CHELIUS DIRK ET AL: "Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 77, no. 18, 15 September 2005 (2005-09-15), pages 6004-6011, XP002407962, ISSN: 0003-2700, DOI: 10.1021/AC050672D (B1)

IVAN R CORREIA: "Stability of IgG isotypes in serum", MABS, vol. 2, 1 January 2010 (2010-01-01), pages 221-232, XP055125978, DOI: 10.4161/mabs.2.3.11788 (B1)

JEFFREY L CLELAND ET AL: "The development of stable protein formulations: A close look at protein aggregation, deamidation, and oxidation", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, BEGELL HOUSE PUBLISHING INC, US, vol. 10, no. 4, 1 January 1993 (1993-01-01), pages 307-377, XP002661804, ISSN: 0743-4863 (B1)

KROON D ET AL: "Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 9, no. 11, 1 November 1992 (1992-11-01), pages 1386-1393, XP002079908, ISSN: 0724-8741, DOI: 10.1023/A:1015894409623 cited in the application (B1)

WO-A2-2011/008092 (B1)

TSAI P K ET AL: "ORIGIN OF THE ISOELECTRIC HETEROGENEITY OF MONOCLONAL IMMUNOGLOBULIN H1B4", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 10, no. 11, 1 November 1993 (1993-11-01), pages 1580-1586, XP009020338, ISSN: 0724-8741, DOI: 10.1023/A:1018912417607 cited in the application (B1)

VLASAK J ET AL: "Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 392, no. 2, 15 September 2009 (2009-09-15), pages 145-154, XP026322897, ISSN: 0003-2697, DOI: 10.1016/J.AB.2009.05.043 [retrieved on 2009-06-02] (B1)

WO-A1-2012/054438 (B1)

WO-A2-2010/019570 (B1)

NOAH E ROBINSON* AND ARTHUR B ROBINSON: "Molecular clocks", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 944-949, XP008166630, ISSN: 0027-8424, DOI: 10.1073/PNAS.98.3.944 (B1)