ANSON D S ET AL: "THE GENE STRUCTURE OF HUMAN ANTI-HAEMOPHILIC FACTOR IX" EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 3, no. 5, 1 January 1984 (1984-01-01) , pages 1053-1060, XP000872222 ISSN: 0261-4189 (B1)

CHANG JINLI ET AL: "Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity" JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 273, no. 20, 15 May 1998 (1998-05-15) , pages 12089-12094, XP002199691 ISSN: 0021-9258 cited in the application (B1)

FRANCHINI MASSIMO ET AL: "Treatment of hemophilia B: focus on recombinant factor IX.", BIOLOGICS : TARGETS & THERAPY 2013, vol. 7, 2013, pages 33-38, ISSN: 1177-5475 (B1)

J.D. FINN ET AL: "FIC-R338L (FIX Padua) as a succesful alternative for the treatment of canine severe hemophilia B.", BLOOD, vol. 114, no. 22, December 2009 (2009-12), page 694, DOI: https://doi.org/ Retrieved from the Internet: URL:http://www.bloodjournal.org/content/11 4/22/694> [retrieved on 2010-07-16] (B1)

MATHUR A ET AL: "Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa." THE JOURNAL OF BIOLOGICAL CHEMISTRY 25 JUN 1999, vol. 274, no. 26, 25 June 1999 (1999-06-25), pages 18477-18486, XP002555906 ISSN: 0021-9258 (B1)

SABATINO DENISE E ET AL: "Novel hemophilia B mouse models exhibiting a range of mutations in the Factor IX gene" BLOOD, vol. 104, no. 9, 1 November 2004 (2004-11-01), pages 2767-2774, XP002555908 ISSN: 0006-4971 (B1)

YAN JING-BIN ET AL: "Transgenic mice can express mutant human coagulation factor IX with higher level of clotting activity." BIOCHEMICAL GENETICS OCT 2006, vol. 44, no. 7-8, October 2006 (2006-10), pages 349-360, XP019447249 ISSN: 0006-2928 (B1)

SCHUETTRUMPF JOERG ET AL: "Factor IX variants improve gene therapy efficacy for hemophilia B" BLOOD, vol. 105, no. 6, 15 March 2005 (2005-03-15), pages 2316-2323, XP002555907 ISSN: 0006-4971 (B1)

SIMIONI PAOLO ET AL: "X-linked thrombophilia with a mutant factor IX (factor IX Padua)." THE NEW ENGLAND JOURNAL OF MEDICINE 22 OCT 2009, vol. 361, no. 17, 22 October 2009 (2009-10-22), pages 1671-1675, XP002555909 ISSN: 1533-4406 (B1)

WO-A-2007/149406 (B1)

WO-A-2008/092643 (B1)

WO-A-99/03496 (B1)

SCHAUB R ET AL: "Preclinical studies of recombinant factor IX", SEMINARS IN HEMATOLOGY, vol. 35, no. 2 SUPPL. 2, April 1998 (1998-04), pages 28-32, ISSN: 0037-1963 (B1)