BLANK CHRISTIAN ET AL: "Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion" CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 56, no. 5, May 2007 (2007-05), pages 739-745, XP002497527 ISSN: 0340-7004 (B1)

ZEHAVI-WILLNER T ET AL: "THE MITOGENIC ACTIVITY OF STAPHYLOCOCCAL ENTEROTOXIN B A MONOVALENT T CELL MITOGEN THAT STIMULATES CYTOLYTIC T LYMPHOCYTES BUT CANNOT MEDIATE THEIR LYTIC INTERACTION" JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 137, no. 8, 1 January 1986 (1986-01-01), pages 2682-2687, XP002164878 ISSN: 0022-1767 (B1)

DEL RIO MARIA-LUISA ET AL: "Antibody-mediated signaling through PD-1 costimulates T cells and enhances CD28-dependent proliferation" EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 35, no. 12, December 2005 (2005-12), pages 3545-3560, XP002497526 ISSN: 0014-2980 (B1)

DONG HAIDONG ET AL: "Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion" NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 8, no. 8, 24 June 2002 (2002-06-24), pages 793-800, XP002397368 ISSN: 1078-8956 (B1)

EIZ-VESPER BRITTA ET AL: "Tetanus toxoid provides efficient T-cell help for the induction of HA-1(H) cytotoxic T cells." TRANSFUSION JUL 2006, vol. 46, no. 7, July 2006 (2006-07), pages 1210-1220, XP002497529 ISSN: 0041-1132 (B1)

FLEISCHER B ET AL: "T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells." THE JOURNAL OF EXPERIMENTAL MEDICINE 1 MAY 1988, vol. 167, no. 5, 1 May 1988 (1988-05-01), pages 1697-1707, XP002497528 ISSN: 0022-1007 (B1)

IWAI YOSHIKO ET AL: "Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 99, no. 19, 17 September 2002 (2002-09-17), pages 12293-12297, XP002398159 ISSN: 0027-8424 (B1)

KABILAN L ET AL: "DETECTION OF INTRACELLULAR EXPRESSION AND SECRETION OF INTERFERON-GAMMA AT THE SINGLE-CELL LEVEL AFTER ACTIVATION OF HUMAN T CELLS WITH TETANUS TOXOID IN VITRO" EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 20, 1 January 1990 (1990-01-01), pages 1085-1089, XP008051762 ISSN: 0014-2980 (B1)

RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 79, no. 6, 1 March 1982 (1982-03-01), pages 1979-1983, XP002986051, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979 (B1)

US-A1- 2006 210 567 (B1)

US-B1- 6 808 710 (B1)

VAUGHAN T J ET AL: "Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library" NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 14, 1 March 1996 (1996-03-01), pages 309-314, XP000196144 ISSN: 1087-0156 (B1)

WALDMANN THOMAS A: "Effective cancer therapy through immunomodulation" ANNUAL REVIEW OF MEDICINE : SELECTED TOPICS IN THE CLINICALSCIENCES, ANNUAL REVIEWS INC., PALO ALTO, CA, vol. 57, 1 January 2006 (2006-01-01), pages 65-81, XP002466285 ISSN: 0066-4219 (B1)

WO-A-2006/121168 (B1)

WONG RAYMOND M ET AL: "Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs" INTERNATIONAL IMMUNOLOGY, vol. 19, no. 10, October 2007 (2007-10), pages 1223-1234, XP002497525 ISSN: 0953-8178 (B1)

DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding" IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, 1 September 1996 (1996-09-01), pages 169-179, XP004070292 ISSN: 1380-2933 (B1)