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Tittel PYRIMIDO-PYRIDAZINONE COMPOUNDS AND USE THEREOF
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Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge (sjekk også detaljer i saken)
Patentnummer NO/EP2748166
Europeisk (EP) publiserings nummer EP2748166
EP levert
EP søknadsnummer 12756865.7
EP meddelt
Avdelt til EP3392252;
Prioritet 2011.08.23, US 201161526525 P
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Asana BioSciences, LLC (US)
Oppfinner VENKATESAN, Aranapakam (US) .... se mer/flere nedenfor
Fullmektig Orsnes Patent ApS (DK)
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Patentkrav 1. Forbindelse med formel (I):  hvori:  R1 er NR4R5,  en C1 til C6 alkoksy, som er usubstituert eller substituert med en eller flere av halogen, OH,  alkoksy,  NH2,  (alkyl)amino‐,  di(alkyl)amino‐,  (alkyl)C(O)N(C1‐C3  alkyl)‐,  (alkyl)karboksyamido‐,  HC(O)NH‐,  H2NC(O)‐,  (alkyl)NHC(O)‐,  di(alkyl)NC(O)‐,  CN,  C(O)OH,  (alkoksy)karbonyl‐,  (alkyl)C(O)‐,  aryl,  heteroaryl,  sykloalkyl,  haloalkyl,  amino(C1‐C6  alkyl)‐,  (alkyl)karboksyl‐, karboksyamidoalkyl‐, eller NO2,  en C6 til C14 aryl, som er usubstituert eller substituert med én eller flere av alkyl, halogen,  haloalkyl, alkoksy, haloalkoksy, OH, hydroksyalkyl,  ‐O‐(hydroksyalkyl),  ‐O‐(alkyl)‐C(O)OH,  -(alkyl)‐(alkoksy)‐halogen,  NH2,  aminoalkyl‐,  dialkylamino‐,  C(O)OH,  ‐C(O)O‐(alkyl),-OC(O)(alkyl),  ‐O‐(alkyl)‐N(alkyl)(alkyl),  N‐alkylamido‐,  ‐C(O)NH2,  (alkyl)amido‐,  NO2,  (aryl)alkyl,  aryloksy,  heteroaryloksy,  (aryl)amino,  (alkoksy)karbonyl‐,  (alkyl)amido‐,  (alkyl)amino, alkylkarboksyl‐, (alkyl)karboksyamido‐, (aryl)alkyl‐, (aryl)amino‐, sykloalkenyl,  heteroaryl,  (heteroaryl)alkyl‐,  heterosyklyl,  ‐O‐(heterosyklyl),  heterosyklyl(alkyl)‐,  (hydroksyalkyl)NH‐, (hydroksyalkyl)2N, ‐SO2(alkyl) eller en spiro‐substituent, en  heteroaryl,  som  er  usubstituert  eller  substituert  med  én  eller  more  av  C1‐C6  alkyl,  halogen,  haloalkyl,  OH,  CN,  hydroksyalkyl,  NH2,  aminoalkyl‐,  dialkylamino‐,  C(O)OH,  -C(O)O‐(alkyl),  ‐OC(O)(alkyl),  N‐alkylamido‐,‐C(O)NH2,  (alkyl)amido‐,  ‐NO2,  (aryl)alkyl,  alkoksy,  aryloksy,  heteroaryloksy,  (aryl)amino,  (alkoksy)karbonyl‐,  (alkyl)amido‐,  (alkyl)amino, aminoalkyl‐, alkylkarboksyl‐,  (alkyl)karboksyamido‐, (aryl)alkyl‐,  (aryl)amino‐,  sykloalkenyl,  heteroaryl,  (heteroaryl)alkyl‐,  heterosyklyl,  heterosyklyl(alkyl)‐,  (hydroksyalkyl)NH‐, (hydroksyalkyl)2N eller en spiro‐substituent,  en 3‐10‐leddet monosyklisk eller bisyklisk sykloalkyl, som er usubstituert eller substituert  med  én  eller  flere  av  halogen,  NH2,  (alkyl)NH,  (alkyl)(alkyl)N‐,  ‐N(alkyl)C(O)(alkyl),  -NHC(O)(alkyl),  ‐NHC(O)H,  ‐C(O)NH2,  ‐C(O)NH(alkyl),  ‐C(O)N(alkyl)(alkyl),  CN,  OH,  alkoksy,   alkyl, C(O)OH, ‐C(O)O(alkyl), ‐C(O)alkyl), aryl, heteroaryl, sykloalkyl, haloalkyl, aminoalkyl‐, -OC(O)(alkyl), karboksyamidoalkyl‐, og NO2, eller  en  3‐10‐leddet  monosyklisk  eller  bisyklisk  heterosyklyl,  som  er  usubstituert  eller  substituert  med  én  eller  flere  av  alkyl,  halogen,  alkoksy,  haloalkyl,  OH,  hydroksyalkyl,  -C(O)‐(hydroksyalkyl), NH2, aminoalkyl‐, dialkylamino‐, C(O)OH, ‐C(O)O‐(alkyl), ‐OC(O)(alkyl),  N‐alkylamido‐, ‐C(O)NH2, (alkyl)amido‐, ‐C(O)‐(alkyl)‐CN, (alkyl)‐CN, eller NO2,  hvori:  (i) 3‐4‐leddet sykloalkyl og heterosyklyl er mettet; (ii)  hydrogenatomer  på  det  samme  karbonatomet  ved  nevnte  sykloalkyl  eller  heterosyklyl er valgfritt erstattet med en 3‐6‐leddet sykloalkyl, som er usubstituert  eller  substituert  med  én  eller  flere  av  halogen,  NH2,  (alkyl)NH,  (alkyl)(alkyl)N‐,  -N(alkyl)C(O)(alkyl),  ‐NHC(O)(alkyl),  ‐NHC(O)H,  ‐C(O)NH2,  ‐C(O)NH(alkyl),  -C(O)N(alkyl)(alkyl),  CN,  OH,  alkoksy,  alkyl,  C(O)OH,  ‐C(O)O(alkyl),‐C(O)alkyl),  aryl,  heteroaryl,  sykloalkyl,  haloalkyl,  aminoalkyl‐,  ‐OC(O)(alkyl),  karboksyamidoalkyl‐,  og NO2,  eller  en  heterosyklyl,  som  er  usubstituert  eller  substituert med  én  eller  flere av alkyl, halogen, alkoksy, haloalkyl, OH, hydroksyalkyl, ‐C(O)‐(hydroksyalkyl),  NH2,  aminoalkyl‐,  dialkylamino‐,  C(O)OH,  ‐C(O)O‐(alkyl),  ‐OC(O)(alkyl),  N-alkylamido‐,  ‐C(O)NH2,  (alkyl)amido‐,  ‐C(O)‐(alkyl)‐CN,  (alkyl)‐CN,  eller  NO2  for  å  danne en spirosykloalkyl eller spiroheterosyklyl; og  (iii) hydrogenatomer på det samme atomet ved nevnte sykloalkyl eller heterosyklyl  er valgfritt erstattet med O for å danne en okso‐substituent; R2 er fenyl,  fenyl substituert med C(O)NR4R5, fenyl substituert med NR4R5, eller fenyl substituert med  (C1 til C6 alkyl) NR4R5, fenyl  substituert  med  én  eller  more  C1  til  C6  alkoksy,  (C1  til  C6  alkyl)halogen,  C1  til  C6  trifluoralkoksy,  (C1  til C6 alkyl)C(O)OH, halogen, nevnte usubstituerte eller substituerte C3  til C8 sykloalkyl, nevnte usubstituerte eller substituerte heterosyklyl, nevnte usubstituerte  eller substituerte heteroaryl, ‐O‐(C1 til C6 alkyl)C(O)OH, ‐O‐(C1 til C6 alkyl)‐NR4R5, ‐O‐(nevnte  usubstituerte  eller  substituerte  heterosykel),  ‐O(C1  til  C6  alkyl)‐N(C1  til  C6  alkyl)(C1  til  C6  alkyl), ‐O‐(C1 til C6 alkyl)NH2, C1 til C6 hydroksyalkyl, ‐O‐(C1 til C6 hydroksyalkyl), O‐(C1 til C6  alkyl)‐C(O)OH,  ‐C1  til  C6  alkoksy‐C1  til  C6  alkoksy, O‐(heterosykel)‐(C1  til  C6  hydroksyalkyl),  SO2‐(C1 til C6 alkyl), eller ‐(C1 til C6 alkyl)‐(C1 til C6 alkoksy)‐halogen;   fenyl substituert med ‐O‐(C1 til C6 alkyl)‐heterosykel; eller  en 5‐6‐leddet heteroaryl, som er usubstituert eller substituert med (C1 til C6 alkyl)NR4R5  eller substituert med NR4R5, med den forutsetning av når R2 er 4‐pyridyl, mangler 4-pyridylet en karbonyl‐substituent ved posisjon nummer 2; R4 og R5 er:  (a)  uavhengig  valgt  fra  gruppen  bestående  av  H,  C1  til  C6  alkyl,  C1  til  C6  hydroksyalkyl, C3 til C8 sykloalkyl, og ‐(C1 til C6 alkyl)N(C1 til C6 alkyl)(C1 til C6 alkyl);  (b)  forenet  for  å  danne  en  3‐8‐leddet  heterosyklyl,  som  er  usubstituert  eller  substituert  med  én  eller  flere  av  alkyl,  halogen,  alkoksy,  haloalkyl,  OH,  hydroksyalkyl,  ‐C(O)‐(hydroksyalkyl),  NH2,  aminoalkyl‐,  dialkylamino‐,  C(O)OH,  -C(O)O‐(alkyl),  ‐OC(O)(alkyl),  N‐alkylamido‐,  ‐C(O)NH2,  (alkyl)amido‐,  ‐C(O)‐(alkyl)-CN, (alkyl)‐CN, eller NO2, hvori;   (bi) hydrogenatomer på det samme karbonatomet ved nevnte heterosyklyl  er valgfritt erstattet med en 3‐6‐leddet sykloalkyl, som er usubstituert eller  substituert med én eller more av halogen, NH2, (alkyl)NH, (alkyl)(alkyl)N‐, -N(alkyl)C(O)(alkyl),  ‐NHC(O)(alkyl),  ‐NHC(O)H,  ‐C(O)NH2,  ‐C(O)NH(alkyl),-C(O)N(alkyl)(alkyl),  CN,  OH,  alkoksy,  alkyl,  C(O)OH,  ‐C(O)O(alkyl) (O)  alkyl),  aryl,  heteroaryl,  sykloalkyl,  haloalkyl,  aminoalkyl‐,  ‐OC(O)(alkyl),  karboksyamidoalkyl‐,  og  NO2,  eller  en  heterosyklyl,  som  er  usubstituert  eller substituert med én eller flere av alkyl, halogen, alkoksy, haloalkyl, OH,  hydroksyalkyl,  ‐C(O)‐(hydroksyalkyl),  NH2,  aminoalkyl‐,  dialkylamino‐,  C(O)OH,  ‐C(O)O‐(alkyl),  ‐OC(O)(alkyl),  N‐alkylamido‐,  ‐C(O)NH2,  (alkyl)  amido‐,  ‐C(O)‐(alkyl)‐CN,  (alkyl)‐CN,  eller  NO2,  for  å  danne  en  spirosykloalkyl eller spiroheterosyklyl; og (bii)  hydrogenatomer på det  samme atomet  ved nevnte heterosyklyl  (b),  sykloalkyl  (bi),  eller  heterosyklyl  (bi),  er  valgfritt  erstattet  med  O  for  å  danne en okso‐substituent;  eller et farmasøytisk akseptabelt salt eller ester av samme. 2. Forbindelse med formel (I):    hvori:   R1 er NR4R5, en C1 til C6 alkoksy, en C6 til C14 aryl, en heteroaryl, en 3‐10‐leddet monosyklisk  eller bisyklisk sykloalkyl, eller en 3‐10‐leddet monosyklisk eller bisyklisk heterosyklyl, hvori:   (i) 3‐4‐leddet sykloalkyl og heterosyklyl er mettet; (ii)  hydrogenatomer  på  det  samme  karbonatomet  ved  nevnte  sykloalkyl  eller  heterosyklyl er valgfritt erstattet med en 3‐6‐leddet sykloalkyl eller heterosyklyl for  å danne en spirosykloalkyl eller spiroheterosyklyl; og  (iii) hydrogenatomer på det samme atomet ved nevnte sykloalkyl eller heterosyklyl  er valgfritt erstattet med O for å danne en okso‐substituent;  R2 er en fenyl eller en 5‐6‐leddet heteroaryl, med den forutsetning at når R2 er 4‐pyridyl,  mangler nevnte 4‐pyridyl en karbonyl‐substituent ved posisjon nummer 2;  R4 og R5 er:  (a)  uavhengig  valgt  fra  gruppen  bestående  av  H,  C1  til  C6  alkyl,  C1  til  C6  hydroksyalkyl, C3 til C8 sykloalkyl, og ‐(C1 til C6 alkyl)N(C1 til C6 alkyl)(C1 til C6 alkyl);  (b) forenet for å danne en 3‐8‐leddet heterosyklyl, hvori;  (bi)  hydrogenatomer  på  det  samme  karbonatomet  ved  nevnte  heterosyklyl  er  valgfritt  erstattet med  en  3‐6‐leddet  sykloalkyl  eller  heterosyklyl  for  å  danne  en  spirosykloalkyl eller spiroheterosyklyl; og  (bii) hydrogenatomer på det samme atomet ved nevnte heterosyklyl (b), sykloalkyl  (bi),  eller  heterosyklyl  (bi),  er  valgfritt  erstattet  med  O  for  å  danne  enn  oksosubstituent; eller et farmasøytisk akseptabelt salt eller ester av samme.  3. Forbindelse ifølge krav 2, hvori R2 er a) fenyl substituert med C(O)NR4R5;b) fenyl substituert med  NR4R5 eller c) fenyl substituert med (C1 til C6 alkyl)NR4R5.  4. Forbindelse ifølge krav 1 eller 3, hvori R2 er fenyl substituert med C(O)NR4R5, hvori C(O)NR4R5 er:     5.  Forbindelse  ifølge  krav  1  eller  3,  hvori  R2  er  fenyl  substituert  med  NR4R5  eller  (C1  til  C6  alkyl)NR4R5, hvori  a) NR4R5 er:   eller b)  R4  og  R5  er  tatt  sammen med  nitrogenatomet  som  de  er  bundet  til  for  å  danne  en  gruppe valgt fra følgende:  b1) hvori R4 og R5 er  tatt  sammen  for å danne en 6‐leddet  ring eller en 7‐leddet  ring;  b2) hvori R4 og R5 er forenet for å danne en heterosyklyl med strukturen:  hvori:  a, b, c, d, og e er, uavhengig, fraværende, (CH2), CH(R3), Z, eller C=O;  R3 er H, C(O)OH, C1 til C6 hydroksyalkyl, eller C(O)O(C1 til C6 alkyl);  R10, R11, R12, og R13 er, uavhengig, H eller C1 til C6 alkyl; og  Z er O, S, eller NH;  b3) hvori R4 og R5 er tatt sammen for å danne en heterosyklyl med strukturen:  hvori:  R10, R11, R12, og R13 er, uavhengig, H eller C1 til C6 alkyl;   Y er O eller NR9; og R9  er  H,  C1  til  C6  alkyl,  OH,  C(O)OH,  C1  til  C6  hydroksyalkyl,  (C1  til  C6  alkyl)NH2, (C1 til C6 alkyl)N(C1 til C6 alkyl)(C1 til C6 alkyl), (C1 til C6 alkyl)(C1 til  C6  alkoksy),  C(O)(C1  til  C6  alkyl)NH2,  (C1  til  C6  alkyl)C(O)OH,  C(O)(C1  til  C6  hydroksyalkyl),  C(O)(C1  til  C6  alkyl)CN,  (C1  til  C6  alkyl)CN,  (C1  til  C6  alkyl)halogen, eller (C1 til C6 alkyl)O(C1 til C6 alkyl)C(O)(C1 til C6 alkyl)NH2;  hvori  2  hydrogenatomer  festet  til  det  samme  karbonatomet  er  valgfritt  erstattet med =O; eller b4)  hvori  R4  og  R5  er  tatt  sammen  for  å  danne  en morfolin  eller  piperazin med  strukturen:   eller   eller hvori   c) R4 og R5 er hver uavhengig (C1 til C6 hydroksyalkyl).  6. Forbindelse ifølge krav 5, hvori R4 og R5 er forenet for å danne en heterosyklyl med strukturen:  hvori:  R10, R11, R12, og R13 er, uavhengig, H eller C1 til C6 alkyl;  R14 er halogen, OH, C(O)OH, C1 til C6 alkoksy, (C1 til C6 alkyl)halogen, (C1 til C6 alkyl)C(O)OH,  C1 til C6 hydroksyalkyl, C3 til C8 sykloalkyl, (C1 til C6 alkyl)C(O)NH2, (C1 til C6 alkyl)C(O)NH(C1  til C6 hydroksyalkyl), (C1 til C6 alkyl)C(O)N(C1 til C6 hydroksyalkyl)2, (C1 til C6 alkyl)CN, (C1 til  C6 alkyl)heteroaryl, eller heteroaryl; og  R18 er C1 til C6 hydroksyalkyl eller C1 til C6 alkyl‐C(O)OH.  7. Forbindelse ifølge krav 6, hvori R4 og R5 er forenet for å danne piperidin eller en diazepan, eller  en substituert piperidin eller diazepan valgt fra gruppen bestående av:             8. Forbindelse ifølge krav 5, hvori R4 og R5 er forenet for å danne:      9. Forbindelse ifølge krav 5, hvori den 6‐leddede ringen er  a)    hvori: R14 er H, OH, C(O)OH, C1 til C6 alkyl, eller (C1 til C6 alkyl)CN; b)  hvori:  Y er O eller NR9; og R9  er  H,  C1  til  C6  alkyl,  OH,  C1  til  C6  hydroksyalkyl,  C(O)  (C1  til  C6  hydroksyalkyl),  C(O)(C1 til C6 alkyl)CN, (C1 til C6 alkyl)CN, (C1 til C6 alkyl)NH2, (C1 til C6 alkyl)halogen,  C(O)  (C1  til C6 alkyl)CN eller  (C1  til C6 alkyl)O(C1 til C6 alkyl)C(O)(C1  til C6 alkyl)NH2;  eller c)  hvori:  a, b, c, d, og e er, uavhengig, absent, (CH2), CH(R3), eller O; og  R3 er H eller C(O)OH  10. Forbindelse ifølge krav 2, hvori R2 er   a) en heteroaryl substituert med (C1 til C6 alkyl)NR4R5; eller  b) hvori R2 er en heteroaryl substituert med NR4R5; eller  c) hvori R2 er fenyl substituert med én eller flere C1 til C6 alkoksy, (C1 til C6 alkyl)halogen, C1  til  C6  trifluoralkoksy,  (C1  til  C6  alkyl)C(O(OH,  halogen,  nevnte  usubstituerte  eller  substituerte C3 til C8 sykloalkyl, nevnte usubstituerte eller substituerte heterosyklyl, nevnte  usubstituerte  eller  substituerte  heteroaryl,  ‐O‐(C1  til  C6  alkyl)C(O)OH,  ‐O‐(C1  til  C6  alkyl)‐  NR4R5, ‐O‐(nevnte usubstituerte eller substituerte heterosykel), ‐O(C1 til C6 alkyl)‐N(C1 til C6  alkyl)(C1  til  C6  alkyl),  ‐O‐(C1  til  C6  alkyl)NH2,  C1  til  C6  hydroksyalkyl,  ‐O‐(C1  til  C6  hydroksyalkyl), O‐(C1 til C6 alkyl)‐C(O)OH, ‐C1 til C6 alkoksy‐C1 til C6 alkoksy, O‐(heterosykel)-(C1 til C6 hydroksyalkyl), SO2‐(C1 til C6 alkyl), eller ‐(C1 til C6 alkyl)‐(C1 til C6 alkoksy)‐halogen;  eller d) hvori R2 er fenyl substituert med ‐O‐(C1 til C6 alkyl)‐heterosykel. 11. Forbindelse ifølge krav 1 eller 10, hvori R2 er:  a)    b)   c)   hvori, R80 er OH, ‐(C1 til C6 alkyl) CN, C1 til C6 hydroksyalkyl, (C1 til C6 alkyl)C(O)NH2, (C1 til C6  alkyl)heterosykel eller ‐(C1 til C6 alkyl)C(O)OH; d)   hvori: p er 1 til 6; og R81 er H eller C(O)OH;   e)  hvori, R90 er H, C1 til C6 alkyl, C(O)(C1 til C6 alkyl) CN, (C1 til C6 alkyl)C(O)OH, eller C(O)C1 til C6  hydroksyalkyl; f)  hvori, R6 er H, (C1 til C6 alkyl)C(O)OH, eller (C1 til C6 alkyl)CN; g)  hvori, z er 1, 2, 3, 4, 5, eller 6; h)  hvori, R6 er H eller (C1 til C6 alkyl)C(O)OH; i)  hvori:  y  er  2  til  6;  og  R50  er  H, OH,  C1  til  C6  alkyl,  C1  til  C6  hydroksyalkyl,  eller  ‐(C1  til  C6  alkyl)C(O)OH; j)     hvori:  m er 2 til 6; y er 0 eller 1; Z er O eller NR60; og  R60 er H, C1 til C6 alkyl, C1 til C6 hydroksyalkyl, ‐(C1 til C6 alkyl)CN, ‐(C1 til C6 alkyl)C(O)  OH, ‐(C1 til C6 alkyl)CONH2, eller ‐C(O)(C1 til C6 alkyl) OH; hvori  2  hydrogenatomer  festet  til  ett  karbonatom  i  nitrogenringen  er  erstattet med  en  okso‐ eller valgfritt substituert 3‐8‐leddet spirosyklisk ring; k)  hvori:  r er 2 til 6; og R70 er H, C(O)OH eller C1 til C6 hydroksyalkyl; l)  eller m)  12. Forbindelse ifølge krav 1 eller 10, nevnte heteroaryl in R2 er pyridin.  13. Forbindelse ifølge krav 1 eller 2, hvori R1 er:  a) N(C1 til C6 alkyl)(C1 til C6 alkyl);   b) C1 til C6 alkoksy; c) fenyl eller en substituert fenyl med strukturen:   hvori, R22, R23, R24, R25, og R26 er, uavhengig, H, C(O)(C1 til C6 alkoksy), C(O)OH, O(C1 til C3  perfluoralkyl),  O(C1  til  C6  perfluoralkoksy),  C1  til  C6  alkoksy,  halogen,  (C1  til  C6  alkyl)heterosyklyl, eller (C1 til C6 alkyl)CN; d)  en  5‐9‐leddet mettet  heterosyklyl  eller  en  substituert  5‐9‐leddet mettet  heterosyklyl  med strukturen  hvori:  R34, R35, R36, og R37 er, uavhengig, H, C1 til C6 alkyl, eller CN; Y er (C(R8)2)x, NR7(C(R8)2)x, O, (S=O), SO2, eller NR7; R7  og  R8  er,  uavhengig,  H,  C1  til  C6  alkyl,  C(O)OH,  (C1  til  C6  alkyl)CN,  (C1  til  C6  alkyl)C(O)OH, C(O)(C1 til C6 alkyl)CN, eller CN; og x er 0 til 2; e) en heterosyklyl med strukturen:  hvori:  f, g, h, j, og m er, uavhengig, absent, (CH2), CH(R3), Z, eller C=O; R3 er H, C(O)OH, eller C(O)O(C1 til C6 alkyl); R45, R46, R47, og R48 er, uavhengig, H eller C1 til C6 alkyl; og Z er O, S, SO, SO2, eller NH; f) en heteroaryl;   g) monosyklisk C3 til C8 sykloalkyl; eller  h) piperidin substituert med C(O)(C1 til C6 alkyl)CN.  14. Forbindelse ifølge krav 13, hvori R1 er:   a) N(CH(CH3)2)2, N(CH3)2, OCH2CH3, eller OCH3; b)       c)           d)   e) tiofen, benzooksol, eller pyridin; f)  sykloheptyl  eller  sykloheksyl,  begge valgfritt  substituert med  ‐N(C1  til  C6  alkyl)(C1  til  C6  alkyl); eller g)   15. Forbindelse ifølge ett av kravene 1 til 14, som er et salt av en syre valgt fra gruppen bestående  av  etansyre,  propionsyre,  melkesyre,  sitronsyre,  tartarsyre,  ravsyre,  fumarsyre,  maleinsyre,  malonsyre,  mandelsyre,  eplesyre,  ftalsyre,  saltsyre,  hydrobromsyre,  fosforsyre,  salpetersyre,  svovelsyre,  metansulfonsyre,  naftalensulfonsyre,  benzensulfonsyre,  toluensulfonsyre,  trifluoretansyre og kamfersulfonsyre. 16. Forbindelse ifølge krav 1 eller 2, som er:  4‐(4‐morfolinofenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  metyl‐4‐(5‐okso‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)benzoat hydroklorid;  2‐morfolino‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  4‐(4‐(morfolinometyl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐(4‐(4‐etylpiperazin‐1‐yl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐(4‐((4‐etylpiperazin‐1‐yl)metyl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐fenyl‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;   2‐fenyl‐4‐(4‐(piperazin‐1‐yl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐(4‐(morfolin‐4‐karbonyl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐(4‐(bis(2‐hydroksyetyl)amino)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐(4‐(4‐(2‐aminoacetyl)piperazin‐1‐yl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)-on hydroklorid;  2‐(4‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)piperazin‐1-yl)etansyre;  1‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)piperidin‐4-karboksylsyre;  4‐(4‐(4‐(2‐aminoacetyl)piperazin‐1‐yl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)-on;  N‐(2‐(dimetylamino)etyl)‐N‐metyl‐4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin-4‐ylamino)benzamid;  4‐(4‐(2‐okso‐1,7‐diazaspiro[3.5]nonan‐7‐yl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin-5(6H)‐on;  4‐(4‐(2‐oksa‐7‐azaspiro[3.5]nonan‐7‐yl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)-on;  4‐(4‐morfolinofenylamino)‐2‐(6‐azaspiro[2.5]oktan‐6‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  6‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  etyl‐6‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylat;  6‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)benzyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  natrium‐6‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylat;  4‐(4‐(2‐oksa‐7‐azaspiro[3.5]nonan‐7‐ylmetyl)fenylamino)‐2‐fenylpyrimido[4,5‐d]pyridazin-5(6H)‐on;  4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)‐2‐(tiofen‐3‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;   6‐(5‐okso‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2‐yl)-6‐azaspiro[2.5]oktan‐1‐karboksylsyre hydroklorid;  4‐(4‐(4‐etylpiperazin‐1‐yl)fenylamino)‐2‐morfolinopyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐(5‐okso‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)benzosyre hydroklorid;  4‐(4‐(4‐etylpiperazin‐1‐yl)fenylamino)‐2‐(4‐(trifluormetoksy)fenyl)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  metyl‐4‐(4‐(4‐morfolinofenylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)benzoat;  4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)‐2‐(piperidin‐1‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  2‐(3‐metoksyfenyl)‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)-on hydroklorid;  2‐(piperazin‐1‐yl)‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  dihydroklorid;  2‐(benzo[d][1,3]dioksol‐5‐yl)‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5-d]pyridazin‐5(6H)‐on hydroklorid;  2‐(1‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)piperidin‐4-yl)etansyre;  1‐(4‐(5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)benzyl)piperidin‐4-karboksylsyre;  2‐(2‐metoksyfenyl)‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)-on hydroklorid;  4‐(4‐(4‐etylpiperazin‐1‐yl)fenylamino)‐2‐(tiofen‐3‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  9‐(5‐okso‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2‐yl)-3,9‐diazaspiro[5.5]undekan‐2,4‐dion hydroklorid;  6‐(4‐(5‐okso‐2‐(tiofen‐3‐yl)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐ylamino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;   2‐(4‐klorfenyl)‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  2‐(4‐metoksyfenyl)‐4‐(4‐(piperazin‐1‐ylmetyl)fenylamino)pyrimido[4,5‐d]pyridazin‐5(6H)-on hydroklorid;  6‐(4‐((2‐morfolino‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(5‐okso‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin-2‐yl)piperidin‐4‐yl)etansyre hydroklorid;  2‐(1‐oksidothiomorfolino)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on hydroklorid;  2‐(4‐metylpiperazin‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on hydroklorid;  6‐(4‐((2‐(4‐metoksyfenyl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  6‐(4‐((2‐(3‐metoksyfenyl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)‐2‐(pyrrolidin‐1‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)-on hydroklorid;  2‐(dimetylamino)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on hydroklorid;  2‐etoksy‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  1‐(5‐okso‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐karboksylsyre hydroklorid;  2‐(azepan‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  6‐(4‐((2‐(2‐metoksyfenyl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(diisopropylamino)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on hydroklorid;   2‐(4‐(morfolinometyl)fenyl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on hydroklorid;  1‐(5‐okso‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐karbonitril hydroklorid;  2‐(4‐etylpiperazin‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on hydroklorid;  4‐((1‐(2‐morfolinoetyl)‐1H‐pyrazol‐4‐yl)amino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1,4‐diazepan‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on dihydroklorid;  2‐(azepan‐1‐yl)‐4‐((4‐morfolinofenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐metoksy‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  6‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐fenyl‐4‐((1‐(2‐(piperazin‐1‐yl)etyl)‐1H‐pyrazol‐4‐yl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on hydroklorid;  4‐((1‐(2‐(4‐metylpiperazin‐1‐yl)etyl)‐1H‐pyrazol‐4‐yl)amino)‐2‐fenylpyrimido[4,5-d]pyridazin‐5(6H)‐on;  4‐((1‐(2‐(4‐etylpiperazin‐1‐yl)etyl)‐1H‐pyrazol‐4‐yl)amino)‐2‐fenylpyrimido[4,5‐d]pyridazin-5(6H)‐on;  6‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(azepan‐1‐yl)‐4‐((3,4,5‐trimetoksyfenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(morfolin‐4‐karbonyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  2‐(1‐(4‐((2‐(4‐(cyanometyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  2‐(1‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;   6‐(4‐((2‐(1,4‐diazepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)-6‐azaspiro[2.5]oktan‐1‐karboksylsyre hydroklorid;  6‐(4‐((2‐(4‐(cyanometyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  6‐(4‐((2‐(4‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(4‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐(4‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  6‐(4‐((2‐sykloheksyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  6‐(4‐((2‐sykloheptyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)piperidin‐4-yl)acetonitril;  4‐((4‐((4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1‐yl)metyl)fenyl)amino)‐2-fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐((4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1-yl)metyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐((4‐metylpiperazin‐1‐yl)metyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(4‐(4‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)piperidin‐1-yl)etansyre;   2‐(4‐(4‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)sykloheksyl)etansyre;  2‐(1‐(4‐((2‐(azocan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on hydroklorid;  2‐(1‐(4‐((2‐sykloheptyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)sykloheksyl)etansyre;  4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)butansyre;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐morfolinoetoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐((4‐(2‐morfolinoetoksy)fenyl)amino)‐2‐fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐metylpiperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)etyl)piperidin‐4‐yl)etansyre;  2‐(1‐(5‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperidin‐4‐yl)acetonitril;  1‐(2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)etyl)piperidin‐4‐karboksylsyre;  2‐(1‐(5‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperidin‐4‐yl)acetamid;  2‐(1‐(4‐((2‐(4‐(2‐cyanopropan‐2‐yl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐4‐yl)amino)fenyl)piperidin‐4‐yl)etansyre;  2‐(1‐(5‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(5‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperidin‐4‐yl)acetamid;   2‐(1‐(5‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(piperazin‐1‐karbonyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid; 2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetamid;  2‐(4‐(2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)etyl)piperazin‐1‐yl)etansyre;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(5‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperidin‐4‐yl)etansyre;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)‐N‐(2‐hydroksyetyl)acetamid;  2‐(azepan‐1‐yl)‐4‐((4‐(((2S,5S)‐5‐(hydroksymetyl)‐1,4‐dioksan‐2-yl)metoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)‐2‐metylpropanenitril;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)‐2‐metylpropanamid;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  2‐(1‐(5‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1-yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(5‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)etansyre;  2‐(1‐(4‐((2‐(3,5‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;   2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)‐N,N‐bis(2‐hydroksyetyl)acetamid;  2‐metyl‐2‐(1‐(4‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)propanenitril;  2‐(4‐(2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)etyl)piperazin‐1‐yl)‐2‐metylpropanenitril;  2‐(1‐(4‐((2‐(2,6‐dimetylmorfolino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  4‐((4‐(((2S,5S)‐5‐(hydroksymetyl)‐1,4‐dioksan‐2‐yl)metoksy)fenyl)amino)‐2-fenylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐((1S,4S)‐4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)sykloheksyl)etansyre;  (2R,5S)‐5‐((4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)metyl)‐1,4‐dioksan‐2‐karboksylsyre;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)etansyre;  2‐(1‐(3‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)propyl)piperidin‐4‐yl)etansyre;  6‐(4‐((2‐(sykloheksylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)spiro[2.5]oktan‐1‐karboksylsyre;  6‐(4‐((5‐okso‐2‐(piperidin‐1‐yl)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)spiro[2.5]oktan‐1‐karboksylsyre;  2‐((1R,4R)‐4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)sykloheksyl)etansyre;  3‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)propionsyre;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)syklopropanekarboksylsyre;  3‐(1‐(4‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)piperidin‐4-yl)propionsyre;   6‐(4‐((2‐(4‐fluorfenyl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  6‐(5‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2‐yl)-6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  6‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)‐2-fluorfenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐(piperazin‐1‐yl)propoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  6‐(5‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2‐yl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  6‐(4‐((5‐okso‐2‐(pyridin‐4‐yl)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐hydroksypropan‐2‐yl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)‐2‐metylpropionsyre;  6‐(4‐((2‐(azocan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐6-azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)‐2‐metylpropionsyre;  2‐metyl‐2‐(1‐(4‐((5‐okso‐2‐fenyl‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)propionsyre;  2‐(2,6‐dimetylpiperidin‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((2‐(2,6‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  6‐(4‐((2‐(2,6‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(2,6‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;   2‐(2,6‐dimetylpiperidin‐1‐yl)‐4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1-yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(5‐((2‐(2,6‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)etansyre;  2‐(3,5‐dimetylpiperidin‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((2‐(3,5‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  6‐(4‐((2‐(3,5‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(3,5‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  2‐(3,5‐dimetylpiperidin‐1‐yl)‐4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperidin‐1-yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(5‐((2‐(3,5‐dimetylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)etansyre;  2‐(2,6‐dimetylmorfolino)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((2‐(2,6‐dimetylmorfolino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  6‐(4‐((2‐(2,6‐dimetylmorfolino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(2,6‐dimetylmorfolino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  2‐(2,6‐dimetylmorfolino)‐4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperidin‐1-yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(5‐((2‐(2,6‐dimetylmorfolino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)etansyre;  2‐(diisopropylamino)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;   2‐(1‐(4‐((2‐(diisopropylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  6‐(4‐((2‐(diisopropylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)-6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(diisopropylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  2‐(diisopropylamino)‐4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperidin‐1-yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(5‐((2‐(diisopropylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)etansyre;  2‐(2‐metylpiperidin‐1‐yl)‐4‐((4‐(piperazin‐1‐ylmetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((2‐(2‐metylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  6‐(4‐((2‐(2‐metylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(2‐metylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperidin‐1‐yl)fenyl)amino)‐2‐(2‐metylpiperidin‐1-yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(5‐((2‐(2‐metylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐2‐(azepan‐1‐yl)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐2‐(azepan‐1-yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;   2‐(1‐(4‐((2‐sykloheptyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐sykloheptyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  6‐(4‐((2‐(3‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(3‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐(3‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((2‐(3‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  1‐(4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐3‐karbonitril;  2‐(1‐(4‐((2‐(3‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐yl)etansyre;  1‐(4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐3‐karbonitril;  1‐(4‐((2‐sykloheptyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐2‐sykloheptylpyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((2‐sykloheptyl‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐yl)etansyre;  4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐2-sykloheptylpyrimido[4,5‐d]pyridazin‐5(6H)‐on;  1‐(4‐((2‐(4‐cyanopiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐karbonitril;   1‐(4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐karbonitril;  1‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  2‐(1‐(4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  1‐(4‐((2‐(4‐(cyanometyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((2‐(4‐(cyanometyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  2‐(4‐(4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperazin‐1‐yl)acetonitril;  2‐(1‐(4‐((2‐(4‐(cyanometyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐yl)etansyre;  2‐(4‐(4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperazin‐1‐yl)acetonitril;  6‐(4‐((2‐(1,4‐diazepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)-6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(1,4‐diazepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐(1,4‐diazepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((2‐(1,4‐diazepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  6‐(4‐((2‐(4‐(2‐cyanoacetyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(4‐(2‐cyanoacetyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;   1‐(4‐((2‐(4‐(2‐cyanoacetyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((2‐(4‐(2‐cyanoacetyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  3‐(4‐(4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperazin‐1‐yl)‐3‐oksopropanenitril;  2‐(1‐(4‐((2‐(4‐(2‐cyanoacetyl)piperazin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐yl)etansyre;  4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐2‐(4‐(2-isocyanoacetyl)piperazin‐1‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  6‐(4‐((2‐(1‐(2‐cyanoacetyl)piperidin‐4‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(1‐(4‐((2‐(1‐(2‐cyanoacetyl)piperidin‐4‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;  1‐(4‐((2‐(1‐(2‐cyanoacetyl)piperidin‐4‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐karboksylsyre;  1‐(4‐((2‐(1‐(2‐cyanoacetyl)piperidin‐4‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐karboksylsyre;  3‐(4‐(4‐((4‐((4‐(2H‐tetrazol‐5‐yl)piperidin‐1‐yl)metyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐1‐yl)‐3‐oksopropanenitril;  2‐(1‐(4‐((2‐(1‐(2‐cyanoacetyl)piperidin‐4‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)benzyl)piperidin‐4‐yl)etansyre;  4‐((4‐((4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)metyl)fenyl)amino)‐2‐(1‐(2-isocyanoacetyl)piperidin‐4‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(4‐(5‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperazin‐1‐yl)etansyre;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)-1,4‐diazepan‐1‐yl)etansyre;  2‐(1‐(4‐((4‐(4‐(2‐hydroksypropan‐2‐yl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;   3‐(1‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)propionsyre;  6‐(5‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  1‐(5‐okso‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐karbonitril;  2‐(1‐(5‐okso‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐etylpiperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐fenyl‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)‐2‐(piperidin‐1‐yl)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(4‐(4‐((5‐okso‐2‐(piperidin‐1‐yl)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)-1,4‐diazepan‐1‐yl)etansyre;  6‐(4‐((2‐(4‐metylpiperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(4‐metylpiperidin‐1‐yl)‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on hydroklorid;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(3‐oksopiperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  6‐(2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)etyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(dietylamino)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;  2‐(sykloheksyl(metyl)amino)‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((2‐(sykloheksyl(metyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)etansyre;   2‐(4‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)etansyre;  2‐(1‐(4‐((2‐(3‐metoksyfenyl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐4‐yl)acetonitril;  4‐((4‐(2‐(1,4‐diazepan‐1‐yl)etoksy)fenyl)amino)‐2‐(azepan‐1‐yl)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐oksopiperazin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(3‐metoksyfenyl)‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(dimetylamino)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(piperidin‐4‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;  2‐(1‐(5‐okso‐4‐((4‐(2‐(piperidin‐4‐yl)etoksy)fenyl)amino)‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  6‐(4‐((2‐(sykloheksyl(metyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylsyre;  4‐((4‐(2‐(1,4‐diazepan‐1‐yl)etoksy)fenyl)amino)‐2‐(piperidin‐1‐yl)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐hydroksypiperidin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐(piperazin‐1‐yl)propyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;  2‐(1‐(5‐okso‐4‐((4‐(3‐(piperazin‐1‐yl)propyl)fenyl)amino)‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐etyl‐3‐oksopiperazin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐morfolino‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;   2‐(2,6‐dimetylmorfolino)‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐etyl‐3‐oksopiperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐(4‐hydroksypiperidin‐1‐yl)propyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐etylpiperazin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  4‐((6‐(2‐(piperazin‐1‐yl)etoksy)pyridin‐3‐yl)amino)‐2‐(piperidin‐1‐yl)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((6‐(2‐(piperazin‐1‐yl)etoksy)pyridin‐3‐yl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  4‐((4‐(2‐(4‐hydroksypiperidin‐1‐yl)etoksy)fenyl)amino)‐2‐(piperidin‐1‐yl)pyrimido[4,5-d]pyridazin‐5(6H)‐on; 2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐hydroksy‐4‐metylpiperidin‐1-yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐(4‐hydroksy‐4‐metylpiperidin‐1‐yl)etoksy)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐hydroksypiperidin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((4‐(4‐etylpiperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin-2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(diisopropylamino)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((4‐(4‐hydroksypiperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐hydroksyetyl)piperazin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(2‐hydroksyetyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(piperazin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;   2‐(1‐(5‐okso‐4‐((4‐(piperazin‐1‐yl)fenyl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(3‐hydroksypropyl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐hydroksyetyl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(2‐hydroksyetyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(2‐(4‐etylpiperazin‐1‐yl)etyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(piperazin‐1‐yl)etyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;  4‐((4‐(2‐aminoetoksy)fenyl)amino)‐2‐(azepan‐1‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐aminoetoksy)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐hydroksypiperidin‐1‐yl)etyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(hydroksymetyl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐(hydroksymetyl)piperidin‐1‐yl)etoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)piperidin‐1‐yl)etyl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(4‐(3‐hydroksypropyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)acetonitril;  2‐(1‐(4‐((4‐(4‐(cyanometyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;   3‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)propionsyre;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐etylpiperazin‐1‐yl)etyl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐hydroksy‐4‐metylpiperidin‐1‐yl)etyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐(2‐hydroksyetyl)piperazin‐1‐yl)etyl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐(4‐(2‐hydroksyetyl)piperazin‐1‐yl)etyl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(4‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)‐2‐metylpropionsyre;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1‐yl)fenyl)  amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  3‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)‐3‐oksopropanenitril;  2‐(1‐(4‐((4‐(4‐(hydroksymetyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((6‐(4‐hydroksypiperidin‐1‐yl)pyridin‐3‐yl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐(4‐(hydroksymetyl)piperidin‐1‐yl)etoksy)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  (fosfonooksy)metyl‐6‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐6‐azaspiro[2.5]oktan‐1‐karboksylat;  3‐(4‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)propionsyre;  2‐(azepan‐1‐yl)‐4‐((6‐(piperazin‐1‐yl)pyridin‐3‐yl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(2‐hydroksyetyl)‐2H‐tetrazol‐5‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;   2‐(1‐(4‐((4‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(2‐(dietylamino)etoksy)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐etyl‐2H‐tetrazol‐5‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;  2‐(1‐(4‐((4‐(2‐etyl‐2H‐tetrazol‐5‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  4‐((4‐(2H‐tetrazol‐5‐yl)fenyl)amino)‐2‐(azepan‐1‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((6‐(4‐etylpiperazin‐1‐yl)pyridin‐3‐yl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((6‐(4‐etylpiperazin‐1‐yl)pyridin‐3‐yl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(4‐(5‐okso‐4‐((4‐(2‐(piperazin‐1‐yl)etoksy)fenyl)amino)‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperazin‐1‐yl)acetonitril;  2‐(1‐(5‐okso‐4‐((6‐(piperazin‐1‐yl)pyridin‐3‐yl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin-2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐3‐yl)etansyre;  2‐(1‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐3‐yl)etansyre;  3‐(4‐(5‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)pyridin‐2-yl)piperazin‐1‐yl)‐3‐oksopropanenitril;  2‐(5‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenyl)‐2H-tetrazol‐2‐yl)etansyre;  2‐(azepan‐1‐yl)‐4‐((6‐(4‐(2‐hydroksyetyl)piperidin‐1‐yl)pyridin‐3‐yl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  3‐(4‐(5‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperazin‐1‐yl)‐3‐oksopropanenitril;   2‐(azepan‐1‐yl)‐4‐((6‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1‐yl)pyridin‐3-yl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐(2‐hydroksyetyl)piperazin‐1-yl)etoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  3‐(4‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperazin‐1‐yl)‐3‐oksopropanenitril;  2‐(5‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)‐2H‐tetrazol‐2‐yl)etansyre;  2‐(azepan‐1‐yl)‐4‐((6‐(4‐metylpiperazin‐1‐yl)pyridin‐3‐yl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((6‐(4‐metylpiperazin‐1‐yl)pyridin‐3‐yl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  4‐((4‐(4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)fenyl)amino)‐2‐(azepan‐1‐yl)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2H‐tetrazol‐5‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐metylpiperazin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)-on;  2‐(1‐(4‐((4‐(4‐metylpiperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(5‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)pyridin‐2‐yl)piperidin‐3‐yl)etansyre;  2‐(1‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)piperidin‐3‐yl)etansyre;  2‐(1‐(4‐((6‐(4‐(2‐hydroksy‐2‐metylpropanoyl)piperazin‐1‐yl)pyridin‐3‐yl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  4‐((6‐(4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)pyridin‐3‐yl)amino)‐2‐(azepan‐1-yl)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;   2‐(1‐(4‐((6‐(4‐((2H‐tetrazol‐5‐yl)metyl)piperidin‐1‐yl)pyridin‐3‐yl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(4‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)piperidin‐1‐yl)etansyre;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐metoksyetyl)piperazin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(2‐metoksyetyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(4‐(2‐aminoetyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(1‐(hydroksymetyl)‐6‐azaspiro[2.5]oktan‐6-yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(1‐(hydroksymetyl)‐6‐azaspiro[2.5]oktan‐6‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(3‐hydroksypropyl)piperazin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(3‐hydroksypropyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(4‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)piperidin‐1‐yl)etansyre;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐hydroksyetyl)‐1,4‐diazepan‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(2‐hydroksyetyl)‐1,4‐diazepan‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(1‐hydroksy‐2‐metylpropan‐2‐yl)piperazin‐1-yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(1‐hydroksy‐2‐metylpropan‐2‐yl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐(dimetylamino)etyl)piperazin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;   2‐(1‐(4‐((4‐(4‐(2‐(dimetylamino)etyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐etylpiperazin‐1‐yl)‐2‐oksoetoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐(4‐etylpiperazin‐1‐yl)‐2‐oksoetoksy)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(2‐(4‐metylpiperazin‐1‐yl)‐2‐oksoetoksy)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐(2‐hydroksyetyl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2,3‐dihydroksypropyl)piperazin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(2,3‐dihydroksypropyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐fluoretyl)piperazin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(2‐fluoretyl)piperazin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((6‐(3‐hydroksypiperidin‐1‐yl)pyridin‐3‐yl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((6‐(3‐hydroksypiperidin‐1‐yl)pyridin‐3‐yl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4,4‐difluorpiperidin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((4‐(4,4‐difluorpiperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐hydroksypiperidin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((4‐(3‐hydroksypiperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;   2‐(azepan‐1‐yl)‐4‐((4‐(2‐(4‐metylpiperazin‐1‐yl)‐2‐oksoetoksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(3‐(hydroksymetyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐(hydroksymetyl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(3‐(2‐hydroksyetyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(4‐metoksypiperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐metoksypiperidin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐fluorpiperidin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐fluorpiperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin-2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐((1‐(2‐hydroksyetyl)piperidin‐4‐yl)oksy)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(piperidin‐4‐yloksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on  hydroklorid;  2‐(1‐(4‐((4‐(2‐hydroksyetoksy)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐hydroksyetoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(3‐hydroksypropoksy)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin-2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐hydroksypropoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(4‐(1‐hydroksy‐2‐metylpropan‐2‐yl)‐1,4‐diazepan‐1‐yl)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(4‐(2‐fluoretyl)piperidin‐1‐yl)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;   2‐(1‐(4‐((4‐(4‐(2‐fluoretyl)piperidin‐1‐yl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((3,5‐dimetoksyfenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(5‐okso‐4‐((4‐(trifluormetoksy)fenyl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((3,5‐dimetoksyfenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐(trifluormetoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  3‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)propionsyre;  3‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenyl)propionsyre;  2‐(azepan‐1‐yl)‐4‐((4‐(bis(2‐hydroksyetyl)amino)fenyl)amino)pyrimido[4,5‐d]pyridazin-5(6H)‐on;  2‐(1‐(4‐((4‐(bis(2‐hydroksyetyl)amino)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(3‐hydroksypropyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(3‐hydroksypropyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((3‐(hydroksymetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((3‐(hydroksymetyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐fluorfenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4-yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐fluorfenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(azepan‐1‐yl)‐4‐((4‐((1‐hydroksy‐2‐metylpropan‐2‐yl)oksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐((1‐hydroksy‐2‐metylpropan‐2‐yl)oksy)fenyl)amino)‐5‐okso‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;   2‐(4‐((2‐(azepan‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4‐yl)amino)fenoksy)‐2-metylpropionsyre;  2‐(4‐((2‐(4‐(cyanometyl)piperidin‐1‐yl)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐4-yl)amino)fenoksy)‐2‐metylpropionsyre;  2‐(azepan‐1‐yl)‐4‐((3,4‐dimetoksyfenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((3,4‐dimetoksyfenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((3‐metoksyfenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((3‐metoksyfenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐hydroksyetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐hydroksyetyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(2‐metoksyetoksy)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(2‐metoksyetoksy)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(5‐okso‐4‐((3,4,5‐trimetoksyfenyl)amino)‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐(benzo[d][1,3]dioksol‐5‐ylamino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐(benzo[d][1,3]dioksol‐5‐ylamino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐((1‐(2‐hydroksyetyl)piperidin‐4‐yl)oksy)fenyl)amino)pyrimido[4,5-d]pyridazin‐5(6H)‐on;  natrium‐(2‐(4‐(cyanometyl)piperidin‐1‐yl)‐4‐((4‐(4‐hydroksypiperidin‐1‐yl)fenyl)amino)‐5-oksopyrimido[4,5‐d]pyridazin‐6(5H)‐yl)metylfosfat;  2‐(azepan‐1‐yl)‐4‐((4‐(hydroksymetyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((4‐(hydroksymetyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;   2‐(1‐(4‐((4‐(metylsulfonyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(azepan‐1‐yl)‐4‐((4‐(metylsulfonyl)fenyl)amino)pyrimido[4,5‐d]pyridazin‐5(6H)‐on;  2‐(1‐(4‐((1H‐benzo[d][1,2,3]triazol‐5‐yl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5-d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(5‐okso‐4‐((2‐okso‐2,3‐dihydro‐1H‐benzo[d]imidazol‐5‐yl)amino)‐5,6-dihydropyrimido[4,5‐d]pyridazin‐2‐yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(3‐fluorpropyl)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril;  2‐(1‐(4‐((4‐(difluormetoksy)fenyl)amino)‐5‐okso‐5,6‐dihydropyrimido[4,5‐d]pyridazin‐2-yl)piperidin‐4‐yl)acetonitril; og  4‐((1H‐benzo[d][1,2,3]triazol‐5‐yl)amino)‐2‐(azepan‐1‐yl)pyrimido[4,5‐d]pyridazin‐5(6H)-on. 17. Farmasøytisk  blanding  som  omfatter  en  forbindelse  ifølge  ett  av  kravene  1  til  16  og  en  farmasøytisk akseptabel bærer.  18. Sett som omfatter en forbindelse ifølge ett av kravene 1 til 16.  19. Forbindelse  ifølge ett av kravene 1 til 16 eller et  farmasøytisk akseptabelt salt av samme for  anvendelse i reduksjon av inflammasjon.  
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Asana BioSciences, LLC
997 Lenox Drive, Suite 220, Princeton Pike Corporation Center NJ08648 LAWRENCEVILLE US
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Asana BioSciences, LLC
997 Lenox Drive, Suite 220 Princeton Pike Corporate Center Lawrenceville, NJ 08648 US
Patentstyrets saksnr. 2018/15011
Din referanse: Henrik E. Ørsnes   Levert  
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VENKATESAN, Aranapakam
7100 Johnsons Farm LaneUnit 105 Chadds Ford, PA 19317 US
SMITH, Roger, Astbury
206 Bayberry Drive Chester Springs, PA 19425 US
HOSAHALLI, Subramanya
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KUNTU, Karunasree
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Din referanse: T5165_NO
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Stolmár & Partner Patentanwälte PartG mbB
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2011.08.23, US 201161526525 P

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DE-A1- 2 046 577 (B1)

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