AMISHIRO N ET AL: "Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole compounds bearing beta-(5',6',7'-trimethoxy-2'-indolyl)acryl oyl group.", BIOORGANIC & MEDICINAL CHEMISTRY JUL 2000 LNKD- PUBMED:10976511, vol. 8, no. 7, July 2000 (2000-07), pages 1637-1643, XP5501882, ISSN: 0968-0896 (B1)

YUQIANG WANG ET AL: "CC-1065 Analogues Bearing Different DNA-Binding Subunits: Synthesis, Antitumor Activity, and Preliminary Toxicity Study", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 4, 1 February 2003 (2003-02-01), pages 634-637, XP55004542, ISSN: 0022-2623, DOI: 10.1021/jm0203433 (B1)

DALE L. BOGER ET AL: "Synthesis and Evaluation of a Series of C3-Substituted CBI Analogues of CC-1065 and the Duocarmycins", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 15, 1 July 2001 (2001-07-01), pages 5163-5173, XP55004443, ISSN: 0022-3263, DOI: 10.1021/jo010309g (B1)

EP-A1- 0 656 360 (B1)

EP-A1- 0 702 014 (B1)

HEIKO J. SCHUSTER ET AL: "Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 8, no. 8, 1 January 2010 (2010-01-01) , page 1833, XP55019053, ISSN: 1477-0520, DOI: 10.1039/b925070k (B1)

LUTZ F. TIETZE ET AL: "Selective Treatment of Cancer: Synthesis, Biological Evaluation and Structural Elucidation of Novel Analogues of the Antibiotic CC-1065 and the Duocarmycins", CHEMISTRY - A EUROPEAN JOURNAL, vol. 13, no. 16, 25 May 2007 (2007-05-25), pages 4396-4409, XP55004444, ISSN: 0947-6539, DOI: 10.1002/chem.200700113 (B1)

NOBUYOSHI AMISHIRO ET AL: "New Water-Soluble Duocarmycin Derivatives: Synthesis and Antitumor Activity of A-Ring Pyrrole Compounds Bearing [beta]-Heteroarylacryloyl Groups", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 4, 1 February 1999 (1999-02-01), pages 669-676, XP55018782, ISSN: 0022-2623, DOI: 10.1021/jm980559y (B1)

Nobuyoshi Amishiro ET AL: "Synthesis and antitumor activity of duocarmycin derivatives", Bioorganic & Medicinal Chemistry, vol. 8, no. 7, 1 July 2000 (2000-07-01), pages 1637-1643, XP055202616, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(00)00086-9 (B1)

PARRISH J P ET AL: "Establishment of Substituent Effects in the DNA Binding subunit of CBI Analogues of the Duocarmycins and CC-1065", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 11, 1 January 2003 (2003-01-01), pages 3815-3838, XP002379853, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(03)00194-9 (B1)

PARRISH J P ET AL: "Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 12, no. 22, 15 November 2004 (2004-11-15), pages 5845-5856, XP004604958, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2004.08.032 (B1)

US-A- 5 502 068 (B1)

US-A1- 2009 162 372 (B1)

WANG Y ET AL: "DESIGN, SYNTHESIS, CYTOTOXIC PROPERTIES AND PRELIMINARY DNA SEQUENCING EVALUATION OF CPI-N-METHYLPYRROLE HYBRIDS. ENHANCING EFFECT OF A TRANS DOUBLE BOND LINKER AND ROLE OF THE TERMINAL AMIDE FUNCTIONALITY ON CYTOTOXIC POTENCY", ANTI-CANCER DRUG DESIGN, OXFORD UNIVERSITY PRESS, BASINGSTOKE, vol. 11, 1 January 1996 (1996-01-01), pages 15-34, XP008049671, ISSN: 0266-9536 (B1)

WO-A1-02/096910 (B1)

WO-A1-03/097635 (B1)

WO-A2-2004/069201 (B1)

WO-A2-2004/101767 (B1)

WO-A2-2005/112919 (B1)

WO-A2-2007/038658 (B1)

WO-A2-2008/103693 (B1)

WO-A2-2010/062171 (B1)

WO-A2-97/44000 (B1)

WO-A2-98/11101 (B1)

ATWELL ET AL: "5-Amino-1-(chloromethyl)-1,2-dihydro-3H-b enz[eindoles:", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 42, no. 17, 1 January 1999 (1999-01-01), pages 3400-3411, XP002294767, ISSN: 0022-2623, DOI: 10.1021/JM990136B (B1)