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Tittel SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS
Status
Hovedstatus
Detaljstatus 		Ikke i kraft info Patent opphørt Ikke betalt årsavgift
Patentnummer NO/EP2648516
Europeisk (EP) publiserings nummer EP2648516
EP levert
EP søknadsnummer 11847595.3
EP meddelt
Prioritet 2010.12.06, US 420074 P
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver Aclaris Therapeutics, Inc. (US)
Oppfinner SELNESS, Shaun, R. (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Patentkrav1. Forbindelse som har strukturen med formel (I):eller et farmasøytisk akseptabelt salt derav, hvori:X og Y er uavhengig valgt blant gruppen som består av CH og N, med det forbehold at når X er CH, Y er N, og når X er N, er Y CH;R1 er valgt blant gruppen som består av C1-C6-alkyl, halogen og -H;R2 er valgt blant gruppen som består av alkyl og alkoksy; hvori alkyl eller alkoksy eventuelt er substituert med én eller flere substituenter uavhengig valgt blant heterosyklyl; og hvori heterosyklylet eventuelt er substituert med én eller flere substituenter uavhengig valgt blant gruppen som består av alkyl, alkoksy og cyano; R3 og R4 er uavhengig valgt blant gruppen som består av alkyl, halogen og -H; og R5 er valgt blant gruppen som består av sykloalkyl og heteroaryl; hvori sykloalkylet betyr en hydrokarbylgruppe som inneholder minst én mettet eller delvis umettet ringstruktur og festet via et ringkarbon, og heteroaryl betyr en monosyklisk, bisyklisk eller trisyklisk ring som har opptil 6 atomer i hver ring hvori minst én ring er aromatisk og inneholder fra 1 til 4 heteroatomer i ringen valgt blant gruppen som består av N, O og S, "heteroaryl" inkludert N-oksidderivatet ifølge ethvert nitrogenholdig heteroaryl; hvori sykloalkylet eventuelt er substituert med én eller flere substituenter uavhengig valgt blant gruppen som består av halogen, cyano, alkyl, hydroksyalkyl, alkoksyalkyl og aminoalkyl; og hvori heteroarylet er substituert med én eller flere substituenter uavhengig valgt blant gruppen som består av cyano, alkyl, hydroksyalkyl, alkoksyalkyl og aminoalkyl.2. Forbindelsen ifølge krav 1, hvori:R1 er valgt blant gruppen som består av C1-C3-alkyl, brom, klor og fluor;R2 er alkoksy, eventuelt substituert med én eller flere heterosyklylsubstituenter eventuelt substituert med én eller flere substituenter uavhengig valgt blant gruppen som består av C1-C3-alkyl og cyano;R3 er C1-C3-alkyl;R4 er valgt blant gruppen som består av -H, C1-C3-alkyl, brom, klor og fluor; og R5 er heteroaryl substituert med én eller flere substituenter uavhengig valgt blant gruppen som består av alkyl, hydroksyalkyl og aminoalkyl.3. Forbindelsen ifølge krav 2, hvori:R1 er metyl, brom eller klor;R2 er alkoksy, eventuelt substituert med fem- eller seksleddet heteroaryl eventuelt substituert med én eller flere substituenter uavhengig valgt blant C1-C3-alkyl;R3 er metyl;R4 er -H, metyl eller klor; ogR5 er fem- eller seksleddet heteroaryl substituert med én eller flere substituenter uavhengig valgt blant gruppen som består av alkyl og hydroksyalkyl.4. Forbindelsen ifølge krav 1, hvori forbindelsen har strukturen med formel (II):hvori:R1 er metyl, brom eller klor;R4 er -H, metyl eller klor;R20 er femleddet heteroaryl eventuelt substituert med én eller flere metylsubstituenter; R50 er -H eller metyl; ogR51 er -H, metyl eller hydroksy.5. Forbindelsen ifølge krav 4, valgt blant gruppen som består av:2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; og3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on.6. Forbindelsen ifølge krav 4, valgt blant gruppen som består av:3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 2'-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; og2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on.7. Forbindelsen ifølge krav 4, valgt blant gruppen som består av:3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,5',6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; og2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on.8. Forbindelsen ifølge krav 4, valgt blant gruppen som består av:3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3,5'-diklor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; og2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,4'-bipyridin]-2-on.9. Forbindelsen ifølge krav 4, valgt blant gruppen som består av:3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,5',6-trimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; og2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((5-metyltiofen-3-yl)metoksy)-2H-[1,4'-bipyridin]-2-on.10. Forbindelsen ifølge krav 1, hvori forbindelsen har strukturen med formel (III):hvori:R1 er metyl eller klor;R4 er -H eller metyl;R20 er femleddet heteroaryl eventuelt substituert med én eller flere metylsubstituenter; ogR51 er metyl eller hydroksy.11. Forbindelsen ifølge krav 10, valgt blant gruppen som består av:5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-2',3,6-trimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-2',3,6-trimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-2',3,6-trimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;3-klor-5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-2',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on; 3-klor-5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-2',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;3-klor-5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-2',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;3-klor-5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;3-klor-5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;3-klor-5'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-2',6-dimetyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-2',6-dimetyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-2',6-dimetyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((2-metyloksazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on;5'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((2-metyltiazol-4-yl)metoksy)-2H-[1,3'-bipyridin]-2-on; og5'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((1-metyl-1H-pyrazol-3-yl)metoksy)-2H-[1,3'-bipyridin]-2-on.12. Forbindelsen ifølge krav 1, hvori forbindelsen har strukturen med formel (VIII):hvori:X og Y er uavhengig valgt blant gruppen som består av CH og N, med det forbehold at når X er CH, Y er N, og når X er N, er Y CH;R1 er metyl, brom eller klor;R4 er -H, metyl eller klor;R21 er metyl eller metoksy;R50 er -H eller metyl; ogR51 er -H, metyl eller hydroksy. 13. Forbindelsen ifølge krav 12, valgt blant gruppen som består av:3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5'-diklor-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-brom-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,5',6-trimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on; 3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,5',6-trimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-5',6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,5',6-trimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-6-metyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-3,6-dimetyl-4-((6-metylpyridin-2-yl)metoksy)-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on; 2'-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,5',6-trimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3,5'-diklor-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-5'-klor-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-3-klor-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,5',6-trimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3,5'-diklor-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-5'-klor-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-3-klor-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(tert-butyl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,5',6-trimetyl-2H-[1,4'-bipyridin]-2-on; 3-brom-5'-klor-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,5',6-trimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-isopropyl-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,5',6-trimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on; 3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)pyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-5',6-dimetyl-2H-[1,4'-bipyridin]-2-on;2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyndin-2-yl)metoksy)-3,5',6-trimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3,5'-diklor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;5'-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on;3-brom-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on;3-klor-2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-6-metyl-2H-[1,4'-bipyridin]-2-on; og2'-(2-(2-hydroksypropan-2-yl)-5-metylpyrimidin-4-yl)-4-((6-metoksypyridin-2-yl)metoksy)-3,6-dimetyl-2H-[1,4'-bipyridin]-2-on.14. Farmasøytisk sammensetning som omfatter en terapeutisk effektiv mengde av en forbindelse ifølge krav 1 eller et farmasøytisk akseptabelt salt derav og en farmasøytisk akseptabel bærer.15. Forbindelse ifølge krav 1 eller farmasøytisk akseptabelt salt derav, for anvendelse i en fremgangsmåte for behandling av et individ for en tilstand valgt blant gruppen som består av autoimmune forstyrrelser, kroniske inflammatoriske forstyrrelser, akutte inflammatoriske forstyrrelser, autoinflammatoriske forstyrrelser, smerte, aterosklerose, diabetes, fibrotiske sykdommer, metabolske forstyrrelser, kreft, neoplasi, leukemi og lymfom.
Hva betyr A1, B, B1, C osv? info

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Innehaver i EP:
Aclaris Therapeutics, Inc.
640 Lee Road, Suite 200 Wayne, PA 19087 US

Oppfinner(e) info chevron_right

SELNESS, Shaun, R.
1875 Cedarmill Drive Chesterfield, MO 63017 US
MONAHAN, Joseph, B.
6 Lombardy Way St. Louis, MO 63138 US
SCHINDLER, John, F.
15801 Timber Valley Rd. Apt. M. Chesterfield, MO 63017 US
DEVADAS, Balekudru
2175 Parasol Drive Chesterfield, MO 63017 US

Fullmektig info chevron_right

Fullmektig i Norge:
ZACCO NORWAY AS
Postboks 488 0213 OSLO NO ( OSLO kommune, Oslo fylke )

Org.nummer: 982702887
Din referanse: V6861NO00
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Kilde: Brønnøysundregistrene
Fullmektig i EP:
Brown, David Leslie
Haseltine Lake LLP Redcliff Quay 120 Redcliff Street Bristol BS1 6HU GB

Prioritet info chevron_right

2010.12.06, US 420074 P

Anførte dokumenter info chevron_right

EP-A1- 1 447 401 (B1)

EP-A1- 1 741 702 (B1)

EP-A1- 2 177 520 (B1)

WO-A2-2005/018557 (B1)

US-A1- 2003 216 382 (B1)

US-A1- 2005 176 775 (B1)

WO-A1-03/068230 (B1)

ESSA HU ET AL: "Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit +", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 11, 1 June 2008 (2008-06-01), pages 3065-3068, XP055108943, ISSN: 0022-2623, DOI: 10.1021/jm800188g (B1)

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