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Tittel TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
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Detaljstatus 		Ikke i kraft info Patent opphørt Ikke betalt årsavgift
Patentnummer NO/EP3071203
Europeisk (EP) publiserings nummer EP3071203
EP levert
EP søknadsnummer 14862604.7
EP meddelt
Prioritet 2013.11.18, US 201361905639 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Forma Therapeutics, Inc. (US)
Oppfinner Bair, Kenneth W. (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Patentkrav1. En forbindelse som har formel IVeller et farmasøytisk akseptabelt salt derav,hvor:R4 er -O(CH2)nRd;R8 er C1-C6-alkyl, sykloalkyl, O-C1-C6-alkyl, eller O-sykloalkyl, hvor C1-C6-alkyl eller sykloalkyl av R8 er eventuelt substituert med én eller flere Re;hver Ra og Rb er uavhengig hydrogen eller C1-C6-alkyl, hvor hver C1-C6-alkyl av Ra og Rb er eventuelt substituert med én eller flere Re;hver Rc er uavhengig -(CH2)nRa, -(CH2)nORa, -C(O)Ra, -C(O)ORa, -C(O)NRaRb-S(O)2Ra, -S(O)2NRaRb, C1-C6-haloalkyl, C1-C6-haloalkoksy, aryl, heteroaryl, sykloalkyl heterosykloalkyl, halo, cyano, eller okso, hvor hver C1-C6-haloalkyl, C1-C6-haloalkoksy, aryl, heteroaryl, sykloalkyl, og heterosykloalkyl av Rc er eventuelt substituert med én eller flere Re;Rd er hydrogen, NH(C1-C6-alkyl), N(C1-C6-alkyl)2, C1-C6-alkyl, sykloalkyl, heterosykloalkyl, aryl, eller heteroaryl, hvor nevnte alkyl, sykloalkyl, heterosykloalkyl, aryl, og heteroaryl av Rd er eventuelt substituert med én eller flere substituenter som er uavhengig valgt fra Ra, Rb, og Rc;hver Re er uavhengig hydrogen, halogen, -OH, C1-C6-alkyl, sykloalkyl, heterosykloalkyl, okso, C1-C6-haloalkyl, C1-C6-haloalkoksy, C1-C6-alkoksy, eller -S(O)2(C1-C6-alkyl); ogn er 0, 1, eller 2.2. Forbindelsen ifølge krav 1, hvor Rc er sykloalkyl eller heterosykloalkyl, hvor hver sykloalkyl og heterosykloalkyl av Rc er eventuelt substituert med én eller flere Re.3. Forbindelsen ifølge krav 2, hvor Rc er usubstituert heterosykloalkyl. 4. Forbindelsen ifølge krav 1, hvor Rd er aryl, heteroaryl, eller sykloalkyl, hvor hver aryl, heteroaryl, eller sykloalkyl av Rd er eventuelt substituert med én eller flere substituenter som er uavhengig valgt fra Ra, Rb, og Rc.5. Forbindelsen ifølge krav 4, hvor Rd er usubstituert sykloalkyl.6. Forbindelsen ifølge krav 1, hvor R8 er sykloalkyl eventuelt substituert med én eller flere Re.7. Forbindelsen ifølge krav 6, hvor R8 er usubstituert sykloalkyl.8. Forbindelsen ifølge krav 1, hvor n er 0.9. Forbindelsen ifølge krav 1, hvor forbindelsen er valgt fra gruppen som består av:metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-{[3-(hydroksymetyl)oksetan-3-yl]metoksy}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-(1-{oktahydrosyklopenta[c]pyrrol-5-yl}-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(3,3-difluorsyklobutoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(azetidin-3-ylmetoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(3-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(2,2,2-trifluoretoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-(3-klorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2,2-difluoretoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2,2-difluorpropoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(4-klorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(1,3-difluorpropan-2-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3,4-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(3-hydroksy-2,2-dimetylpropoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-2-metylpropanamid;(2S)-1-syklopropankarbonyl-5-(2-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(3,3,3-trifluorpropoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;(2S)-1-syklopropankarbonyl-5-(3-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;1-(2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)pyrrolidin-2-on;(2S)-1-syklopropankarbonyl-5-(4-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(2-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-(2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)-1λ6,2-thiazolidine-1,1-dion;metyl(2S)-5-(3-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}metansulfonamid;metyl(2S)-5-(4-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylmetansulfonamid;metyl(2S)-2-metyl-5-fenoksy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[2-(oksetan-3-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-5-fenoksy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(2,2-difluorsyklopropyl)metoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 3-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-{[3-(hydroksymetyl)oksetan-3-yl]metoksy}-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyridin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(3-fluoroksetan-3-yl)metoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(3-metoksyfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(3,3-difluorsyklobutoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(azetidin-3-ylmetoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin;(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-6-(1-metyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-({1-[(tert-butoksy)karbonyl]azetidin-3-yl}oksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(azetidin-3-yloksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-5-(azetidin-3-yloksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-syklobutoksy-6-[1-(1,1-diokso-1λ6-thietan-3-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-[1-(1,1-diokso-1λ6-thian-3-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2R)-2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-2-fluoracetamid;(2S)-2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-2-fluoracetamid;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(3-fluoroksetan-3-yl)metoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-2,2-difluoracetamid;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-fluor-2-metylpropoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(oksan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylacetamid;metyl(2S)-5-[(dimetylkarbamoyl)metoksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N-etylacetamid;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-fluoretoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(2,2,2-trifluoretoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2,2-difluoretoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-fluoretoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2,2-difluorpropoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(3,3,3-trifluorpropoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(karbamoyldifluormetoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(1,3-difluorpropan-2-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-fluor-2-metylpropoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(3-hydroksy-2,2-dimetylpropoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-(1-karbamoyl-1-metyletoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(R)-karbamoyl(fluor)metoksy]-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(S)-karbamoyl(fluor)metoksy]-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(etylkarbamoyl)metoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-[2-(azetidin-1-yl)-2-oksoetoksy]-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[2-okso-2-(piperidin-1-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[2-(2-oksopyrrolidin-1-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[2-(morpholin-4-yl)-2-oksoetoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[2-(1,1-diokso-1λ6,2-thiazolidin-2-yl)etoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(sulfamoylmetoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(dimetylsulfamoyl)metoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[2-(oksetan-3-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(2,2-difluorsyklopropyl)metoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(quinazolin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(1,3-benzoksazol-2-yloksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(1,3-benzoksazol-2-yloksy)-2-metyl-6-[1-(oksetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-(pyrimidin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karboksamid;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{1H-pyrazolo[3,4-d]pyrimidin-6-yloksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(1,3-thiazol-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karbonitril;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[4-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-5-[(3-klorpyridin-2-yl)oksy]-6-(l-syklopropyl-IH-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(pyridin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(4,6-dimetylpyrimidin-2-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;6-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridazine-3-karbonitril;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[2-(trifluormetyl)pyrimidin-4-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-(1-{oktahydrosyklopenta[c]pyrrol-5-yl}-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-5-syklopropoksy-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-(4-klor-2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-cyano-4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-klor-4-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-(4-cyano-2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat2-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;metyl(2S)-5-(2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2-cyanofenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2-cyano-3-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;4-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(3-klorpyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karbonitril;1-[(2S)-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-(4-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-cyano-3-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(3-klor-2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;2-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-6-fluorbenzonitril;4-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-3-fluorbenzonitril;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril; metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3-klor-4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;4-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzamid;1-[(2S)-5-(2-klorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-klorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-klorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-karbamoylfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(3-cyano-4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(3-klor-4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-5-(4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-5-(2-klorfenoksy)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-5-(4-klorfenoksy)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;4-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;(2S)-1-syklopropankarbonyl-2-metyl-5-fenoksy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-5-(3-klor-4-fluorfenoksy)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-5-(3-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-5-(3,4-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(3-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(3,4-difluorfenoksy)-2-metyl-1,2,3 ,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(3,4-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3-klorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3-klorfenoksy)-1-syklopropankarbonyl-2-metyl-1,2,3,4-tetrahydroquinolin;(2S)-5-(3-klorfenoksy)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3,5-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(3,5-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(3,5-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-5-(3,5-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;4-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzamid;metyl(2S)-6-[1-(1,1-diokso-1λ6-thian-3-yl)-1H-pyrazol-4-yl]-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(1,1-diokso-1λ6-thietan-3-yl)-1H-pyrazol-4-yl]-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-2-metyl-6-(1-metyl-1H-pyrazol-4-yl)-5-fenoksy-1,2,3,4-tetrahydroquinolin;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(4-klorfenoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-ffuorofenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 3-{4-[(2S)-1-syklopropankarbonyl-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thietan-1,1-dion;3-{4-[(2S)-1-syklopropankarbonyl-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thietan-1,1-dion;1-[(2S)-5-(2-klorfenoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-cyanofenoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-klorfenoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-klorfenoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-karbamoylfenoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;4-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;metyl(2S)-5-(4-klor-2-cyanofenoksy)-2-metyl-6-[1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[1-(propan-2-yl)azetidin-3-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-2-metyl-6-[1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}benzonitril;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-(1-{2-metyl-oktahydrosyklopenta[c]pyrrol-5-yl}-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(1-metylpyrrolidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-(1-{2-metyloktahydrosyklopenta[c]pyrrol-5-yl}-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(1-etylazetidin-3-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[1-(propan-2-yl)azetidin-3-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(1-etylazetidin-3-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-6-(-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(4-metylpyridin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(6-metylpyridin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(isoquinolin-1-yloksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-(2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-5-(2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(2-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2,4-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-5-(2,4-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(2,4-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2,4-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-5-(2,3-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1 1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(2,3-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(2,3-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2,3-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2,5-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(2,5-difluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(2,5-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; (2S)-1-syklopropankarbonyl-5-(2,5-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;1-[(2S)-5-(3,4-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(2,5-difluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-onmetyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(1-metylazetidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(1-metylazetidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(1-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(3-metylpyridin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(5-metylpyridin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(5-klorpyridin-2-yl)oksy]-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(7H-purin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-syklobutoksy-6-[1-(3-metoksypiperidin-4-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-6-[1-(3-metoksypiperidin-4-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-[1-(3-metoksy-1-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-6-[1-(3-metoksy-1-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;3-{4-[(2S)-1-syklopropankarbonyl-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thian-1,1-dion;3-{4-[(2S)-1-syklopropankarbonyl-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thian-1,1-dion;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(2-oksopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(2-oksopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-{1-[(2S)-2-metylazetidin-3-yl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-{1-[(2S)-2-metylazetidin-3-yl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-[1-(3-hydroksysyklobutyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-{[(2S)-1-acetyl-2-metyl-6-[1-(oksetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N-metylacetamid;1-[(2S)-2-metyl-5-(1,2-oksazol-5-ylmetoksy)-6-[1-(oksetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;N-(2-{[(2S)-1-acetyl-2-metyl-6-[1-(oksetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)metansulfonamid;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(1,2-oksazol-5-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;N-(2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)metansulfonamid;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N-metylacetamid;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(oksetan-3-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(syklopentylmetoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[2-(dimetylamino)etoksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(propan-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-syklobutoksy-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(syklopropylmetoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}acetamid;1-[(2S)-5-(syklobutylmetoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(benzyloksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(3-metyloksetan-3-yl)metoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(syklopentyloksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}acetonitril;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-(2-metoksyetoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(pyridin-3-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylacetamid;1-[(2S)-5-(syklohexylmetoksy)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(pyridin-2-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-metoksy-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(1-metyl-1H-pyrazol-3-yl)metoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(1,3-thiazol-5-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-syklobutoksy-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-syklobutoksy-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-syklobutoksy-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-syklobutoksy-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-5-(oksan-4-ylmetoksy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylacetamid;2-{[(2S)-1-acetyl-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylacetamid;2-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylacetamid;1-[(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-5-(2-metylpropoksy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(syklopentylmetoksy)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(syklopentylmetoksy)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(syklopentylmetoksy)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-(syklopentylmetoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;2-{[(2S)-1-acetyl-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-1-(pyrrolidin-1-yl)etan-1-on;2-{[(2S)-1-acetyl-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-1-(pyrrolidin-1-yl)etan-1-on;2-{[(2S)-1-acetyl-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-1-(pyrrolidin-1-yl)etan-1-on;2-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-1-(pyrrolidin-1-yl)etan-1-on; (5R)-5-({[(2S)-1-acetyl-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}metyl)pyrrolidin-2-on;(5R)-5-({[(2S)-1-acetyl-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}metyl)pyrrolidin-2-on;(5R)-5-({[(2S)-1-acetyl-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}metyl)pyrrolidin-2-on;(5R)-5-({[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}metyl)pyrrolidin-2-on;N-(2-{[(2S)-1-acetyl-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)-N-metylmetansulfonamid;N-(2-{[(2S)-1-acetyl-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)-N-metylmetansulfonamid;N-(2-{[(2S)-1-acetyl-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)-N-metylmetansulfonamid;N-(2-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}etyl)-N-metylmetansulfonamid;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1 -one;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1 ,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-(oksan-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-5-(oksan-4-ylmetoksy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(dimetylkarbamoyl)metoksy]-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(dimetylkarbamoyl)metoksy]-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(dimetylkarbamoyl)meto-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1 -(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-(2-metylpropoksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-2-metyl-5-(2-metylpropoksy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(syklopentylmetoksy)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(syklopentylmetoksy)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(syklopentylmetoksy)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(syklopentylmetoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-[2-okso-2-(pyrrolidin-1-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-[2-okso-2-(pyrrolidin-1-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-[2-okso-2-(pyrrolidin-1-yl)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-5-[2-okso-2-(pyrrolidin-1-yl)etoksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-{[(2R)-5-oksopyrrolidin-2-yl]metoksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-{[(2R)-5-oksopyrrolidin-2-yl]metoksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-{[(2R)-5-oksopyrrolidin-2-yl]metoksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-5-{[(2R)-5-oksopyrrolidin-2-yl]metoksy}-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-[2-(N-metylmetansulfonamido)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-[2-(N-metylmetansulfonamido)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-[2-(N-metylmetansulfonamido)etoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-5-[2-(N-metylmetansulfonamido)etoksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(5-metyl-1,3-oksazol-2-yl)metoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(pyridin-4-ylmetoksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-syklobutoksy-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-2-metyl-5-propoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-6-[1-(oksan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;3-{4-[(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thian-1,1-dion;3-{4-[(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thietan-1,1-dion;1-[(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrimidin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[4-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[2-(trifluormetyl)pyrimidin-4-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-2-metyl-5-{[6-(morpholin-4-yl)pyrimidin-4-yl]oksy}-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(6-syklopropylpyrimidin-4-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 2-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karboksamid;1-[(2S)-5-{[3-fluor-5-(trifluormetyl)pyridin-2-yl]oksy}-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl 6-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karboksylat;6-{[(2S)-1-acetyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karboksamid;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrimidin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[4-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[2-(trifluormetyl)pyrimidin-4-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-5-{[6-(morpholin-4-yl)pyrimidin-4-yl]oksy}-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(6-syklopropylpyrimidin-4-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-{[3-fluor-5-(trifluormetyl)pyridin-2-yl]oksy}-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-{[5-(metoksykarbonyl)pyridin-2-yl]oksy}-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(5-karbamoylpyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin;2-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}pyridin-3-karbonitril;(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; 1-[(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(4,6-dimetylpyrimidin-2-yl)oksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(propan-2-yl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-5-[(5-metoksypyrimidin-2-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(1-hydroksy-2-metylpropan-2-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[5-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-(pyrazin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[3-(trifluormetyl)pyridin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(5-syklopropylpyrimidin-2-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(5-fluorpyrimidin-2-yl)oksy]-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-[(5-fluorpyrimidin-2-yl)oksy]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1 -(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-{[5-(trifluormetyl)pyrimidin-2-yl]oksy}-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(5-metylpyrimidin-2-yl)oksy]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-karbamoylpyridin-2-yl)oksy]-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-karbamoylpyridin-2-yl)oksy]-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-{[3-fluor-5-(trifluormetyl)pyridin-2-yl]oksy}-6-[1-(2-metansulfonyletyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-{[3-fluor-5-(trifluormetyl)pyridin-2-yl]oksy}-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-{[3-fluor-5-(trifluormetyl)pyridin-2-yl]oksy}-6-[1-(2-hydroksyetyl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-5-{[3-fluor-5-(trifluormetyl)pyridin-2-yl]oksy}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(oksan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;4-{[(2S)-1-acetyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-N,N-dimetylbenzamid;metyl(2S)-5-(3-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-syklopropankarbonyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin;metyl-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-fenoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-2-metyl-6-[1-(oksetan-3-yl)-1H-pyrazol-4-yl]-5-[(3R)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-2-metyl-6-[1-(oksetan-3-yl)-1H-pyrazol-4-yl]-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(3R)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-(1-syklopropyl-1H-pyrazol-4-yl)-2-metyl-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;1-[(2S)-6-[1-(2-hydroksy-2-metylpropyl)-1H-pyrazol-4-yl]-2-metyl-5-[(3S)-pyrrolidin-3-ylmetoksy]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;(2S)-1-syklopropankarbonyl-2-metyl-5-[(6-metylpyridin-2-yl)oksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-5-[(2,6-dimetylpyridin-3-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-5-[(2,6-dimetylpyridin-4-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-5-[(6-klorpyridin-2-yl)oksy]-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyridin-2-yloksy)-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-5-[(6-fluorpyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;metyl(2S)-2-metyl-5-[(6-metylpyridin-2-yl)oksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyridin-2-yloksy)-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-2-metyl-5-[(6-metylpyridin-2-yl)oksy]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;(2S)-1-syklopropankarbonyl-5-[(6-metoksypyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-[(6-metoksypyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-5-[(6-metoksypyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-syklobutoksy-6-[1-(1,1-diokso-1λ6-thian-4-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;4-{4-[(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-1,2,3,4-tetrahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1λ6-thian-1,1-dion;metyl(2S)-5-syklobutoksy-6-{1-[(3S,4R)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-{1-[(3R,4S)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-{1-[(3S,4S)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-6-{1-[(3S,4S)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-6-{1-[(3S,4R)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-6-{1-[(3R,4S)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-6-{1-[(3R,4R)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-fluorfenoksy)-6-{1-[(3R,4R)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(2-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-syklobutoksy-2-metyl-6-[1-(2-metylpiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;(2S)-5-syklobutoksy-1-syklopropankarbonyl-6-{1-[(3S,4R)-3-fluorpiperidin-4-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-syklobutoksy-6-[5-fluor-1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; metyl(2S)-5-syklobutoksy-6-{1-[(3R*,4S*)-4-fluorpyrrolidin-3-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin-1-karboksylat; og(2S)-5-syklobutoksy-1-syklopropankarbonyl-6-{1-[(3R*,4S*)-4-fluorpiperidin-3-yl]-1H-pyrazol-4-yl}-2-metyl-1,2,3,4-tetrahydroquinolin.10. Forbindelsen ifølge krav 1, hvor forbindelsen er en forbindelse som er valgt fra gruppen som består av:11. Forbindelsen ifølge krav 1, hvor forbindelsen er valgt fra:(2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin;metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(4-cyano-2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(2-cyano-3-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(3-klor-2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;2-{[(2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oksy}-6-fluorbenzonitril;1-[(2S)-5-(2-klorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[l-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;metyl(2S)-5-(3-klor-4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat; (2S)-1-syklopropankarbonyl-5-(4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-1-syklopropankarbonyl-2-metyl-5-fenoksy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin;(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-syklopropankarbonyl-5-(4-fluorfenoksy)-2-metyl-1,2,3,4-tetrahydroquinolin;metyl(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat;1-[(2S)-5-(4-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]etan-1-on; ogmetyl(2S)-5-(2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat.12. Forbindelsen ifølge krav 1, hvor forbindelsen er (2S)-5-syklobutoksy-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin.13. Forbindelsen ifølge krav 1, hvor forbindelsen er (2S)-1-syklopropankarbonyl-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin.14. Forbindelsen ifølge krav 1, hvor forbindelsen er metyl(2S)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoksy-1,2,3,4-tetrahydroquinolin-1-karboksylat.15. Forbindelsen ifølge krav 1, hvor forbindelsen er metyl(2S)-5-(4-cyano-2-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat.16. Forbindelsen ifølge krav 1, hvor forbindelsen er metyl(2S)-5-(2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat.17. Forbindelsen ifølge krav 1, hvor forbindelsen er metyl(2S)-5-[(3-cyanopyridin-2-yl)oksy]-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat.18. Forbindelsen ifølge krav 1, hvor forbindelsen er metyl(2S)-5-(2-cyano-3-fluorfenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat. 19. Forbindelsen ifølge krav 1, hvor forbindelsen er metyl(2S)-5-(3-klor-2-cyanofenoksy)-2-metyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-karboksylat.20. En farmasøytisk sammensetning som omfatter en forbindelse som er valgt fra gruppen som består av forbindelsene ifølge et hvilket som helst av kravene 1-19 og en farmasøytisk akseptabel bærer.
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Forma Therapeutics, Inc.
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Bair, Kenneth W.
41 Cartwright Road Wellesley, Massachusetts 02482 US
Herbertz, Torsten
25 Woodland Way Stow, Massachusetts 01775 US
Kauffman, Goss Stryker
4 Cranwood Road Ledyard, Connecticut 06339 US
Kayser-Bricker, Katherine J.
186 Alps Road Branford, Connecticut 06405 US
Luke, George P.
17 Vienna Lane Clinton, Connecticut 06413 US
Martin, Matthew W.
98 Forest Street Arlington, Massachusetts 02474 US
Millan, David S.
500 Arsenal Street Suite 100 Watertown, Massachusetts 02472 US
Schiller, Shawn E.R.
614 Hilldale Avenue Haverhill, Massachusetts 01832 US
Talbot, Adam C.
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Grund, Martin
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2013.11.18, US 201361905639 P

2014.09.24, US 201462054811 P

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CACCHI S ET AL: "The palladium-catalysed conjugate addition type reaction of 2-(n-acylamino)-arylmercury compounds with @a,@b-enones: a new entry to the quinoline skeleton", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 20, 1 January 1983 (1983-01-01), pages 3373-3383, XP028087796, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)91589-3 [retrieved on 1983-01-01] (B1)

CORINNE LE GOFF ET AL: "Synthesis of some novel fused tetracyclic quinolonecarboxylic acids via 7-methyl-6,7,8,9-tetrahydro-3 H -imidazo[4,5- f ]quinoline and 6-methyl-5,6,7,8-tetrahydro-1 H -imidazo[4,5- g ]quinoline", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, no. 1, 1 January 1994 (1994-01-01), pages 153-160, XP055363851, US ISSN: 0022-152X, DOI: 10.1002/jhet.5570310126 (B1)

EP-A1- 0 555 183 (B1)

HU S ET AL: "An Efficient and Practical Chemoenzymatic Preparation of Optically Active Secondary Amines", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052,, vol. 7, no. 20, 27 August 2005 (2005-08-27), pages 4329-4331, XP002395193, ISSN: 1523-7060, DOI: 10.1021/OL051392N (B1)

ZHEN JIANG ET AL: "Direct synthesis of 8-aryl tetrahydroquinolines via pd-catalyzed ortho-arylation of arylureas in water", RSC ADVANCES: AN INTERNATIONAL JOURNAL TO FURTHER THE CHEMICAL SCIENCES, vol. 3, no. 4, 15 November 2012 (2012-11-15), pages 1025-1028, XP055364072, GB ISSN: 2046-2069, DOI: 10.1039/C2RA22901C (B1)

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