1H-indazol-7-karboksylat;Metyl-5-[2-(difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1H-indazol-7-karboksylat;2-(Difluormetyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;5-[2-(Difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-metylindolin-2-on;5-[2-(Difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-fluorindolin-2-on;3-(4-Metyl-1H-indazol-6-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin; 6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-4-brom-3H-1,3-benzoksazo1-2-on;3-(1H-Indazol-6-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1,3-dihydropyrrolo[2,3-b]-pyridin-2-on;3-(1H-Pyrrolo[2,3-b]pyridin-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Metyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin;5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1H-indazol-3-karbonitril;5-[2-(Difluormetyl)-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1H-indazol-3-ol;6-[2-Cyklopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;3-(3-Brom-1H-indazol-5-yl)-2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;7-Klor-5-[2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;3-(7-Klor-1H-indazol-5-yl)-6-fluor-2-isopropylimidazo[4,5-b]pyridin;5-[2-Isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-1,3-dihydropyrrolo-[2,3-b]pyridin-2-on;2-Isopropyl-3-(1H-pyrazolo[3,4-b]pyridin-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;2-Isopropyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin;3-(7-Allyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(7-(Prop-1-en-2-yl)-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo-[4,5-b]pyridin; 3-(7-Klor-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-cyklopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-cyklobutyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;7-Metyl-5-[2-metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;5-[2-Isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-metylindolin-2-on;2-Isopropyl-3-(4-metyl-1H-indazol-6-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;7-Klor-5-[2-metyl-5-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;3-(7-Klor-1H-indazol-5-yl)-2-etyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;2-Etyl-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(7-Metyl-1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;7-Metyl-5-[2-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on;2-Metyl-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]pyridin;3-(1H-Indazol-5-yl)-5-(2-pyridyl)-2-(trifluormetyl)imidazo[4,5-b]pyridin;2-Cyklopropyl-5-(difluormetyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;5-(Difluormetyl)-2-(4-fluorfenyl)-3-(1H-indazol-5-yl)imidazo[4,5-b]pyridin;5-(Difluormetyl)-3-(1H-indazol-5-yl)-2-fenylimidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-5-(difluormetyl)-2-(trifluormetyl)imidazo[4,5-b]-pyridin; 5-[5-(Difluormetyl)-2-(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-7-fluorindolin-2-on;5-(Difluormetyl)-3-(7-metyl-1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(2-fluor-4-pyridyl)-5-metylimidazo[4,5-b]pyridin;3-(7-Brom-1H-indazol-5-yl)-2-(2-fluor-4-pyridyl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;5-(2-(Hydroksymetyl)-6-(trifluormetyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;(1-(1H-Indazol-5-yl)-6-(trifluormetyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)metanol;7-Metyl-5-(2-metyl-6-(trifluormetyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;5-(2-Isopropyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metyl-1H-indazol;1-(7-Klor-1H-indazol-5-yl)-2-metylpyrrolo[2,3-b]pyridin;5-[6-(Difluormetyl)-2-isopropylpyrrolo[2,3-b]pyridin-1-yl]-7-metylindolin-2-on;1-(1H-Indazol-5-yl)-2-isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;5-[2-(Difluormetyl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-7-metylindolin-2-on;6-[2-(Difluormetyl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-3H-1,3-benzotiazol-2-on;7-Klor-5-(2-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;1-(7-Metyl-1H-indazol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-3-ol;3-(Difluormetyl)-1-(7-metyl-1H-indazol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]-pyridin; 6-Metyl-1-(7-metyl-1H-indazol-5-yl)pyrrolo[2,3-b]pyridin;5-(2-Isopropyl-6-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;2-(4-Fluorfenyl)-1-(1H-indol-5-yl)-6-metoksy-pyrrolo[2,3-b]pyridin;2-(4-Fluorfenyl)-1-indolin-5-ylpyrrolo[2,3-b]pyridin;2-(4-Fluorfenyl)-1-(1H-indol-5-yl)pyrrolo[2,3-b]pyridin;5-[3-Brom-2-(4-fluorfenyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[2-(4-Fluorfenyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;6-Fluor-2-(4-fluorfenyl)-1-(1H-indol-5-yl)pyrrolo[2,3-b]pyridin;5-[3-Brom-6-fluor-2-(4-fluorfenyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[6-Fluor-2-(4-fluorfenyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;1-(1H-Indol-5-yl)-2-metyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;5-[2-Metyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;7-Metyl-5-(2-metyl-1H-pyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;5-(2-Metyl-6-(trifluormetyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-1H-indazol;6-(2-Metyl-6-(trifluormetyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)benzo[d]tiazol-2(3H)-on;1-(7-Klor-1H-indazol-5-yl)-2-isopropylpyrrolo[2,3-b]pyridin;7-Klor-5-(2-isopropylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;5-(2-Isopropylpyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;5-(2-Cyklopropylpyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on; 5-(2-Isopropyl-6-metylpyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;7-Fluor-5-(2-isopropylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;7-Fluor-5-(2-isopropyl-6-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;7-Fluor-5-(2-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;7-Fluor-5-[2-metyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;(RS)-7-Fluor-5-[2-tetrahydrofuran-3-yl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;7-Fluor-5-[2-(metoksymetyl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[2-Isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-7-metylindolin-2-on;(RS)-5-[2-(1-Metoksyetyl)pyrrolo[2,3-b]pyridin-1-yl]-7-metylindolin-2-on;7-Fluor-5-[2-isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;2-Isopropyl-1-(7-metyl-1H-indazol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;2-(3-Fluorpropyl)-1-(7-metyl-1H-indazol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]-pyridin;1-(7-Klor-1H-indazol-5-yl)-2-(3-fluorpropyl)-6-(trifluormetyl)pyrrolo[2,3-b]-pyridin;2-Metyl-1-(7-metyl-1H-indazol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;1-(7-Klor-1H-indazol-5-yl)-2-metyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;2-Metyl-1-(7-metyl-1H-indazol-5-yl)pyrrolo[2,3-b]pyridin;5-[2-Isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-1H-pyrazolo[3,4-b]-pyridin; 1-(7-Metyl-1H-indazol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;7-Metyl-5-(6-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;7-Fluor-5-(6-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;5-(2-Cyklopropyl-6-metylpyrrolo[2,3-b]pyridin-1-yl)indolin-2-on;2-(4-Fluorfenyl)-1-(1H-indol-5-yl)-6-metylpyrrolo[2,3-b]pyridin;5-[2-(4-Fluorfenyl)-6-metylpyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[6-Klor-2-(4-fluorfenyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[2-(4-Fluorfenyl)-6-metoksypyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;6-Klor-2-(4-fluorfenyl)-1-(1H-indol-5-yl)pyrrolo[2,3-b]pyridin;6-tert-Butoksy-2-(4-fluorfenyl)-1-(1H-indol-5-yl)pyrrolo[2,3-b]pyridin;2-(4-Fluorfenyl)-1-(1H-indol-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;1-(1H-Indol-5-yl)-2-fenyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;5-[3-Brom-2-cyklopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;6-Metyl-2-fenyl-1-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,3-b]pyridin;2-Isopropyl-1-(1H-pyrrolo[2,3-b]pyridin-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]-pyridin;2-Metyl-1-(1H-pyrrolo[2,3-b]pyridin-5-yl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin;5-(3-Brom-6-metyl-2-fenylpyrrolo[2,3-b]pyridin-1-yl)-1,3-dihydropyrrolo-[2,3-b]pyridin-2-on; 5-[3-Brom-2-isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-1,3-dihydropyrrolo[2,3-b]pyridin-2-on;5-[3-Brom-2-metyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-1,3-dihydropyrrolo[2,3-b]pyridin-2-on;5-[2-Isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[2-Fenyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[2-(4-Fluorfenyl)-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-[2-Cyklopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on;5-(6-Metyl-2-fenylpyrrolo[2,3-b]pyridin-1-yl)-1,3-dihydropyrrolo[2,3-b]pyridin-2-on;5-[2-Isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-1,3-dihydropyrrolo-[2,3-b]pyridin-2-on;5-[2-Metyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-1,3-dihydropyrrolo-[2,3-b]pyridin-2-on;5-(2-Etylpyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;(*R)-2-(sec-Butyl)-3-(7-klor-1H-indazol-5-yl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;(*S)-2-(sec-Butyl)-3-(7-klor-1H-indazol-5-yl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;(*R)-2-(sec-Butyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;(*S)-2-(sec-Butyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin; (*R)-3-(7-Klor-1H-indazol-5-yl)-2-(1-fluoretyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;(*S)-3-(7-Klor-1H-indazol-5-yl)-2-(1-fluoretyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(1,1-difluoretyl)-5-metyl-3H-imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(cyklopropylmetyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-propyl-5-(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(metoksymetyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-isobutyl-5-(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-5-metoksy-2-(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(2,2,2-trifluoretyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;2-(1,1-Difluorpropyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Metyl-1H-indazol-5-yl)-5-(trifluormetyl)-2-(3,3,3-trifluorpropyl)-3H-imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2,6-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin;5-(5-Fluor-2-isopropyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;5-(6-(Difluormetyl)-2-metyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on; 1-(7-Metyl-2-oksoindolin-5-yl)-6-(trifluormetyl)-1H-pyrrolo[2,3-b]pyridin-2-karbaldehyd;2-(2-Klor-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-(2-Brom-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-(2-19Fluor-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;2-(2-[18F]fluor-4-pyridyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin;og farmasøytisk akseptable salter derav; eller:b) gruppen bestående av:3-(7-Etyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(7-Isopropyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin;5-(2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]pyridin-3-yl)-1H-indazol-7-karbonitril;3-(7-Klor-1H-indazol-5-yl)-2-isopropyl-6-(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-6-metyl-2-(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-7-metyl-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;7-Metyl-3-(7-metyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]-pyridin; 3-(7-Klor-1H-indazol-5-yl)-2-isopropyl-7-metyl-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-7-metoksy-2,5-bis(trifluormetyl)-3H-imidazo[4,5-b]-pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(1-cyklopropyletyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(1-metylcyklopropyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;3-(7-Metyl-1H-indazol-5-yl)-2-(1-metylcyklopropyl)-5-(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-2-(1-metoksyetyl)-5-(trifluormetyl)-3H-imidazo-[4,5-b]pyridin;6-Klor-3-(7-klor-1H-indazol-5-yl)-2-(trifluormetyl)-3H-imidazo[4,5-b]pyridin;3-(7-Klor-1H-indazol-5-yl)-5-(trifluormetyl)-2-(1,1,1-trifluorpropan-2-yl)-3H-imidazo[4,5-b]pyridin;5-(4-(Dimetylamino)-2-metyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;5-(4-(Azetidin-1-yl)-2-metyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;5-(4-Metoksy-2-metyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on; og5-(2,4-Dimetyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-metylindolin-2-on;og farmasøytisk akseptable salter, N-oksider eller solvater derav.12. Forbindelse ifølge krav 11, hvor forbindelsen er: a) 5-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]indolin-2-on, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:b) 2-(Difluormetyl)-3-(1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:c) 3-(1H-Indazol-5-yl)-2-isopropyl-5-(trifluormetyl)imidazo[4,5-b]pyridin, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:d) 6-[2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin-3-yl]-3H-1,3-benzotiazol-2-on, og farmasøytisk akseptable salter, N-oksider eller solvater derav eller:e) 2-Isopropyl-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo[4,5-b]-pyridin, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:f) 2-(Difluormetyl)-3-(7-metyl-1H-indazol-5-yl)-5-(trifluormetyl)imidazo-[4,5-b]pyridin, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:g) 3-(7-Metyl-1H-indazol-5-yl)-2,5-bis(trifluormetyl)imidazo[4,5-b]pyridin, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:h) 7-Fluor-5-[2-isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]indolin-2-on, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:i) 5-(Difluormetyl)-3-(1H-indazol-5-yl)-2-(trifluormetyl)imidazo[4,5-b]-pyridin, og farmasøytisk akseptable salter, N-oksider eller solvater derav; eller:j) 5-[2-Isopropyl-6-(trifluormetyl)pyrrolo[2,3-b]pyridin-1-yl]-7-metylindolin-2-on, og farmasøytisk akseptable salter, N-oksider eller solvater derav.13. Farmasøytisk sammensetning omfattende:(A) en virksom mengde av minst én forbindelse ifølge krav 1; eller et farmasøytisk akseptabelt salt, N-oksid eller solvat derav; og(B) minst én farmasøytisk akseptabel eksipiens. 14. Farmasøytisk sammensetning omfattende en virksom mengde av minst én forbindelse ifølge krav 12 i) eller 12 j) og minst én farmasøytisk akseptabel eksipiens.15. Forbindelse ifølge krav 1; eller et farmasøytisk akseptabelt salt, N-oksid eller solvat derav av forbindelser med formel (I), for anvendelse ved behandling av et individ som lider av eller er blitt diagnostisert med en sykdom, forstyrrelse eller medisinsk tilstand som medieres av AMPA-receptoraktivitet, hvilken behandling omfatter å administrere en virksom mengde av forbindelsen med formel (I) til et individ som har behov for slik behandling; hvor:a) den AMPA-receptormedierte sykdom, forstyrrelse eller medisinske tilstand er valgt fra cerebral iskjemi, hodeskade, ryggradskade, Alzheimers sykdom, Parkinsons sykdom, amyotrofisk lateral sklerose (ALS), Huntingtons korea, AIDS nerveforstyrrelse, epilepsi, mental forstyrrelse, mobilitetsforstyrrelse, smerte, spastisitet, nerveforstyrrelse av toksin i mat, forskjellige neurodegenerative sykdommer, forskjellige mentale sykdommer, kronisk smerte, migrene, kreftsmerter, diabetisk neuropati, encefalitt, akutt spredt encefalogenmyelitt, akutt demyelinerende polyneuropati (Guillain Barre-syndrom), kronisk inflammatorisk demyelinerende polyneuropati, multippel sklerose, Marchifava-Bignami-sykdom, sentral pontin myelinolyse, Devic-syndrom, Balo-sykdom, HIV- eller HTLV-myelopati, progressiv multifokal leucoencefalogenpati, en sekundær demyelinerende forstyrrelse (for eksempel CNS-lupus erythematoder, polyarteritt nodosa, Sjogren-syndrom, sarkoidose og isolert cerebral vaskulitt), schizofreni, prodromal schizofreni, kognitiv forstyrrelse, depresjon, angstforstyrrelser, engstelig depresjon og bipolar forstyrrelse; eller:b) den AMPA-receptormedierte sykdom, forstyrrelse eller tilstand er depresjon, post-traumatisk stressforstyrrelse, epilepsi, schizofreni, prodromal schizofreni eller en kognitiv forstyrrelse.
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BERRY, Cynthia G.B.
3210 Merryfield Row San Diego, California 92121 US
CHEN, Gang
3210 Merryfield Row San Diego, California 92121 US
JOURDAN, Fabrice Loic
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LEBOLD, Terry Patrick
3210 Merryfield Row San Diego, California 92121 US
LIN, David Wei
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PENA PIÑÓN, Miguel Angel
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RAVULA, Suchitra
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SAVALL, Bradley M.
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SWANSON, Devin M.
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WU, Dongpei
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ZHANG, Wei
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AMERIKS, Michael K.
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MACOR J E ET AL: "The discovery of a novel and potent benzodiazepine receptor pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 5, no. 20, 19 October 1995 (1995-10-19), pages 2397-2402, XP004135272, ISSN: 0960-894X, DOI: 10.1016/0960-894X(95)00418-S (B1)

WO-A2-00/01376 (B1)

WO-A2-2011/156245 (B1)

WO-A2-2010/005528 (B1)

WO-A2-2007/135529 (B1)

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Hva betyr A1, B, B1, C osv? info
Kapitler uten data er fjernet. Melding opprettet: 29.04.2025 06:31:18