Andrew P. Cairns ET AL: "The CD14+ CD16+ monocyte subset in rheumatoid arthritis and systemic lupus erythematosus", Rheumatology International, vol. 21, no. 5, 1 March 2002 (2002-03-01), pages 189-192, XP055204387, ISSN: 0172-8172, DOI: 10.1007/s00296-001-0165-8 (B1)

WO-A2-2010/030979 (B1)

G. BUCHAN ET AL.: 'Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-la'' CLIN. EXP. IMMUNOL . vol. 73, 1988, pages 449 - 455, XP055070232 (B1)

GARRONE P ET AL: "Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1 alpha specific inhibitor", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 33, no. 7-8, 1 May 1996 (1996-05-01), pages 649-658, XP002410040, ISSN: 0161-5890, DOI: 10.1016/0161-5890(96)00017-X (B1)

HATA ET AL.: 'Distinct contribution of IL-6, TNF- a ,IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice' JOURNAL OF CLINICAL INVESTIGATION vol. 114, no. 4, August 2004, pages 582 - 588, XP055070234 (B1)

LUBBERTS ERIK ET AL: "Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US, vol. 50, no. 2, 1 February 2004 (2004-02-01), pages 650-659, XP002580291, ISSN: 0004-3591 (B1)

MIOSSEC P: "Anti-interleukin 1alpha autoantibodies", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 61, no. 7, 1 July 2002 (2002-07-01), pages 577-579, XP002668460, ISSN: 0003-4967 (B1)

Norikuni Kawanaka ET AL: "CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis", Arthritis & Rheumatism, vol. 46, no. 10, 1 October 2002 (2002-10-01), pages 2578-2586, XP055204473, ISSN: 0004-3591, DOI: 10.1002/art.10545 (B1)

PASCUAL ET AL.: 'Role of interleukin-I (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade' JEM vol. 201, no. 9, 02 May 2005, pages 1479 - 1486, XP055070230 (B1)

Royal College Of Physicians: "RHEUMATOID ARTHRITIS National clinical guideline for management and treatment in adults", , 1 February 2009 (2009-02-01), XP055204522, Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/books/NBK5 1812/pdf/Bookshelf_NBK51812.pdf [retrieved on 2015-07-24] (B1)

SIMON A K ET AL: "DIVERGENT T-CELL CYTOKINE PATTERNS IN INFLAMMATORY ARTHRITIS", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, NATIONAL ACADEMY OF SCIENCES, US, vol. 91, 1 August 1994 (1994-08-01), pages 8562-8566, XP002021361, ISSN: 0027-8424, DOI: 10.1073/PNAS.91.18.8562 (B1)

US-A1- 2009 215 992 (B1)

US-A1- 2009 298 096 (B1)

WO-A1-2007/120828 (B1)

BAS SYLVETTE ET AL: "CD14 is an acute-phase protein", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 172, no. 7, 1 April 2004 (2004-04-01) , pages 4470-4479, XP002764419, ISSN: 0022-1767 (B1)