BRENTJENS RENIER J ET AL: "Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 9, no. 3, 1 March 2003 (2003-03-01), pages 279-286, XP002389127, ISSN: 1078-8956 (B1)

C. M. KOWOLIK ET AL: "CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor Enhances In vivo Persistence and Antitumor Efficacy of Adoptively Transferred T Cells", CANCER RESEARCH, vol. 66, no. 22, 15 November 2006 (2006-11-15), pages 10995-11004, XP055044266, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-06-0160 (B1)

GADE TERENCE P F ET AL: "Targeted elimination of prostate cancer by genetically directed human T lymphocytes", CANCER RESEARCH, vol. 65, no. 19, October 2005 (2005-10), page 9080, XP002571428, ISSN: 0008-5472 (B1)

GROSENBACH D W ET AL: "A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 222, 1 March 2003 (2003-03-01), pages 45-57, XP002995005, ISSN: 0008-8749 (B1)

KOWOLIK CLAUDIA M ET AL: "CD28-costimulation provided through a CD19-specific chimeric immunoreceptor enhances in vivo persistence and anti-tumor efficacy of adoptively transferred T cells.", BLOOD, vol. 106, no. 11, Part 1, November 2005 (2005-11), page 372A, XP009130374, & 47TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 10 -13, 2005 ISSN: 0006-4971 (B1)

ZHONG ET AL: "Integrated CD28 and 4-1BB Signals Strongly Potentiate CD8+ T Cell Mediated radication of Metastatic Prostate Cancer", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 13, 1 January 2006 (2006-01-01), page S103, XP005675376, ISSN: 1525-0016 (B1)

MELERO I ET AL: "AMPLIFICATION OF TUMOR IMMUNITY BY GENE TRANSFER OF THE CO-STIMULATORY 4-1BB LIGAND: SYNERGY WITH THE CD28 CO-STIMULATORY PATHWAY", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 28, no. 3, 1 January 1998 (1998-01-01), pages 1116-1121, XP000914703, ISSN: 0014-2980 (B1)

SADELAIN M ET AL: "TARGETING TUMOURS WITH GENETICALLY ENHANCED T LYMPHOCYTES", NATURE REVIEWS. CANCER, NATUR PUBLISHING GROUP, LONDON, GB, vol. 3, no. 1, 1 January 2003 (2003-01-01) , pages 35-45, XP009026020, ISSN: 1474-175X (B1)

STEPHAN MATTHIAS T ET AL: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection", NATURE MEDICINE, vol. 13, no. 12, December 2007 (2007-12), pages 1440-1449, XP002571429, ISSN: 1078-8956 (B1)

XIAO-SONG ZHONG ET AL: "Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell-mediated Tumor Eradication", MOLECULAR THERAPY, vol. 18, no. 2, 1 February 2010 (2010-02-01), pages 413-420, XP055023623, ISSN: 1525-0016, DOI: 10.1038/mt.2009.210 (B1)

MAUS M V ET AL: "Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1 BB", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 20, no. 2, 1 February 2002 (2002-02-01), pages 143-148, XP002225278, ISSN: 1087-0156 (B1)