C. H. DIEP ET AL: "Synergistic Effect between Erlotinib and MEK Inhibitors in KRAS Wild-Type Human Pancreatic Cancer Cells", CLINICAL CANCER RESEARCH, vol. 17, no. 9, 8 March 2011 (2011-03-08), pages 2744-2756, XP055132319, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-10-2214 (B1)

FEI-YU NIU ET AL: "Novel agents and strategies for overcoming EGFR TKIs resistance", EXPERIMENTAL HEMATOLOGY & ONCOLOGY, BIOMED CENTRAL LTD, LONDON, UK, vol. 3, no. 1, 11 January 2014 (2014-01-11), pages 1-5, XP021175239, ISSN: 2162-3619, DOI: 10.1186/2162-3619-3-2 (B1)

HUANG MING-HUNG ET AL: "MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib", MOLECULAR ONCOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 1, 1 February 2013 (2013-02-01), pages 112-120, XP008165510, ISSN: 1574-7891, DOI: 10.1016/J.MOLONC.2012.09.002 [retrieved on 2012-10-13] (B1)

US-A1- 2013 053 409 (B1)

SONG JI-YOUNG ET AL: "Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation.", INVESTIGATIONAL NEW DRUGS DEC 2013, vol. 31, no. 6, December 2013 (2013-12), pages 1458-1465, XP002740844, ISSN: 1573-0646 (B1)

SUN CHONG ET AL: "Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3", CELL REPORTS 10 APR 2014, vol. 7, no. 1, 27 March 2014 (2014-03-27), pages 86-93, XP002740911, ISSN: 2211-1247 (B1)

MISALE SANDRA ET AL: "Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer", SCIENCE TRANSLATIONAL MEDICINE 19 FEB 2014, vol. 6, no. 224, 19 February 2014 (2014-02-19), page 224ra26, XP002740843, ISSN: 1946-6242 (B1)