ZHOU T ET AL: "Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses", BIOSYSTEMS, vol. 81, no. 1, 1 July 2005 (2005-07-01), pages 77-86, XP004905562, NORTH-HOLLAND, AMSTERDAM, NL ISSN: 0303-2647, DOI: 10.1016/J.BIOSYSTEMS.2005.03.002 (B1)

WO-A2-02/095363 (B1)

Gao et al, Virology 2015 Nov;485:135-44 (B2)

Li et al. J Virol. 2018 Aug 16:92(17) (B2)

Martrus el al, Retrovirology 2013 Jul 25; 10:78 (B2)

WO-A1-00/07622 (B2)

WO-A1-98/41619 (B2)

BURNS CARA CARTHEL ET AL: "Modulation of poliovirus replicative fitness in HeLa cells by deoptimization of synonymous codon usage in the capsid region", JOURNAL OF VIROLOGY, vol. 80, no. 7, April 2006 (2006-04), pages 3259-3272, XP002633525, -& WO 2006/042156 A2 (US GOV HEALTH & HUMAN SERV [US]; KEW OLEN M [US]; BURNS CARA C [US]; S) 20 April 2006 (2006-04-20) (B1)

COLEMAN J ROBERT ET AL: "Virus attenuation by genome-scale changes in codon pair bias.", SCIENCE, vol. 320, no. 5884, 27 June 2008 (2008-06-27), pages 1784-1787, XP002633528, ISSN: 1095-9203 (B1)

DATABASE EMBL [Online] 10 September 2007 (2007-09-10), "Synthetic construct capsid protein P1-Min gene, partial cds.", XP002633527, retrieved from EBI accession no. EM_SY:EU095953 Database accession no. EU095953 (B1)

GU WANJUN ET AL: "Analysis of synonymous codon usage in SARS Coronavirus and other viruses in the Nidovirales.", VIRUS RESEARCH, vol. 101, no. 2, May 2004 (2004-05), pages 155-161, XP002633530, ISSN: 0168-1702 (B1)

MUELLER STEFFEN ET AL: "Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity.", JOURNAL OF VIROLOGY, vol. 80, no. 19, October 2006 (2006-10), pages 9687-9696, XP002633526, ISSN: 0022-538X (B1)

TOYODA HIDEMI ET AL: "Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model.", CANCER RESEARCH, vol. 67, no. 6, 15 March 2007 (2007-03-15) , pages 2857-2864, XP002633529, ISSN: 0008-5472 (B1)

US-A1- 2004 209 241 (B1)

US-A9- 2004 097 439 (B1)

US-B1- 6 696 289 (B1)

WIMMER ECKARD ET AL: "Synthetic viruses: a new opportunity to understand and prevent viral disease", NATURE BIOTECHNOLOGY, vol. 27, no. 12, December 2009 (2009-12), pages 1163-1172, XP002633531, ISSN: 1087-0156 (B1)

DE JESUS et al.: "Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence", J. Virol., vol. 79, no. 22, November 2005 (2005-11), pages 14235-14243, (B2)