ADAM BISAGA ET AL: "Therapeutic potential of NMDA receptor antagonists in the treatment of alcohol and substance use disorders", EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 9, no. 10, October 2000 (2000-10), pages 2233-2248, XP055088701, ISSN: 1354-3784, DOI: 10.1517/13543784.9.10.2233 (B1)

CODD E E ET AL: "SEROTONIN AND NOREPINEPHRINE UPTAKE INHIBITING ACTIVITY OF CENTRALLY ACTING ANALGESICS: STRUCTURAL DETERMINANTS AND ROLE IN ANTINOCICEPTION", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 274, no. 3, January 1995 (1995-01), pages 1263-1270, XP000909294, ISSN: 0022-3565 cited in the application (B1)

ELKADER A K ET AL: "Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patients", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 2009 LIPPINCOTT WILLIAMS AND WILKINS USA, vol. 29, no. 1, February 2009 (2009-02), pages 77-81, XP009174098, ISSN: 0271-0749 (B1)

GORMAN A L ET AL: "The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord.", NEUROSCIENCE LETTERS 14 FEB 1997, vol. 223, no. 1, 14 February 1997 (1997-02-14), pages 5-8, XP055087219, ISSN: 0304-3940 cited in the application (B1)

ZARATE C A ET AL: "A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression", ARCHIVES OF GENERAL PSYCHIATRY,, vol. 63, no. 8, August 2006 (2006-08), pages 856-864, XP002565718, DOI: 10.1001/ARCHPSYC.63.8.856 cited in the application (B1)

TENNANT ET AL: "(-)-alpha-Acetylmethadol for treatment of chronic pain patients who abuse opioids", DRUG AND ALCOHOL DEPENDENCE, ELSEVIER SCIENTIFIC PUBLISHERS, IR, vol. 12, no. 3, November 1983 (1983-11), pages 243-247, XP026202467, ISSN: 0376-8716, DOI: 10.1016/0376-8716(83)90066-2 [retrieved on 1983-11-01] (B1)

TIMOTHY B. MITCHELL ET AL: "Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 58, no. 6, December 2004 (2004-12), pages 609-617, XP055088699, ISSN: 0306-5251, DOI: 10.1111/j.1365-2125.2004.02221.x (B1)

TRULLAS R ET AL: "Functional antagonists at the NMDA receptor complex exhibit antidepressant actions", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 185, no. 1, 21 August 1990 (1990-08-21), pages 1-10, XP025545284, ISSN: 0014-2999, DOI: 10.1016/0014-2999(90)90204-J [retrieved on 1990-08-21] cited in the application (B1)

SNYDER, FREDERICK R: "Methadone and acetylmethadol: Systematic versus differential effects on affective states", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, ELSEVIER, US, vol. 25, no. 1, July 1986 (1986-07), page 310, XP025527438, ISSN: 0091-3057, DOI: 10.1016/0091-3057(86)90318-7 [retrieved on 1986-07-01] (B1)