1348540-80-6, DATABASE REGISTRY [Online] 21 December 2007 XP003032821 Database accession no.959318-74-2, CARROLL TEMPLE, JR. ET AL.: '1,2-Dihydropyrido[3,4-b] pyrazines: Structure-Activity Relationships.' J. MED. CHEM. vol.26, no.1, 1983, pages 91 - 95, XP002112043, JEFFREY W. WILLIAMS ET AL.: 'The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition.' BIOCHEMICAL PHARMACOLOGY vol.29, no.4, 1980, pages 589 - 595, XP023730157, WO-A2-2004/005472, WO-A2-2011/014795, BRITTA NISIUS ET AL.: 'Development of a Fingerprint Reduction Approach for Bayesian Similarity Searching Based on Kullback-Leibler Divergence Analysis.' J. CHEM. INF. MODEL. vol.49, no.6, 2009, pages 1347 - 1358, XP055139297, ROBERT D. ELLIOTT ET AL.: 'Potential Folic Acid Antagonists. VI. The Syntheses of 1- and 3-Deazamethotrexate.' J. ORG. CHEM. vol.36, no.19, 1971, pages 2818 - 2823, XP055139301, C. CHOO HOFFMANN ET AL.: 'Comparative effects of selected antifolates on transforming human lymphocytes and on established human lymphoblastic cell lines.' BIOCHEMICAL PHARMACOLOGY vol.25, no.17, 1976, pages 1947 - 1954, XP023718954, DELIANG CHEN ET AL.: 'Computational Selection of Inhibitors of A-beta Aggregation and Neuronal Toxicity.' BIOORG MED CHEM. vol.17, no.14, 15 July 2009, pages 5189 - 5197, XP026302987, ROBERT D . ELLIOTT ET AL.: 'The Isomeric Pyridopyrazines from the Reaction of Some Tetraaminopyridines with Pyruvaldehyde and Benzil.' THE JOURNAL OF ORGANIC CHEMISTRY vol.33, no.6, June 1968, pages 2393 - 2397, XP055139316, DATABASE REGISTRY [Online] 21 December 2007 XP003032810 Database accession no.959372-94-2, DATABASE REGISTRY [Online] 02 December 2011 XP003032812 Database accession no.

1347587-04-5, WO-A1-2009/099801

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