BAUER D E ET AL: "Reawakening fetal hemoglobin: prospects for new therapies for the beta-globin disorders", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 120, no. 15, 17 August 2012 (2012-08-17), pages 2945-2953, XP002721961, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2012-06-292078 [retrieved on 2012-08-17] (B8)

WO-A2-2014/186585 (B8)

FYODOR D. URNOV ET AL: "Genome editing with engineered zinc finger nucleases", NATURE REVIEWS GENETICS, vol. 11, no. 9, 1 September 2010 (2010-09-01), pages 636-646, XP055198280, ISSN: 1471-0056, DOI: 10.1038/nrg2842 (B8)

NATHALIA HOLT ET AL: "Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo", NATURE BIOTECHNOLOGY, vol. 28, no. 8, 2 July 2010 (2010-07-02), pages 839-847, XP055101952, ISSN: 1087-0156, DOI: 10.1038/nbt.1663 (B8)

NING SUN ET AL: "Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease", MOLECULAR BIOSYSTEMS, vol. 8, no. 4, 1 January 2012 (2012-01-01) , page 1255, XP055081815, ISSN: 1742-206X, DOI: 10.1039/c2mb05461b (B8)

SANKARAN VIJAY G ET AL: "Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 322, no. 5909, 19 December 2008 (2008-12-19), pages 1839-1842, XP002603797, ISSN: 0036-8075 (B8)

SEDGEWICK A E ET AL: "BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies", BLOOD CELLS, MOLECULES AND DISEASES, LAJOLLA, US, vol. 41, no. 3, 1 November 2008 (2008-11-01), pages 255-258, XP025504678, ISSN: 1079-9796, DOI: 10.1016/J.BCMD.2008.06.007 [retrieved on 2008-08-08] (B8)

UDA MANUELA ET AL: "Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and Amelioration of the phenotype of beta-thalassemia", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 105, no. 5, 1 February 2008 (2008-02-01), pages 1620-1625, XP002506825, ISSN: 0027-8424, DOI: 10.1073/PNAS.0711566105 (B8)

US-A1- 2010 261 271 (B8)

US-A1- 2012 142 062 (B8)

US-B1- 8 012 946 (B8)

VIJAY G. SANKARAN ET AL: "Developmental and species-divergent globin switching are driven by BCL11A", NATURE, vol. 460, no. 7259, 5 August 2009 (2009-08-05), pages 1093-1097, XP055260135, United Kingdom ISSN: 0028-0836, DOI: 10.1038/nature08243 (B8)

VITTORIO SEBASTIANO ET AL: "In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases", STEM CELLS., vol. 29, no. 11, 25 October 2011 (2011-10-25), pages 1717-1726, XP055260055, US ISSN: 1066-5099, DOI: 10.1002/stem.718 (B8)

WO-A1-2013/126794 (B8)

WO-A2-02/42459 (B8)

WO-A2-2010/030963 (B8)

DANIEL E BAUER ET AL: "Update on fetal hemoglobin gene regulation in hemoglobinopathies", CURRENT OPINION IN PEDIATRICS., vol. 23, no. 1, 1 February 2011 (2011-02-01), pages 1-8, XP055259213, US ISSN: 1040-8703, DOI: 10.1097/MOP.0b013e3283420fd0 (B8)