Ahmed Kamal ET AL: "Recent Developments Towards Podophyllotoxin Congeners as Potential Apoptosis Inducers", Anti-Cancer Agents in Medicinal Chemistry, 1 January 2015 (2015-01-01), pages 565-574, XP055464819, Retrieved from the Internet: URL:https://www.researchgate.net/profile/M ohammed_Ali_Syed/publication/269182814_Rec ent_Developments_Towards_Podophyllotoxin_C ongeners_as_Potential_Apoptosis_Inducers/l inks/55da9bb608aec156b9ae7d8c/Recent-Devel opments-Towards-Podophyllotoxin-Congeners- as-Potential-Apoptosis-Inducers.pdf (B1)

CANEL C ET AL: "Podophyllotoxin", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 54, no. 2, 1 May 2000 (2000-05-01), pages 115-120, XP027253885, ISSN: 0031-9422 [retrieved on 2000-05-01] (B1)

Carlos Galmarini: "Lurbinectedin (PM01183) synergizes with topoisomerase I inhibitors in vitro and in vivo", Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1, 15 April 2013 (2013-04-15), XP055140973, Retrieved from the Internet: URL:http://cancerres.aacrjournals.org/cgi/ content/short/73/8_MeetingAbstracts/5499 [retrieved on 2014-09-17] (B1)

EP-A1- 1 806 349 (B1)

HANDE ET AL: "Topoisomerase II inhibitors", UPDATE ON CANCER THERAPEUTICS, ELSEVIER, AMSTERDAM, NL, vol. 3, no. 1, 25 March 2008 (2008-03-25), pages 13-26, XP022547503, ISSN: 1872-115X, DOI: 10.1016/J.UCT.2008.02.001 (B1)

HUI XU ET AL: "A Review on Hemisynthesis, Biosynthesis, Biological Activities, Mode of Action, and Structure-Activity Relationship of Podophyllotoxins: 2003- 2007", CURRENT MEDICINAL CHEMISTRY, vol. 16, no. 3, 1 January 2009 (2009-01-01), pages 327-349, XP055464813, NL ISSN: 0929-8673, DOI: 10.2174/092986709787002682 (B1)

WO-A2-2009/140675 (B1)

José Guillén ET AL: "In vivo combination studies of PM01183 with alkylating, antimetabolites, DNA-topoisomerase inhibitors and tubulin binding agents", , 5 April 2011 (2011-04-05), XP055021187, Retrieved from the Internet: URL:http://www.abstractsonline.com/Plan/Vi ewAbstract.aspx?sKey=17ec9ca9-693a-4df8-8e 8c-857ab3e72dc7&cKey=09c40d0f-78d3-44d9-ba c5-c1117328e5c6&mKey={507D311A-B6EC-436A-B D67-6D14ED39622C} [retrieved on 2012-03-07] (B1)

MARTINO EMANUELA ET AL: "The long story of camptothecin: From traditional medicine to drugs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 27, no. 4, 31 December 2016 (2016-12-31), pages 701-707, XP029906416, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2016.12.085 (B1)

Mullangi Ramesh ET AL: "Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives", BIOMEDICAL CHROMATOGRAPHY., vol. 24, no. 1, 1 January 2010 (2010-01-01), pages 104-123, XP055464812, GB ISSN: 0269-3879, DOI: 10.1002/bmc.1345 (B1)

POMMIER Y: "Topoisomerase I inhibitors: Camptothecins and beyond", NATURE REVIEWS. CANCER, NATUR PUBLISHING GROUP, LONDON, GB, vol. 6, no. 10, 1 October 2006 (2006-10-01), pages 789-802, XP008111523, ISSN: 1474-175X, DOI: 10.1038/NRC1977 (B1)

TF Imbert: "Discovery of podophyllotoxins", Biochimie, 1 January 1998 (1998-01-01), pages 207-222, XP055464815, Retrieved from the Internet: URL:https://ac.els-cdn.com/S03009084988000 47/1-s2.0-S0300908498800047-main.pdf?_tid= 7f3ff6d4-a7b2-4849-87bc-62ad2b8f02df&acdna t=1522922356_86b7682bf61733479afdec0102b93 ae2 (B1)

JFM LEAL ET AL: "PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity", BRITISH JOURNAL OF PHARMACOLOGY, vol. 161, no. 5, 2 July 2010 (2010-07-02), pages 1099-1110, XP055013260, ISSN: 0007-1188, DOI: 10.1111/j.1476-5381.2010.00945.x (B1)