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Beskrivelse	Verdi
Saken / databasen er sist oppdatert	2025.05.17 12:28:00 info
Tittel	SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS
Status Hovedstatus Detaljstatus	Ikke i kraft info 2024.09.30 Patent opphørt 2025.04.15 Ikke betalt årsavgift (sjekk også detaljer i saken)
Patentnummer	NO/EP3041842
Europeisk (EP) publiserings nummer	EP3041842
EP levert	2014.09.05
EP søknadsnummer	14786383.1
EP meddelt	2019.10.23
Prioritet	2013.09.06, US 201361874545 P, .... se mer/flere nedenfor
Sakstype	Europeisk
Løpedag	2014.09.05
Utløpsdato	2034.09.05
Allment tilgjengelig	2016.07.13
Validert i Norge	2020.06.22
Innehaver	Altavant Sciences GmbH (CH)
Oppfinner	DE LOMBAERT, Stéphane (US) .... se mer/flere nedenfor
Fullmektig	ACAPO AS (NO)
Lenke til European patent Register	Informasjon i saken, dokumenter og patentfamilie
Patentfamilie	Se i Espacenet

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Beskrivelse

Krav

PATENTKRAV:

1. Forbindelse ifølge formel I:

or et farmasøytisk akseptabelt salt derav, hvor:

Ring A er C_3-10cykloalkyl, C_6-10aryl, 4 to 10-leddet heterocykloalkyl, eller 5 to 10-leddet heteroaryl;

L er O eller NR⁴;

W er N eller CR⁵;

X er N eller CR⁶;

Y er N eller CR⁷;

hvor bare én av X og Y er N;

R¹er H, C_1-10alkyl, C_3-10cykloalkyl, fenyl, -(CR⁸R⁹)_pOC(O)R¹⁰, -(CR⁸R⁹)_pNR¹¹R¹², eller -(CR⁸R⁹)_pC(O)NR¹¹R¹², hvor nevnte C_1-10alkyl, C_3-10cykloalkyl og fenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra F, Cl, Br, CN, C_1-4alkyl og C_1-

₄haloalkyl;

R²og R³er hver uavhengig valgt fra H, C_1-4alkyl og C_1-4haloalkyl;

R⁴er H eller C_1-4alkyl;

R⁵og R⁶er hver uavhengig valgt fra H, halo og C_1-4alkyl;

R⁷er H, C_1-4alkyl, C_2-6alkenyl, C_3-10cykloalkyl, C_3-10cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-

₁₀aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl, (5-10 leddet heteroaryl)-C_1-4alkyl, NR¹³R¹⁴, OR¹⁵, C(O)R¹⁶, S(O)_qR¹⁷, hvor nevnte C_1-4alkyl, C_2-6alkenyl, C_3-10cykloalkyl, C_3-10cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl og (5-10 leddet heteroaryl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, eller 3 substituents valgt fra halo, C_1-4alkyl, C_2-6alkenyl, amino, C_1-4alkylamino, C_2-8dialkylamino, hydroksy og C_1-4alkoksy;

R⁸og R⁹er hver uavhengig valgt fra H og C_1-4alkyl;

R¹⁰er C_1-6alkyl valgfritt substituert med 1, 2 eller 3 substituenter uavhengig valgt fra C_1-6haloalkyl, C_3-10cykloalkyl, OR^aog NR^cR^d;

R¹¹og R¹²er hver uavhengig valgt fra H og C_1-6alkyl;

R¹³er H eller C_1-4alkyl;

R¹⁴er H, C_1-4alkyl, C_3-7cykloalkyl, C_3-7cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl, eller (5-10 leddet heteroaryl)-C_1-4alkyl, C(O)R^b1, C(O)OR^a1, C(O)NR^c1R^d1, S(O)R^b1, S(O)₂R^b1, eller S(O)₂NR^c1R^d1, hvor nevnte C_1-4alkyl, C_3-7cykloalkyl, C_3-7cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl og (5-10 leddet heteroaryl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_1-4alkyl, C_1-4haloalkyl, CN, NO₂, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)OR^a1, NR^c1C(O)NR^c1R^d1, NR^c1S(O)R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1og S(O)₂NR^c1R^d1;

eller R¹³og R¹⁴sammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, halo, CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1;

R¹⁵er H, C_1-4alkyl, C_3-7cykloalkyl, C_3-7cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl, eller (5-10 leddet heteroaryl)-C_1-4alkyl, hvor nevnte C_1-4alkyl, C_3-7cykloalkyl, C_3-7cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl og (5-10 leddet heteroaryl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1;

R¹⁶er C_1-4alkyl eller NR^18aR^18bhvor nevnte C_1-4alkyl er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1;

R¹⁷er C_1-4alkyl, NR^18aR^18b, eller OR^18c, hvor nevnte C_1-4alkyl er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1;

R^18aog R^18ber hver uavhengig valgt fra H og C_1-4alkyl hvor nevnte C_1-4alkyl er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c4C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1;

or R^18aog R^18bsammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, halo, CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)NR^c1R^d1, NR^c1C(O)OR^a1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1og S(O)₂NR^c1R^d1;

R^18cer H, C_1-6alkyl, C_3-10cykloalkyl, C_3-7cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl, eller (5-10 leddet heteroaryl)-C_1-4alkyl, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, C_3-10cykloalkyl-C_1-4alkyl, C_6-10aryl, C_6-10aryl-C_1-4alkyl, 4-10 leddet heterocykloalkyl, (4-10 leddet heterocykloalkyl)-C_1-4alkyl, 5-10 leddet heteroaryl og (5-10 leddet heteroaryl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_1-4alkyl, C_1-4haloalkyl, CN, NO₂, OR^a1, SR^a1, C(O)R^b1, C(O)NR^c1R^d1, C(O)OR^a1, OC(O)R^b1, OC(O)NR^c1R^d1, NR^c1R^d1, NR^c1C(O)R^b1, NR^c1C(O)OR^a1, NR^c1C(O)NR^c1R^d1, NR^c1S(O)R^b1, NR^c1S(O)₂R^b1, NR^c1S(O)₂NR^c1R^d1, S(O)R^b1, S(O)NR^c1R^d1, S(O)₂R^b1og S(O)₂NR^c1R^d1;

R^Aer H, Cy¹, halo, C_1-6alkyl, C_2-6alkenyl, CN, NO₂, OR^a2, SR^a2, C(O)R^b2, C(O)NR^c2R^d2, C(O)OR^a2, OC(O)R^b2, OC(O)NR^c2R^d2, NR^c2R^d2, NR^c2C(O)R^b2, NR^c2C(O)OR^a2, NR^c2C(O)NR^c2R^d2, NR^c2S(O)R^b2, NR^c2S(O)₂R^b2, NR^c2S(O)₂NR^c2R^d2, S(O)R^b2, S(O)NR^c2R^d2, S(O)₂R^b2, eller S(O)₂NR^c2R^d2, hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra Cy¹, halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a2, SR^a2, C(O)R^b2, C(O)NR^c2R^d2, C(O)OR^a2, OC(O)R^b2, OC(O)NR^c2R^d2, NR^c2R^d2, NR^c2C(O)R^b2, NR^c2C(O)OR^a2, NR^c2C(O)NR^c2R^d2, NR^c2S(O)R^b2, NR^c2S(O)₂R^b2, NR^c2S(O)₂NR^c2R^d2, S(O)R^b2, S(O)NR^c2R^d2, S(O)₂R^b2og S(O)₂NR^c2R^d2;

R^Ber H, Cy², halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c3S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3, eller S(O)₂NR^c3R^d3, hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra Cy², halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c1S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3og

S(O)₂NR^c3R^d3;

R^Cog R^Der uavhengig valgt fra H, halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a4, SR^a4, C(O)R^b4, C(O)NR^c4R^d4, C(O)OR^a4, OC(O)R^b4, OC(O)NR^c4R^d4, NR^c4R^d4, NR^c4C(O)R^b4, NR^c4C(O)OR^a4, NR^c4C(O)NR^c4R^d4, NR^c4S(O)R^b4, NR^c4S(O)₂R^b4, NR^c4S(O)₂NR^c4R^d4, S(O)R^b4, S(O)NR^c4R^d4, S(O)₂R^b4og S(O)₂NR^c4R^d4; hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a4, SR^a4, C(O)R^b4, C(O)NR^c4R^d4, C(O)OR^a4, OC(O)R^b4, OC(O)NR^c4R^d4, NR^c4R^d4, NR^c4C(O)R^b4, NR^c4C(O)OR^a4, NR^c4C(O)NR^c4R^d4, NR^c4S(O)R^b4, NR^c4S(O)₂R^b4, NR^c4S(O)₂NR^c4R^d4, S(O)R^b4, S(O)NR^c4R^d4, S(O)₂R^b4og S(O)₂NR^c4R^d4;

Cy¹og Cy²er hver uavhengig valgt fra C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl og 4-10 leddet heterocykloalkyl, som hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy;

hver R^Cyer uavhengig valgt fra halo, C_1-6alkyl, C_1-6haloalkyl, C_2-6alkenyl, C_6-10aryl, C_3-

₁₀cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, CN, NO₂, OR^a5, SR^a5, C(O)R^b5, C(O)NR^c5R^d5, C(O)OR^a5, OC(O)R^b5, OC(O)NR^c5R^d5, NR^c5R^d5, NR^c5C(O)R^b5, NR^c5C(O)OR^a5, NR^c5C(O)NR^c5R^d5, NR^c5S(O)R^b5, NR^c5S(O)₂R^b5, NR^c5S(O)₂NR^c5R^d5, S(O)R^b5, S(O)NR^c5R^d5, S(O)₂R^b5og S(O)₂NR^c5R^d5, hvor nevnte C_1-6alkyl, C_2-6alkenyl C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl og 4-10 leddet heterocykloalkyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra halo , C_1-6alkyl, CN, NO₂, OR^a5, SR^a5, C(O)R^b5, C(O)NR^c5R^d5, C(O)OR^a5, OC(O)R^b5, OC(O)NR^c5R^d5, NR^c5R^d5, NR^c5C(O)R^b5, NR^c5C(O)OR^a5, NR^c5C(O)NR^c5R^d5, NR^c5S(O)R^b5, NR^c5S(O)₂R^b5, NR^c5S(O)₂NR^c5R^d5, S(O)R^b5, S(O)NR^c5R^d5, S(O)₂R^b5og S(O)₂NR^c5R^d5;

hver R^a, R^a1, R^a2, R^a3, R^a4og R^a5er uavhengig valgt fra H, C_1-6alkyl, C_1-4haloalkyl, C_2-6alkenyl, C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, C_6-10aryl-C_1-4alkyl, C_3-10cykloalkyl-C_1-4alkyl, (5-10 leddet heteroaryl)-C_1-4alkyl, eller (4-10 leddet heterocykloalkyl)-C_1-4alkyl, hvor nevnte C_1-6alkyl, C_2-6alkenyl, C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, C_6-10aryl-C_1-4alkyl, C_3-10cykloalkyl-C_1-4alkyl, (5-10 leddet heteroaryl)-C_1-4alkyl og (4-10 leddet heterocykloalkyl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra C_1-4alkyl, halo, CN, OR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

hver R^b1, R^b2, R^b3, R^b4, og R^b5er uavhengig valgt fra H, C_1-6alkyl, C_1-4haloalkyl, C_2-6alkenyl, C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, C_6-10aryl-C_1-4alkyl, C_3-10cykloalkyl-C_1-4alkyl, (5-10 leddet heteroaryl)-C_1-4alkyl, eller (4-10 leddet heterocykloalkyl)-C_1-4alkyl, hvor nevnte C_1-6alkyl, C_2-6alkenyl, C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, C_6-10aryl-C_1-4alkyl, C_3-10cykloalkyl-C_1-4alkyl, (5-10 leddet heteroaryl)-C_1-4alkyl og (4-10 leddet heterocykloalkyl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra C_1-4alkyl, halo, CN, OR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

hver R^c, R^d, R^c1, R^d1, R^c2, R^d2, R^c3, R^d3, R^c4, R^d4, R^c5og R^d5er uavhengig valgt fra H, C_1-6alkyl, C_1-4haloalkyl, C_2-6alkenyl, C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, C_6-10aryl-C_1-4alkyl, C_3-10cykloalkyl-C_1-4alkyl, (5-10 leddet heteroaryl)-C_1-4alkyl, eller (4-10 leddet heterocykloalkyl)-C_1-4alkyl, hvor nevnte C_1-6alkyl, C_2-6alkenyl, C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, C_6-10aryl-C_1-4alkyl, C_3-10cykloalkyl-C_1-4alkyl, (5-10 leddet heteroaryl)-C_1-4alkyl og (4-10 leddet heterocykloalkyl)-C_1-4alkyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra C_1-4alkyl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

eller hvilken som helst R^cog R^dsammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

eller hvilken som helst R^c1og R^d1sammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

eller hvilken som helst R^c2og R^d2sammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl, C_1-6haloalkyl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

eller hvilken som helst R^c3og R^d3sammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, C_1-6haloalkyl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

eller hvilken som helst R^c4og R^d4sammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, C_1-6haloalkyl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

eller hvilken som helst R^c5og R^d5sammen med N-atomet som de er bundet til, danner en 4-, 5-, 6-, eller 7-leddet heterocykloalkyl-gruppe valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl, 5-6 leddet heteroaryl, C_1-6haloalkyl, halo, CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6, hvor nevnte C_1-6alkyl, C_3-7cykloalkyl, 4-7 leddet heterocykloalkyl, C_6-10aryl og 5-6 leddet heteroaryl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , CN, OR^a6, SR^a6, C(O)R^b6, C(O)NR^c6R^d6, C(O)OR^a6, OC(O)R^b6, OC(O)NR^c6R^d6, NR^c6R^d6, NR^c6C(O)R^b6, NR^c6C(O)NR^c6R^d6, NR^c6C(O)OR^a6, S(O)R^b6, S(O)NR^c6R^d6, S(O)₂R^b6, NR^c6S(O)₂R^b6, NR^c6S(O)₂NR^c6R^d6og S(O)₂NR^c6R^d6;

hver R^a6, R^b6, R^c6og R^d6er uavhengig valgt fra H, C_1-4alkyl, C_2-4alkenyl, C_3-7cykloalkyl, fenyl, 5-6 leddet heteroaryl og 4-7 leddet heterocykloalkyl, hvor nevnte C_1-4alkyl, C_2-4alkenyl, C_3-7cykloalkyl, fenyl, 5-6 leddet heteroaryl og 4-7 leddet heterocykloalkyl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra OH, CN, amino, halo, C_1-4alkyl, C_1-4alkoksy, C_1-4alkyltio, C_1-4alkylamino og di(C_1-4alkyl)amino;

n er 1 eller 2;

p er 1, 2, eller 3; og

q er 1 eller 2;

hvor en hvilken som helst nevnte 4-10 eller 4-7 leddet heterocykloalkyl-gruppe valgfritt omfatter 1, 2, eller 3 oksosubstituenter, hvor hver oksosubstituent som er til stede er substituert med et ringdannende karbon-, nitrogen- eller svovelatom i en 4-10 eller 4-7 leddet heterocykloalkylgruppe.

2. Forbindelse ifølge krav 1, eller et farmasøytisk akseptabelt salt derav, hvor L er O.

3. Forbindelse ifølge krav 1, eller et farmasøytisk akseptabelt salt derav, hvor L er NR⁴.

4. Forbindelse ifølge et hvilket som helst av kravene 1-3, eller et farmasøytisk akseptabelt salt derav, hvor W er CR⁵; X er N; og Y er CR⁷.

5. Forbindelse ifølge et hvilket som helst av kravene 1-3, eller et farmasøytisk akseptabelt salt derav, hvor W er N; X er N; og Y er CR⁷.

6. Forbindelse ifølge et hvilket som helst av kravene 1-3, eller et farmasøytisk akseptabelt salt derav, hvor W er CR⁵; X er CR⁶; og Y er N.

7. Forbindelse ifølge et hvilket som helst av kravene 1-3, eller et farmasøytisk akseptabelt salt derav, hvor W er CR⁵; X er CR⁶; og Y er CR⁷.

8. Forbindelse ifølge et hvilket som helst av kravene 1-3, eller et farmasøytisk akseptabelt salt derav, hvor W er N; X er CR⁶; og Y er CR⁷.

9. Forbindelse ifølge et hvilket som helst av kravene 1-8, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R²er H og R³er H; eller

b) R²er H og R³er C_1-4alkyl; eller

c) R²er H og R³er metyl; eller

d) R²er H og R³er C_1-4haloalkyl; eller

e) R²er H og R³er trifluormetyl.

10. Forbindelse ifølge et hvilket som helst av kravene 1-9, eller et farmasøytisk akseptabelt salt derav, hvor:-a) n er 1; eller

b) n er 2.

11. Forbindelse ifølge et hvilket som helst av kravene 1-10, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R¹er H; eller

b) R¹er C_1-10alkyl, C_3-10cykloalkyl, fenyl, -(CR⁸R⁹)_pOC(O)R¹⁰, -(CR⁸R⁹)_pNR¹¹R¹², eller -(CR⁸R⁹)_pC(O)NR¹¹R¹², hvor nevnte C_1-10alkyl, C_3-10cykloalkyl og fenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra F, Cl, Br, CN, C_1-4alkyl og C_1-

₄haloalkyl; eller

c) R¹er C_1-10alkyl.

12. Forbindelse ifølge et hvilket som helst av kravene 1 og 3-11, eller et farmasøytisk akseptabelt salt derav, hvor R⁴er H.

13. Forbindelse ifølge et hvilket som helst av kravene 1-4 og 6-12, eller et farmasøytisk akseptabelt salt derav, hvor R⁵er H.

14. Forbindelse ifølge et hvilket som helst av kravene 1-3 og 6-13, eller et farmasøytisk akseptabelt salt derav, hvor R⁶er H.

15. Forbindelse ifølge et hvilket som helst av kravene 1-5 og 7-13, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R⁷er annet enn H; eller

b) R⁷er C_1-4alkyl, NR¹³R¹⁴, eller OR¹⁵; eller

c) R⁷er NR¹³R¹⁴; eller

d) R⁷er NH₂; eller

e) R⁷er C_1-4alkyl; eller

f) R⁷er OR¹⁵.

16. Forbindelse ifølge et hvilket som helst av kravene 1-15, eller et farmasøytisk akseptabelt salt derav, hvor:-a) Ring A er C_3-10cykloalkyl; eller

b) Ring A er C_6-10aryl; eller

c) Ring A er fenyl; eller

d) Ring A er 4 to 10-leddet heterocykloalkyl; eller

e) Ring A er fenyl, adamantanyl, naftyl, 1,2,3,4-tetrahydrokinoksalinyl, 3,4-dihydrokinazolinyl, 1,2,3,4-tetrahydrokinazolinyl, eller pyridyl; eller

f) Ring A er 5 to 10-leddet heteroaryl.

17. Forbindelse ifølge et hvilket som helst av kravene 1-16, eller et farmasøytisk akseptabelt salt derav, hvor:-a) minst en av R^A, R^B, R^Cog R^Der annet enn hydrogen; eller

b) minst to av R^A, R^B, R^Cog R^Der annet enn hydrogen.

18. Forbindelse ifølge et hvilket som helst av kravene 1-17, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Aer Cy¹; eller

b) R^Aer C_6-10aryl eller 5-10 leddet heteroaryl, som hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

c) R^Aer 5-10 leddet heteroaryl som er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

d) R^Aer pyrazolyl som er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

e) R^Aer 3-metyl-1H-pyrazol-1-yl; eller

f) R^Aer C_6-10aryl valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

g) R^Aer fenyl valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra R^Cy.

19. Forbindelse ifølge et hvilket som helst av kravene 1-18, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Ber H; eller

b) R^Ber Cy², halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c3S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3, eller S(O)₂NR^c3R^d3, hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra Cy², halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c1S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3og S(O)₂NR^c3R^d3; eller

c) R^Ber Cy²; eller

d) R^Ber C_6-10aryl eller 5-10 leddet heteroaryl, som hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

e) R^Ber halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c3S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3, eller S(O)₂NR^c3R^d3, hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra Cy², halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c1S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3og S(O)₂NR^c3R^d3; eller

f) R^Ber halo.

20. Forbindelse ifølge et hvilket som helst av kravene 1-19, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Cer H; eller

b) R^Cer halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a4, SR^a4, C(O)R^b4, C(O)NR^c4R^d4, C(O)OR^a4, OC(O)R^b4, OC(O)NR^c4R^d4, NR^c4R^d4, NR^c4C(O)R^b4, NR^c4C(O)OR^a4, NR^c4C(O)NR^c4R^d4, NR^c4S(O)R^b4, NR^c4S(O)₂R^b4, NR^c4S(O)₂NR^c4R^d4, S(O)R^b4, S(O)NR^c4R^d4, S(O)₂R^b4, eller S(O)₂NR^c4R^d4; hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a4, SR^a4, C(O)R^b4, C(O)NR^c4R^d4, C(O)OR^a4, OC(O)R^b4, OC(O)NR^c4R^d4, NR^c4R^d4, NR^c4C(O)R^b4, NR^c4C(O)OR^a4, NR^c4C(O)NR^c4R^d4, NR^c4S(O)R^b4, NR^c4S(O)₂R^b4, NR^c4S(O)₂NR^c4R^d4, S(O)R^b4, S(O)NR^c4R^d4, S(O)₂R^b4og S(O)₂NR^c4R^d4.

21. Forbindelse ifølge et hvilket som helst av kravene 1-20, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Der H; eller

b) R^Der halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a4, SR^a4, C(O)R^b4, C(O)NR^c4R^d4, C(O)OR^a4, OC(O)R^b4, OC(O)NR^c4R^d4, NR^c4R^d4, NR^c4C(O)R^b4, NR^c4C(O)OR^a4, NR^c4C(O)NR^c4R^d4, NR^c4S(O)R^b4, NR^c4S(O)₂R^b4, NR^c4S(O)₂NR^c4R^d4, S(O)R^b4, S(O)NR^c4R^d4, S(O)₂R^b4, eller S(O)₂NR^c4R^d4; hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra C_6-10aryl, C_3-10cykloalkyl, 5-10 leddet heteroaryl, 4-10 leddet heterocykloalkyl, halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, NO₂, OR^a4, SR^a4, C(O)R^b4, C(O)NR^c4R^d4, C(O)OR^a4, OC(O)R^b4, OC(O)NR^c4R^d4, NR^c4R^d4, NR^c4C(O)R^b4, NR^c4C(O)OR^a4, NR^c4C(O)NR^c4R^d4, NR^c4S(O)R^b4, NR^c4S(O)₂R^b4, NR^c4S(O)₂NR^c4R^d4, S(O)R^b4, S(O)NR^c4R^d4, S(O)₂R^b4og S(O)₂NR^c4R^d4.

22. Forbindelse ifølge et hvilket som helst av kravene 1-21, eller et farmasøytisk akseptabelt salt derav:-a) med formel IIa:

IIa; eller

b) med formel IIb:

IIb; eller

c) med formel IIc:

IIc; eller

d) med formel IId:

IId; eller e) med formel IIe:

IIe.

23. Forbindelse ifølge krav 22, eller et farmasøytisk akseptabelt salt derav, hvor:-a) L er O; eller

b) L er NR₄.

24. Forbindelse ifølge et hvilket som helst av kravene 22-23, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R³er H; eller

b) R²er CF₃og R³er H.

25. Forbindelse ifølge et hvilket som helst av kravene 22-24, eller et farmasøytisk akseptabelt salt derav, hvor R¹er H eller C_1-10alkyl.

26. Forbindelse ifølge et hvilket som helst av kravene 22-25, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Aer 5-10 leddet heteroaryl som er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

b) R^Aer 5 to 6-leddet heteroaryl valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra R^Cy; eller

c) R^Aer C_6-10aryl valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

d) R^Aer fenyl valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra R^Cy.

27. Forbindelse ifølge et hvilket som helst av kravene 22-26, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Ber Cy²; eller

b) R^Ber H, halo, C_1-6alkyl, C_2-6alkenyl, C_1-6haloalkyl, CN, OR^a3, C(O)NR^c3R^d3, eller C(O)OR^a3, hvor nevnte C_1-6alkyl og C_2-6alkenyl hver er valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra halo , C_1-6haloalkyl, CN, NO₂, OR^a3, SR^a3, C(O)R^b3, C(O)NR^c3R^d3, C(O)OR^a3, OC(O)R^b3, OC(O)NR^c3R^d3, NR^c3R^d3, NR^c3C(O)R^b3, NR^c3C(O)OR^a3, NR^c3C(O)NR^c3R^d3, NR^c3S(O)R^b3, NR^c1S(O)₂R^b3, NR^c3S(O)₂NR^c3R^d3, S(O)R^b3, S(O)NR^c3R^d3, S(O)₂R^b3og S(O)₂NR^c3R^d3.

28. Forbindelse ifølge et hvilket som helst av kravene 22-27, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Cer H; og/eller

b) R^Der H; og/eller

c) R⁵er H; og/eller

d) R⁶er H.

29. Forbindelse ifølge et hvilket som helst av kravene 1-21, eller et farmasøytisk akseptabelt salt derav, med formel IIIa eller IIIb:

IIIb.

30. Forbindelse ifølge et hvilket som helst av kravene 1-21, eller et farmasøytisk akseptabelt salt derav, med formel IV:

IV.

31. Forbindelse ifølge et hvilket som helst av kravene 1-21, eller et farmasøytisk akseptabelt salt derav, med formel Va:

Va.

32. Forbindelse ifølge et hvilket som helst av kravene 29-31, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Aer 5-10 leddet heteroaryl valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra R^Cy; eller

b) R^Aer 5 to 6-leddet heteroaryl valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra R^Cy; eller

c) R^Aer C_6-10aryl valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra R^Cy; eller

d) R^Aer fenyl valgfritt substituert med 1, 2, eller 3 substituenter uavhengig valgt fra R^Cy.

33. Forbindelse ifølge et hvilket som helst av kravene 1-21, eller et farmasøytisk akseptabelt salt derav, med formel VI:

VI.

34. Forbindelse ifølge et hvilket som helst av kravene 1-33, eller et farmasøytisk akseptabelt salt derav, hvor karbonet som –R²er festet til har en R-konfigurasjon.

35. Forbindelse ifølge et hvilket som helst av kravene 1-21, eller et farmasøytisk akseptabelt salt derav, med formel VII:

VII

hvor a er 0, 1, 2, eller 3.

36. Forbindelse ifølge krav 35, eller et farmasøytisk akseptabelt salt derav, hvor R^Cyer halo, C_1-6alkyl, C_1-6haloalkyl, 4-10 leddet heterocykloalkyl, CN, NO₂, OR^a5, SR^a5, C(O)R^b5, C(O)NR^c5R^d5, C(O)OR^a5, NR^c5R^d5, S(O)₂R^b5og S(O)₂NR^c5R^d5, hvor nevnte C_1-6alkyl og 4-10 leddet heterocykloalkyl hver er valgfritt substituert med 1, 2, 3, 4, eller 5 substituenter uavhengig valgt fra halo , C_1-6alkyl, CN, NO₂, OR^a5, SR^a5, C(O)R^b5, C(O)NR^c5R^d5, C(O)OR^a5, OC(O)R^b5, OC(O)NR^c5R^d5, NR^c5R^d5, NR^c5C(O)R^b5, NR^c5C(O)OR^a5, NR^c5C(O)NR^c5R^d5, NR^c5S(O)R^b5, NR^c5S(O)₂R^b5, NR^c5S(O)₂NR^c5R^d5, S(O)R^b5, S(O)NR^c5R^d5, S(O)₂R^b5og S(O)₂NR^c5R^d5.

37. Forbindelse ifølge et hvilket som helst av kravene 29, 30 og 33-36, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Cer H; og/eller

b) R^Der H.

38. Forbindelse ifølge et hvilket som helst av kravene 29-37, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R²er CF₃; og/eller

b) R¹er H eller C_1-10alkyl.

39. Forbindelse ifølge et hvilket som helst av kravene 29-38, eller et farmasøytisk akseptabelt salt derav, hvor:-a) R^Ber Cy²; eller

40. Forbindelse ifølge et hvilket som helst av kravene 1-39, eller et farmasøytisk akseptabelt salt derav, hvor det kirale karbonet som –C(O)OR¹er festet til har en S-konfigurasjon.

41. Forbindelse ifølge krav 1:-a) valgt fra:

(3S)-8-(2-amino-6-((1R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metylsulfinyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metyltio)-[1,1'-bifenyl]-4-yl) etoksy)pyrimidin-4-yl)-2,8-diazaspiro [4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-karboksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-karboksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(1,2,3,6-tetrahydropyridin-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre; (S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(pyridin-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(1-metyl-1H-pyrazol-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(isoksazol-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(3,6-dihydro-2H-pyran-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metoksypyridin-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-metyl-1H-indazol-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(tert-butyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metoksypyrimidin-5-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(6-metoksypyridin-3-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-2',3',4',5'-tetrahydro-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-cyan-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4'-(acetamidmetyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4'-(2-acetamidetyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(kinolin-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-(1H-indol-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(aminometyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(kinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-diklor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(pyrimidin-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(piperidin-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(1-(metylsulfonyl)piperidin-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-(1-acetylpiperidin-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(tetrahydro-2H-pyran-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-4'-(metoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(3-karboksypropyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(2-karboksyetyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(3-etoksy-3-oksopropyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(R)-8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(trifluormetyl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-metyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-fluor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-metoksy-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(5-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-metoksy-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-brom-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-brom-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(6-metyl-2-(3-metyl-1H-pyrazol-1-yl)pyridin-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-etyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-propylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-butyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(3S)-8-(2-amino-6-((1R)-1-(4-(1,2-dihydroksyetyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-cyan-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-karbamoyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-karboksy-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(etoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(((1,1,1,3,3,3-hexafluor-2-metylpropan-2-yl)oksy)karbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(propoksykarbonyl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(butoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(tert-butoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(isobutoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-((cyklopentyloksy)karbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-vinylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-((E)-prop-1-en-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-((E)-but-1-en-1-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-((E)-2-karboksyvinyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-dimetyl-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-karboksy-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-karboksy-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-((E)-2-karboksyvinyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre; (S)-8-(2-amino-6-((R)-1-(4'-((E)-2-karboksyvinyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(2-karboksyetyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(2-karboksyetyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(hydroksymetyl)-3'-metyl-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(hydroksymetyl)-4'-metyl-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-difluor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-diklor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2'-(etoksykarbonyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(etoksykarbonyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-etyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-propylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-butyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-(etoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluor etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-karboksy-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(hydroksymetyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-((dimetylamino)metyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-Bromo-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre ;

(S)-8-(6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-metyl pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(4-(2-metoksypyridin-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metylsulfonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(3',4'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(3'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(4-(6-metoksypyridin-3-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(4-(2-metoksypyrimidin-5-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(2',4'-dimetoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre; (S)-8-(6-((R)-1-(4'-(dimetylkarbamoyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(4-(2-metoksypyridin-3-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(3'-(dimetylkarbamoyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(2',4',6'-trimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(2'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-metoksy-4'-(metoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4'-(tert-butyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-metylpyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-(metoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(pyrimidin-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-isopropyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(pyridin-3-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(3'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-metyl-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(pyridin-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-fenoksypyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-(cyklohexyloksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-(cyklohexylamino)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-(cyklobutankarboksamid)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(2-oksopyrrolidin-1-yl)fenyl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(2'-amino-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(5-klor-3'-nitro-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(3'-amino-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(5-klor-4'-nitro-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(2-amino-6-((R)-1-(4'-amino-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(6-metylpyridin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(etylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(propylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(butylsulfonyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(hydroksymetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(metylsulfonamid)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(2-oksopyrrolidin-1-yl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(3-metyl-2-oksoimidazolidin-1-yl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(5-klortiofen-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(1-metyl-1H-pyrazol-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-sulfamoyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-hydroksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-cyan-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-metoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(aminometyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(3'-(akrylamidmetyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-karboksy-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-karbamoyl-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-sulfamoyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4',5-diklor-3'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-etoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-4'-etoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-4'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-4'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-fluor-4'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4',5-diklor-3'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-5'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-5'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-fluor-5'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-metoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4',5-diklor-3'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3',5'-difluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-4'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3',4'-difluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-4'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(etoksykarbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(2-metoksyetoksy)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(3S)-8-(6-(1-((1r,3r,5S,7S)-adamantan-2-yl)etoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((1r,3r,5S,7S)-adamantan-2-ylmetoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(4-amino-6-((naftalen-2-ylmetyl)amino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(4-(([1,1'-bifenyl]-4-ylmetyl)amino)-6-amino-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(4-amino-6-((2-(piperidin-1-yl)benzyl)amino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(4-(([1,1'-bifenyl]-3-ylmetyl)amino)-6-amino-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(4-amino-6-(((R)-1-(naftalen-2-yl)etyl)amino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

8-(4-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((2-(piperidin-1-yl)benzyl)amino)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((2-fenoksy-6-(piperidin-1-yl)benzyl)amino)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(3S)-8-(6-(((3S,5S)-adamantan-1-ylmetyl)amino)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

3S)-8-(6-((1-((1R,3S,5S)-adamantan-1-yl)etyl)amino)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(5-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyridazin-3-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(4-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyridin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(4-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyridin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(4-((R)-1-(4-Kloro-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-6-fenoksypyrimidin-2-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(3S)-8-(2-amino-6-(1-(2,6-dibromfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2,5-dibromfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-4-propyl-[1,1'-bifenyl]-2-yl)etoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-4-((E)-prop-1-en-1-yl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-([1,1':4',1''-terfenyl]-2'-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-([1,1':3',1''-terfenyl]-2'-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3,4-dimetyl-3''-(metylsulfonyl)-[1,1':3',1''-terfenyl]-4'-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-5-(kinolin-6-yl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-5-((E)-prop-1-en-1-yl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-5-propyl-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-([1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-1H-indazol-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-1H-benzo[d]imidazol-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-(1H-benzo[d]imidazol-5-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(benzo[d]isotiazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(benzo[d]isoksazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-(1H-indazol-6-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-1H-indazol-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(benzo[d]isotiazol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(benzo[d]tiazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(naftalen-2-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-4'-metyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-5'-metyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(5'-metoksy-2'-metyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-dimetoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-4'-(pyrrolidin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-okso-1,3-dihydroisobenzofuran-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-okso-1,2-dihydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-2-okso-1,2-dihydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-okso-1,2,3,4-tetrahydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(4-(1H-indazol-5-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(1,3-dimetyl-1H-indazol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(1,3-dimetyl-1H-indol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-5'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-cyan-5'-metoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-okso-2,3-dihydrobenzo[d]oksazol-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-metyl-1H-indol-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(3'-acetoksy-4'-(metoksykarbonyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-okso-2H-kromen-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-6-okso-1,6-dihydropyridin-3-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-karboksy-3'-hydroksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metoksykinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-(metyltio)kinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-2-okso-1,2,3,4-tetrahydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(3S)-8-(2-amino-6-(2,2,2-trifluor-1-(3'-fluor-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(3S)-8-(2-amino-6-(2,2,2-trifluor-1-(3'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-5'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5'-difluor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-etoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-isopropoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(pyridin-3-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(pyridin-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(pyrimidin-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-metyl-1H-indazol-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(1,3-dimetyl-1H-indazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(2,3-dimetyl-2H-indazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-okso-1,2,3,4-tetrahydroisokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(isokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(isokinolin-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-((dimetylamino)metyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinolin-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinoksalin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metyl-1-okso-1,2,3,4-tetrahydroisokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinazolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-fluor-2'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2'-fluor-3'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2'-fluor-5'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(6-metylpyridin-3-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(pyrrolidin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-karboksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-karboksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-propyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(hydroksymetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2'-(hydroksymetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(dimetylkarbamoyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(piperidin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2'-((dimetylamino)metyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-etyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-hydroksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-hydroksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2',4'-dimetoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2',6'-difluor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2',6'-dimetyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-dimetyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(tert-butyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-isopropyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-diklor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2',3'-dimetyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3',4',5'-trifluor-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-2'-metyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5'-dimetyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-difluor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2',5'-dimetyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-butyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(metylsulfonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-metyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(benzofuran-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(5'-fluor-2'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-oksokroman-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1,2,3,4-tetrahydrokinoksalin-6-yl) fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3,4-dihydrokinazolin-6-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(1,2,3,4-tetrahydrokinazolin-6-yl)etoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-bromfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(naftalen-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

9-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-3,9-diazaspiro[5.5]undekan-2-karboksylsyre;

(S)-8-(2-amino-6-((4-(3-metyl-1H-indazol-6-yl)fenoksy)metyl)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((5-klor-3'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)metoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(benzo[d]tiazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(4-(1H-indazol-5-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-4'-(pyrrolidin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-nitro-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(benzo[d]isotiazol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(benzo[d]isotiazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-dimetoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-2-okso-1,2-dihydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-amino-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-5-propyl-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(1,3-dimetyl-1H-indol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(3'-akrylamid-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-6-okso-1,6-dihydropyridin-3-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-okso-1,2,3,4-tetrahydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-okso-1,2-dihydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-5-((E)-prop-1-en-1-yl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-4-propyl-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-4-((E)-prop-1-en-1-yl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(etylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(propylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(butylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-okso-1,3-dihydroisobenzofuran-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metoksykinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(hydroksymetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(2-oksopyrrolidin-1-yl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(3-metyl-2-oksoimidazolidin-1-yl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-3'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(metylsulfonamid)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2-brom-5-klorfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-metyl-2-okso-1,2,3,4-tetrahydrokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-(metyltio)kinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2,5-dibromfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-([1,1':4',1''-terfenyl]-2'-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; (S)-etyl 8-(2-amino-6-((R)-1-(3'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(etoksykarbonyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2,6-dibromfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metyltio)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-diklor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(2-oksopyrrolidin-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-metoksy-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-etyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-propylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-butyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-(etoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(etoksykarbonyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-((E)-3-etoksy-3-oksoprop-1-en-1-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-(3-etoksy-3-oksopropyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(6-metyl-2-(3-metyl-1H-pyrazol-1-yl)pyridin-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-((E)-prop-1-en-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-propylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-etyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-butyl-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-vinylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-((E)-but-1-en-1-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(1-metyl-1H-pyrazol-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(1-metyl-1H-pyrazol-3-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(1,3-dimetyl-1H-indazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(2,3-dimetyl-2H-indazol-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(1-okso-1,2,3,4-tetrahydroisokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(isokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(3-etoksy-3-oksopropyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(isokinolin-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-(4-etoksy-4-oksobutyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(4-etoksy-4-oksobutyl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(4-etoksy-4-oksobutyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-cyan-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-cyan-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-metoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-sulfamoyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-hydroksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(aminometyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinolin-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinoksalin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(4'-(acetamidmetyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(4'-(2-acetamidetyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(kinolin-7-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metoksypyridin-4-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(4-(1H-indol-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(etoksykarbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

2'-((R)-1-((2-amino-6-((S)-3-(etoksykarbonyl)-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-4-yl)oksy)-2,2,2-trifluoretyl)-5'-klor-[1,1'-bifenyl]-3-karboksylsyre;

(S)-etyl 8-(6-((R)-1-(3'-(akrylamidmetyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-karbamoyl-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-sulfamoyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat

(S)-etyl 8-(2-amino-6-((R)-1-(2'-(etoksykarbonyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(etoksykarbonyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(etoksykarbonyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(3S)-etyl 8-(2-amino-6-((1R)-1-(4-(1,2-dihydroksyetyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(aminometyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-((E)-3-etoksy-3-oksoprop-1-en-1-yl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-((E)-3-etoksy-3-oksoprop-1-en-1-yl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(3-etoksy-3-oksopropyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; (S)-etyl 8-(2-amino-6-((R)-1-(4'-(3-etoksy-3-oksopropyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(kinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(3S)-etyl 8-(2-amino-6-((1R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(2-okso-1,3-dioksolan-4-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(2-metyl-1-okso-1,2,3,4-tetrahydroisokinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(4-(acetamidmetyl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(3S)-etyl 8-(2-amino-6-((1R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-((2-((2-oksotetrahydrofuran-3-yl)tio)etyl)karbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3,4-dimetyl-3''-(metylsulfonyl)-[1,1':3',1''-terfenyl]-4'-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(metylsulfonyl)-5-(kinolin-6-yl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(hydroksymetyl)-3'-metyl-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(hydroksymetyl)-4'-metyl-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(metoksykarbonyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

3'-((S)-1-((2-amino-6-((R)-3-(etoksykarbonyl)-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-4-yl)oksy)-2,2,2-trifluoretyl)-4'-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-karboksylsyre;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(1-okso-1,3-dihydroisobenzofuran-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(kinazolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(pyrimidin-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat

(S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-difluor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-diklor-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4',5-diklor-3'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-etoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-4'-etoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-5'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-5'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-fluor-5'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-metoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-4'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-4'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-fluor-4'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4',5-diklor-3'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4',5-diklor-3'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-4'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3',5'-difluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-4'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3',4'-difluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-octyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-cyklopentyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-pentyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-cyklohexyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-propyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-neopentyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-butyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-isopropyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-tert-butyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-tert-butyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-propylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-2-(dimetylamino)etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-2-(dimetylamino)-2-oksoetyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-2-(((R)-2-amino-3-metylbutanoyl)oksy)etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; og

(3S)-1-(pivaloyloksy)etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; eller et farmasøytisk akseptabelt salt av hvilket som helst av de nevnte; eller

b) valgt fra:

(S)-8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-3-(3-metyl-1H-pyrazol-1-yl)-5'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-4'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-5'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre

(S)-8-(2-amino-6-((R)-1-(3'-klor-4'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-etoksy-5'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(tert-butyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-fluor-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-isopropyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-karbamoyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-3',5'-bis(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-etoksy-4'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-3',5'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5'-diklor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre; (S)-8-(2-amino-6-((R)-1-(3'-klor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-3-(3-metyl-1H-pyrazol-1-yl)-4'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3',4'-dimetyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-etoksy-3'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3',5'-dimetyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-metyl-4'-(trifluormetoksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4',5-diklor-3',5'-dimetyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-fluor-3'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',5-diklor-5'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3',4',5'-trifluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(trifluormetoksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3',5'-bis(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-isopropyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3',5,5'-triklor-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-fluor-3'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-fluor-5'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5-klor-5'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-fluor-4'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(pyridin-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-etoksy-4'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3',4'-dimetyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4',5-diklor-3',5'-dimetyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-etoksy-3'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3',5'-dimetyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5-diklor-5'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-fluor-3'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-metyl-4'-(trifluormetoksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(trifluormetoksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-isopropyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3',5'-bis(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-fluor-4'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3',5,5'-triklor-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-fluor-3'-(trifluormetyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(pyridin-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-fluor-5'-isopropoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-etoksy-5'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5-klor-5'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-cyan-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-etoksy-5'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-4'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-etoksy-4'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-5'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(tert-butyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-4'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-difluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-3-(3-metyl-1H-pyrazol-1-yl)-5'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; (S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-3',5'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-fluor-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-etoksy-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',5'-diklor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-isopropyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-klor-3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-3-(3-metyl-1H-pyrazol-1-yl)-4'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-karbamoyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-3',5'-bis(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-etoksy-4'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-5'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; og

(S)-etyl 8-(2-amino-6-((R)-1-(4'-etoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

eller et farmasøytisk akseptabelt salt av hvilket som helst av de nevnte; eller

c) valgt fra:

(S)-8-(2-amino-6-((R)-1-(4'-etoksy-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3',4',5'-trifluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-4'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-5'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-5'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-klor-3-(3-metyl-1H-pyrazol-1-yl)-3'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-5'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-klor-4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(naftalen-2-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(benzyloksy)-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-butoksy-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-(5-metyl-1,3,4-oksadiazol-2-yl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metylsulfonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-((2-morfolinetyl)karbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-sulfamoyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-karbamoyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metylkarbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(piperazin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(dimetylkarbamoyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isobutoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(dietylkarbamoyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(neopentyloksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(kroman-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(cinnolin-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(hydroksymetyl)-4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(hydroksymetyl)-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(6-etoksypyridin-3-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((S)-1-(3',4'-bis(hydroksymetyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-(trifluormetyl)-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-brom-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(3-(trifluormetyl)-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2-(3-(tert-butyl)-1H-pyrazol-1-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(3-isopropyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(3-cyklopropyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(hydroksymetyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(prop-1-en-2-yl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro [4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(2-(dimetylamino)pyridin-4-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(naftalen-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(2-isopropylpyridin-4-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4',5-diklor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-4'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-2',3',4',5'-tetrahydro-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-isobutoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(pyrrolidin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(cyklopentyloksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(((1R,4R)-4-hydroksycyklohexyl)karbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-etyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-isopropyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-((2-(pyrrolidin-1-yl)etyl)karbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(morfolin-4-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(4-metylpiperazin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(2-metyltiazol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(1-metyl-2-okso-1,2-dihydropyridin-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(N-metylsulfamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(N,N-dimetylsulfamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(metylkarbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(dimetylkarbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(dietylkarbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(2-(1H-benzo[d]imidazol-4-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(piperazin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(4-cyklopropylpiperazin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(pyridin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(pyrimidin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(pyrazin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(5-klor-3'-(2-metoksyetoksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-(2-(1H-benzo[d]imidazol-1-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(1H-indazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-brom-2-(piperazin-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(piperazin-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-morfolin-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-([1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-isopropoksy-[1,1':3',1''-terfenyl]-4'-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-propoksy-[1,1':3',1''-terfenyl]-4'-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(5-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-fluor-4-propoksy-[1,1':3',1''-terfenyl]-4'-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(3,4-dimetyl-[1,1':3',1''-terfenyl]-4'-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(6-((R)-1-([1,1':3',1''-terfenyl]-4'-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(R)-8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(R)-8-(2-amino-6-((S)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((S)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((S)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(R)-8-(2-amino-6-((S)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(R)-8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-fluorkinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(dietylkarbamoyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-karbamoyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(metylkarbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-((2-morfolinetyl)karbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(metylsulfonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-sulfamoyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-(dimetylkarbamoyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(piperazin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-etoksy-3'-fluor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4'-etoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(cinnolin-6-yl)fenyl)-2,2,2-trifluoretoksy )pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(4-(kroman-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-fluorkinolin-6-yl)-2-metylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-8-(2-amino-6-((R)-1-(2-etyl-4-(3-fluorkinolin-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3',4',5'-trifluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(1-metyl-2-okso-1,2-dihydropyridin-4-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-4'-(trifluormetoksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-5'-(trifluormetyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-5'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-cyklopropyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-klor-4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2-(benzo[d]tiazol-5-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(2-(dimetylamino)pyridin-4-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(naftalen-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3'-(tert-butyl)-5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(2-(1H-benzo[d]imidazol-1-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(1H-indazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(2-isopropylpyridin-4-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-fluor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4',5-diklor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-4'-metyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(2-(3-metyl-1H-pyrazol-1-yl)-4-(naftalen-2-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-2',3',4',5'-tetrahydro-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(benzyloksy)-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-isobutoksy-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-isopropoksy-[1,1':3',1''-terfenyl]-4'-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-fluorkinolin-6-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-butoksy-3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-(5-metyl-1,3,4-oksadiazol-2-yl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(pyrrolidin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(cyklopentyloksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(morfolin-4-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(((1R,4R)-4-hydroksycyklohexyl)karbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-etyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-isopropyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2-etyl-4-(3-fluorkinolin-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(4-metylpiperazin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(3-fluorkinolin-6-yl)-2-metylfenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(dietylkarbamoyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-karbamoyl-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(2-metyltiazol-5-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-propoksy-[1,1':3',1''-terfenyl]-4'-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(5-klortiofen-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(metylsulfonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metylsulfonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(dietylkarbamoyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(metylkarbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-sulfamoyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-sulfamoyl-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-((2-morfolinetyl)karbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-((2-morfolinetyl)karbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(dimetylkarbamoyl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(piperazin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(piperazin-1-karbonyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(1-metyl-2-okso-1,2-dihydropyridin-3-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-(dimetylkarbamoyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-metoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-fluor-4'-propoksy-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(metylkarbamoyl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(N-metylsulfamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(N,N-dimetylsulfamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-morfolin-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(metylkarbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(dimetylkarbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-etoksy-3'-fluor-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4'-etoksy-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(5-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(dietylkarbamoyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isobutoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-(3-metyl-1H-pyrazol-1-yl)-4'-(neopentyloksy)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-(2-(1H-benzo[d]imidazol-4-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(kroman-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(piperazin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(4-cyklopropylpiperazin-1-karbonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(cinnolin-6-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-(trifluormetyl)-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(2-(3-(tert-butyl)-1H-pyrazol-1-yl)-4-klorfenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-isopropyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(3-cyklopropyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-(trifluormetyl)-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(3,4-dimetyl-[1,1':3',1''-terfenyl]-4'-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3-fluor-4-propoksy-[1,1':3',1''-terfenyl]-4'-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-([1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(6-((R)-1-([1,1':3',1''-terfenyl]-4'-yl)-2,2,2-trifluoretoksy)-2-aminopyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(hydroksymetyl)-4-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-3-yl)etoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(kroman-6-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(pyridin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(pyrimidin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(3'-(hydroksymetyl)-4'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-(hydroksymetyl)-3'-metyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-(6-etoksypyridin-3-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4-(6-metoksypyridin-3-yl)-2-(3-metyl-1H-pyrazol-1-yl)fenyl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(5-klor-3'-(2-metoksyetoksy)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((R)-1-(4-klor-2-(pyrazin-2-yl)fenyl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-etyl 8-(2-amino-6-((S)-1-(3',4'-bis(hydroksymetyl)-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-tert-butyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-tert-butyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; (S)-isopropyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-cyklopentyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5] dekan-3-karboksylat;

(S)-metyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5] dekan-3-karboksylat;

(S)-propyl 8-(2-amino-6-((R)-1-(3',4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5] dekan-3-karboksylat;

(S)-isopropyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-cyklopentyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro [4.5]dekan-3-karboksylat;

(S)-propyl 8-(2-amino-6-((R)-2,2,2-trifluor-1-(4'-isopropoksy-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)etoksy)pyrimidin-4-yl)-2,8-diazaspiro [4.5]dekan-3-karboksylat;

(S)-isopropyl 8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-cyklopentyl 8-(2-amino-6-((R)-1-(4'-klor-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-propyl 8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-metyl 8-(2-amino-6-((R)-1-(5-klor-3'-(metylsulfonyl)-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; og

(S)-metyl 8-(2-amino-6-((R)-1-(5-klor-3'-sulfamoyl-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

eller et farmasøytisk akseptabelt salt av hvilket som helst av de nevnte.

42. Forbindelse ifølge krav 1 som er (S)-etyl 8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat, eller et farmasøytisk akseptabelt salt derav.

43. Forbindelse ifølge krav 1 som er (S)-etyl 8-(2-amino-6-((R)-1-(5-klor- [1,1'-bifenyl]-2-yl) -2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro [4.5] dekan-3-karboksylat.

44. Forbindelse ifølge krav 1 som er (S)-8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre, eller et farmasøytisk akseptabelt salt derav.

45. Forbindelse ifølge krav 1 som er (S)-8-(2-amino-6-((R)-1-(5-klor-[1,1'-bifenyl]-2-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre.

46. Forbindelse ifølge krav 1 som er:

(S) -etyl 8-(2-amino-6-((R)-1-(3 ', 4'-dimetyl-3-(3-metyl-1 H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-8-(2-amino-6-((R)-1-(3', 4'-dimetyl-3-(3-metyl-1H-pyrazol-1-yl)-[1,1'-bifenyl]-4-yl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S)-etyl 8-(2-amino-6 -((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl) fenyl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat;

(S)-8-(2-amino-6-((R)-1-(4-klor-2-(3-metyl-1H-pyrazol-1-yl) fenyl)-2,2,2-trifluoretoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

(S) -etyl 8-(2-amino-6 -((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)-4'-propoksy-[1,1'-bifenyl]-4-yl) etoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylat; eller (S)-8-(2-amino-6 -((R)-2,2,2-trifluor-1-(3'-fluor-3-(3-metyl-1H-pyrazol-1-yl)- 4'-propoksy- [1,1'-bifenyl]-4-yl) etoksy) pyrimidin-4-yl)-2,8-diazaspiro[4.5]dekan-3-karboksylsyre;

eller et farmasøytisk akseptabelt salt derav.

47. Farmasøytisk sammensetning som omfatter en forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, og minst en farmasøytisk akseptabel bærer.

48. Fremgangsmåte for å hemme TPH1 som omfatter å kontakte TPH1 in vitro med en forbindelse ifølge hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav.

49. Forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, for anvendelse i en metode for å senke perifert serotonin i en pasient.

50. Forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, for anvendelse i en fremgangsmåte for å behandle eller forebygge en sykdom hos en pasient, hvor sykdommen er valgt fra beinsykdom, hjerte- og karsykdommer, metabolsk sykdom, lungesykdom, mage- og tarmsykdom, leversykdom, kreft og betennelsessykdom.

51. Forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, for anvendelse i en fremgangsmåte for å behandle en sykdom hos en pasient, hvor nevnte sykdom er osteoporose, osteoporosis pseudoglioma syndrom (OPPG), osteopeni, osteomalacia, renal osteodystrofi, Pagets sykdom, beinbrudd, beinmetastase, pulmonal arteriell hypertensjon (PAH), assosiert pulmonal arteriell hypertensjon (APAH), diabetes, hyperlipidemia, kronisk obstruktiv lungesykdom (KOLS), lungeemboli, inflammatorisk tarmsykdom (IBD), irritabel tarmsyndrom (IBS), kolitt, kemoterapi-indusert emesis, diaré, karsinoidsyndrom, cøliaki, Crohns sykdom, magesmerter, dyspepsi, forstoppelse, laktoseintoleranse, MEN-typer I og II, Ogilvies syndrom, bukspyttkjertelkolera-syndrom, pancreasinsuffisiens, feokromocytom, sklerodermi, somatiseringsforstyrrelse, Zollinger-Ellison-syndrom, kronisk leversykdom, leverkreft, brystkreft, kolangiokarsinom, kolonkreft, tykktarmskreft, nevroendokrin-svulster, kreft i bukspyttkjertelen, prostatakreft, beinkreft, blodkreft eller allergisk luftveisbetennelse.

52. Forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, for anvendelse i en fremgangsmåte for å behandle pulmonal arteriell hypertensjon (PAH) hos en pasient.

53. Forbindelse for anvendelse ifølge krav 52, hvor nevnte PAH er assosiert pulmonal arteriell hypertensjon (APAH) i en pasient.

54. Forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, for anvendelse i en fremgangsmåte for å behandle karsinoidsyndrom.

55. Forbindelse ifølge et hvilket som helst av kravene 1-46, eller et farmasøytisk akseptabelt salt derav, for anvendelse i en metode for å behandle leversykdom.

Hva betyr A1, B, B1, C osv?

Klasser chevron_right

IPC-klasse

C07D 471/10 A61K 31/438 A61P 1/00 A61P 9/00 A61P 29/00 A61P 35/00

Innehaver(e) chevron_right

Innehaver i Norge:

Altavant Sciences GmbH

Viaduktstrasse 8 4051 BASEL CH

Innehaver i EP:

Roivant Sciences GmbH

Viaduktstrasse 8 4051 Basel CH

Historikk

Patentstyrets saksnr. 2021/13147

Din referanse: P19914NOEP Levert 2021.09.21

Gjeldende status 2021.10.04 Avgjort

Avsender

ACAPO AS

Edvard Griegs vei 1 5059 BERGEN NO ( BERGEN kommune, Vestland fylke )

Org.nummer: 915113737

Statushistorie for 2021/13147

Liste over statusendringer i sakshistorikk
Hovedstatus	Beslutningsdato, detaljstatus
2021.10.04 Avgjort	2021.10.04 Forespørsel tatt til følge
2021.09.22 Under behandling	2021.09.22 Mottatt

Korrespondanse for 2021/13147

Liste over sakshistorikk og korrespondanse
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2021.10.04 Utgående GH Forespørsel ACAPO AS
02-01 Via Altinn-sending GH Forespørsel
2021.09.21 Innkommende, AR447138645 Generell henvendelse ACAPO AS
01-01 Generell henvendelse Generell henvendelse
01-02 Overdragelsesdokument P19914NOEP Assignment
01-03 Fullmakt P19914NOEP Fullmakt

Oppfinner(e) chevron_right

17 Hunting Ridge Farms Road Branford, Connecticut 06405 US

31 Highland Avenue Redding, Connecticut 06896 US

345 Camino Al Lago Menlo Park, California 94027 US

442 Dell Avenue Mountain View, California 94043 US

4205 Ellisfield Drive Durham, North Carolina 27705 US

Fullmektig chevron_right

Fullmektig i Norge:

ACAPO AS

Edvard Griegs vei 1 5059 BERGEN NO ( BERGEN kommune, Vestland fylke )

Org.nummer: 915113737

Din referanse: P19914NOEP

Org.nummer:
Foretaksnavn:
Foretaksform:
Næring:
Forretningsadresse:
Postaddresse:

Kilde: Brønnøysundregistrene

Åpne i Enhetsregisteret

Fullmektig i EP:

Carpmaels & Ransford LLP

One Southampton Row London WC1B 5HA GB

Prioritet chevron_right

2013.09.06, US 201361874545 P

2013.11.05, US 201361899943 P

2014.05.29, US 201462004385 P

Anførte dokumenter chevron_right

JIN H ET AL: "Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminop ropanoic acids as novel tryptophan hydroxylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 19, no. 17, September 2009 (2009-09), pages 5229-5232, XP026458597, ISSN: 0960-894X [retrieved on 2009-07-08] cited in the application (B1)

LIU QINGYUN ET AL: "Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 325, no. 1, April 2008 (2008-04), pages 47-55, XP009104653, ISSN: 0022-3565, DOI: 10.1124/JPET.107.132670 cited in the application (B1)

SHI ZHI-CAI ET AL: "Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 51, no. 13, 10 July 2008 (2008-07-10) , pages 3684-3687, XP002497512, ISSN: 0022-2623, DOI: 10.1021/JM800338J [retrieved on 2008-06-17] cited in the application (B1)

WO-A1-2012/048222 (B1)

WO-A1-2008/100412 (B1)

WO-A1-2010/046109 (B1)

WO-A1-2011/103196 (B1)

US-A1- 2010 331 294 (B1)

Oppreisning chevron_right

Patentstyrets saksnr. 2020/00250

Oppreisning

Levert 2020.05.26

Gjeldende status 2020.06.12 Avgjort

Kravstiller

ACAPO AS

Edvard Griegs vei 1 5059 BERGEN NO ( BERGEN kommune, Vestland fylke )

Org.nummer: 915113737

Org.nummer:
Foretaksnavn:
Foretaksform:
Næring:
Forretningsadresse:
Postaddresse:

Kilde: Brønnøysundregistrene

Åpne i Enhetsregisteret

Statushistorie for 2020/00250

Liste over statusendringer i sakshistorikk
Hovedstatus	Beslutningsdato, detaljstatus
2020.06.12 Avgjort	2020.06.12 Fortsatt behandling innvilget
2020.05.26 Under behandling	2020.05.29 Mottatt

Korrespondanse for 2020/00250

Liste over sakshistorikk og korrespondanse
Dato Type korrespondanse Journal beskrivelse Til/fra
2020.06.12 Utgående Oversendelsesbrev med avgjørelse uten klagefrist ACAPO AS
03-01 Via Altinn-sending Oversendelsesbrev med avgjørelse uten klagefrist
03-02 Vedlegg IAFO04- Avgjørelse - fristoversittelse_1292612
2020.06.02 Innkommende Korrespondanse (Hovedbrev inn) ACAPO AS
02-01 Korrespondanse (Hovedbrev inn) Korrespondanse (Hovedbrev inn)
2020.05.26 Innkommende, AR375188083 Nytt overprøvningskrav (OP)
01-01 Nytt overprøvningskrav (OP) Nytt overprøvningskrav (OP)
01-02 Fullmakt Fullmakt
01-03 Annet dokument P19914NOEP - vedlegg 5 EP3041842B8
01-04 Hovedbrev Hovedbrev
01-05 Annet dokument P19914NOEP - kvittering på innbetalt valideringsgebyr
01-06 Annet dokument P19914NOEP - vedlegg 2 oppdragsbrev
01-07 Annet dokument P19914NOEP - vedlegg 1 epost 02.01.2020 og 24.04.2020
01-08 Annet dokument P19914NOEP - vedlegg 4 EP3041842B1
01-09 Annet dokument P19914NOEP - vedlegg 3 norsk oversettelse av patentkrav

Sakshistorikk chevron_right

Statushistorie

Liste over statusendringer i sakshistorikk
Hovedstatus	Beslutningsdato, detaljstatus
2024.09.30 Patent opphørt	2025.04.15 Ikke betalt årsavgift
2020.06.22 EP patent gjort gjeldende i Norge	2020.06.22 EP patent besluttet gjeldende i Norge
2020.05.26 EP under behandling	2020.06.12 Fortsatt behandling er innvilget
2020.01.23 EP patent ikke gjort gjeldende i Norge	2020.06.03 Begjæring om fortsatt behandling er innkommet og under behandling
2020.01.23 EP patent ikke gjort gjeldende i Norge	2020.05.26 Oversettelse er ikke innlevert innen fristen
2020.05.26 EP under behandling	2020.05.26 Forespørsel om å gjøre EP patent gyldig er mottatt

Korrespondanse

Liste over sakshistorikk og korrespondanse
Dato Type korrespondanse Journal beskrivelse Til/fra
2025.04.15 Utgående EP Opphørt for ikke betalt årsavgift (3206) ACAPO AS
22-01 Via Altinn-sending EP Opphørt for ikke betalt årsavgift (3206)
2025.02.02 Utgående EP Påminnelse om ikke betalt årsavgift (3331) (PTEP3041842) ACAPO AS
21-01 Via Altinn-sending EP Påminnelse om ikke betalt årsavgift (3331) (PTEP3041842)
2023.07.12 Innkommende EP Publiseringsdokument fra EPO
20-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2022.09.07 Innkommende EP Publiseringsdokument fra EPO
19-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2022.04.20 Innkommende EP Publiseringsdokument fra EPO
18-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2021.10.27 Innkommende EP Publiseringsdokument fra EPO
17-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.12.16 Innkommende EP Publiseringsdokument fra EPO
16-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.11.25 Innkommende EP Publiseringsdokument fra EPO
15-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.09.30 Innkommende EP Publiseringsdokument fra EPO
14-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.09.16 Innkommende EP Publiseringsdokument fra EPO
13-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.08.26 Innkommende EP Publiseringsdokument fra EPO
12-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.08.12 Utgående EP Registreringsbrev (3210) (PTEP3041842)
11-01 Brev UT EP Registreringsbrev (3210) (PTEP3041842)
2020.08.07 Utgående EP Registreringsbrev (3210) (PTEP3041842)
10-01 Brev UT EP Registreringsbrev (3210) (PTEP3041842)
2020.08.05 Innkommende EP Publiseringsdokument fra EPO
09-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.08.03 Utgående EP Varsel om betaling av første årsavgift (3319) (PTEP3041842)
08-01 Via Altinn-sending EP Varsel om betaling av første årsavgift (3319) (PTEP3041842)
2020.06.22 Utgående EP Registreringsbrev (3210) (PTEP3041842)
07-01 Brev UT EP Registreringsbrev (3210) (PTEP3041842)
2020.06.10 Innkommende EP Publiseringsdokument fra EPO
06-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO
2020.06.02 Utgående Generelt brev Patent uten frist ACAPO AS
05-01 Via Altinn-sending Generelt brev Patent uten frist
2020.06.02 Innkommende Korrespondanse (Hovedbrev inn) ACAPO AS
04-01 Korrespondanse (Hovedbrev inn) Korrespondanse (Hovedbrev inn)
2020.05.26 Utgående EP Avslag ACAPO AS
03-01 Via Altinn-sending EP Avslag
2020.05.26 Innkommende, AR375173041 Søknadsskjema Patent ACAPO AS
01-01 Søknadsskjema Patent Søknadsskjema Patent
01-02 EP oversettelse EP oversettelse
01-03 Fullmakt Fullmakt
01-04 EP oversettelse EP oversettelse
01-05 EP oversettelse EP krav
01-06 Patenttegninger kvittering på innbetalt valideringsgebyr
2020.05.20 Innkommende EP Publiseringsdokument fra EPO
02-01 EP Publiseringsdokument fra EPO EP Publiseringsdokument fra EPO

Betaling chevron_right

Til betaling:

Betalingshistorikk:

Liste av betalinger
Beskrivelse / Fakturanummer	Betalingsdato	Beløp	Betaler	Status
Årsavgift 10. avg. år (EP)	2023.09.27	3200	COMPUTER PACKAGES INC.	Betalt og godkjent
Årsavgift 9. avg. år (EP)	2022.09.28	2850	COMPUTER PACKAGES INC.	Betalt og godkjent
Årsavgift 8. avg. år (EP)	2021.09.29	2550	COMPUTER PACKAGES INC.	Betalt og godkjent
Årsavgift 7. avg. år (EP)	2020.09.23	2200	MASTER DATA CENTER INC	Betalt og godkjent
32008183	2020.05.26	5500	ACAPO AS	Betalt
Valideringsgebyr EP-patent 5500 = 1 X 5500

Denne oversikten kan mangle informasjon, spesielt for eldre saker, om tilbakebetaling, internasjonale varemerker og internasjonale design.

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Hva betyr A1, B, B1, C osv?

Kapitler uten data er fjernet. Melding opprettet: 23.05.2025 07:13:34

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