JODI L MCBRIDE ET AL: "Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease", MOLECULAR THERAPY, vol. 19, no. 12, 25 December 2011 (2011-12-25), pages 2152-2162, XP055192172, ISSN: 1525-0016, DOI: 10.1038/mt.2011.219 cited in the application (B1)

MCBRIDE JODI L ET AL: "Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 105, no. 15, 15 April 2008 (2008-04-15), pages 5868-5873, XP002513712, ISSN: 0027-8424, DOI: 10.1073/PNAS.0801775105 (B1)

NICHOLAS R FRANICH ET AL: "AAV Vector-mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease", MOLECULAR THERAPY, vol. 16, no. 5, 25 March 2008 (2008-03-25) , pages 947-956, XP055192031, ISSN: 1525-0016, DOI: 10.1038/mt.2008.50 (B1)

RODRIGUEZ-LEBRON ET AL: "Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 12, no. 4, 12 July 2005 (2005-07-12), pages 618-633, XP005078441, ISSN: 1525-0016, DOI: 10.1016/J.YMTHE.2005.05.006 (B1)

WO-A2-2011/133889 (B1)

US-A1- 2008 015 158 (B1)

WO-A2-2005/105995 (B1)

WO-A2-2008/134646 (B1)

WO-A2-2008/150897 (B1)

RYAN L BOUDREAU ET AL: "Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice", MOLECULAR THERAPY, vol. 17, no. 6, 24 February 2009 (2009-02-24), pages 1053-1063, XP055192169, ISSN: 1525-0016, DOI: 10.1038/mt.2009.17 (B1)