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Tittel Apoptosis signal-regulating kinase inhibitors
Status
Hovedstatus
Detaljstatus 		I kraft info EP patent gjort gjeldende i Norge EP patent besluttet gjeldende i Norge
Patentnummer NO/EP2933252
Europeisk (EP) publiserings nummer EP2933252
EP levert
EP søknadsnummer 15151030.2
EP meddelt
Avdelt fra EP2454250
Avdelt til EP3363797;
Prioritet 2009.07.13, US 225076 P, .... se mer/flere nedenfor
Sakstype Europeisk
Løpedag
Utløpsdato
Allment tilgjengelig
Validert i Norge
Innehaver GILEAD SCIENCES, INC. (US)
Oppfinner CORKEY, Britton (US) .... se mer/flere nedenfor
Fullmektig ZACCO NORWAY AS (NO)
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Beskrivelse

Enclosed is a translation of the patent claims in Norwegian. Please note that as per the Norwegian Patents Acts, section 66i the patent will receive protection in Norway only as far as there is agreement between the translation and the language of the application/patent granted at the EPO. In matters concerning the validity of the patent, language of the application/patent granted at the EPO will be used as the basis for the decision. The patent documents published by the EPO are available through Espacenet (http://worldwide.espacenet.com) or via the search engine on our website here: https://search.patentstyret.no/

Krav

Patentkrav1. Forbindelse med formel I for anvendelse ved behandling av en akutt kardiovaskulær sykdomshendelse, hvori forbindelsen med formel I administreres samtidig med et terapeutisk middel, og formel I er:hvori:R1 er alkyl med 1-10 karbonatomer, sykloalkyl med 3-8 karbonatomer, alkenyl med 2-10 karbonatomer, alkynyl med 2-10 karbonatomer, aryl, heteroaryl eller heterosyklyl, som alle eventuelt er substituert med 1, 2, eller 3 substituenter valgt fra halogen, okso, alkyl med 1-6 karbonatomer, sykloalkyl med 3-8 karbonatomer, heterosyklyl, fenyl, fenoksy, halogen, -CN, -O-R6, -C(O)-R6, -OC(O)-R6 -C(O)-O-R6, - N(R6)-C(O)-O-R7, -N(R6)-C(O)-R7,-N(R6)-C(O)-N(R6)(R7), og -C(O)-N(R6)(R7), hvori alkyl, sykloalkyl, heterosyklyl, fenyl og fenoksy eventuelt er substituert med 1, 2 eller 3 substituenter valgt fra alkyl med 1-6 karbonatomer, sykloalkyl med 3-8 karbonatomer, alkoksy med 1-6 karbonatomer, hydroksyl og halogen; gitt at R1 ikke er metyl når R3 er morfolinyl eller furyl;hvori R6 og R7 er uavhengig valgt fra gruppen som består av hydrogen, alkyl med 1-6 karbonatomer eller sykloalkyl med 3-8 karbonatomer; ellerR6 og R7 når de tas sammen med nitrogenet de er bundet til, danner en heterosyklus;R2 er hydrogen, halogen, cyano, alkoksy, eller alkyl eventuelt substituert med halogen;R3 er aryl, heteroaryl eller heterosyklyl, som alle eventuelt er substituert med 1, 2 eller 3 substituenter valgt fra alkyl med 1-6 karbonatomer, alkoksy med 1-6 karbonatomer, sykloalkyl med 3-8 karbonatomer, sykloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterosyklyl, heterosyklylalkyl, halogen, halogenalkoksy, okso, -CN, -O-R6, - O-C(O)-R6, -O-C(O)-N(R6)(R7), -S-R6,-N(R6)(R7), -S(=O)-R6, -S(=O)2R6, -S(=O)2-N(R6)(R7), -S(=O)2-O-R6,-N(R6)-C(O)-R7, -N(R6)-C(O)-O-R7, -N(R6)-C(O)-N(R6)(R7), -C(O)-R6,-C(O)-O-R6, -C(O)-N(R6)(R7), og -N(R6)-S(=O)2-R7, hvori alkylet, alkoksyet, sykloalkylet, arylet, heteroarylet eller heterosyklylet eventuelt er substituert med én eller flere substituenter valgt fra halogen, hydroksyl, okso, -CN, og -O-R6;med det forbehold at heteroaryl- eller heterosyklylresten inkluderer minst ett ringnitrogenatom;X1, X2, X3, X4, X5, X6, X7 og X8 er uavhengig C(R4) eller N, der hver R4 er uavhengig hydrogen, hydroksyl, halogen, alkyl med 1-6 karbonatomer, alkoksy med 1-6 karbonatomer eller sykloalkyl med 3-8 karbonatomer, hvori alkylet eller sykloalkylet er videre eventuelt substituert med én eller flere substituenter valgt fra halogen, hydroksyl, okso, -CF3, -O-CF3, -N(R6)(R7), -C(O)-R6, -C(O)-O-R7, -C(O)-N(R6)(R7), -CN, -O-R6; ellerX5 og X6 eller X6 og X7 sammenføyes for å tilveiebringe kondensert sykloalkyl, kondensert aryl eller kondensert heteroaryl, som alle eventuelt er substituert med alkyl med 1-6 karbonatomer, hydroksyl eller halogen; ogmed det forbehold at minst én av X2, X3, og X4 er C(R4);minst to av X5, X6, X7, og X8 er C(R4); ogminst én av X2, X3, X4, X5, X6, X7 og X8 er N.2. Forbindelsen for anvendelse ifølge rav 1, hvori det terapeutiske midlet er for anvendelse ved behandling av sykdommer eller tilstander som er kardiovaskulære av art, lungeforstyrrelser, metabolske forstyrrelser eller gastrointestinale forstyrrelser; eller tilstander som drar fordel av administrering av terapeutiske midler valgt fra gruppen som består av antibiotika, analgetika, antidepressiva og anti-angstmidler.3. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er for anvendelse ved behandling av kardiovaskulære sykdommer, eventuelt hvori sykdommen er valgt fra gruppen som består av angina, arytmier, tilbakevendende halting, myokardinfarkt, hjertesvikt og tilbakevendende iskemi.4. Forbindelsen for anvendelse ifølge krav 1 eller krav 3, hvori det terapeutiske midlet er valgt fra gruppen som består av anti-anginaler, hjertesviktmidler, antitrombotiske midler, antiarytmiske midler, antihypertensive midler og lipidsenkende midler.5. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er for anvendelse ved behandling av lungeforstyrrelser, eventuelt hvori forstyrrelsen er valgt fra gruppen som består av astma, kronisk obstruktiv lungesykdom (KOLS), bronkitt og emfysem.6. Forbindelsen ifølge krav 1 eller krav 5, hvori det terapeutiske midlet er en bronkodilator, kortikosteroid eller et elektrolyttilskudd.7. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er for anvendelse ved behandling av metabolske forstyrrelser, idet den metabolske forstyrrelsen eventuelt er valgt fra gruppen som består av diabetes, metabolsk syndrom, dyslipidemi, fedme, glukoseintoleranse, hypertensjon, forhøyet serumkolesterol og forhøyede triglyserider.8. Forbindelsen for anvendelse ifølge krav 1 eller krav 7, hvori det terapeutiske midlet er valgt fra gruppen som består av antihypertensive midler, lipidsenkende midler, insulin, sulfonylureaer, biguanider, alfa-glukosidasehemmere og inkretinetterlignere.9. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er for anvendelse ved behandling av gastrointestinale forstyrrelser, den gastrointestinale forstyrrelsen er eventuelt valgt fra gruppen som består av gastroøsofageal reflukssykdom (GERD), inflammatorisk tarmsykdom (IBD), gastroenteritt, gastritt og peptisk sårsykdom og pankreatitt.10. Forbindelsen for anvendelse ifølge krav 1 eller krav 9, hvori det terapeutiske midlet er valgt fra gruppen som består av protonpumpehemmere, H2-blokkere, prostaglandiner, sukralfat og antacider.11. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er et antibiotisk middel valgt fra gruppen som består av β-laktamantibiotika, tetrasykliner, makrolidantibiotika, aminoglykosider, kinoloner, sykliske peptider, linkosamider og sulfaantibiotika.12. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er et analgetisk middel valgt fra gruppen som består av opiater, morfinoetterlignere, NSAID-er og COX-2-hemmere.13. Forbindelsen for anvendelse ifølge krav 1, hvori det terapeutiske midlet er et antidepressivt middel og anti-angstmiddel valgt fra gruppen som består av benzodiazepiner, enzodiazepiner, barbiturater, glutetimid, klorhydrat, meprobamat, sertralin, escitalopram, fluoksetin, venlafaksin, citalopram, paroksetin, trazodon, amitriptylin og bupropion.14. Farmasøytisk sammensetning som omfatter en forbindelse med formel I som definert i krav 1 og et terapeutisk middel som definert i ett av kravene 4, 6, 8 og 10 til 13.15. Forbindelsen for anvendelse ifølge ett av kravene 1 til 13 eller den farmasøytiske sammensetningen ifølge krav 14, hvori forbindelsen med formel I er valgt fra gruppen som består av:6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(2-syklopropylpyrimidin-5-yl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(2,2,2-trifluoretyl)-3,4'-bipyridin-2'-karboksamid;4-(imidazo[1,2-a]pyridin-3-yl)-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-pikolinamid;4-(2-aminopyrimidin-5-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-fenylpikolinamid;N-(3-(4-(tetrahydro-2H-pyran-4-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1H-imidazol-1-yl)pikolinamid; N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-4-fenylpikolinamid;N-(3-(4-(3-amino-3-oksopropyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1H-1,2,4-triazol-1-yl)pikolinamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-6-fenylpikolinamid;N-(3-(4-(2-acetamidoetyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-metylpiperazin-1-yl)pikolinamid; N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-2,3'-bipyridin-6-karboksamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-4-morfolinopikolinamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(kinolin-6-yl)pikolinamid;(R)-N-(3-(4-(1-hydroksypropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-hydroksy-3,4'-bipyridin-2'-karboksamid;(S)-N-(3-(4-(1-hydroksypropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(3-oksopiperazin-1-yl)pikolinamid; N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-metoksy-3,4'-bipyridin-2'-karboksamid;4-(3-aminopyrrolidin-1-yl)-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid; 6-amino-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;(R)-N-(3-(4-(2-hydroksypropyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;5-metoksy-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;Metyl 2'-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenylkarbamoyl)-3,4'-bipyridin-6-ylkarbamat;(S)-N-(3-(4-(2-hydroksypropyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;4-(1-metyl-1H-imidazol-5-yl)-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1-metyl-1H-imidazol-5-yl)pikolinamid;4-(1H-benzo[d]imidazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(2,4-dimetoksypyrimidin-5-yl)pikolinamid;N-(3-(4-((1-hydroksysyklopropyl)metyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-fenyl-1H-imidazol-1-yl)pikolinamid;N-(3-(4-syklobutyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N2'-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2',6-dikarboksamid;(S)-N-(3-(4-(1,1,1-trifluorpropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopentyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(trifluormetyl)-3,4'-bipyridin-2'-karboksamid;N2'-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2',5-dikarboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(2-metyl-1H-imidazol-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-metyl-3,4'-bipyridin-2'-karboksamid;5-cyano-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-metyl-1H-imidazol-1-yl)pikolinamid;2-amino-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4,5-dimetyl-1H-imidazol-1-yl)pikolinamid;N-(3-(4-((1S,2S)-2-metylsyklopropyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-2-metoksy-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(trifluormetyl)-1H-imidazol-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(2,2,2-trifluoretoksy)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1-metyl-1H-pyrazol-4-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(2-metoksypyrimidin-5-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-metyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(imidazo[1,2-a]pyridin-3-yl)pikolinamid;6'-metyl-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N-(3-(4-(2,2,2-trifluoretyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-klor-[3,2',5',4"]terpyridin-2"-karboksylsyre [3-(4-syklopropyl-4H-[1,2,4]triazol-3-yl)-fenyl]amid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(pyrrolidin-1-yl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5-(trifluormetyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1,2-dimetyl-1H-imidazol-5-yl)pikolinamid;4-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-sulfamoylfenyl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5-metoksy-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-fluor-5-metyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5-fluor-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-2-metyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(N-metylsulfamoyl)fenyl)pikolinamid;N5-tert-butyl-N2'-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2',5-dikarboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(pyrazin-2-yl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(N-isopropylsulfamoyl)fenyl)pikolinamid;5-klor-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(3-(metylsulfonyl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(isokinolin-4-yl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(2-(metylsulfonyl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1,5-dimetyl-1H-pyrazol-4-yl)pikolinamid;6-syklobutyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-isopropyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(metylsulfonyl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(dimetylamino)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)pikolinamid;6-syklopropoksy-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1H-imidazo[4,5-b]pyridin-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-fluor-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(2-oksoimidazolidin-1-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(3H-imidazo[4,5-b]pyridin-3-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-isopropoksy-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1H-imidazo[4,5-c]pyridin-1-yl)pikolinamid;6-syklobutoksy-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(kinolin-3-yl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(N-syklopropylsulfamoyl)fenyl)pikolinamid;6-syklopentyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(imidazo[2,1-b][1,3,4]tiadiazol-5-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(5-syklopropylpyrazin-2-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(1-metyl-2-oksopyrrolidin-3-yl)-3,4'-bipyridin-2'-karboksamid;4-(4-klor-1H-imidazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5-fluor-3,4'-bipyridin-2'-karboksamid;(S)-4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(3-metylbutan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;6'-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-2,3'-bipyridin-6-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(5-metyl-4-(trifluormetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)pikolinamid;4-(5-syklopropyl-4-metyl-4H-1,2,4-triazol-3-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(3-syklopropyl-1,2,4-oksadiazol-5-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(3-metyl-1,2,4-oksadiazol-5-yl)pikolinamid;6-syklopropyl-N-(3-(4-(3-hydroksybutan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(5-(1-hydroksyetyl)-1,3,4-oksadiazol-2-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(6-metoksykinolin-3-yl)pikolinamid; 6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5'-metyl-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6'-metyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1-(2,2,2-trifluoretyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1-isopropyl-1H-pyrrolo[3,2-b]pyridin-6-yl)pikolinamid;(S)-6-syklopropyl-N-(3-(4-(3,3-dimetylbutan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-sek-butyl-4H-1,2,4-triazol-3-yl)fenyl)-6-syklopropyl-3,4'-bipyridin-2'-karboksamid;(S)-6-syklopropyl-N-(3-(4-(1-syklopropyletyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(pentan-3-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;(S)-6-syklopropyl-N-(3-(4-(1-metoksypropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;(S)-N-(3-(4-sek-butyl-4H-1,2,4-triazol-3-yl)fenyl)-6-syklopropyl-3,4'-bipyridin-2'-karboksamid;(S)-6-syklopropyl-N-(3-(4-(3-metylbutan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;(R)-6-syklopropyl-N-(3-(4-(1-(2,6-dimetylfenoksy)propan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;(S)-6-syklopropyl-N-(3-(4-(1,1,1-trifluorpropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklobutyl-4H-1,2,4-triazol-3-yl)fenyl)-6-syklopropyl-3,4'-bipyridin-2'-karboksamid;(S)-6-syklopropyl-N-(3-(4-(1-fenyletyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-isopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-(syklopropylmetyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; 4-(4-syklopropyl-2-metyl-1H-imidazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-isopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(syklopropylmetyl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(1-fenyletyl)-4H-1H-1,2,4-triazol-3-yl)fenyl)pikolinamid;(R)-4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(1,1,1-trifluorpropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1,5-naftyridin-3-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(trifluormetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(perfluoretyl)-1H-imidazol-1-yl)pikolinamid;4-(3-syklopropyl-1H-1,2,4-triazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(5-syklopropyl-1H-1,2,4-triazol-1-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(2,2,2-trifluor-1-hydroksyetyl)-1H-imidazol-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(2-etylpyrimidin-5-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5-etyl-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)-4-fluorfenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)-4-fluorfenyl)-6-etyl-3,4'-bipyridin-2'-karboksamid;6-tert-butyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(5,6,7,8-tetrahydro-1,6-naftyridin-3-yl)pikolinamid; 6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)-2-fluorfenyl)-3,4'-bipyridin-2'-karboksamid;5-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)-2-fluorfenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-etyl-1H-imidazol-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(6-(2,2,2-trifluoretyl)-5,6,7,8-tetrahydro-1,6-naftyridin-3-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-isopropyl-1H-imidazol-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(2-hydroksypropan-2-yl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)-5-fluorfenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)-5-fluorfenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(6-isopropyl-5,6,7,8-tetrahydro-1,6-naftyridin-3-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(6-metyl-5,6,7,8-tetrahydro-1,6-naftyridin-3-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(3-hydroksypiperidin-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-etyl-3-oksopiperazin-1-yl)pikolinamid;N-(3-(4-isopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-propyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-neopentyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1-metyl-2-fenyl-1H-imidazol-5-yl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(etylsulfonyl)fenyl)-pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(isopropylsulfonyl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(etylamino)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(syklopropylamino)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6'-(trifluormetyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(kinolin-3-yl)-6-(trifluormetyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(1H-pyrrolo[3,2-b]pyridin-6-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-syklopropylfenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(metyltio)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(isobutyltio)-3,4'-bipyridin-2'-karboksamid;5-klor-6-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(2-metoksyetylamino)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-(metylsulfonyl)piperazin-1-yl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-etyl-5-fluor-3,4'-bipyridin-2'-karboksamid;5-klor-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-etyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-5,6-dietyl-3,4'-bipyridin-2'-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(furo[3,2-b]pyridin-6-yl)pikolinamid; N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(3-metyl-3H-imidazo[4,5-b]pyridin-6-yl)pikolinamid;6-syklopropyl-N-(3-(4-(2-fenylsyklopropyl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;(S)-4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(1,1,1-trifluorpropan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(syklopropylmetyl)-3,4'-bipyridin-2'-karboksamid;4-(5-syklopropyl-1,3,4-tiadiazol-2-yl)-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(kinolin-3-yl)benzamid; N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-(6-syklopropylpyridin-3-yl)-2,4-difluorbenzamid;4-klor-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-(6-syklopropylpyridin-3-yl)-2-fluorbenzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(4-(2,2,2-trifluor-1-metoksyetyl)-1H-imidazol-1-yl)benzamid;3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-metoksybenzamid;4-klor-3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-(6-syklopropylpyridin-3-yl)-2-fluorbenzamid;3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid;(S)-3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-(1-fenyletyl)-4H-1H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(1,5-naftyridin-3-yl)benzamid;3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(4-isopropyl-1H-imidazol-1-yl)benzamid; 3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-metylbenzamid;5-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-metylbenzamid;3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-metylbenzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(6-(2-hydroksypropan-2-yl)pyridin-3-yl)benzamid;3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-fluorbenzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(4-(2,2,2-trifluor-1-hydroksyetyl)-1H-imidazol-1-yl)benzamid;3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-metylbenzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(4,5-dimetyl-1H-imidazol-1-yl)benzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-1-yl)benzamid;1-(3-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-ylkarbamoyl)fenyl)-5-metyl-1H-imidazol-4-karboksylsyre;(S)-3-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-(1-fenyletyl)-4H-1H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid;(S)-3-(4,5-dimetyl-1H-imidazol-1-yl)-N-(6-(4-(1,1,1-trifluorpropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(6-syklopropylpyridin-3-yl)benzamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(pyridin-3-yl)benzamid; N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-(6-syklopropylpyridin-3-yl)-2,4-difluorbenzamid;4-klor-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5-(6-syklopropylpyridin-3-yl)-2-fluorbenzamid;3-(4-syklopropyl-1H-1,2,3-triazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamid N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(6-syklopropylpyridin-3-yl)-7,8-dimetylkinolin-2-karboksamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-4-(pyridin-3-yl)kinolin-2-karboksamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-3,3'-bipyridin-5-karboksamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-5-fenylnikotinamid;N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-2-fenylisonikotinamid;6'-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-2,3'-bipyridin-6-karboksamid;6'-syklopropyl-N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-2,3'-bipyridin-4-karboksamid;5-(2,5-difluorfenyl)-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)nikotinamid;N-(3-(4-syklopropyl-4H-1,2,4-triazol-3-yl)fenyl)-6-(6-syklopropylpyridin-3-yl)pyrimidin-4-karboksamid;6'-syklopropyl-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2,3'-bipyridin-4-karboksamid;2-hydroksy-N-(3-(4-metyl-4H-1,2,4-triazol-3-yl)fenyl)-6-fenylpyrimidin-4-karboksamid;N-(6-(1-syklopropyl-1H-imidazol-5-yl)pyridin-2-yl)-4-(4,5-dimetyl-1H-imidazol-1-yl)pikolinamid;N-(6-(1-syklopropyl-1H-imidazol-5-yl)pyridin-2-yl)-6-(2-hydroksypropan-2-yl)-3,4'-bipyridin-2'-karboksamid;N-(6-(1-syklopropyl-1H-imidazol-5-yl)pyridin-2-yl)-4-(kinolin-3-yl)pikolinamid; 6-syklopropyl-N-(6-(1-syklopropyl-1H-imidazol-5-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(1-syklopropyl-1H-imidazol-5-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(1-syklopropyl-1H-imidazol-5-yl)fenyl)-3,4'-bipyridin-2'-karboksamid; 4-(1H-benzo[d]imidazol-1-yl)-N-(3-(1-syklopropyl-1H-imidazol-5-yl)fenyl)pikolinamid;N-(3-(1-syklopropyl-1H-imidazol-5-yl)fenyl)-4-(kinolin-3-yl)pikolinamid; 6-syklopropyl-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4,5-dimetyl-1H-imidazol-1-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-(2-hydroksypropan-2-yl)-3,4'-bipyridin-2'-karboksamid.6'-syklopropyl-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2,3'-bipyridin-6-karboksamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(5-metyl-4-(trifluormetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)pikolinamid; 6-syklopropyl-N-(6-(4-((2R)-3-hydroksybutan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(6-(4-((2S,3R)-3-hydroksybutan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(6-(4-((2S,3S)-3-hydroksybutan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(6-(4-(1-(pyrrolidin-1-yl)propan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(6-syklopropylpyridin-3-yl)-7,8-dimetylkinolin-2-karboksamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)kinolin-2-karboksamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(6-syklopropylpyridin-3-yl)kinolin-2-karboksamid;4-(4-syklopropyl-2-metyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-1-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-(trifluormetyl)-1H-imidazol-1-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-(trifluormetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-(perfluoretyl)-1H-imidazol-1-yl)pikolinamid; 4-(3-syklopropyl-1H-1,2,4-triazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-(2,2,2-trifluor-1-hydroksyetyl)-1H-imidazol-1-yl)pikolinamid;6-syklopropyl-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-5'-metyl-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(2-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-4-yl)-3,4'-bipyridin-2'-karboksamid;N-(2-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-4-yl)-4-(kinolin-3-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-metyl-1H-imidazol-1-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-isopropyl-1H-imidazol-1-yl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(3-hydroksypiperidin-1-yl)pikolinamid;6-syklopropyl-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-etyl-3-oksopiperazin-1-yl)pikolinamid;(R)-6-syklopropyl-N-(6-(4-(1,1,1-trifluorpropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-(N-metylsulfamoyl)fenyl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(kinolin-3-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-fenyl-1H-imidazol-1-yl)pikolinamid;N-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-(4-(metylsulfonyl)fenyl)pikolinamidN-(6-(4-syklopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3,4'-bipyridin-2'-karboksamid; 6-syklopropyl-N-(3-(4-fenyl-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(pyrimidin-5-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;N-(3-(4-(but-2-ynyl)-4H-1,2,4-triazol-3-yl)fenyl)-6-syklopropyl-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(1-(pyridin-3-yloksy)propan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;6-syklopropyl-N-(3-(4-(1-(2,2,2-trifluoretoksy)propan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)-3,4'-bipyridin-2'-karboksamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-fenyl-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(pyrimidin-5-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid;N-(3-(4-(but-2-ynyl)-4H-1,2,4-triazol-3-yl)fenyl)-4-(4-syklopropyl-1H-imidazol-1 - yl)pikolinamid;4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(1-(pyridin-3-yloksy)propan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid; og4-(4-syklopropyl-1H-imidazol-1-yl)-N-(3-(4-(1-(2,2,2-trifluoretoksy)propan-2-yl)-4H-1,2,4-triazol-3-yl)fenyl)pikolinamid.
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Innehaver i EP:
GILEAD SCIENCES, INC.
333 Lakeside Drive Foster City,California 94404 US

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CORKEY, Britton
355 Buena Vista Ave EastApt 415 San Francisco, CA 94117 US
Graupe, Michael
1131 Banyan Way Pacifica, CA 94044 US
Koch, Keith
384 Baker Lane Erie, CO 80516 US
Melvin, Lawrence S.
7623 Crestview Drive Longmont, CO 80504 US
Notte, Gregory
707 Highland Ave , Apt 2 San Mateo, CA 94401 US

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Fullmektig i Norge:
ZACCO NORWAY AS
Postboks 488 0213 OSLO NO ( OSLO kommune, Oslo fylke )

Org.nummer: 982702887
Din referanse: V5843NO00
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Kilde: Brønnøysundregistrene
Fullmektig i EP:
Wallace, Sheila Jane
Marks & Clerk LLP 90 Long Acre London WC2E 9RA GB

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2009.07.13, US 225076 P

2009.07.13, US 225079 P

2009.12.22, US 289263 P

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EP-A1- 2 058 309 (B1)

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